Iain Clarke

Resilience of Small Ruminants to Climate Change and Increased Environmental Temperature: A Review

Aleena Joy, Frank R Dunshea, Brian J Leury, Iain J Clarke, Kristy DiGiacomo, Surinder S Chauhan

Journal article  |  2020  |  Animals

Climate change is a major global threat to the sustainability of livestock systems. Climatic factors such as ambient temperature, ..

Expression of genes for Kisspeptin (KISS1), Neurokinin B (TAC3), Prodynorphin (PDYN), and gonadotropin inhibitory hormone (RFRP) across natural puberty in ewes.

Qun Li, Jeremy T Smith, Belinda Henry, Alexandra Rao, Alda Pereira, Iain J Clarke

Journal article  |  2020  |  Physiological Reports

Expression of particular genes in hypothami of ewes was measured across the natural pubertal transition by in situ hybridization. ..

Genetic Selection for Thermotolerance in Ruminants

Richard Osei-Amponsah, Surinder S Chauhan, Brian J Leury, Long Cheng, Brendan Cullen, Iain J Clarke, Frank R Dunshea

Journal article  |  2019  |  Animals

Variations in climatic variables (temperature, humidity and solar radiation) negatively impact livestock growth, reproduction, and..

Perennial Ryegrass Alkaloids Increase Respiration Rate and Decrease Plasma Prolactin in Merino Sheep under Both Thermoneutral and Mild Heat Conditions

Michelle LE Henry, Stuart Kemp, Iain J Clarke, Frank R Dunshea, Brian J Leury

Journal article  |  2019  |  Toxins

Lipopolysaccharide reduces gonadotrophin-releasing hormone (GnRH) gene expression: role of RFamide-related peptide-3 and kisspeptin

Chooi Yeng Lee, ShengYun Li, Xiao Feng Li, Daniel AE Stalker, Claire Cooke, Bei Shao, Haluk Kelestimur, Belinda A Henry, Gregory Conductier, Kevin T O'Byrne, Iain J Clarke

Journal article  |  2019  |  Reproduction, Fertility and Development

RFamide-related peptide (RFRP)-3 reduces luteinising hormone (LH) secretion in rodents. Stress has been shown to upregulate the ex..

Brown adipose tissue thermogenesis in polycystic ovary syndrome

Soulmaz Shorakae, Eveline Jona, Barbora de Courten, Gavin W Lambert, Elisabeth A Lambert, Sarah E Phillips, Iain J Clarke, Helena J Teede, Belinda A Henry

Journal article  |  2019  |  Clinical Endocrinology

Epitope mapping of an uncertain endogenous antigen implies secretogranin II peptide splicing.

David R Howlett, Iain J Clarke, Russell P Newton, John E Hart

Journal article  |  2019  |  F1000Research

Background: The search for a tissue-mass reducing reproductive hormone involved a bioassay-guided physicochemical fractionation of..

Sheep as a Model for Control of Appetite and Energy Expenditure

Iain Clarke, Belinda Henry

Book Chapter  |  2019

Animal models have been extensively used to interrogate the mechanisms underpinning the neuroendocrine control of body weight. Thi..

Exercise counteracts the homeostatic decrease in thermogenesis caused by caloric restriction in sheep

John-Paul Fuller-Jackson, Iain J Clarke, Alexandra Rao, Belinda A Henry

Journal article  |  2018  |  The FASEB Journal

Brown adipose tissue thermogenesis in women with polycystic ovary syndrome

Soulmaz Shorakae, Eveline Jona, Gavin Lambert, Elisabeth Lambert, Sarah Phillips, Iain Clarke, Helena Teede, Belinda Henry

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Effect of caloric-restriction and exercise on hypothalamic appetite-regulating peptides in the ewe

John-Paul Fuller-Jackson, Iain J Clarke, Alix Rao, Belinda A Henry

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Stimulation of growth hormone by kisspeptin antagonists in ewes

JT Smith, A Roseweir, M Millar, IJ Clarke, RP Millar

Journal article  |  2018  |  Journal of Endocrinology

Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen

I Clarke

Book Chapter  |  2018

Wireless multichannel optogenetic stimulators enabled by narrow bandwidth resonant tank circuits

Ammar Aldaoud, Artemio Soto-Breceda, Wei Tong, Greg Conductier, Mary A Tonta, Harold A Coleman, Helena C Parkington, Iain Clarke, Jean-Michel Redoute, David J Garrett, Steven Prawer

Journal article  |  2018  |  Sensors and Actuators A: Physical

Continuous Kisspeptin Restores Luteinizing Hormone Pulsatility Following Cessation by a Neurokinin B Antagonist in Female Sheep

Iain J Clarke, Qun Li, Belinda A Henry, Robert P Millar

Journal article  |  2018  |  Endocrinology

Is centrally induced alveolar bone loss in a large animal model preventable by peripheral hormone substitution?

Maciej JK Simon, Frank Timo Beil, Pia Pogoda, Eik Vettorazzi, Iain Clarke, Michael Amling, Ralf Oheim

Journal article  |  2018  |  Clinical Oral Investigations

Glucocorticoid treatment facilitates development of a metabolic syndrome in ovariectomized Macaca Mulatta fed a high fat diet

Linzhao Li, Guang Yang, Guangneng Liao, Jie Mei, Lan Li, Chengshi Wang, Yujia Yuan, Yujun Shi, Jingping Liu, Zhihui Zhong, Jingqiu Cheng, Yanrong Lu, Iain J Clarke, Younan Chen

Journal article  |  2017  |  Steroids

Mysterious inhibitory cell regulator investigated and found likely to be secretogranin II related

John E Hart, Iain J Clarke, Gail P Risbridger, Ben Ferneyhough, Monica Vega-Hernandez

Journal article  |  2017  |  PeerJ

Alteration in the relationship between tanycytes and gonadotrophin-releasing hormone neurosecretory terminals following long-term metabolic manipulation in the sheep

R Pouchain Ribeiro Neto, IJ Clarke, G Conductier

Journal article  |  2017  |  Journal of Neuroendocrinology

Kisspeptin Stimulates Growth Hormone Release by Utilizing Neuropeptide Y Pathways and Is Dependent on the Presence of Ghrelin in the Ewe

Chad D Foradori, Brian K Whitlock, Jay A Daniel, Arthur D Zimmerman, Melaney A Jones, Casey C Read, Barbara P Steele, Jeremy T Smith, Iain J Clarke, Theodore H Elsasser, Duane H Keisler, James L Sartin

Journal article  |  2017  |  Endocrinology

Ontogeny and Thermogenic Role for Sternal Fat in Female Sheep

Belinda A Henry, Mark Pope, Mark Birtwistle, Rachael Loughnan, Reham Alagal, John-Paul Fuller-Jackson, Viv Perry, Helen Budge, Iain J Clarke, Michael E Symonds

Journal article  |  2017  |  Endocrinology

Effect of gonadotropin-inhibitory hormone on luteinizing hormone secretion in humans

JT George, M Hendrikse, JD Veldhuis, IJ Clarke, RA Anderson, RP Millar

Journal article  |  2017  |  Clinical Endocrinology

Sheep model for osteoporosis: The effects of peripheral hormone therapy on centrally induced systemic bone loss in an osteoporotic sheep model

Ralf Oheim, Maciej JK Simon, Malte Steiner, Eik Vettorazzi, Florian Barvencik, Anita Ignatius, Michael Amling, Iain J Clarke, Pia Pogoda, F Timo Beil

Journal article  |  2017  |  Injury

Effects of Season and Estradiol on KNDy Neuron Peptides, Colocalization With D2 Dopamine Receptors, and Dopaminergic Inputs in the Ewe

Peyton Weems, Jeremy Smith, Iain J Clarke, Lique M Coolen, Robert L Goodman, Michael N Lehman

Journal article  |  2017  |  Endocrinology

Animal Models for Manipulation of Thermogenesis

John-Paul Fuller-Jackson, Iain J Clarke, Belinda A Henry

Book Chapter  |  2017

Reduction in thermogenesis due to caloric restriction is attenuated by exercise

John-Paul Fuller-Jackson, Iain J Clarke, Belinda A Henry

Conference Proceedings  |  2017  |  CLINICAL ENDOCRINOLOGY

Plasticity in input to kisspeptin (Kiss) neurons in the hypothalamus of the ewe explains the hypogonadotropic condition caused by reduced body weight

Gregory Conductier, Iain J Clarke

Conference Proceedings  |  2017  |  CLINICAL ENDOCRINOLOGY

Stress Increases Gonadotropin Inhibitory Hormone Cell Activity and Input to GnRH Cells in Ewes

Iain J Clarke, Danielle Bartolini, Gregory Conductier, Belinda A Henry

Journal article  |  2016  |  Endocrinology

alpha-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

Pablo J Enriori, Weiyi Chen, Maria C Garcia-Rudaz, Bernadette E Grayson, Anne E Evans, Sarah M Comstock, Ursel Gebhardt, Hermann L Mueller, Thomas Reinehr, Belinda A Henry, Russell D Brown, Clinton R Bruce, Stephanie E Simonds, Sara A Litwak, Sean L McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H Tschoep, Matthew J Watt, et al.

