Thomas Mikeska

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  Clinical Cancer Research

LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness

Jia-Min B Pang, Ramyar Molania, Ashwini Chand, Kevin Knower, Elena A Takano, David J Byrne, Thomas Mikeska, Ewan KA Millar, Cheok Soon Lee, Sandra A O'Toole, Colin Clyne, Kylie L Gorringe, Alexander Dobrovic, Stephen B Fox

Journal article  |  2017  |  Oncotarget

Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer

Geoffrey Liu, Dongsheng Tu, Marcia Lewis, Dangxiao Cheng, Leslie A Sullivan, Zhuo Chen, Eric Morgen, John Simes, Timothy J Price, Niall C Tebbutt, Jeremy D Shapiro, G Mark Jeffery, J Daniel Mellor, Thomas Mikeska, Shakeel Virk, Lois E Shepherd, Derek J Jonker, Christopher J O'Callaghan, John R Zalcberg, Christos S Karapetis, et al.

Journal article  |  2016  |  Clinical Cancer Research

Epigenetic basis of human cancer

T Mikeska, A Dobrovic

Book Chapter  |  2016

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

Katie T Huang, Thomas Mikeska, Jason Li, Elena A Takano, Ewan KA Millar, Peter H Graham, Samantha E Boyle, Ian G Campbell, Terence P Speed, Alexander Dobrovic, Stephen B Fox

Journal article  |  2015  |  BMC Cancer

Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Joshy George, Kathryn Alsop, Dariush Etemadmoghadam, Heather Hondow, Thomas Mikeska, Alexander Dobrovic, Anna DeFazio, Gordon K Smyth, Douglas A Levine, Gillian Mitchell, David D Bowtell

Journal article  |  2013  |  Clinical Cancer Research

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell, Alexander Dobrovic

Journal article  |  2013  |  Journal of Ovarian Research

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

Bradley N Bidwell, Clare Y Slaney, Nimali P Withana, Sam Forster, Yuan Cao, Sherene Loi, Daniel Andrews, Thomas Mikeska, Niamh E Mangan, Shamith A Samarajiwa, Nicole A de Weerd, Jodee Gould, Pedram Argani, Andreas Moeller, Mark J Smyth, Robin L Anderson, Paul J Hertzog, Belinda S Parker

Journal article  |  2012  |  Nature Medicine

No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia

Thomas Mikeska, Dennis A Carney, John F Seymour, Alexander Dobrovic

Journal article  |  2012  |  Leukemia and Lymphoma

RANK (TNFRSF11A) Is Epigenetically Inactivated and Induces Apoptosis in Gliomas

Anna von dem Knesebeck, Joerg Felsberg, Anke Waha, Wolfgang Hartmann, Bjoern Scheffler, Martin Glas, Jennifer Hammes, Thomas Mikeska, Pearlly S Yan, Elmar Endl, Matthias Simon, Guido Reifenberger, Torsten Pietsch, Andreas Waha

Journal article  |  2012  |  Neoplasia

DNA methylation biomarkers in cancer: progress towards clinical implementation

Thomas Mikeska, Christoph Bock, Hongdo Do, Alexander Dobrovic

Journal article  |  2012  |  Expert Reviews in Molecular Medicine

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer

Katie T Huang, Elena A Takano, Thomas Mikeska, David J Byrne, Alexander Dobrovic, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research and Treatment

p75(NTR) induces apoptosis in medulloblastoma cells

Jan Kuechler, Wolfgang Hartmann, Anke Waha, Arend Koch, Elmar Endl, Peter Wurst, Dagmar Kindler, Thomas Mikeska, Andreas Waha, Cynthia G Goodyer, Reinhard Buettner, Karl Schilling, Torsten Pietsch

Journal article  |  2011  |  International Journal of Cancer

Assessing combined methylation-sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation

Ida LM Candiloro, Thomas Mikeska, Alexander Dobrovic

Journal article  |  2011  |  Epigenetics

Analysing DNA Methylation Using Bisulphite Pyrosequencing

Thomas Mikeska, Joerg Felsberg, Chelsee A Hewitt, Alexander Dobrovic

Journal article  |  2011  |  Methods in Molecular Biology

Methylation-sensitive High Resolution Melting for the Rapid Analysis of DNA Methylation

Thomas Mikeska, Alexander Dobrovic

Book Chapter  |  2011

Closed-Tube PCR Methods for Locus-Specific DNA Methylation Analysis

Ida LM Candiloro, Thomas Mikeska, Alexander Dobrovic

Book Chapter  |  2011  |  Methods in Molecular Biology

A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues

Elena A Takano, Thomas Mikeska, Alexander Dobrovic, David J Byrne, Stephen B Fox

Journal article  |  2010  |  BMC Biotechnology

DNA methylation analysis of the HIF-1 alpha prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas

Katie T Huang, Thomas Mikeska, Alexander Dobrovic, Stephen B Fox

Journal article  |  2010  |  Histopathology

The implications of heterogeneous DNA methylation for the accurate quantification of methylation

Thomas Mikeska, Ida LM Candiloro, Alexander Dobrovic

Journal article  |  2010  |  Epigenomics

Epigenetic Downregulation of Mitogen-Activated Protein Kinase Phosphatase MKP-2 Relieves Its Growth Suppressive Activity in Glioma Cells

Anke Waha, Joerg Felsberg, Wolfgang Hartmann, Anna von dem Knesebeck, Thomas Mikeska, Stefan Joos, Marietta Wolter, Arend Koch, Pearlly S Yan, Elmar Endl, Otmar D Wiestler, Guido Reifenberger, Torsten Pietsch, Andreas Waha

Journal article  |  2010  |  Cancer Research

Aberrant Methylation and Reduced Expression of LHX9 in Malignant Gliomas of Childhood

Valentina Vladimirova, Thomas Mikeska, Andreas Waha, Niels Soerensen, Jingying Xu, Patrick Reynolds, Torsten Pietsch

Journal article  |  2009  |  Neoplasia

Validation of a primer optimisation matrix to improve the performance of reverse transcription - quantitative real-time PCR assays.

