Prof Axel Kallies

Find out more about Axel Kallies' experience

Axel Kallies' highlights

FEATURED Journal article

CCR2 enhances CD25 expression by FoxP3 regulatory T cells and regulates their abundance independently of chemotaxis and CCR2 myeloid cells.

Axel Kallies' selected work

Understanding The Dynamic Regulation Of Exhausted And Tissue-Resident Memory T Cells Diffe..

NEWS ARTICLE

Precursor exhausted T cells: key to successful immunotherapy?

Journal article

Transcriptional And Metabolic Regulation Of Effector And Memory Lymphocyte Differentiation

Research Grant

What malaria can tell us about ‘switching off’ diseases like HIV

NEWS ARTICLE

A new species of the genus Toleria Walker, [1865] from northern Vietnam and Laos with esta..

Projects

Displaying the 8 most recent projects by Axel Kallies.

Understanding The Dynamic Regulation Of Exhausted And Tissue-Resident Memory T Cells Differentiation In Tumors

2020 - 2022

Active

Transcriptional And Metabolic Regulation Of Effector And Memory Lymphocyte Differentiation

I am an internationally recognized expert in the field of lymphocyte biology. My work has shed light on antibody production, T cell response..

2018 - 2023

Active

Molecular Pathways That Control Differentiation And Function Of Tissue-Resident Memory T Cells

T cells residing in organs such as gut, liver or skin guard against infection and are critical for preventing tumour development. We found t..

2018 - 2021

Active

Protective Mechanisms Of Map Kinase Phosphatase 5 In Adipose Tissue Fibrosis, Hepatic Steatosis And Atherosclerosis

Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Re..

2018 - 2021

Active

Collaborative Research And Licence Agreement (Kallies Lab) – Wehi - To Allow Transfer Of Materials To The University Of Melbourne (Lex 31104/ Ta 38954)

2017 - 2020

Active

Regulation Of Metabolic Dysfunction And Exhaustion Of Virus-Specific T Cells During Chronic Infection

T cells control infections and cancer cells. During chronic infection or tumor development, however, loss of function of T cells prevents ef..

2017 - 2018

Completed

Maintenance Of Regulatory T Cells During Inflammation And Tumor Development By Il-33

Regulatory T cells (Tregs) are required for preventing inflammation in tissues such as lung, fat and skin. We found recently, that the signa..

2017 - 2018

Completed

Transcriptional And Epigenetic Control Of Conventional And Regulatory T Cell Differentiation

2013 - 2018

Completed

8

Projects

Project Types

Research Grant

Research Contracts

Scholarly Works

Displaying the 179 most recent scholarly works by Axel Kallies.

CCR2 enhances CD25 expression by FoxP3 regulatory T cells and regulates their abundance independently of chemotaxis and CCR2 myeloid cells.

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article | 2020 | Cellular & Molecular Immunology

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

Precursor exhausted T cells: key to successful immunotherapy?

Axel Kallies, Dietmar Zehn, Daniel T Utzschneider

Journal article | 2020 | Nature Reviews Immunology

Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+ T cells ..

A new species of the genus Toleria Walker, [1865] from northern Vietnam and Laos with establishment of a new generic synonymy in Cissuvorini (Lepidoptera, Sesiidae)

Axel Kallies, Hiromichi Ogane, Naoki Yata

Journal article | 2020 | Zootaxa

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K Smyth, Wei Shi, Axel Kallies

Journal article | 2020 | Nature Communications

Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; howe..

IL-17( ) CD8( ) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

Christina Lueckel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, et al.

Journal article | 2019 | Nature Communications

A large hornet mimic clearwing moth of the genus Lamellisphecia Kallies & Arita, 2004 (Lepidoptera, Sesiidae) from Nanling, Guangdong, southern China

Yutaka Arita, Axel Kallies, Naoki Yata

Journal article | 2019 | Zootaxa

We here describe a new species, Lamellisphecia minwangi Arita & Kallies sp. nov., from Nanling, Guangdong, southern China. Further..

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Michael Sze Yuan Low, Erica J Brodie, Pasquale L Fedele, Yang Liao, George Grigoriadis, Andreas Strasser, Axel Kallies, Simon N Willis, Julie Tellier, Wei Shi, Sarah Gabriel, Kristy O'Donnell, Catherine Pitt, Stephen L Nutt, David Tarlinton

Journal article | 2019 | Cell Reports

The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasm..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells.

H-F Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y d'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nüssing, K Kedzierska, et al.

