Michael Lawrence

Understanding insulin and its receptor from their three-dimensional structures.

Michael C Lawrence

Journal article  |  2021  |  Mol Metab

BACKGROUND: Insulin's discovery 100 years ago and its ongoing use since that time to treat diabetes belies the molecular complexit..

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor

Yibin Xu, Nicholas S Kirk, Hariprasad Venugopal, Mai B Margetts, Tristan Croll, Jarrod J Sandow, Andrew Webb, Carlie A Delaine, Briony E Forbes, Michael C Lawrence

Journal article  |  2020  |  STRUCTURE

Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor..

Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.

Xiaochun Xiong, John G Menting, Maria M Disotuar, Nicholas A Smith, Carlie A Delaine, Gabrielle Ghabash, Rahul Agrawal, Xiaomin Wang, Xiao He, Simon J Fisher, Christopher A MacRaild, Raymond S Norton, Joanna Gajewiak, Briony E Forbes, Brian J Smith, Helena Safavi-Hemami, Baldomero Olivera, Michael C Lawrence, Danny Hung-Chieh Chou

Journal article  |  2020  |  Nat Struct Mol Biol

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Xiaochun Xiong, John G Menting, Maria M Disotuar, Nicholas A Smith, Carlie A Delaine, Gabrielle Ghabash, Rahul Agrawal, Xiaomin Wang, Xiao He, Simon J Fisher, Christopher A MacRaild, Raymond S Norton, Joanna Gajewiak, Briony E Forbes, Brian J Smith, Helena Safavi-Hemami, Baldomero Olivera, Michael C Lawrence, Danny Hung-Chieh Chou

Journal article  |  2020  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human insulin and its current therapeutic analogs all show propensity, albeit varyingly, to self-associate into dimers and hexamer..

Insulin and its receptor: a grand challenge in structural biology.

Michael C Lawrence

Journal article  |  2019  |  Biophys Rev

The signalling conformation of the insulin receptor ectodomain

Felix Weis, John G Menting, Mai B Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart, Thomas Langer, Christoph W Mueller, Matthias K Dreyer, Michael C Lawrence

Journal article  |  2018  |  NATURE COMMUNICATIONS

Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin..

A thing of beauty: Structure and function of insulin's "aromatic triplet"

Michael A Weiss, Michael C Lawrence

Journal article  |  2018  |  DIABETES OBESITY & METABOLISM

The classical crystal structure of insulin was determined in 1969 by D.C. Hodgkin et al. following a 35-year program of research. ..

How ligand binds to the type 1 insulin-like growth factor receptor

Yibin Xu, Geoffrey K-W Kong, John G Menting, Mai B Margetts, Carlie A Delaine, Lauren M Jenkin, Vladislav V Kiselyov, Pierre De Meyts, Briony E Forbes, Michael C Lawrence

Journal article  |  2018  |  NATURE COMMUNICATIONS

Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing no..

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

Michael D Glidden, Khadijah Aldabbagh, Nelson B Phillips, Kelley Carr, Yen-Shan Chen, Jonathan Whittaker, Manijeh Phillips, Nalinda P Wickramasinghe, Nischay Rege, Mamuni Swain, Yi Peng, Yanwu Yang, Michael C Lawrence, Vivien C Yee, Faramarz Ismail-Beigi, Michael A Weiss

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Thermal degradation of insulin complicates its delivery and use. Previous efforts to engineer ultra-stable analogs were confounded..

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

Michael D Glidden, Yanwu Yang, Nicholas A Smith, Nelson B Phillips, Kelley Carr, Nalinda P Wickramasinghe, Faramarz Ismail-Beigi, Michael C Lawrence, Brian J Smith, Michael A Weiss

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Domain-minimized insulin receptors (IRs) have enabled crystallographic analysis of insulin-bound "micro-receptors." In such struct..