Journal article  |  2016  |  Molecular Metabolism

The F0F1 ATP Synthase Complex Localizes to Membrane Rafts in Gonadotrope Cells

Krystal Allen-Worthington, Jianjun Xie, Jessica L Brown, Alexa M Edmunson, Abigail Dowling, Amy M Navratil, Kurt Scavelli, Hojean Yoon, Do-Geun Kim, Margaret S Bynoe, Iain Clarke, Mark S Roberson

Journal article  |  2016  |  Molecular Endocrinology

Ewes With Divergent Cortisol Responses to ACTH Exhibit Functional Differences in the Hypothalamo-Pituitary-Adrenal (HPA) Axis

Sakda D Hewagalamulage, Iain J Clarke, Alexandra Rao, Belinda A Henry

Journal article  |  2016  |  Endocrinology

Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity

SD Hewagalamulage, TK Lee, IJ Clarke, BA Henry

Journal article  |  2016  |  Domestic Animal Endocrinology

There is a strong inter-relationship between activation of the hypothalamo-pituitary-adrenal axis and energy homeostasis. Patients..

New concepts of the central control of reproduction, integrating influence of stress, metabolic state, and season

IJ Clarke, L Arbabi

Journal article  |  2016  |  Domestic Animal Endocrinology

Gonadotropin releasing hormone is the primary driver of reproductive function and pulsatile GnRH secretion from the brain causes t..

Triiodothyronine Administration in a Model of Septic Shock: A Randomized Blinded Placebo-Controlled Trial

Matthew J Maiden, Marianne J Chapman, David J Torpy, Timothy R Kuchel, Iain J Clarke, Coralie H Nash, Jonathan D Fraser, Guy L Ludbrook

Journal article  |  2016  |  Critical Care Medicine

Expression of regulatory neuropeptides in the hypothalamus of red deer (Cervus elaphus) reveals anomalous relationships in the seasonal control of appetite and reproduction

GK Barrell, MJ Ridgway, M Wellby, A Pereira, BA Henry, IJ Clarke

Journal article  |  2016  |  General and Comparative Endocrinology

Sex and age-dependent effects of a maternal junk food diet on the mu-opioid receptor in rat offspring

Jessica R Gugusheff, Sung Eun Bae, Alexandra Rao, Iain J Clarke, Lucilla Poston, Paul D Taylor, Clive W Coen, Beverly S Muhlhausler

Journal article  |  2016  |  Behavioural Brain Research

Production and physiological effects of perennial ryegrass alkaloids under thermoneutral conditions in Merinos

MLE Henry, S Kemp, IJ Clarke, FR Dunshea, BJ Leury

Journal article  |  2016  |  Animal Production Science

Rosiglitazone maleate increases weight gain and body fat content in growing lambs

FT Fahri, IJ Clarke, DW Pethick, RD Warner, FR Dunshea

Journal article  |  2016  |  Animal Production Science

The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle

Graeme L Fraser, Hamid R Hoveyda, Iain J Clarke, Suresh Ramaswamy, Tony M Plant, Claudia Rose, Robert P Millar

Journal article  |  2015  |  Endocrinology

Pathways for Stress Effects on Reproduction

Iain Clarke

Conference Proceedings  |  2015  |  ACTA PHYSIOLOGICA

Innate Differences Energy Expenditure Predict the Propensity to become 'Obese'.

Iain Clarke

Conference Proceedings  |  2015  |  ACTA PHYSIOLOGICA

Growth axis maturation is linked to nutrition, growth and developmental rate

Jennifer A Hetz, Brandon R Menzies, Geoffrey Shaw, Alexandra Rao, Lain J Clarke, Marilyn B Renfree

Journal article  |  2015  |  Molecular and Cellular Endocrinology

Betaine improves milk yield under thermoneutral conditions and after heat stress in dairy cows

JJ Cottrell, ML Sullivan, JB Gaughan, K Digiacomo, BJ Leury, P Celi, IJ Clarke, RJ Collier, FR Dunshea

Conference Proceedings  |  2015  |  Proceedings of the 66th European Federation of Animal Science

Differences in mitochondrial DNA inheritance and function align with body conformation in genetically lean and fat sheep

BA Henry, R Loughnan, J Hickford, IR Young, JC St John, I Clarke

Journal article  |  2015  |  Journal of Animal Science

IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes

SW Yau, VC Russo, IJ Clarke, FR Dunshea, GA Werther, MA Sabin

Journal article  |  2015  |  International Journal of Obesity

Kisspeptin Is a Component of the Pulse Generator for GnRH Secretion in Female Sheep But Not THE Pulse Generator

Ahmed Ezzat, Alda Pereira, Iain J Clarke

Journal article  |  2015  |  Endocrinology

High Cortisol Response to Adrenocorticotrophic Hormone Identifies Ewes with Reduced Melanocortin Signalling and Increased Propensity to Obesity

SD Hewagalamulage, IJ Clarke, IR Young, A Rao, BA Henry

Journal article  |  2015  |  Journal of Neuroendocrinology

Hypothalamus as an Endocrine Organ

IJ Clarke

Journal article  |  2015  |  Comprehensive Physiology

Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep

Qun Li, Robert P Millar, Iain J Clarke, Jeremy T Smith

Journal article  |  2015  |  Neuroendocrinology

Effect of incremental levels of crude degummed canola oil on milk progesterone, plasma luteinizing and follicle stimulating hormones of primiparous Holstein-Friesian cows in a pasture-based system

JR Otto, BS Malau-Aduli, A Rao, IJ Clarke, AEO Malau-Aduli

Journal article  |  2014  |  International Journal of Veterinary Science and Medicine

Stress-induced behavioral and metabolic adaptations lead to an obesity-prone phenotype in ewes with elevated cortisol responses

T Kevin Lee, Caroline Lee, Robert Bischof, Gavin W Lambert, Iain J Clarke, Belinda A Henry

Journal article  |  2014  |  Psychoneuroendocrinology

Dietary Antioxidants at Supranutritional Doses Improve Oxidative Status and Reduce the Negative Effects of Heat Stress in Sheep

SS Chauhan, P Celi, BJ Leury, IJ Clarke, FR Dunshea

Journal article  |  2014  |  Journal of Animal Science

The present study was undertaken to investigate the impact of heat (thermal) stress and dietary antioxidant supplementation on the..

Interface between metabolic balance and reproduction in ruminants: Focus on the hypothalamus and pituitary

Iain J Clarke

Journal article  |  2014  |  Hormones and Behavior

Leptin Enhances Insulin Sensitivity by Direct and Sympathetic Nervous System Regulation of Muscle IGFBP-2 Expression: Evidence From Nonrodent Models

Steven W Yau, Belinda A Henry, Vincenzo C Russo, Glenn K McConell, Iain J Clarke, George A Werther, Matthew A Sabin

Journal article  |  2014  |  Endocrinology

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

Troy L Merry, Melanie Tran, Maria Stathopoulos, Florian Wiede, Barbara Christianne Fam, Garron T Dodd, Iain Clarke, Matthew J Watt, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2014  |  Antioxidants & Redox Signaling

Gonadotropin-Inhibitory Hormone Promoter-Driven Enhanced Green Fluorescent Protein Expression Decreases During Aging in Female Rats

Tomoko Soga, Takashi Kitahashi, Iain J Clarke, Ishwar S Parhar

Journal article  |  2014  |  Endocrinology

Gonadotropin inhibitory hormone (GnIH) as a regulator of gonadotropes

Iain J Clarke, Helena C Parkington

Journal article  |  2014  |  Molecular and Cellular Endocrinology

Modifying the mitochondrial genome to enhance animal production

JC St. John, K Srirattana, IJ Clarke

Journal article  |  2014  |  Australasian Biotechnology

High cortisol responses identify propensity for obesity that is linked to thermogenesis in skeletal muscle

T Kevin Lee, Iain J Clarke, Justin St John, I Ross Young, Brian L Leury, Alexandra Rao, Zane B Andrews, Belinda A Henry

Journal article  |  2014  |  FASEB Journal

Paradoxical Effect of Gonadotrophin-Inhibiting Hormone to Negatively Regulate Neuropeptide Y Neurones in Mouse Arcuate Nucleus

JS Jacobi, HA Coleman, PJ Enriori, HC Parkington, Q Li, A Pereira, MA Cowley, IJ Clarke

Journal article  |  2013  |  Journal of Neuroendocrinology

Kiss1 and Kiss1 receptor expression in the rhesus monkey testis: a possible local regulator of testicular function

Amna R Tariq, Muhammad Shahab, Iain J Clarke, Alda Pereira, Jeremy T Smith, Saeed-ul-Hasan Khan, Javeria Sultan, Sehrish Javed, Tayyaba Anwar

Journal article  |  2013  |  Open Life Sciences

Amelioration of thermal stress impacts in dairy cows

Frank R Dunshea, Brian J Leury, Fahri Fahri, Kristy DiGiacomo, Alex Hung, Surinder Chauhan, Iain J Clarke, Robert Collier, Stephen Little, Lance Baumgard, John B Gaughan

Journal article  |  2013  |  Animal Production Science

Heat stress negatively impacts on a variety of animal production parameters. Advances in management strategies have alleviated som..