Journal article | 2019 | Science Immunology

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ann Ly, Yang Liao, Halina Pietrzak, Lisa J Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z Qin, Joanna R Groom, Gabrielle T Belz, Kim L Good-Jacobson, Wei Shi, Axel Kallies, Diana S Hansen

Journal article | 2019 | Cell Reports

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity agai..

Defining 'T cell exhaustion'

Christian U Blank, W Nicholas Haining, Werner Held, Patrick G Hogan, Axel Kallies, Enrico Lugli, Rachel C Lynn, Mary Philip, Anjana Rao, Nicholas P Restifo, Andrea Schietinger, Ton N Schumacher, Pamela L Schwartzberg, Arlene H Sharpe, Daniel E Speiser, E John Wherry, Benjamin A Youngblood, Dietmar Zehn

Journal article | 2019 | Nature Reviews Immunology

'T cell exhaustion' is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first i..

Three new species of the genus Paradoxecia Hampson, 1919 (Lepidoptera: Sesiidae) from China

Tiantian Yu, Yutaka Arita, Axel Kallies, Min Wang

Journal article | 2019 | Zootaxa

Three new species of the genus Paradoxecia Hampson, 1919 (Lepidoptera: Sesiidae) are described from China: Paradoxecia kishidai Yu..

Exhausted memory T cells maintain T cell responses in chronic infections and cancer

SS Gabriel, D Utzschneider, A Kallies

Conference Proceedings | 2019 | EUROPEAN JOURNAL OF IMMUNOLOGY

Blimp1 prevents methylation of Foxp3 and loss of regulatory T cell identity at sites of inflammation

A Muschaweckh, H Moreno, S Floess, M Hiltensperger, G Schotta, J Huehn, A Kallies, T Korn

Conference Proceedings | 2019 | EUROPEAN JOURNAL OF IMMUNOLOGY

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article | 2019 | Immunity

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

Phylotranscriptomics resolves phylogeny of the Heliozelidae (Adeloidea: Lepidoptera) and suggests a Late Cretaceous origin in Australia

Liz Milla, Adnan Moussalli, Stephen A Wilcox, Erik J van Nieukerken, David A Young, Mike Halsey, Thomas McConville, Theresa M Jones, Axel Kallies, Douglas J Hilton

Journal article | 2019 | Systematic Entomology

Tissue-resident memory T cells keep cancer dormant

Sarah Sharon Gabriel, Axel Kallies

Journal article | 2019 | Cell Research

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article | 2019 | Blood

c-Maf-dependent T-reg cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis

Christian Neumann, Jonas Blume, Urmi Roy, Peggy P Teh, Ajithkumar Vasanthakumar, Alexander Beller, Yang Liao, Frederik Heinrich, Teresita L Arenzana, Jason A Hackney, Celine Eidenschenk, Eric JC Galvez, Christina Stehle, Gitta A Heinz, Patrick Maschmeyer, Tom Sidwell, Yifang Hu, Derk Amsen, Chiara Romagnani, Hyun-Dong Chang, et al.

Journal article | 2019 | Nature Immunology

Interleukin (IL)-33 and the IL-1 Family of Cytokines-Regulators of Inflammation and Tissue Homeostasis

Ajithkumar Vasanthakumar, Axel Kallies

Journal article | 2019 | Cold Spring Harbor Perspectives in Biology

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garima Garg, Andreas Muschaweckh, Helena Moreno, Ajithkumar Vasanthakumar, Stefan Floess, Gildas Lepennetier, Rupert Oellinger, Yifan Zhan, Tommy Regen, Michael Hiltensperger, Christian Peter, Lilian Aly, Benjamin Knier, Lakshmi Reddy Palam, Reuben Kapur, Mark H Kaplan, Ari Waisman, Roland Rad, Gunnar Schotta, Jochen Huehn, et al.

Journal article | 2019 | Cell Reports

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Xiaoxiao Jia, Catarina F Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn S Meehan, Axel Kallies, Dale I Godfrey, Patrick C Reading, et al.

Journal article | 2018 | Nature Communications

A new species of Pharmacis Hubner, 1820 from Spain with a brief review of the genera Pharmacis and Korscheltellus Borner, 1920 (Lepidoptera, Hepialidae)

Axel Kallies, Teresa Farino

Journal article | 2018 | Nota Lepidopterologica

The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS

Chelsea L Edwards, Marcela Montes de Oca, Fabian de Labastida Rivera, Rajiv Kumar, Susanna S Ng, Yulin Wang, Fiona H Amante, Kohei Kometani, Tomohiro Kurosaki, Tom Sidwell, Axel Kallies, Christian R Engwerda

