Marnie Blewitt

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL -mediated Necroptosis From Contributing to Liver Pathologies

Simon P Preston, Michael D Stutz, Cody C Allison, Ueli Nachbur, Quentin Gouil, Manh Tran Bang, Valerie Duvivier, Philip Arandjelovic, James P Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, et al.

Journal article  |  2022  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury incl..

A method for stabilising the XX karyotype in female mESC cultures

Andrew Keniry, Natasha Jansz, Peter F Hickey, Kelsey A Breslin, Megan Iminitoff, Tamara Beck, Quentin Gouil, Matthew E Ritchie, Marnie E Blewitt

Journal article  |  2022  |  DEVELOPMENT

Female mouse embryonic stem cells (mESCs) present differently from male mESCs in several fundamental ways; however, complications ..

The dendritic cell receptor Clec9A: receptor regulation and immune modulation

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Marnie Blewitt, Irina Caminschi, Ken Shortman, Anthony W Purcell, Nicos Nicola, Jian-Guo Zhang, Mireille H Lahoud

Journal article  |  2022  |  Molecular Immunology

Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo.

Natalia Benetti, Quentin Gouil, Andres Tapia Del Fierro, Tamara Beck, Kelsey Breslin, Andrew Keniry, Edwina McGlinn, Marnie E Blewitt

Journal article  |  2022  |  Nat Commun

Parents transmit genetic and epigenetic information to their offspring. Maternal effect genes regulate the offspring epigenome to ..

Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation

Iromi Wanigasuriya, Sarah A Kinkel, Tamara Beck, Ellise A Roper, Kelsey Breslin, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt, Quentin Gouil

Journal article  |  2022  |  EPIGENETICS & CHROMATIN

Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequat..

Epigenetic modifier SMCHD1 maintains a normal pool of long-term hematopoietic stem cells

Sarah A Kinkel, Joy Liu, Tamara Beck, Kelsey A Breslin, Megan Iminitoff, Peter Hickey, Marnie E Blewitt

Journal article  |  2022  |  ISCIENCE

SMCHD1 (structural maintenance of chromosomes hinge domain containing 1) is a noncanonical SMC protein that mediates long-range re..

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Andrew Keniry, Natasha Jansz, Linden J Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M Nefzger, Peter F Hickey, Quentin Gouil, Joy Liu, Kelsey A Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A Kinkel, Phillippa C Taberlay, Tracy Willson, Miha Pakusch, Matthew E Ritchie, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

The process of epigenetic silencing, while fundamentally important, is not yet completely understood. Here we report a replenishab..

NanoMethViz: An R/Bioconductor package for visualizing long-read methylation data

Shian Su, Quentin Gouil, Marnie E Blewitt, Dianne Cook, Peter F Hickey, Matthew E Ritchie

Journal article  |  2021  |  PLOS COMPUTATIONAL BIOLOGY

A key benefit of long-read nanopore sequencing technology is the ability to detect modified DNA bases, such as 5-methylcytosine. T..

Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence

Katherine D Drummond, Michelle L Waring, Geoffrey J Faulkner, Marnie E Blewitt, Christina J Perry, Jee Hyun Kim

Journal article  |  2021  |  NEUROBIOLOGY OF STRESS

Impaired extinction of conditioned fear is associated with anxiety disorders. Common lifestyle factors, like isolation stress and ..

SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization

Alexandra D Gurzau, Christopher R Horne, Yee-Foong Mok, Megan Iminitoff, Tracy A Willson, Samuel N Young, Marnie E Blewitt, James M Murphy

Journal article  |  2021  |  BIOCHEMICAL JOURNAL

Structural maintenance of chromosomes flexible hinge domain-containing 1 (SMCHD1) is an epigenetic regulator that mediates gene ex..