Axel Kallies

BATF3 programs CD8( )T cell memory

Marco A Ataide, Karl Komander, Konrad Knoepper, Annika E Peters, Hao Wu, Sarah Eickhoff, Tea Gogishvili, Justus Weber, Anika Grafen, Axel Kallies, Natalio Garbi, Hermann Einsele, Michael Hudecek, Georg Gasteiger, Michael Hoelzel, Martin Vaeth, Wolfgang Kastenmueller

Journal article  |  2020  |  Nature Immunology

Methio "mine"! Cancer cells steal methionine and impair CD8 T-cell function

Patrick M Gubser, Axel Kallies

Journal article  |  2020  |  Immunology & Cell Biology

Tumor cells steal methionine from CD8 T cells. High expression of the methionine transporters SLC7A5 and SLC43A2 allows tumor cell..

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  Nature Immunology

Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.

Takumi Kobayashi, Pui Yeng Lam, Hui Jiang, Karolina Bednarska, Renee Elyse Gloury, Valentine Murigneux, Joshua Tay, Nicolas Jacquelot, Rui Li, Zewen Kelvin Tuong, Graham Leggatt, Maher K Gandhi, Michelle M Hill, Gabrielle T Belz, Shyuan Ngo, Axel Kallies, Stephen R Mattarollo

Journal article  |  2020  |  Blood

NK cells play critical roles in protection against haematological malignancies but can acquire a dysfunctional state, which limits..

The clearwing moths (Lepidoptera, Sesiidae) of Australia, New Guinea and the Pacific Islands

Axel Kallies

Journal article  |  2020  |  Zootaxa

In this study, the clearwing moths (Sesiidae) of Australia, New Guinea and the Pacific Islands are reviewed. A total of 58 species..

Human effector T cells express TOX-Not so "TOX"ic after all

Daniel T Utzschneider, Axel Kallies

Journal article  |  2020  |  Science Immunology

TOX expression is not restricted to exhausted T cells but a characteristic of all human effector CD8+ T cells.

IRF4 instructs effector Treg differentiation and immune suppression in human cancer

Giorgia Alvisi, Jolanda Brummelman, Simone Puccio, Emilia MC Mazza, Elisa Paoluzzi Tomada, Agnese Losurdo, Veronica Zanon, Clelia Peano, Federico S Colombo, Alice Scarpa, Marco Alloisio, Ajithkumar Vasanthakumar, Rahul Roychoudhuri, Marinos Kallikourdis, Massimiliano Pagani, Egesta Lopci, Pierluigi Novellis, Jonas Blume, Axel Kallies, Giulia Veronesi, et al.

Journal article  |  2020  |  Journal of Clinical Investigation

The molecular mechanisms responsible for the high immunosuppressive capacity of CD4+ Tregs in tumors are not well known. High-dime..

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2020  |  Nature

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..

CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article  |  2020  |  Cellular & Molecular Immunology

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

Precursor exhausted T cells: key to successful immunotherapy?

Axel Kallies, Dietmar Zehn, Daniel T Utzschneider

Journal article  |  2020  |  Nature Reviews Immunology

Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+ T cells ..