Sheep model for osteoporosis: Sustainability and biomechanical relevance of low turnover osteoporosis induced by hypothalamic-pituitary disconnection

Ralf Oheim, Frank Timo Beil, Till Koehne, Tim Wehner, Florian Barvencik, Anita Ignatius, Michael Amling, Iain J Clarke, Pia Pogoda

Journal article  |  2013  |  Journal of Orthopaedic Research

Distribution and sequence of gonadotropin-inhibitory hormone and its potential role as a molecular link between feeding and reproductive systems in the Pekin duck (Anas platyrhynchos domestica)

GS Fraley, E Coombs, E Gerometta, S Colton, PJ Sharp, Q Li, IJ Clarke

Journal article  |  2013  |  General and Comparative Endocrinology

Kisspeptin Signaling Is Required for the Luteinizing Hormone Response in Anestrous Ewes following the Introduction of Males

Julie-Ann P De Bond, Qun Li, Robert P Millar, Iain J Clarke, Jeremy T Smith

Journal article  |  2013  |  PLoS ONE

Acetylation

Q Li, IJ Clarke, AI Smith

Book Chapter  |  2013

Amelioration of thermal stress impacts in dairy cows

Frank R Dunshea, Brian J Leury, Fahri Fahri, Kristy DiGiacomo, Alex Hung, Surinder Chauhan, Iain J Clarke, Robert Collier, Stephen Little, Lance Baumgard, John B Gaughan

Conference Proceedings  |  2013  |  Proceedings of the 5th Australasian Dairy Science Symposium 2012

Heat stress negatively impacts on a variety of animal production parameters. Advances in management strategies have alleviated som..

Kisspeptin and Seasonality of Reproduction

Iain J Clarke, Alain Caraty

Journal article  |  2013  |  Advances in Experimental Medicine and Biology

Wild and domesticated species display seasonality in reproductive function, controlled predominantly by photoperiod. Seasonal alte..

Animal Models for Manipulation of Thermogenesis

Belinda A Henry, Iain J Clarke

Book Chapter  |  2013

Differential Effects of Acute and Chronic Estrogen Treatment on Thermogenic and Metabolic Pathways in Ovariectomized Sheep

Scott D Clarke, Iain J Clarke, Alexandra Rao, Roger G Evans, Belinda A Henry

Journal article  |  2013  |  Endocrinology

Circumventricular Organs

MJ McKinley, IJ Clarke, BJ Oldfield

Book Chapter  |  2012

Neurochemical Characterization and Sexual Dimorphism of Projections from the Brain to Abdominal and Subcutaneous White Adipose Tissue in the Rat

Elaine S Adler, Jacob H Hollis, Iain J Clarke, David R Grattan, Brian J Oldfield

Journal article  |  2012  |  Journal of Neuroscience

Postprandial heat production in skeletal muscle is associated with altered mitochondrial function and altered futile calcium cycling

Scott D Clarke, Kevin Lee, Zane B Andrews, Robert Bischof, Fahri Fahri, Roger G Evans, Iain J Clarke, Belinda A Henry

Journal article  |  2012  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Low turnover osteoporosis in sheep induced by hypothalamic-pituitary disconnection

Frank Timo Beil, Ralf Oheim, Florian Barvencik, Tim N Hissnauer, Jan M Pestka, Anita Ignatius, Johannes M Rueger, Thorsten Schinke, Iain J Clarke, Michael Amling, Pia Pogoda

Journal article  |  2012  |  Journal of Orthopaedic Research

Gonadotropin-Inhibitory Hormone (GnIH) Secretion into the Ovine Hypophyseal Portal System

Jeremy T Smith, I Ross Young, Johannes D Veldhuis, Iain J Clarke

Journal article  |  2012  |  Endocrinology

Targeting the lateral but not the third ventricle induces bone loss in ewe: An experimental approach to generate an improved large animal model of osteoporosis

Ralf Oheim, Frank Timo Beil, Florian Barvencik, Marcus Egermann, Michael Amling, Iain J Clarke, Pia Pogoda

Journal article  |  2012  |  The Journal of Trauma and Acute Care Surgery

Sex Differences in the Metabolic Effects of Testosterone in Sheep

Scott D Clarke, Iain J Clarke, Alexandra Rao, Michael A Cowley, Belinda A Henry

Journal article  |  2012  |  Endocrinology

Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor

Qun Li, Alexandra Roa, Iain J Clarke, Jeremy T Smith

Journal article  |  2012  |  Neuroendocrinology

Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding

Iain J Clarke, Jeremy T Smith, Belinda A Henry, Brian J Oldfield, Aneta Stefanidis, Robert P Millar, Ika Puspita Sari, Keefe Chng, Claude Fabre-Nys, Alain Caraty, Beng Ti Ang, Louiza Chan, Gregory S Fraley

Journal article  |  2012  |  Neuroendocrinology

Neuroendocrine Control of Reproduction

Iain J Clarke, Rebecca Campbell, Jeremy T Smith, Vincent Prevot, Susan Wray

Book Chapter  |  2012

Dietary Monounsaturated Fat in Early Life Regulates IGFBP2: Implications for Fat Mass Accretion and Insulin Sensitivity

Matthew A Sabin, Steven W Yau, Vincenzo C Russo, Iain J Clarke, Frank R Dunshea, Jillian Chau, Maree Cox, George A Werther

Journal article  |  2011  |  Obesity

Noninvasive Analytical Estimation of Endogenous GnRH Drive: Analysis Using Graded Competitive GnRH-Receptor Antagonism and a Calibrating Pulse of Exogenous GnRH

Daniel M Keenan, Iain J Clarke, Johannes D Veldhuis

Journal article  |  2011  |  Endocrinology

Improved detection of mycobacteria species in formalin-fixed tissue sections

John S Pedersen, Iain Clarke, John Mills

Journal article  |  2011  |  Histopathology

Kisspeptin Cells in the Ovine Arcuate Nucleus Express Prolactin Receptor but not Melatonin Receptor

Q Li, A Rao, A Pereira, IJ Clarke, JT Smith

Journal article  |  2011  |  Journal of Neuroendocrinology

Mesenteric Infusion of a Volatile Fatty Acid Prevents Body Weight Loss and Transiently Restores Luteinising Hormone Pulse Frequency in Ovariectomised, Food-Restricted Ewes

LA Szymanski, JE Schneider, A Satragno, FR Dunshea, IJ Clarke

Journal article  |  2011  |  Journal of Neuroendocrinology

Control of GnRH secretion: One step back

Iain J Clarke

Journal article  |  2011  |  Frontiers in Neuroendocrinology

Central Leptin Activates Mitochondrial Function and Increases Heat Production in Skeletal Muscle

Belinda A Henry, Zane B Andrews, Alexandra Rao, Iain J Clarke

Journal article  |  2011  |  Endocrinology

Evidence that RF-Amide Related Peptide-3 is not a Mediator of the Inhibitory Effects of Psychosocial Stress on Gonadotrophin Secretion in Ovariectomised Ewes

MM Papargiris, ETA Rivalland, IJ Clarke, JT Smith, A Pereira, AJ Tilbrook

Journal article  |  2011  |  Journal of Neuroendocrinology

Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence

Jeremy T Smith, Qun Li, Kai Sing Yap, Muhammad Shahab, Antonia K Roseweir, Robert P Millar, Iain J Clarke

Journal article  |  2011  |  Endocrinology

Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep

Rhianna C Laker, Belinda A Henry, Glenn D Wadley, Iain J Clarke, Benedict J Canny, Glenn K McConell

Journal article  |  2011  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Hypothalamic Expression of KISS1 and Gonadotropin Inhibitory Hormone Genes During the Menstrual Cycle of a Non-Human Primate

