Diana Hansen

CyTOF mass cytometry analysis of human memory CD4 T cells and memory B cells.

Lisa J Ioannidis, Andrew J Mitchell, Tian Zheng, Diana S Hansen

Journal article  |  2022  |  STAR Protoc

High-dimensional mass cytometry provides unparalleled insight into the cellular composition of the immune system. Here, we describ..

Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

Stephanie Studniberg, Lisa J Ioannidis, Retno AS Utami, Leily Trianty, Yang Liao, Waruni Abeysekera, Connie SN Li-Wai-Suen, Halina M Pietrzak, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Alan F Cowman, Ric N Price, et al.

Journal article  |  2022  |  MOLECULAR SYSTEMS BIOLOGY

Clinical immunity to P. falciparum malaria is non-sterilizing, with adults often experiencing asymptomatic infection. Historically..

Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection.

Steven J Mileto, Melanie L Hutton, Sarah L Walton, Antariksh Das, Lisa J Ioannidis, Don Ketagoda, Kylie M Quinn, Kate M Denton, Diana S Hansen, Dena Lyras

Journal article  |  2022  |  Gut Microbes

Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea, with disease mediated by two major..

High-dimensional mass cytomet identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria

Lisa J Ioannidis, Halina M Pietrzak, Ann Ly, Retno As Utami, Emily M Eriksson, Stephanie Studniberg, Waruni Abeysekera, Connie SN Li-Wai-Suen, Dylan Sheerin, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah N Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Leily Trianty, et al.

Journal article  |  2021  |  JCI INSIGHT

IFN-γ-driven responses to malaria have been shown to modulate the development and function of T follicular helper (TFH) cells and ..

Transcriptional Memory-Like Imprints and Enhanced Functional Activity in gamma delta T Cells Following Resolution of Malaria Infection

Rasika Kumarasingha, Lisa J Ioannidis, Waruni Abeysekera, Stephanie Studniberg, Dinidu Wijesurendra, Ramin Mazhari, Daniel P Poole, Ivo Mueller, Louis Schofield, Diana S Hansen, Emily M Eriksson

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

γδ T cells play an essential role in the immune response to many pathogens, including Plasmodium. However, long-lasting effects of..

Identifying Barriers to Career Progression for Women in Science: Is COVID-19 Creating New Challenges?

Diana S Hansen

Journal article  |  2020  |  TRENDS IN PARASITOLOGY

This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in Febru..

IgM( )memory B cells induced in response toPlasmodium bergheiadopt a germinal centre B cell phenotype during secondary infection

Halina M Pietrzak, Lisa J Ioannidis, Diana S Hansen

Journal article  |  2020  |  PARASITOLOGY

Emerging evidence started to delineate multiple layers of memory B cells, with distinct effector functions during recall responses..

CD14( ) monocytes are the main leucocytic sources of CXCL10 in response to Plasmodium falciparum

Lisa J Ioannidis, Emily Eriksson, Diana S Hansen

Journal article  |  2020  |  PARASITOLOGY

The CXCR3 chemokine CXCL10 or IFN-γ inducible protein 10 (IP-10) has been identified as an important biomarker of cerebral malaria..

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ann Ly, Yang Liao, Halina Pietrzak, Lisa J Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z Qin, Joanna R Groom, Gabrielle T Belz, Kim L Good-Jacobson, Wei Shi, Axel Kallies, Diana S Hansen

Journal article  |  2019  |  CELL REPORTS

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity agai..

Development of B Cell Memory in Malaria

Ann Ly, Diana S Hansen

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

A single exposure to many viral and bacterial pathogens typically induces life-long immunity, however, the development of the prot..