Gabrielle Belz

Innate lymphoid cells: potential targets for cancer therapeutics.

Chun Ki Ng, Gabrielle T Belz

Journal article  |  2023  |  Trends Cancer

Innate lymphoid cells (ILCs) comprise a number of different subsets, including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and..

Gutsy sensations modulate intestinal disease

Wang Cao, Gabrielle Belz

Journal article  |  2022  |  TRENDS IN IMMUNOLOGY

Pain is a hallmark symptom associated with intestinal inflammation. Two related articles published in Cell by Zhang et al. and by ..

Metabolic features of innate lymphoid cells

Huiyang Yu, Nicolas Jacquelot, Gabrielle T Belz

Journal article  |  2022  |  JOURNAL OF EXPERIMENTAL MEDICINE

Innate and adaptive immune cells are found in distinct tissue niches where they orchestrate immune responses. This requires intrin..

Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage

Arutha Kulasinghe, Ning Liu, Chin Wee Tan, James Monkman, Jane E Sinclair, Dharmesh D Bhuva, David Godbolt, Liuliu Pan, Andy Nam, Habib Sadeghirad, Kei Sato, Gianluigi Li Bassi, Ken O'Byrne, Camila Hartmann, Anna Flavia Ribeiro Dos Santos Miggiolaro, Gustavo Lenci Marques, Lidia Zytynski Moura, Derek Richard, Mark Adams, Lucia de Noronha, et al.

Journal article  |  2022  |  IMMUNOLOGY

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ comp..

A protocol to isolate bone marrow innate lymphoid cells for alymphoid mouse reconstitution.

Nicolas Jacquelot, Qiutong Huang, Gabrielle T Belz, Cyril Seillet

Journal article  |  2022  |  STAR Protoc

Innate lymphoid cells (ILCs) and adaptive T cells remain a challenge to study because of a significant overlap in their transcript..

CIS and TGF-β regulatory pathways influence immunity to bacterial infection.

Timothy R McCulloch, Gustavo R Rossi, Jaring Schreuder, Gabrielle T Belz, Timothy J Wells, Fernando Souza-Fonseca-Guimaraes

Journal article  |  2022  |  Immunology

Immunotherapy has revolutionized cancer therapy by reactivating tumour-resident cytotoxic lymphocytes. More recently, immunotherap..

The unique role of innate lymphoid cells in cancer and the hepatic microenvironment.

Sophie Curio, Gabrielle T Belz

Journal article  |  2022  |  Cell Mol Immunol

Cancer is a complex disease, and despite incredible progress over the last decade, it remains the leading cause of death worldwide..

ZBTB46 in ILC3: shared transcriptional infrastructure defines gut-protective capabilities

Sophie Curio, Gabrielle T Belz

Journal article  |  2022  |  TRENDS IN IMMUNOLOGY

Group 3 innate lymphoid cells (ILC3s) are distributed along the gastrointestinal tract at the interface between the immune system ..

Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures

Arutha Kulasinghe, Chin Wee Tan, Anna Flavia Ribeiro Dos Santos Miggiolaro, James Monkman, Habib SadeghiRad, Dharmesh D Bhuva, Jarbas da Silva Motta Junior, Caroline Busatta Vaz de Paula, Seigo Nagashima, Cristina Pellegrino Baena, Paulo Souza-Fonseca-Guimaraes, Lucia de Noronha, Timothy McCulloch, Gustavo Rodrigues Rossi, Caroline Cooper, Benjamin Tang, Kirsty R Short, Melissa J Davis, Fernando Souza-Fonseca-Guimaraes, Gabrielle T Belz, et al.

Journal article  |  2022  |  EUROPEAN RESPIRATORY JOURNAL

BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in late 2019 has spread globally, causi..

Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage

Charis E Teh, Simon P Preston, Alissa K Robbins, Michael D Stutz, James Cooney, Michelle P Clark, Antonia N Policheni, Cody C Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C Rankin, Peggy P Teh, Gabrielle T Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel HD Gray

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

Targeting the potent immunosuppressive properties of FOXP3+ regulatory T cells (Tregs) has substantial therapeutic potential for t..