Jeremy T Smith, Muhammad Shahab, Alda Pereira, K-Y Francis Pau, Iain J Clarke

Journal article  |  2010  |  Biology of Reproduction

Stressor Specificity of Sex Differences in Hypothalamo-Pituitary-Adrenal Axis Activity: Cortisol Responses to Exercise, Endotoxin, Wetting, and Isolation/Restraint Stress in Gonadectomized Male and Female Sheep

AI Turner, ETA Rivalland, IJ Clarke, AJ Tilbrook

Journal article  |  2010  |  Endocrinology

Disparate effects of feeding on core body and adipose tissue temperatures in animals selectively bred for Nervous or Calm temperament

Belinda A Henry, Dominique Blache, Alexandra Rao, Iain J Clarke, Shane K Maloney

Journal article  |  2010  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Seasonal breeding as a neuroendocrine model for puberty in sheep

Jeremy T Smith, Lain J Clarke

Journal article  |  2010  |  Molecular and Cellular Endocrinology

Citalopram (antidepressant) administration causes sexual dysfunction in male mice through RF-amide related peptide in the dorsomedial hypothalamus

Tomoko Soga, Dutt Way Wong, Iain J Clarke, Ishwar S Parhar

Journal article  |  2010  |  Neuropharmacology

Dietary Fat, but Not Sugar, in Early Life Promotes Visceral Adiposity and Insulin Resistance in Maturing Piglets - Pointers to a Role of IFGBP2 in the Nutritional Regulation of Insulin Sensitivity.

MA Sabin, SW Yau, JZY Chau, IJ Clarke, VC Russo, FR Dunshea, M Cox, G Werther

Conference Proceedings  |  2010  |  ENDOCRINE REVIEWS

The Action of Leptin on Appetite-Regulating Cells in the Ovine Hypothalamus: Demonstration of Direct Action in the Absence of the Arcuate Nucleus

Yue Qi, Belinda A Henry, Brian J Oldfield, Iain J Clarke

Journal article  |  2010  |  Endocrinology

Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

Kathryn Backholer, Jeremy T Smith, Alix Rao, Alda Pereira, Javed Iqbal, Satoshi Ogawa, Qun Li, Iain J Clarke

Journal article  |  2010  |  Endocrinology

CNS Leptin Action Modulates Immune Response and Survival in Sepsis

Johannes Tschoep, Ruben Nogueiras, Sarah Haas-Lockie, Kevin R Kasten, Tamara R Castaneda, Nadine Huber, Kelsey Guanciale, Diego Perez-Tilve, Kirk Habegger, Nickki Ottaway, Stephen C Woods, Brian Oldfield, Iain Clarke, Streamson Chua, I Sadaf Farooqi, Stephen O'Rahilly, Charles C Caldwell, Matthias H Tschoep

Journal article  |  2010  |  Journal of Neuroscience

Gonadotropin inhibitory hormone function in mammals

Jeremy T Smith, Iain J Clarke

Journal article  |  2010  |  Trends in Endocrinology & Metabolism

Hypothalamic expression of the kisspeptin gene (Kiss1) and the RFamide-related peptide (RFRP) gene during the menstrual cycle of a non-human primate

Jeremy T Smith, Aida Periera, Muhammad Shahab, K-Y Francis Pau, Iain J Clarke

Conference Proceedings  |  2010  |  ENDOCRINE JOURNAL

Whatever Way Weight Goes, Inflammation Shows

Iain J Clarke

Journal article  |  2010  |  Endocrinology

ESTRADIOL-17 beta-RESPONSIVE A1 AND A2 NORADRENERGIC CELLS OF THE BRAIN STEM PROJECT TO BED NUCLEUS OF THE STRIA TERMINALIS IN THE EWE BRAIN: A POSSIBLE ROUTE FOR REGULATION OF GONADOTROPIN RELEASING HORMONE CELLS

A Pereira, J Rawson, A Jakubowska, IJ Clarke

Journal article  |  2010  |  Neuroscience

Expression of Genes for Appetite-Regulating Peptides in the Hypothalamus of Genetically Selected Lean and Fat Sheep

Chantacha Anukulkitch, Alexandra Rao, Alda Pereira, John McEwan, Iain J Clarke

Journal article  |  2010  |  Neuroendocrinology

Altered "set-point" of the hypothalamus determines effects of cortisol on food intake, adiposity, and metabolic substrates in sheep

BA Henry, D Blache, FR Dunshea, IJ Clarke

Journal article  |  2010  |  Domestic Animal Endocrinology

Stressor specificity of sex differences in hypothalamo-pituitary-adrenal axis activity: Cortisol responses to exercise, endotoxin, wetting, and isolation/restraint stress in gonadectomized male and female sheep

AI Turner, ETA Rivalland, IJ Clarke, AJ Tilbrook

Journal article  |  2010  |  The Journal of Clinical Endocrinology & Metabolism

Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes

Kathryn Backholer, Marissa Bowden, Kevin Gamber, Christian Bjorbaek, Javed Iqbal, Iain J Clarke

Journal article  |  2010  |  Neuroendocrinology

The role of kisspeptin and gonadotropin inhibitory hormone (GnIH) in the seasonality of reproduction in sheep

IJ Clarke, JT Smith

Journal article  |  2010  |  Society of Reproduction and Fertility supplement

Sheep are seasonal breeders and reproductive status is controlled by photoperiod. Recent recognition of the significant role for k..

Targeting energy expenditure in muscle as a means of combating obesity

Iain J Clarke, Belinda A Henry

Conference Proceedings  |  2010  |  Clinical and Experimental Pharmacology and Physiology

The Nexus Between Metabolic and Reproductive Circuits in the Hypothalamus

Iain J Clarke

Conference Proceedings  |  2010  |  BIOLOGY OF REPRODUCTION

Effect of RF-Amide-Related Peptide-3 on Luteinizing Hormone and Follicle-Stimulating Hormone Synthesis and Secretion in Ovine Pituitary Gonadotropes

Ika P Sari, Alexandra Rao, Jeremy T Smith, Alan J Tilbrook, Iain J Clarke

Journal article  |  2009  |  Endocrinology

Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe

Kathryn Backholer, Jeremy Smith, Iain J Clarke

Journal article  |  2009  |  Endocrinology

Kisspeptin Neurons in the Ovine Arcuate Nucleus and Preoptic Area Are Involved in the Preovulatory Luteinizing Hormone Surge

JT Smith, Q Li, A Pereira, IJ Clarke

Journal article  |  2009  |  Endocrinology

Estradiol-17 beta Inhibits Gonadotropin-Releasing Hormone-Induced Ca2 in Gonadotropes to Regulate Negative Feedback on Luteinizing Hormone Release

Javed Iqbal, Olivier Latchoumanin, Ika P Sari, Richard J Lang, Harold A Coleman, Helena C Parkington, Iain J Clarke

Journal article  |  2009  |  Endocrinology

Projections of RFamide-related Peptide-3 Neurones in the Ovine Hypothalamus, with Special Reference to Regions Regulating Energy Balance and Reproduction

Y Qi, BJ Oldfield, IJ Clarke

Journal article  |  2009  |  Journal of Neuroendocrinology

Evidence that RF-amide related peptides are inhibitors of reproduction in mammals

Iain J Clarke, Y Qi, I Puspita Sari, Jeremy T Smith

Journal article  |  2009  |  Frontiers in Neuroendocrinology

Cortisol disrupts the ability of estradiol-17 beta to induce the LH surge in ovariectomized ewes

BN Pierce, IJ Clarke, AI Turner, ETA Rivalland, AJ Tilbrook

Journal article  |  2009  |  Domestic Animal Endocrinology

Stress disrupts the preovulatory luteinizing hormone (LH) surge in females, but the mechanisms are unknown. We tested the hypothes..

A test of the lipostat theory in a seasonal (ovine) model under natural conditions reveals a close relationship between adiposity and melanin concentrating hormone expression

Chantacha Anukulkitch, Alexandra Rao, Frank R Dunshea, Iain J Clarke

Journal article  |  2009  |  Domestic Animal Endocrinology

Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation

Antonia K Roseweir, Alexander S Kauffman, Jeremy T Smith, Kathryn A Guerriero, Kevin Morgan, Justyna Pielecka-Fortuna, Rafael Pineda, Michelle L Gottsch, Manuel Tena-Sempere, Suzanne M Moenter, Ei Terasawa, Iain J Clarke, Robert A Steiner, Robert P Millar

Journal article  |  2009  |  Journal of Neuroscience

The Development of Kisspeptin Antagonists for Therapeutic Interventions.