Thomas Mikeska, Alexander Dobrovic

Journal article  |  2009  |  BMC Research Notes

BACKGROUND: The development of reverse transcription - quantitative real-time PCR (RT-qPCR) platforms that can simultaneously meas..

A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation

Osman El-Maarri, Michael S Kareta, Thomas Mikeska, Tim Becker, Amalia Diaz-Lacava, Judith Junen, Nicole Nuesgen, Frank Behne, Thomas Wienker, Andreas Waha, Johannes Oldenburg, Frederic Chedin

Journal article  |  2009  |  Human Molecular Genetics

Quality Control of Astrocyte-Directed Cre Transgenic Mice: The Benefits of a Direct Link Between Loss of Gene Expression and Reporter Activation

Robert Pascal Requardt, Lech Kaczmarczyk, Pavel Dublin, Anke Wallraff-Beck, Thomas Mikeska, Joachim Degen, Andreas Waha, Christian Steinhaeuser, Klaus Willecke, Martin Theis

Journal article  |  2009  |  Glia

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs (vol 99, pg 294, 2008)

DM Ashley, CD Riffkin, MM Lovric, T Mikeska, A Dobrovic, JA Maxwell, HS Friedman, KJ Drummond, AH Kaye, HK Gan, TG Johns, CJ Hawkins

Journal article  |  2009  |  British Journal of Cancer

MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays

Peter Schueffler, Thomas Mikeska, Andreas Waha, Thomas Lengauer, Christoph Bock

Journal article  |  2009  |  Genome Biology

Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene

Ida LM Candiloro, Thomas Mikeska, Peter Hokland, Alexander Dobrovic

Journal article  |  2008  |  Epigenetics and Chromatin

SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas

A Waha, A Koch, W Hartmann, U Milde, J Felsberg, A Huebner, T Mikeska, CG Goodyer, N Soerensen, I Lindberg, OD Wiestler, T Pietsch, A Waha

Journal article  |  2007  |  Oncogene

Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer

Beatrix Versmold, Joerg Felsberg, Thomas Mikeska, Denise Ehrentraut, Juliane Koehler, Juergen A Hampl, Gabriele Roehn, Dieter Niederacher, Beate Betz, Martin Hellmich, Torsten Pietsch, Rita K Schmutzler, Andreas Waha

Journal article  |  2007  |  International Journal of Cancer

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas

Arend Koch, Aksana Hrychyk, Wolfgang Hartmann, Anke Waha, Thomas Mikeska, Andreas Waha, Ulrich Schueller, Nils Soerensen, Frank Berthold, Cynthia G Goodyer, Otmar D Wiestler, Walter Birchmeier, Juergen Behrens, Torsten Pietsch

Journal article  |  2007  |  International Journal of Cancer

Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

Thomas Mikeska, Christoph Bock, Osman El-Maarri, Anika Huebner, Denise Ehrentraut, Johannes Schramm, Joerg Felsberg, Philip Kahl, Reinhard Buettner, Torsten Pietsch, Andreas Waha

Journal article  |  2007  |  The Journal of Molecular Diagnostics

Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation

P Lund, K Weisshaupt, T Mikeska, D Jammas, X Chen, R-J Kuban, U Ungethum, U Krapfenbauer, H-P Herzel, R Schafer, J Walter, C Sers

Journal article  |  2006  |  Oncogene

CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure

Christoph Bock, Martina Paulsen, Sascha Tierling, Thomas Mikeska, Thomas Lengauer, Joern Walter

Journal article  |  2006  |  PLoS Genetics

BiQ analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing

C Bock, S Reither, T Mikeska, M Paulsen, J Walter, T Lengauer

Journal article  |  2005  |  Bioinformatics

Crystal structures of O-acetylated 2-acylamino-2-deoxy-D-galactose derivatives

T Mikeska, M Nieger, H Mansikkamaki, J Daniels, T Kolter

Journal article  |  2003  |  Carbohydrate Research

1,1-dimethylethyl N-propanoylcarbamate

S Brodesser, T Mikeska, M Nieger, T Kolter

Journal article  |  2003  |  Acta Crystallographica Section E Structure Reports Online

(4S,5S)-4-[(1R)-1,2-Dihydroxyethyl]-5-tridecyl-1,3-oxazolidin-2-one

P Sawatzki, T Mikeska, M Nieger, M Bolte, T Kolter

Journal article  |  2003  |  Acta Crystallographica Section C Crystal Structure Communications

6(S)-Methyl-3(S)-(1-methylethyl)piperazin-2-one

P Sawatzki, T Mikeska, K Sandhoff, M Nieger, T Kolter

Journal article  |  2003  |  Acta Crystallographica Section E Structure Reports Online

2(S)-N-tert-butoxycarbonylamino-N-methoxy-N-methylbutanamide

P Sawatzki, T Mikeska, M Nieger, H Hupfer, T Kolter

Journal article  |  2002  |  Acta Crystallographica Section E Structure Reports Online

tert-Butyl 4-acetyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

P Sawatzki, T Mikeska, M Nieger, H Hupfer, T Kolter

Journal article  |  2002  |  Acta Crystallographica Section E Structure Reports Online