Marnie Blewitt

NanoMethViz: an R/Bioconductor package for visualizing long-read methylation data

Shian Su, Quentin Gouil, Marnie Blewitt, Dianne Cook, Peter Hickey, Matthew Ritchie

Journal article  |  2021

Motivation A key benefit of long-read nanopore sequencing technology is the ability to detect modified DNA bases, such as 5-methyl..

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  eLife

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..

Smchd1 is a maternal effect gene required for genomic imprinting

Iromi Wanigasuriya, Quentin Gouil, Sarah A Kinkel, Andres Tapia del Fierro, Tamara Beck, Ellise A Roper, Kelsey Breslin, Jessica Stringer, Karla Hutt, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt

Journal article  |  2020  |  eLife

Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific ..

Relating SMCHD1 structure to its function in epigenetic silencing

Alexandra D Gurzau, Marnie E Blewitt, Peter E Czabotar, James M Murphy, Richard W Birkinshaw

Journal article  |  2020  |  Biochemical Society Transactions

The structural maintenance of chromosomes hinge domain containing protein 1 (SMCHD1) is a large multidomain protein involved in ep..

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues

Kelan Chen, Richard W Birkinshaw, Alexandra D Gurzau, Iromi Wanigasuriya, Ruoyun Wang, Megan Iminitoff, Jarrod J Sandow, Samuel N Young, Patrick J Hennessy, Tracy A Willson, Denise A Heckmann, Andrew Webb, Marnie E Blewitt, Peter E Czabotar, James M Murphy

Journal article  |  2020  |  Science Signaling

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  Nature

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

Using long-read sequencing to detect imprinted DNA methylation

Scott Gigante, Quentin Gouil, Alexis Lucattini, Andrew Keniry, Tamara Beck, Matthew Tinning, Lavinia Gordon, Chris Woodruff, Terence P Speed, Marnie E Blewitt, Matthew E Ritchie

Journal article  |  2019  |  Nucleic Acids Research

Development of a KDM6b shRNA conditional knock down mouse model

Julia Prier, Marnie Blewitt, Ross Dickins, Stephen Turner

Journal article  |  2019

Abstract Antigen-specific CD8 + T cell differentiation in response to infection is associated with specific changes in the chromat..

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  Cell Reports