Michael Lawrence

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Francois Moreau, Nicholas S Kirk, Fa Zhang, Vasily Gelfanov, Edward O List, Martina Chrudinova, Hari Venugopal, Michael C Lawrence, Veronica Jimenez, Fatima Bosch, John J Kopchick, Richard D DiMarchi, Emrah Altindis, C Ronald Kahn

Journal article  |  2022  |  NATURE COMMUNICATIONS

Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral insulin/IGF-1 like peptides (VILPs) with high ho..

Single-chain insulin analogs threaded by the insulin receptor αCT domain.

Nicholas A Smith, John G Menting, Michael A Weiss, Michael C Lawrence, Brian J Smith

Journal article  |  2022  |  Biophys J

Insulin is a mainstay of therapy for diabetes mellitus, yet its thermal stability complicates global transportation and storage. C..

Activation of the human insulin receptor by non-insulin-related peptides

Nicholas S Kirk, Qi Chen, Yingzhe Ginger Wu, Anastasia L Asante, Haitao Hu, Juan F Espinosa, Francisco Martinez-Olid, Mai B Margetts, Faiz A Mohammed, Vladislav V Kiselyov, David G Barrett, Michael C Lawrence

Journal article  |  2022  |  NATURE COMMUNICATIONS

The human insulin receptor signalling system plays a critical role in glucose homeostasis. Insulin binding brings about extensive ..

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

Yibin Xu, Mai B Margetts, Hari Venugopal, John G Menting, Nicholas S Kirk, Tristan I Croll, Carlie Delaine, Briony E Forbes, Michael C Lawrence

Journal article  |  2022  |  STRUCTURE

Monomers of the insulin receptor and type 1 insulin-like growth factor receptor (IGF-1R) can combine stochastically to form hetero..

Symmetric and asymmetric receptor conformation continuum induced by a new insulin

Xiaochun Xiong, Alan Blakely, Jin Hwan Kim, John G Menting, Ingmar B Schaefer, Heidi L Schubert, Rahul Agrawal, Theresia Gutmann, Carlie Delaine, Yi Wolf Zhang, Gizem Olay Artik, Allanah Merriman, Debbie Eckert, Michael C Lawrence, Uenal Coskun, Simon J Fisher, Briony E Forbes, Helena Safavi-Hemami, Christopher P Hill, Danny Hung-Chieh Chou

Journal article  |  2022  |  NATURE CHEMICAL BIOLOGY

Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features..

Understanding insulin and its receptor from their three-dimensional structures

Michael C Lawrence

Journal article  |  2021  |  MOLECULAR METABOLISM

BACKGROUND: Insulin's discovery 100 years ago and its ongoing use since that time to treat diabetes belies the molecular complexit..

Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation

Yen-Shan Chen, Jeremy Gleaton, Yanwu Yang, Balamurugan Dhayalan, Nelson B Phillips, Yule Liu, Laurie Broadwater, Mark A Jarosinski, Deepak Chatterjee, Michael C Lawrence, Thomas Hattier, M Dodson Michael, Michael A Weiss

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations..

Insertion of a Synthetic Switch Into Insulin Provides Metabolite-Dependent Regulation of Hormone-Receptor Activation

Yen-Shan Chen, Jeremy Gleaton, Yanwu Yang, Balamurugan Dhayalan, Nelson B Phillips, Yule Liu, Laurie Broadwater, Mark Jarosinski, Deepak Chatterjee, Michael C Lawrence, Thomas Hattier, Dodson M Michael, Michael Aaron Weiss

Journal article  |  2021  |  Journal of the Endocrine Society

Abstract Insulin signaling requires conformational change: whereas the free hormone and its receptor each adopt aut..

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor

Yibin Xu, Nicholas S Kirk, Hariprasad Venugopal, Mai B Margetts, Tristan Croll, Jarrod J Sandow, Andrew Webb, Carlie A Delaine, Briony E Forbes, Michael C Lawrence

Journal article  |  2020  |  STRUCTURE

Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor..

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles (vol 27, pg 615, 2020)

Xiaochun Xiong, John G Menting, Maria M Disotuar, Nicholas A Smith, Carlie A Delaine, Gabrielle Ghabash, Rahul Agrawal, Xiaomin Wang, Xiao He, Simon J Fisher, Christopher A MacRaild, Raymond S Norton, Joanna Gajewiak, Briony E Forbes, Brian J Smith, Helena Safavi-Hemami, Baldomero Olivera, Michael C Lawrence, Danny Hung-Chieh Chou

Journal article  |  2020  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

An amendment to this paper has been published and can be accessed via a link at the top of the paper.