Antonia K Roseweir, Alexander S Kauffman, Jeremy T Smith, Kathryn A Guerriero, Kevin Morgan, Justyna Pielecka-Fortuna, Rafael Pineda, Michelle L Gottsch, Manuel Tena-Sempere, Suzanne M Moenter, Ei Terasawa, Iain J Clarke, Robert A Steiner, Robert P Millar

Conference Proceedings  |  2009  |  REPRODUCTIVE SCIENCES

Inhibition of compensatory renal growth by the N-terminus of a sheep-derived peptide

JL Haylor, E Parker, GP Risbridger, D Beale, BL Brown, PRM Dobson, IJ Clarke, JE Hart

Journal article  |  2009  |  Regulatory Peptides

Gonadotropin, Neural and Hormonal Control

IJ Clarke, AJ Tilbrook

Book Chapter  |  2009

Estradiol Enables Cortisol to Act Directly upon the Pituitary to Suppress Pituitary Responsiveness to GnRH in Sheep

BN Pierce, CA Stackpole, KM Breen, IJ Clarke, FJ Karsch, ETA Rivalland, AI Turner, DJ Caddy, ER Wagenmaker, AE Oakley, AJ Tilbrook

Journal article  |  2009  |  Neuroendocrinology

Kisspeptin and seasonality in sheep

Iain J Clarke, Jeremy T Smith, Alain Caraty, Robert L Goodman, Michael N Lehman

Journal article  |  2009  |  Peptides

Seasonal and Cyclical Change in the Luteinizing Hormone Response to Kisspeptin in the Ewe

Jeremy T Smith, Sofie NH Saleh, Iain J Clarke

Journal article  |  2009  |  Neuroendocrinology

Cortisol Reduces Gonadotropin-Releasing Hormone Pulse Frequency in Follicular Phase Ewes: Influence of Ovarian Steroids

Amy E Oakley, Kellie M Breen, Iain J Clarke, Fred J Karsch, Elizabeth R Wagenmaker, Alan J Tilbrook

Journal article  |  2009  |  Endocrinology

Hypothalamic Paraventricular and Periventricular Nuclei in the Female Sheep Brain, Using Retrograde Tracing and Immunohistochemistry

Yue Qi, MR Namavar, J Iqbal, BJ Oldfield, IJ Clarke

Journal article  |  2009  |  Neuroendocrinology

Potent Action of RFamide-Related Peptide-3 on Pituitary Gonadotropes Indicative of a Hypophysiotropic Role in the Negative Regulation of Gonadotropin Secretion

Iain J Clarke, Ika P Sari, Yue Qi, Jeremy T Smith, Helena C Parkington, Takayoshi Ubuka, Javed Iqbal, Qun Li, Alan Tilbrook, Kevin Morgan, Adam J Pawson, Kazuyoshi Tsutsui, Robert P Millar, George E Bentley

Journal article  |  2008  |  Endocrinology

Variation in Kisspeptin and RFamide-Related Peptide ( RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep

Jeremy T Smith, Lique M Coolen, Lance J Kriegsfeld, Ika P Sari, Mohammad R Jaafarzadehshirazi, Matthew Maltby, Katherine Bateman, Robert L Goodman, Alan J Tilbrook, Takayoshi Ubuka, George E Bentley, Iain J Clarke, Michael N Lehman

Journal article  |  2008  |  Endocrinology

A leptin receptor glycopeptide agonist for leptin replacement therapy

Laszlo Otvos, Marco Cassone, Marianna Terrasi, Laura Scolaro, John Wade, Daniel Knappe, Falf Hoffmann, Belinda Henry, Iain Clarke, Eva Surmacz

Conference Proceedings  |  2008  |  JOURNAL OF PEPTIDE SCIENCE

Psychosocial stress suppresses attractivity, proceptivity and pulsatile LH secretion in the ewe

BN Pierce, PH Hemsworth, ETA Rivalland, ER Wagenmaker, AD Morrissey, MM Papargiris, IJ Clarke, FJ Karsch, AI Turner, AJ Tilbrook

Journal article  |  2008  |  Hormones and Behavior

The preovulatory LH surge in the ewe appears to be essentially timed by the hypothalamus

S Ben Said, IJ Clarke, D Lomet, A Caraty

Conference Proceedings  |  2008  |  REPRODUCTION IN DOMESTIC ANIMALS

Adipose tissue hormones and the regulation of food intake

BA Henry, IJ Clarke

Journal article  |  2008  |  Journal of Neuroendocrinology

The effect of testosterone and season on prodynorphin messenger RNA expression in the preoptic area-hypothalamus of the ram

Christopher J Scott, Iain J Clarke, Alan J Tilbrook

Journal article  |  2008  |  Domestic Animal Endocrinology

Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: Evidence that gonadotropes are not direct targets of kisspeptin in vivo

JT Smith, A Rao, A Pereira, A Caraty, RP Millar, IJ Clarke

Journal article  |  2008  |  Endocrinology

Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration

Belinda A Henry, Frank R Dunshea, Merryn Gould, Iain J Clarke

Journal article  |  2008  |  Endocrinology

Neural connectivity in the mediobasal hypothalamus of the sheep brain

Y Qi, J Iqbal, BJ Oldfield, IJ Clarke

Journal article  |  2008  |  Neuroendocrinology

Redefining the limits of day length responsiveness in a seasonal mammal

Gabriela C Wagner, Jonathan D Johnston, Iain J Clarke, Gerald A Lincoln, David G Hazlerigg

Journal article  |  2008  |  Endocrinology

Models of 'Obesity' in large animals and birds

Iain J Clarke

Book  |  2008  |  Frontiers of Hormone Research

Most laboratory-based research on obesity is carried out in rodents, but there are a number of other interesting models in the ani..

Responses of the hypothalamopituitary adrenal axis and the sympathoadrenal system to isolation/restraint stress in sheep of different adiposity

Alan J Tilbrook, Elizabeth AT Rivalland, Anne I Turner, Gavin W Lambert, Iain J Clarke

Journal article  |  2008  |  Neuroendocrinology

Inherent food safety of a synthetic gonadotropin-releasing factor (GnRF) vaccine for the control of boar taint in entire male pigs

Iain Clarke, John Walker, David Hennessy, John Kreeger, John Nappier, John Crane

Journal article  |  2008  |  INTERNATIONAL JOURNAL OF APPLIED RESEARCH IN VETERINARY MEDICINE

Rapid in vivo effects of estradiol-17 beta in ovine pituitary gonadotropes are displayed by phosphorylation of extracellularly regulated kinase, serine/threonine kinase, and 3 ',5 '-cyclic adenosine 5 '-monophosphate-responsive element-binding protein

Javed Iqbal, Olivier Latchoumanin, Iain J Clarke

Journal article  |  2007  |  Endocrinology

Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin a and neurokinin B

Robert L Goodman, Michael N Lehman, Jeremy T Smith, Lique M Coolen, Cleusa VR De Oliveira, Mohammad R Jafarzadehshirazi, Alda Pereira, Javed Iqbal, Alain Caraty, Philippe Ciofi, Iain J Clarke

Journal article  |  2007  |  Endocrinology

Kisspeptin synchronizes Preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes

A Caraty, JT Smith, D Lomet, S Ben Saied, A Morrissey, J Cognie, B Doughton, G Baril, C Briant, IJ Clarke

Journal article  |  2007  |  Endocrinology

Neuroendocrinology: Introduction

C Kordon, I Clarke

Journal article  |  2007  |  Neuroendocrinology

Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes

LA Szymanski, JE Schneider, MI Friedman, H Ji, Y Kurose, D Blache, A Rao, FR Dunshea, IJ Clarke

Journal article  |  2007  |  Journal of Neuroendocrinology

Oxytocin reduces the stress of weaning and increases gastric expression of ghrelin and leptin in neonatal pigs

Josie Marie Ferrari, John R Pluske, David W Miller, Iain J Clarke, Frank R Dunshea

Conference Proceedings  |  2007  |  FASEB JOURNAL

Isolation and restraint stress results in differential activation of corticotrophin-releasing hormone and arginine vasopressin neurons in sheep

ETA Rivalland, IJ Clarke, AI Turner, S Pompolo, J Tilbrook

Journal article  |  2007  |  Neuroscience

Kisspeptin expression in the brain: Catalyst for the initiation of puberty

JT Smith, IJ Clarke

Journal article  |  2007  |  Reviews in Endocrine and Metabolic Disorders

KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season

Jeremy T Smith, Colin M Clay, Alain Caraty, Iain J Clarke

Journal article  |  2007  |  Endocrinology

Food Intake and Stress, Non-Human

BA Henry, IJ Clarke

Book Chapter  |  2007

Influence of photoperiod and gonadal status on food intake, adiposity, and gene expression of hypothalamic appetite regulators in a seasonal mammal

Chantacha Anukulkitch, Alexandra Rao, Frank R Dunshea, Dominique Blache, Gerald A Lincoln, Iain J Clarke