Journal article | 2018 | Frontiers in Immunology

Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 Tcells

Natasja AM Kragten, Felix M Behr, Felipe A Vieira Braga, Ester BM Remmerswaal, Thomas H Wesselink, Anna E Oja, Pleun Hombrink, Axel Kallies, Rene AW van Lier, Regina Stark, Klaas PJM van Gisbergen

Journal article | 2018 | European Journal of Immunology

A new species of Aschistophleps from Thailand and Laos, with a new generic synonymy (Lepidoptera, Sesiidae)

Axel Kallies, Vladimir Stolc

Journal article | 2018 | Zootaxa

Transplantation of Tissue-Resident Lymphocytes

Amy Prosser, Wen Hua Huang, Liu Liu, Bastiaan de Boer, Irma Larma-Cornwall, Gary Jeffrey, Silvana Gaudieri, Axel Kallies, Michaela Lucas

Conference Proceedings | 2018 | Transplantation

Transcription Factor Theft-PU.1 Caught Red-Handed

Axel Kallies, Stephen L Nutt

Journal article | 2018 | Immunity

A new zygaenid moth species from Kangaroo Island, South Australia (Lepidoptera: Zygaenidae: Procridinae)

Axel Kallies, Bernard Mollet, David A Young

Journal article | 2018 | Zootaxa

Follicular B Cells Promote Atherosclerosis via T Cell-Mediated Differentiation Into Plasma Cells and Secreting Pathogenic Immunoglobulin G

Christopher Tay, Yu-Han Liu, Peter Kanellakis, Axel Kallies, Yi Li, Anh Cao, Hamid Hosseini, Peter Tipping, Ban-Hock Toh, Alex Bobik, Tin Kyaw

Journal article | 2018 | Arteriosclerosis, Thrombosis, and Vascular Biology

Cord Blood CD8( ) T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner

Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison

Journal article | 2018 | Frontiers in Immunology

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn Meehan, Dale Godfrey, Patrick Reading, Alexandra Corbett, James McCluskey, et al.

Journal article | 2018 | Nature Communications

Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lung..

A new genus and species of myrmecophile clearwing moth (Lepidoptera: Sesiidae) from East Africa

David Agassiz, Axel Kallies

Journal article | 2018 | Zootaxa

Identifying low-grade cellular rejection after heart transplantation in children by using gene expression profiling

Annie Xin, Melissa GY Lee, Yifang Hu, Vera Ignjatovic, William Y Shi, Anne Shipp, Slavica Praporski, Axel Kallies, Robert G Weintraub, Paul T Monagle, Gordon K Smyth, Igor E Konstantinov

Journal article | 2018 | Physiological Genomics

A preliminary molecular phylogeny of shield- bearer moths (Lepidoptera: Adeloidea: Heliozelidae) highlights rich undescribed diversity

Liz Milla, Erik J van Nieukerken, Ruben Vijverberg, Camiel Doorenweerd, Stephen A Wilcox, Mike Halsey, David A Young, Theresa M Jones, Axel Kallies, Douglas J Hilton

Journal article | 2018 | Molecular Phylogenetics and Evolution

Tissue-Resident Lymphocytes in Solid Organ Transplantation: Innocent Passengers or the Key to Organ Transplant Survival?

Amy C Prosser, Axel Kallies, Michaela Lucas

Journal article | 2018 | Transplantation

A new sun moth species from the Flinders Ranges in South Australia (Lepidoptera, Castniidae)

Axel Kallies, Ted Edwards

Journal article | 2018 | Zootaxa

Transcription Factor IRF4 Promotes CD8( ) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

Kevin Man, Sarah S Gabriel, Yang Liao, Renee Gloury, Simon Preston, Darren C Henstridge, Marc Pellegrini, Dietmar Zehn, Friederike Berberich-Siebelt, Mark A Febbraio, Wei Shi, Axel Kallies

Journal article | 2017 | Immunity

The immune system of the liver: 50 years of strangeness

Michaela Lucas, Axel Kallies, Paul Klenerman

Journal article | 2017 | Clinical & Translational Immunology

Understanding tissue residency in organ transplantation

A Prosser, WH Huang, B de Boer, L Liu, I Larma-Cornwall, S Gaudieri, A Kallies, M Lucas

Conference Proceedings | 2017 | EUROPEAN JOURNAL OF IMMUNOLOGY

THE TRANSCRIPTION FACTOR T-BET COMPROMISES HUMORAL IMMUNITY TO BLOOD-STAGE MALARIA BY INHIBITING THE EFFICIENT DEVELOPMENT OF GERMINAL CENTRE RESPONSES

Diana S Hansen, Ann Ly, Lisa J Ioannidis, Axel Kallies

Conference Proceedings | 2017 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The TNF Receptor Superfamily-NF-kappa B Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F Pascutti, Anna E Oja, Alexandra L Garnham, Renee Gloury, Jessica C Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W Kuijpers, Najoua Lalaoui, Lisa A Mielke, Vanessa L Bryant, Philip D Hodgkin, John Silke, Gordon K Smyth, Martijn A Nolte, Wei Shi, et al.

