Jose Villadangos

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

Caroline L Ashley, Brian P McSharry, Hamish EG McWilliam, Richard J Stanton, Ceri A Fielding, Rommel A Mathias, David P Fairlie, James McCluskey, Jose A Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman

Journal article  |  2023  |  FRONTIERS IN IMMUNOLOGY

INTRODUCTION: The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to presen..

Intestinal microbe-derived metabolites instruct macrophages in the lungs

Antoine Roquilly, Jose A Villadangos

Journal article  |  2022  |  NATURE IMMUNOLOGY

New participants and pathways in immune receptor trafficking

Justine Mintern, Haiyin Liu, Andrew Webb, Angus Johnston, Jose Villadangos

Journal article  |  2022  |  Molecular Immunology

A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells

Hui Jing Lim, Jacinta M Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey YW Mak, Abderrahman Hachani, Regan J Anderson, Gavin F Painter, Jesse Goyette, Shanika L Amarasinghe, Matthew E Ritchie, Antoine Roquilly, David P Fairlie, Katharina Gaus, Jamie Rossjohn, Jose A Villadangos, Hamish EG McWilliam

Journal article  |  2022  |  JOURNAL OF CELL BIOLOGY

MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B-related metabolite antigens from div..

Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

Marine Gros, Elodie Segura, Derek C Rookhuizen, Blandine Baudon, Sandrine Heurtebise-Chretien, Nina Burgdorf, Mathieu Maurin, Eugene A Kapp, Richard J Simpson, Patrycja Kozik, Jose A Villadangos, Mathieu JM Bertrand, Marianne Burbage, Sebastian Amigorena

Journal article  |  2022  |  CELL REPORTS

Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation..

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

Tanguy Chaumette, Raphael Cinotti, Alice Molle, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish EG McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cedric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Regis Josien, Jose A Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, et al.

Journal article  |  2022  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rationale: Brain injury induces systemic immunosuppression, increasing the risk of viral reactivations and altering neurological r..

Transfusion-Related Renal Dysfunction After Cardiac Surgery The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

Mickael Vourc'h, Antoine Roquilly, Adrien Foucher, Christelle Retiere, Fanny Feuillet, Sapna Devi, Hamish EG McWilliam, Cecile Braudeau, Geraldine Bourreille, Abderrahman Hachani, Dermot O'Kane, Scott N Mueller, Joseph Ischia, Jean-Christian Roussel, Jean-Christophe Rigal, Regis Josien, Bertrand Rozec, Jose A Villadangos, Karim Asehnoune

Journal article  |  2022  |  JACC-BASIC TO TRANSLATIONAL SCIENCE

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the co..

Unlocking autofluorescence in the era of full spectrum analysis: Implications for immunophenotype discovery projects

Vanta J Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K Mackay, Axel Kallies, Jose A Villadangos, Hamish EG McWilliam, Alexis Perez-Gonzalez

Journal article  |  2022  |  CYTOMETRY PART A

Understanding the complex elements affecting signal resolution in cytometry is key for quality experimental design and data. In th..

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

Haiyin Liu, Kayla R Wilson, Ashley M Firth, Christophe Macri, Patrick Schriek, Annabelle B Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish EG McWilliam, Andrew F Hill, Laura E Edgington-Mitchell, Irina Caminschi, Mireille H Lahoud, Elodie Segura, Marco J Herold, Jose A Villadangos, Justine D Mintern

Journal article  |  2022  |  NATURE COMMUNICATIONS

The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, mo..

Differential antigen requirements by diverse MR1-restricted T cells (vol 100, pg 112, 2022)

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Correction to: Immunol Cell Biol 2022; 100: 112–126; https://doi.org/10.1111/imcb.12519 The authors omitted a grant from the Natio..