Natalie Binder

Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model.

Natalie K Binder, Natasha de Alwis, Sally Beard, Elif Kadife, Alesia Harper, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Natalie J Hannan

Journal article  |  2023  |  Placenta

INTRODUCTION: Development of a therapeutic that targets the pathophysiological elements of preeclampsia would be a major advance f..

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

Bridget M Arman, Natalie K Binder, Natasha de Alwis, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2023  |  REPRODUCTION

IN BRIEF: Preterm birth is the leading cause of perinatal morbidity and mortality; however, current therapies offer limited effica..

The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health

Natasha de Alwis, Natalie K Binder, Sally Beard, Yeukai Tm Mangwiro, Elif Kadife, James SM Cuffe, Emerson Keenan, Bianca R Fato, Tu'uhevaha J Kaituiu-Lino, Fiona C Brownfoot, Sarah A Marshall, Natalie J Hannan

Journal article  |  2022  |  LIFE SCIENCE ALLIANCE

Preeclampsia affects ∼2-8% of pregnancies worldwide. It is associated with increased long-term maternal cardiovascular disease ris..

The effect of metformin on cardiovascular markers in female mice consuming a high fat diet.

Natasha de Alwis, Natalie K Binder, Yeukai TM Mangwiro, Natasha Pritchard, Sally Beard, Tu'uhevaha J Kaitu'u-Lino, Fiona Brownfoot, Natalie J Hannan

Journal article  |  2022  |  Obes Res Clin Pract

BACKGROUND: Metformin, widely used to treat diabetes, is now considered a candidate therapeutic for treatment of cardiovascular di..

Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction

Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Stephen Tong, Lisa Hui, Natalie J Hannan

Journal article  |  2022  |  ANTIOXIDANTS

Previously, we identified elevated transcripts for the gene Oleoyl-ACP Hydrolase (OLAH) in the maternal circulation of pregnancies..

Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease

Natasha de Alwis, Bianca R Fato, Sally Beard, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Kenji Onda, Natalie J Hannan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Previously, we demonstrated that the proton pump inhibitor, esomeprazole magnesium hydrate (MH), could have potential as a repurpo..

Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries-A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development

Bianca R Fato, Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New-onset maternal hypertension is a hallmark of preeclampsia, driven by widespread endothelial dysfunction and systemic vasoconst..

Placental DAAM2 is unaltered in preeclampsia, but upregulated by treatment with proton pump inhibitors

Natasha De Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Stephen Tong, Tu'uhevana J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2022  |  PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

BACKGROUND: Dishevelled Associated Activator Of Morphogenesis 2 (DAAM2) levels are elevated in the maternal circulation and placen..

Actions of Esomeprazole on the Maternal Vasculature in Lean and Obese Pregnant Mice with Impaired Nitric Oxide Synthesis: A Model of Preeclampsia

Natasha de Alwis, Natalie K Binder, Yeukai TM Mangwiro, Sally Beard, Natasha Pritchard, Elif Kadife, Bianca R Fato, Emerson Keenan, Fiona C Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preeclampsia is a devastating, multisystem disorder of pregnancy. It has no cure except delivery, which if premature can impart si..

Hydroxychloroquine reduces soluble Flt-1 secretion from human cytotrophoblast, but does not mitigate markers of endothelial dysfunction in vitro.

Elif Kadife, Natalie Hannan, Alesia Harper, Natalie Binder, Sally Beard, Fiona C Brownfoot

Journal article  |  2022  |  PLoS One

Preeclampsia is a multi-system disease that can have severe, even fatal implications for the mother and fetus. Abnormal placentati..