Journal article  |  2007  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Characterizing a mammalian circannual pacemaker

Gerald A Lincoln, Iain J Clarke, Roelof A Hut, David G Hazlerigg

Journal article  |  2006  |  Science

Sex difference in the suppressive effect of cortisol on pulsatile secretion of luteinizing hormone in sheep

Catherine A Stackpole, Iain J Clarke, Kellie M Breen, Anne I Turner, Fred J Karsch, Alan J Tilbrook

Journal article  |  2006  |  Endocrinology

Leptin inhibits bone formation not only in rodents, but also in sheep

Pia Pogoda, Marcus Egermann, Johann C Schnell, Matthias Priemel, Arndt F Schilling, Mauro Alini, Thorsten Schinke, Johannes M Rueger, Erich Schneider, Lain Clarke, Michael Amling

Journal article  |  2006  |  Journal of Bone and Mineral Research

Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

KM Estrada, CM Clay, S Pompolo, JT Smith, IJ Clarke

Journal article  |  2006  |  Journal of Neuroendocrinology

Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress

AJ Tilbrook, IJ Clarke

Journal article  |  2006  |  Frontiers in Neuroendocrinology

Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes: Effect of the presence of the lamb and suckling

AJ Tilbrook, AI Turner, MD Ibbott, IJ Clarke

Journal article  |  2006  |  Endocrinology

The role of noradrenaline in the generation of the preovulatory LH surge in the ewe

Iain J Clarke, Christopher J Scott, Alda Pereira, Sueli Pompolo

Journal article  |  2006  |  Domestic Animal Endocrinology

Kisspeptin is co-localized in a subset of dynorphin neurons in the ovine arcuate nucleus

MN Lehman, LM Coolen, CVR de Oliveira, IJ Clarke, RL Goodman

Conference Proceedings  |  2006  |  Frontiers in Neuroendocrinology

Influence of photoperiod and gonadal status on changes in gene expression for appetite regulating peptides and leptin receptor (Ob-Rb) in the hypothalamus of Soay rams

Chantacha Anukulkitch, Alexandra Rao, Gerald Lincoln, Iain Clarke

Conference Proceedings  |  2006  |  Frontiers in Neuroendocrinology

Isolation/restraint stress in sheep activates projections to the preoptic area arising from the paraventricular nucleus but not those arising from the bed nucleus of the stria terminalis or the arcuate nucleus

AJ Tilbrook, ETA Rivalland, AI Turner, S Pompolo, IJ Clarke

Conference Proceedings  |  2006  |  Frontiers in Neuroendocrinology

Kisspeptin-10 stimulates luteinising hormone release from the ovine pituitary gland in vitro

JT Smith, A Pereira, A Rao, IJ Clarke

Conference Proceedings  |  2006  |  Frontiers in Neuroendocrinology

Expression of NPY and POMC in the hypothalamic arcuate nucleus of genetically lean and fat sheep

Chantacha Anukulkitch, Alexandra Rao, John McEwan, Iain Clarke

Conference Proceedings  |  2006  |  Frontiers in Neuroendocrinology

Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain

S Pompolo, A Pereira, KM Estrada, IJ Clarke

Journal article  |  2006  |  Endocrinology

Projections to the preoptic area from the paraventricular nucleus, arcuate nucleus and the bed nucleus of the stria terminalis are unlikely to be involved in stress-induced suppression of GnRH secretion in sheep

Elizabeth TA Rivalland, Alan J Tilbrook, Anne I Turner, Javed Iqbal, Sueli Pompolo, Iain J Clarke

Journal article  |  2006  |  Neuroendocrinology

Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep

J Iqbal, Y Kurose, B Canny, IJ Clarke

Journal article  |  2006  |  Endocrinology

Role of sex and sex steroids in mediating pituitary-adrenal responses to acute buspirone treatment in sheep

JH Broadbear, BN Pierce, IJ Clarke, BJ Canny

Journal article  |  2005  |  Journal of Neuroendocrinology

Reduction in adiposity affects the extent of afferent projections to growth hormone-releasing hormone and somatostatin neurons and the degree of colocalization of neuropeptides in growth hormone-releasing hormone and somatostatin cells of the ovine hypothalamus

J Iqbal, TR Manley, P Ciofi, IJ Clarke

Journal article  |  2005  |  Endocrinology

Activin A: From sometime reproductive factor to genuine cytokine

DJ Phillips, KL Jones, IJ Clarke, JPY Scheerlinck, DM de Kretser

Journal article  |  2005  |  Veterinary Immunology and Immunopathology

Synthesis and secretion of GnRH

LJ Clarke, S Pompolo

Journal article  |  2005  |  Animal Reproduction Science

Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means

Y Kurose, J Iqbal, A Rao, Y Murata, Y Hasegawa, Y Terashima, M Kojima, K Kangawa, IJ Clarke

Journal article  |  2005  |  Journal of Neuroendocrinology

Noradrenergic regulation of hypothalamic cells that produce growth hormone-releasing hormone and somatostatin and the effect of altered adiposity in sheep

J Iqbal, TR Manley, Q Yue, MR Namavar, IJ Clarke

Journal article  |  2005  |  Journal of Neuroendocrinology

Expression of pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1R) in the ewe hypothalamus: Distribution and colocalization with tyrosine hydroxylase-immunoreactive neurones

ST Anderson, DHL Kusters, IJ Clarke, DV Pow, JD Curlewis

Journal article  |  2005  |  Journal of Neuroendocrinology

Effects of changing gonadotropin-releasing hormone pulse frequency and estrogen treatment on levels of estradiol receptor-alpha and induction of fos and phosphorylated cyclic adenosine monophosphate response element binding protein in pituitary gonadotropes: Studies in hypothalamo-pituitary disconnected ewes

IJ Clarke, VA Tobin, S Pompolo, A Pereira

Journal article  |  2005  |  Endocrinology

Y2 receptor-selective agonist delays the estrogen-induced luteinizing hormone surge in ovariectomized ewes, but Y1-receptor-selective agonist stimulates voluntary food intake

IJ Clarke, K Backholer, AJ Tilbrook

Journal article  |  2005  |  Endocrinology

Neuropeptide Y (NPY) plays a major role in the regulation of food intake, regulation of homeostasis, and neuroendocrine function. ..

Evidence that projections from the bed nucleus of the stria terminalis and from the lateral and medial regions of the preoptic area provide input to gonadotropin releasing hormone (GNRH) neurons in the female sheep brain

S Pompolo, O Ischenko, A Pereira, J Iqbal, IJ Clarke

Journal article  |  2005  |  Neuroscience

Cortisol delays the estradiol-induced LH surge: Is this dependent on prior ovarian steroid exposure?

ER Wagenmaker, KM Breen, IJ Clarke, AE Oakley, AJ Tilbrook, AI Turner, FJ Karsch

Conference Proceedings  |  2005  |  BIOLOGY OF REPRODUCTION

Co-localization and distribution of corticotrophin-releasing hormone, arginine vasopressin and enkephalin in the paraventricular nucleus of sheep: A sex comparison

ETA Rivalland, J Iqbal, IJ Clarke, AI Turner, AJ Tilbrook

Journal article  |  2005  |  Neuroscience

Progesterone-receptive dopaminergic and neuropeptide Y neurons project from the arcuate nucleus to gonadotropin-releasing hormone-rich regions of the ovine preoptic area

L Dufourny, A Caraty, IJ Clarke, JE Robinson, DC Skinner

Journal article  |  2005  |  Neuroendocrinology

Progesterone-receptive beta-endorphin and dynorphin B neurons in the arcuate nucleus project to regions of high gonadotropin-releasing hormone neuron density in the ovine preoptic area - A retrograde labeling study

L Dufourny, A Caraty, IJ Clarke, JE Robinson, DC Skinner

Journal article  |  2005  |  Neuroendocrinology

Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe

CJ Scott, IJ Clarke, A Rao, AJ Tilbrook

Journal article  |  2004  |  Journal of Neuroendocrinology

Antidepressants, sex steroids and pituitary-adrenal response in sheep

JH Broadbear, T Nguyen, IJ Clarke, BJ Canny

Journal article  |  2004  |  Psychopharmacology

Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe

KL Jones, DM de Kretser, IJ Clarke, JPY Scheerlinck, DJ Phillips

Journal article  |  2004  |  Journal of Endocrinology

Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone?