Journal article | 2017 | Cell Reports

Local Modulation of Antigen-Presenting Cell Development after Resolution of Pneumonia Induces Long-Term Susceptibility to Secondary Infections

Antoine Roquilly, Hamish EG McWilliam, Cedric Jacqueline, Zehua Tian, Raphael Cinotti, Marie Rimbert, Linda Wakim, Irina Caminschi, Mireille H Lahoud, Gabrielle T Belz, Axel Kallies, Justine D Mintern, Karim Asehnoune, Jose A Villadangos

Journal article | 2017 | Immunity

IL-17-producing gamma delta Tcells switch migratory patterns between resting and activated states

Duncan R McKenzie, Ervin E Kara, Cameron R Bastow, Timona S Tyllis, Kevin A Fenix, Carly E Gregor, Jasmine J Wilson, Rachelle Babb, James C Paton, Axel Kallies, Stephen L Nutt, Anne Brustle, Matthias Mack, Iain Comerford, Shaun R McColl

Journal article | 2017 | Nature Communications

Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System

Axel Kallies, Kim L Good-Jacobson

Journal article | 2017 | Trends in Immunology

Eomesodermin promotes the development of type 1 regulatory T (T(R)1) cells

Ping Zhang, Jason S Lee, Kate H Gartlan, Iona S Schuster, Iain Comerford, Antiopi Varelias, Md Ashik Ullah, Slavica Vuckovic, Motoko Koyama, Rachel D Kuns, Kelly R Locke, Kirrilee J Beckett, Stuart D Olver, Luke D Samson, Marcela Montes de Oca, Fabian de labastida Rivera, Andrew D Clouston, Gabrielle T Belz, Bruce R Blazar, Kelli P MacDonald, et al.

Journal article | 2017 | Science Immunology

A non-canonical function of Ezh2 preserves immune homeostasis

Ajithkumar Vasanthakumar, Dakang Xu, Aaron TL Lun, Andrew J Kueh, Klaas PJM van Gisbergen, Nadia Iannarella, Xiaofang Li, Liang Yu, Die Wang, Bryan RG Williams, Stanley CW Lee, Ian J Majewski, Dale I Godfrey, Gordon K Smyth, Warren S Alexander, Marco J Herold, Axel Kallies, Stephen L Nutt, Rhys S Allan

Journal article | 2017 | EMBO reports

T cell responses in the central nervous system

Thomas Korn, Axel Kallies

Journal article | 2017 | Nature Reviews Immunology

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection

Selma Tuzlak, Robyn L Schenk, Ajithkumar Vasanthakumar, Simon P Preston, Manuel D Haschka, Dimitra Zotos, Axel Kallies, Andreas Strasser, Andreas Villunger, Marco J Herold

Journal article | 2017 | Cell Death & Differentiation

Transcriptional Regulation of Tissue-Resident Lymphocytes

Laura K Mackay, Axel Kallies

Journal article | 2017 | Trends in Immunology

THE TRANSCRIPTION FACTOR T-BET SUPPRESSES GERMINAL CENTRE DEVELOPMENT AND HUMORAL IMMUNITY TO BLOOD-STAGE PLASMODIUM INFECTION

Ann Ly, Victoria Ryg-Cornejo, Chris Y Chiu, Lisa J Ioannidis, Kim L Good-Jacobson, Gabrielle T Belz, Axel Kallies, Diana S Hansen

Conference Proceedings | 2017 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A new species and new records of Melittiini from China and Vietnam (Lepidoptera, Sesiidae)

Axel Kallies, Yutaka Arita, Wang Min

Journal article | 2016 | Zootaxa

Sugars and fat - A healthy way to generate functional regulatory T cells

Sarah Sharon Gabriel, Axel Kallies

Journal article | 2016 | European Journal of Immunology

CXCR5( ) follicular cytotoxic T cells control viral infection in B cell follicles

Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man, Claire Deleage, Martina Minnich, Benjamin J Meckiff, Yunbo Wei, Zhaohua Hou, Dimitra Zotos, Kevin A Fenix, Anurag Atnerkar, Simon Preston, Jeffrey G Chipman, Greg J Beilman, Cody C Allison, Lei Sun, Peng Wang, Jiawei Xu, et al.

Journal article | 2016 | Nature Immunology