Axel Kallies

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome.

Momeneh Foroutan, Ramyar Molania, Aline Pfefferle, Corina Behrenbruch, Sebastian Scheer, Axel Kallies, Terence P Speed, Joseph Cursons, Nicholas D Huntington

Journal article  |  2021  |  Cancer Immunol Res

Immunotherapy success in colorectal cancer is mainly limited to patients whose tumors exhibit high microsatellite instability (MSI..

Transforming growth factor-b-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

Sarah S Gabriel, Carlson Tsui, David Chisanga, Flora Weber, Manuela Llano-Leon, Patrick M Gubser, Laurent Bartholin, Fernando Souza-Fonseca-Guimaraes, Nicholas D Huntington, Wei Shi, Daniel T Utzschneider, Axel Kallies

Journal article  |  2021  |  IMMUNITY

Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exha..

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X Shi, Michael A Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S Anstee, Boris Reljic, Sarah S Gabriel, Tirta M Djajawi, Chris D Riffkin, Brandon J Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, et al.

Journal article  |  2021  |  BLOOD

Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative treatment for patients with various leukemi..

A molecular phylogeny and revision of the genus Pyropteron Newman, 1832 (Lepidoptera, Sesiidae) reveals unexpected diversity and frequent hostplant switch as a driver of speciation

Daniel Bartsch, Franz Puehringer, Liz Milla, Arthur Lingenhoele, Axel Kallies

Journal article  |  2021  |  ZOOTAXA

We here revise the genus Pyropteron Newman, 1832 using molecular and morphological analyses. Our data support the monophyly of Pyr..

Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation

Amy Prosser, Wen Hua Huang, Liu Liu, Sarah Dart, Monalyssa Watson, Bastiaan de Boer, Philip Kendrew, Andrew Lucas, Irma Larma-Cornwall, Silvana Gaudieri, Gary P Jeffrey, Luc Delriviere, Axel Kallies, Michaela Lucas

Journal article  |  2021  |  CELL REPORTS

The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity a..

A molecular phylogeny and revision of the genus Pyropteron Newman, 1832 (Lepidoptera, Sesiidae) reveals unexpected diversity and frequent hostplant switch as a driver of speciation

D Bartsch, F Pühringer, L Milla, A Lingenhöle, A Kallies

Journal article  |  2021  |  Zootaxa

We here revise the genus Pyropteron Newman, 1832 using molecular and morphological analyses. Our data support the monophyly of Pyr..

Antigen-driven EGR2 expression is required for exhausted CD8( ) T cell stability and maintenance

Mayura Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nuessing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhau..

Cellular networks controlling T cell persistence in adoptive cell therapy

Jack D Chan, Junyun Lai, Clare Y Slaney, Axel Kallies, Paul A Beavis, Phillip K Darcy

Journal article  |  2021  |  NATURE REVIEWS IMMUNOLOGY

The antitumour activity of endogenous or adoptively transferred tumour-specific T cells is highly dependent on their differentiati..

A new species of the genus Paranthrenella Strand, 1916 (Lepidoptera: Sesiidae) from China

Tiantian Yu, Lei Gao, Axel Kallies, Yutaka Arita, Min Wang

Journal article  |  2021  |  ZOOTAXA

A new clearwing moth, Paranthrenella cinnamoma sp. nov., is described from southern China. Adults and genitalia are illustrated, D..