Jose Villadangos

Dendritic cell Flt3-regulation, roles and repercussions for immunotherapy

Kayla R Wilson, Jose A Villadangos, Justine D Mintern

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

Dendritic cells (DCs) are essential for initiating immune responses. Depending on the environment, the type of DC and the way in w..

CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.

Nicholas A Gherardin, Samuel J Redmond, Hamish EG McWilliam, Catarina F Almeida, Katherine HA Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J Ross, Catriona V Nguyen-Robertson, Shian Su, Matthew E Ritchie, Jose A Villadangos, D Branch Moody, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

Journal article  |  2021  |  Science Immunology

CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool...

Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT

Shengbo Zhang, Hannah D Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J Kueh, Daniel Brown, Wang Cao, Nicolas Jacquelot, Angela D'Amico, Andrew M Lew, Yifan Zhan, Christopher J Tonkin, Jose A Villadangos, Gordon K Smyth, Michael Chopin, Stephen L Nutt

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

The functional diversification of dendritic cells (DCs) is a key step in establishing protective immune responses. Despite the imp..

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  ELIFE

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..

Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4( ) T Cells

Haiyin Liu, Kayla R Wilson, Patrick Schriek, Christophe Macri, Annabelle B Blum, Lauren Francis, Melanie Heinlein, Champa Nataraja, James Harris, Sarah A Jones, Daniel HD Gray, Jose A Villadangos, Justine D Mintern

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

MHC class II (MHC II) displays peptides at the cell surface, a process critical for CD4+ T cell development and priming. Ubiquitin..

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey, et al.

Journal article  |  2020  |  Science Immunology

The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis (vol 21, pg 636, 2020)

Antoine Roquilly, Cedric Jacqueline, Marion Davieau, Alice Molle, Abderrahmane Sadek, Cynthia Fourgeux, Paul Rooze, Alexis Broquet, Barbara Misme-Aucouturier, Tanguy Chaumette, Mickael Vourc'h, Raphael Cinotti, Nadege Marec, Vanessa Gauttier, Hamish EG McWilliam, Frederic Altare, Jeremie Poschmann, Jose A Villadangos, Karim Asehnoune

Journal article  |  2020  |  NATURE IMMUNOLOGY

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  CELL HOST & MICROBE

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

MR1: a multi-faceted metabolite sensor for T cell activation

Hamish EG McWilliam, Jose A Villadangos

Journal article  |  2020  |  Current Opinion in Immunology

The major histocompatibility complex class I-related molecule MR1 captures and presents small metabolites to MR1- restricted T cel..