Thomas Mikeska

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  CLINICAL CANCER RESEARCH

Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dra..

LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness

Jia-Min B Pang, Ramyar Molania, Ashwini Chand, Kevin Knower, Elena A Takano, David J Byrne, Thomas Mikeska, Ewan KA Millar, Cheok Soon Lee, Sandra A O'Toole, Colin Clyne, Kylie L Gorringe, Alexander Dobrovic, Stephen B Fox

Journal article  |  2017  |  ONCOTARGET

The significance and regulation of liver receptor homologue 1 (LRH-1, NR5A2), a tumour-promoting transcription factor in breast ca..

Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer

Geoffrey Liu, Dongsheng Tu, Marcia Lewis, Dangxiao Cheng, Leslie A Sullivan, Zhuo Chen, Eric Morgen, John Simes, Timothy J Price, Niall C Tebbutt, Jeremy D Shapiro, G Mark Jeffery, J Daniel Mellor, Thomas Mikeska, Shakeel Virk, Lois E Shepherd, Derek J Jonker, Christopher J O'Callaghan, John R Zalcberg, Christos S Karapetis, et al.

Journal article  |  2016  |  CLINICAL CANCER RESEARCH

PURPOSE: Two germline Fc-γ receptor (FCGR) polymorphisms, rs1801274 [FCGR2A;His(H)131Arg(R)] and rs396991 [FCGR3A;Phe(F)158Val(V)]..

Epigenetic basis of human cancer

T Mikeska, A Dobrovic

Book Chapter  |  2016

It is now overwhelmingly clear that any comprehensive study of cancer genomes should address epigenetics. The study of cancer epig..

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

Katie T Huang, Thomas Mikeska, Jason Li, Elena A Takano, Ewan KA Millar, Peter H Graham, Samantha E Boyle, Ian G Campbell, Terence P Speed, Alexander Dobrovic, Stephen B Fox

Journal article  |  2015  |  BMC CANCER

BACKGROUND: Patients with breast cancer have an increased risk of developing subsequent breast cancers. It is important to disting..

Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Joshy George, Kathryn Alsop, Dariush Etemadmoghadam, Heather Hondow, Thomas Mikeska, Alexander Dobrovic, Anna DeFazio, Gordon K Smyth, Douglas A Levine, Gillian Mitchell, David D Bowtell

Journal article  |  2013  |  CLINICAL CANCER RESEARCH

PURPOSE: High-grade serous carcinoma (HGSC) accounts for the majority of epithelial ovarian cancer deaths. Genomic and functional ..

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell, Alexander Dobrovic

Journal article  |  2013  |  JOURNAL OF OVARIAN RESEARCH

BACKGROUND: High-grade serous ovarian cancers are a distinct histological subtype of ovarian cancer often characterised by a dysfu..

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

Bradley N Bidwell, Clare Y Slaney, Nimali P Withana, Sam Forster, Yuan Cao, Sherene Loi, Daniel Andrews, Thomas Mikeska, Niamh E Mangan, Shamith A Samarajiwa, Nicole A de Weerd, Jodee Gould, Pedram Argani, Andreas Moeller, Mark J Smyth, Robin L Anderson, Paul J Hertzog, Belinda S Parker

Journal article  |  2012  |  NATURE MEDICINE

Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metast..

No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia

Thomas Mikeska, Dennis A Carney, John F Seymour, Alexander Dobrovic

Journal article  |  2012  |  LEUKEMIA & LYMPHOMA

DNA methylation biomarkers in cancer: progress towards clinical implementation

Thomas Mikeska, Christoph Bock, Hongdo Do, Alexander Dobrovic

Journal article  |  2012  |  EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Altered DNA methylation is ubiquitous in human cancers and specific methylation changes are often correlated with clinical feature..