KM Breen, CA Stackpole, IJ Clarke, AV Pytiak, AJ Tilbrook, ER Wagenmaker, EA Young, FJ Karsch

Journal article  |  2004  |  Endocrinology

Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements

DM Keenan, S Alexander, CHG Irvine, I Clarke, C Scott, A Turner, AJ Tilbrook, BJ Canny, JD Veldhuis

Journal article  |  2004  |  Proceedings of the National Academy of Sciences

Leptin-mediated effects of undernutrition or fasting on luteinizing hormone and growth hormone secretion in ovariectomized ewes depend on the duration of metabolic perturbation

BA Henry, JW Goding, AJ Tilbrook, FR Dunshea, D Blache, IJ Clarke

Journal article  |  2004  |  Journal of Neuroendocrinology

Sex differences in the pituitary-adrenal response following acute antidepressant treatment in sheep

JH Broadbear, LC Hutton, IJ Clarke, BJ Canny

Journal article  |  2004  |  Psychopharmacology

Does cortisol disrupt the positive feedback effects of estradiol on the preovulatory LH surge

ER Wagenmaker, KM Breen, AJ Tillbrook, AI Turner, IJ Clarke, FJ Karsch

Conference Proceedings  |  2004  |  BIOLOGY OF REPRODUCTION

Effect of testosterone and season on proenkephalin messenger RNA expression in the preoptic area of the hypothalamus in the ram

CJ Scott, M Mariani, IJ Clarke, AJ Tilbrook

Journal article  |  2003  |  Biology of Reproduction

Circumventricular Organs

MJ McKinley, IJ Clarke, BJ Oldfield

Book Chapter  |  2003

Neuropeptide Y (NPY) delays the oestrogen-induced luteinizing hormone (LH) surge in the ovariectomized ewe: Further evidence that NPY has a predominant negative effect on LH secretion in the ewe

KM Estrada, S Pompolo, MJ Morris, AJ Tilbrook, IJ Clarke

Journal article  |  2003  |  Journal of Neuroendocrinology

Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter-2

S Pompolo, A Pereira, CJ Scott, F Fujiyma, IJ Clarke

Journal article  |  2003  |  The Journal of Comparative Neurology

Seasonal differences in the effect of isolation and restraint stress on the luteinizing hormone response to gonadotropin-releasing hormone in hypothalamopituitary disconnected, gonadectomized rams and ewes

CA Stackpole, AL Turner, IJ Clarke, GW Lambert, AJ Tilbrook

Journal article  |  2003  |  Biology of Reproduction

Prolactin cycles in sheep under constant photoperiod: Evidence that photorefractoriness develops within the pituitary gland independently of the prolactin output signal

GA Lincoln, H Andersson, IJ Clarke

Journal article  |  2003  |  Biology of Reproduction

Seasonal changes in the inputs to gonadotropin-releasing hormone neurones in the ewe brain: An assessment by conventional fluorescence and confocal microscopy

S Pompolo, A Pereira, T Kaneko, IJ Clarke

Journal article  |  2003  |  Journal of Neuroendocrinology

Neuronal inputs from the hypothalamus and brain stem to the medial preoptic area of the ram: Neurochemical correlates and comparison to the ewe

CJ Scott, LJ Clarke, AJ Tilbrook

Journal article  |  2003  |  Biology of Reproduction

Photoperiod effects on gene expression for hypothalamic appetite-regulating peptides and food intake in the ram.

Iain J Clarke, Alexandra Rao, Yves Chilliard, Carole Delavaud, Gerald A Lincoln

Journal article  |  2003  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Relationship between voluntary food intake (VFI) and gene expression for appetite-regulating peptides was examined in the brains o..

Cortisol does not suppress the luteinizing hormone (LH) response to gonadotropin-releasing hormone (GnRH) in hypothalamo-pituitary disconnected rams and ewes.

CA Stackpole, AI Turner, IJ Clarke, AJ Tilbrook

Conference Proceedings  |  2003  |  BIOLOGY OF REPRODUCTION

Long-term alteration in bodyweight and food restriction does not affect the gene expression of either preproorexin or prodynorphin in the sheep

J Iqbal, BA Henry, S Pompolo, A Rao, IJ Clarke

Journal article  |  2003  |  Neuroscience

Noradrenaline, but not neuropeptide Y, is elevated in cerebrospinal fluid from the third cerebral ventricle following audiovisual stress in gonadectomised rams and ewes

AI Turner, ETA Rivalland, IJ Clarke, GW Lambert, MJ Morris, AJ Tilbrook

Journal article  |  2002  |  Neuroendocrinology

Perinatal growth and plasma GH profiles in adolescent and adult sheep.

KL Gatford, IJ Clarke, MJ De Blasio, IC McMillen, undefined J S Robinson, JA Owens

Journal article  |  2002  |  Journal of Endocrinology

Poor prenatal growth is associated with limited evidence of GH deficiency in adult humans, which may contribute to their increased..

Influence of sex and gonadal status of sheep on cortisol secretion in response to ACTH and on cortisol and LH secretion in response to stress: importance of different stressors

AI Turner, BJ Canny, RJ Hobbs, JD Bond, IJ Clarke, AJ Tilbrook

Journal article  |  2002  |  Journal of Endocrinology

Multifarious effects of estrogen on the pituitary gonadotrope with special emphasis on studies in the ovine species.

IJ Clarke

Conference Proceedings  |  2002  |  Archives of Physiology and Biochemistry

The gonadotrope is a complex cell that expresses receptors for gonadotropin releasing hormone (GnRH) and estrogen. It has syntheti..

Hypophyseal-portal somatostatin (SRIH) and jugular venous growth hormone secretion in the conscious unrestrained ewe

JD Veldhuis, TP Fletcher, KL Gatford, AR Egan, IJ Clarke

Journal article  |  2002  |  Neuroendocrinology

Selective regulation of glutamic decarboxylase isoform 65, but not isoform 67, in the bed nucleus of the stria terminalis and the preoptic area of the ewe brain across the estrous cycle

S Pompolo, CJ Scott, LJ Clarke

Journal article  |  2002  |  Endocrinology

Two decades of measuring GnRH secretion

IJ Clarke

Journal article  |  2002  |  Reproduction (Cambridge, England) Supplement

Stress and Reproduction: Central Mechanisms and Sex Differences in Non-rodent Species

AJ Tilbrook, AI Turner, IJ Clarke

Journal article  |  2002  |  Stress

Stress and reproduction

I Clarke

Journal article  |  2002  |  Stress

Noradrenaline and dopamine regulation of prolactin secretion in sheep: role in prolactin homeostasis but not photoperiodism.

GA Lincoln, IJ Clarke

Journal article  |  2002  |  Journal of Neuroendocrinology

The role of noradrenaline (NA) and dopamine (DA) in the hypothalamic control of prolactin (PRL) secretion was investigated in hypo..

Intensive direct cavernous sinus sampling identifies high-frequency, nearly random patterns of FSH secretion in ovariectomized ewes: Combined appraisal by RIA and bioassay

I Clarke, L Moore, J Veldhuis

Journal article  |  2002  |  Endocrinology

Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

J Iqbal, S Pompolo, T Sakurai, IJ Clarke

Journal article  |  2001  |  Journal of Neuroendocrinology

Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus

J Iqbal, S Pompolo, T Murakami, E Grouzmann, T Sakurai, B Meister, IJ Clarke

Journal article  |  2001  |  Brain Research

Differential expression of cocaine- and amphetamine-regulated transcript and agouti related-protein in chronically food-restricted sheep

BA Henry, A Rao, BA Ikenasio, KG Mountjoy, AJ Tilbrook, IJ Clarke

Journal article  |  2001  |  Brain Research

Cells of the arcuate nucleus and ventromedial nucleus of the ovariectomized ewe that respond to oestrogen: A study using Fos immunohistochemistry

IJ Clarke, S Pompolo, CJ Scott, JA Rawson, D Caddy, AE Jakubowska, AM Pereira

Journal article  |  2001  |  Journal of Neuroendocrinology

The percentage of pituitary gonadotropes with immunoreactive oestradiol receptors increases in the follicular phase of the ovine oestrous cycle

VA Tobin, S Pompolo, IJ Clarke

Journal article  |  2001  |  Journal of Neuroendocrinology

Hypothalamic control of photoperiod-induced cycles in food intake, body weight, and metabolic hormones in rams

GA Lincoln, SM Rhind, S Pompolo, IJ Clarke

Journal article  |  2001  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

This study used a hypothalamo-pituitary disconnected (HPD) sheep model to investigate the central regulation of long-term cycles i..

Chronic food-restriction alters the expression of somatostatin and growth hormone-releasing hormone in the ovariectomised ewe

BA Henry, A Rao, AJ Tilbrook, IJ Clarke

Journal article  |  2001  |  Journal of Endocrinology

Changes in the secretion of GH induced by long-term alterations in nutritional status are thought to result from alterations in so..

Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neurons

S Pompolo, JA Rawson, IJ Clarke

Journal article  |  2001  |  Brain Research

Sex, Fat and the Tilt of the Earth: effects of sex and season on the feeding response to centrally administered leptin in sheep.

