Jose Villadangos

COMPOSITIONS AND METHODS FOR MANIPULATING AN IMMUNE RESPONSE

ML LIN, Y ZHAN, J VILLADANGOS, R SUTHERLAND, A LEW, E CARRINGTON, R KLUCK, undefined others

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  eLife

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..

Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4( ) T Cells

Haiyin Liu, Kayla R Wilson, Patrick Schriek, Christophe Macri, Annabelle B Blum, Lauren Francis, Melanie Heinlein, Champa Nataraja, James Harris, Sarah A Jones, Daniel HD Gray, Jose A Villadangos, Justine D Mintern

Journal article  |  2020  |  The Journal of Immunology

MHC class II (MHC II) displays peptides at the cell surface, a process critical for CD4+ T cell development and priming. Ubiquitin..

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey, et al.

Journal article  |  2020  |  Science Immunology

The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis (vol 21, pg 636, 2020)

Antoine Roquilly, Cedric Jacqueline, Marion Davieau, Alice Molle, Abderrahmane Sadek, Cynthia Fourgeux, Paul Rooze, Alexis Broquet, Barbara Misme-Aucouturier, Tanguy Chaumette, Mickael Vourc'h, Raphael Cinotti, Nadege Marec, Vanessa Gauttier, Hamish EG McWilliam, Frederic Altare, Jeremie Poschmann, Jose A Villadangos, Karim Asehnoune

Journal article  |  2020  |  Nature Immunology

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  Cell Host & Microbe

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

MR1: a multi-faceted metabolite sensor for T cell activation

Hamish EG McWilliam, Jose A Villadangos

Journal article  |  2020  |  Current Opinion in Immunology

The major histocompatibility complex class I-related molecule MR1 captures and presents small metabolites to MR1- restricted T cel..

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

Antoine Roquilly, Cedric Jacqueline, Marion Davieau, Alice Molle, Abderrahmane Sadek, Cynthia Fourgeux, Paul Rooze, Alexis Broquet, Barbara Misme-Aucouturier, Tanguy Chaumette, Mickael Vourc'h, Raphael Cinotti, Nadege Marec, Vanessa Gauttier, Hamish EG McWilliam, Frederic Altare, Jeremie Poschmann, Jose A Villadangos, Karim Asehnoune

Journal article  |  2020  |  Nature Immunology

Sepsis and trauma cause inflammation and elevated susceptibility to hospital-acquired pneumonia. As phagocytosis by macrophages pl..

Butyrophilin molecules govern gamma delta T cell reactivity against phosphoantigens

Marc Rigau, Simone Ostrouska, Tom Fulford, Darryl Neil Johnson, Katherine Woods, Zheng Ruan, Hamish McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Hammet, Anne M Verhagen, Gino Vairo, Eugene Maraskovsky, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

Journal article  |  2020  |  Science Immunology

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..