IJ Clarke, AJ Tilbrook, AI Turner, BW Doughton, JW Goding

Journal article  |  2001  |  Endocrinology

Changes in preoptic and hypothalamic levels of progesterone receptor mRNA across the oestrous cycle of the ewe

CJ Scott, AM Pereira, AJ Tilbrook, JA Rawson, IJ Clarke

Journal article  |  2001  |  Journal of Neuroendocrinology

Progesterone and testosterone in combination act in the hypothalamus of castrated rams to regulate the secretion of LH

AI Turner, AJ Tilbrook, IJ Clarke, CJ Scott

Journal article  |  2001  |  Journal of Endocrinology

Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males

AJ Tilbrook, IJ Clarke

Journal article  |  2001  |  Biology of Reproduction

The in vitro effect of leptin on growth hormone secretion from primary cultured ovine somatotrophs

C Chen, SG Roh, GY Nie, K Loneragan, RW Xu, M Ruan, IJ Clarke, JW Goding, A Gertler

Journal article  |  2001  |  Endocrine

Influence of the degree of stimulation of the pituitary by gonadotropin-releasing hormone on the action of inhibin and testosterone to suppress the secretion of the gonadotropins in rams

AJ Tilbrook, DM de Kretser, IJ Clarke

Conference Proceedings  |  2001  |  Biology of Reproduction

Noradrenergic projections from the A1 field to the preoptic area in the brain of the ewe and Fos responses to oestrogen in the A1 cells

JA Rawson, CJ Scott, A Pereira, A Jakubowska, IJ Clarke

Journal article  |  2001  |  Journal of Neuroendocrinology

Dopaminergic input to the ventromedial hypothalamus facilitates the oestrogen-induced luteinizing hormone surge in ewes

ST Anderson, JP Walsh, Y Tillet, IJ Clarke, JD Curlewis

Journal article  |  2001  |  Neuroendocrinology

Proenkephalin and opioid mu-receptor mRNA expression in ovine hypothalamus across the estrous cycle

JP Walsh, A Rao, RC Thompson, IJ Clarke

Journal article  |  2001  |  Neuroendocrinology

Sex and season are major determinants of voluntary food intake in sheep

IJ Clarke

Journal article  |  2001  |  Reproduction, Fertility and Development

Long-term alterations in body weight do not affect the expression of melanocortin receptor-3 and-4 mRNA in the ovine hypothalamus

J Iqbal, S Pompolo, LM Dumont, CS Wu, KG Mountjoy, BA Henry, IJ Clarke

Journal article  |  2001  |  Neuroscience

Leptin and the regulation of food intake and the neuroendocrine axis in sheep

IJ Clarke, B Henry, J Iqbal, JW Goding

Conference Proceedings  |  2001  |  Clinical and Experimental Pharmacology and Physiology

Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight

BA Henry, JW Goding, AJ Tilbrook, FR Dunshea, IJ Clarke

Journal article  |  2001  |  Journal of Endocrinology

Localization of long-form leptin receptor in the somatostatin-containing neurons in the sheep hypothalamus

J Iqbal, S Pompolo, T Murakami, IJ Clarke

Journal article  |  2000  |  Brain Research

Seasonal changes in the expression of neuropeptide Y and pro-opiomelanocortin mRNA in the arcuate nucleus of the ovariectomized ewe: Relationship to the seasonal appetite and breeding cycles

IJ Clarke, CJ Scott, A Rao, S Pompolo, ML Barker-Gibb

Journal article  |  2000  |  Journal of Neuroendocrinology

Tissue-specific regulation of gastrin-releasing peptide synthesis, storage and secretion by oestrogen and progesterone

JC Whitley, AS Giraud, AO Mahoney, IJ Clarke, A Shulkes

Journal article  |  2000  |  Journal of Endocrinology

The Distribution of Cells Containing Estrogen Receptor- (ER ) and ER Messenger Ribonucleic Acid in the Preoptic Area and Hypothalamus of the Sheep: Comparison of Males and Females

CJ Scott

Journal article  |  2000  |  Endocrinology

The distribution of cells containing estrogen receptor-alpha (ER alpha) and ER beta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: Comparison of males and females

CJ Scott, AJ Tilbrook, DM Simmons, JA Rawson, S Chu, PJ Fuller, NH Ing, IJ Clarke

Journal article  |  2000  |  Endocrinology

Diverse intracellular signalling systems used by growth hormone-releasing hormone in regulating voltage-gated Ca2 or K channels in pituitary somatotropes

C Chen, RW Xu, IJ Clarke, M Ruan, K Loneragan, SG Roh

Conference Proceedings  |  2000  |  Immunology & Cell Biology

Neuropeptidases regulating gonadal function

AI Smith, CN Shrimpton, UM Norman, IJ Clarke, AJ Wolfson, RA Lew

Conference Proceedings  |  2000  |  Biochemical Society Transactions

Gonadal steroid receptors in the regulation of GnRH secretion in farm animals

CJ Scott, AJ Tilbrook, JA Rawson, IJ Clarke

Conference Proceedings  |  2000  |  Animal Reproduction Science

Effect of season on neuropeptide Y and galanin within the hypothalamus of the ewe in relation to plasma luteinizing hormone concentrations and the breeding season: An immunohistochemical analysis

ML Barker-Gibb, IJ Clarke

Journal article  |  2000  |  Journal of Neuroendocrinology

The distribution of progesterone receptor immunoreactivity and mRNA in the preoptic area and hypothalamus of the ewe: Upregulation of progesterone receptor mRNA in the mediobasal hypothalamus by oestrogen

CJ Scott, AM Pereira, JA Rawson, DM Simmons, WG Rossmanith, NH Ing, IJ Clarke

Journal article  |  2000  |  Journal of Neuroendocrinology

Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences

AJ Tilbrook, AI Turner, IJ Clarke

Journal article  |  2000  |  Reviews of Reproduction

Localization of leptin receptor-like immunoreactivity in the corticotropes, somatotropes, and gonadotropes in the ovine anterior pituitary

J Iqbal, S Pompolo, RV Considine, IJ Clarke

Journal article  |  2000  |  Endocrinology

Long-term alterations in adiposity affect the expression of melanin-concentrating hormone and enkephalin but not proopiomelanocortin in the hypothalamus of ovariectomized ewes

BA Henry, AJ Tilbrook, FR Dunshea, A Rao, D Blache, GB Martin, IJ Clarke

Journal article  |  2000  |  Endocrinology

Role of the pituitary gland in the development of photorefractoriness and generation of long-term changes in prolactin secretion in rams

GA Lincoln, IJ Clarke

Journal article  |  2000  |  Biology of Reproduction

Growth hormone-releasing hormone decreases voltage-gated potassium currents in GH4C1 cells

R Xu, IJ Clarke, S Chen, C Chen

Journal article  |  2000  |  Journal of Neuroendocrinology

Effects of active and passive gonadotrophin-releasing hormone immunization on recognition and establishment of pregnancy in pigs

A Tast, RJ Love, IJ Clarke, G Evans

Journal article  |  2000  |  Reproduction, Fertility and Development

Effect of the degree of stimulation of the pituitary by GnRH on the direct pituitary actions of testosterone and inhibin to influence gonadotropin secretion in rams.

AJ Tilbrook, DM de Kretser, IJ Clarke

Conference Proceedings  |  2000  |  BIOLOGY OF REPRODUCTION

Prolactin levels in sudden unexpected death in epilepsy

K Opeskin, I Clarke, SF Berkovic

Journal article  |  2000  |  Epilepsia

Influence of photoperiod on spermatic and jugular vein concentrations of total follistatin in rams.

AI Turner, S Maddocks, FR Dunshea, DM de Kretser, DJ Phillips, IJ Clarke, AJ Tilbrook

Conference Proceedings  |  2000  |  BIOLOGY OF REPRODUCTION

Oestrogen receptors in the brainstem of the female sheep: Relationship to noradrenergic cells and cells projecting to the medial preoptic area

CJ Scott, JA Rawson, AM Pereira, IJ Clarke

Journal article  |  1999  |  Journal of Neuroendocrinology

Central administration of corticotrophin releasing hormone but not arginine vasopressin stimulates the secretion of luteinizing hormone in rams in the presence and absence of testosterone

AJ Tilbrook, BJ Canny, BJ Stewart, MD Serapiglia, IJ Clarke

Journal article  |  1999  |  Journal of Endocrinology

The influence of sex and gonadectomy on the hypothalamo-pituitary-adrenal axis of the sheep

BJ Canny, KA O'Farrell, IJ Clarke, AJ Tilbrook

Journal article  |  1999  |  Journal of Endocrinology

Levels of dopamine beta hydroxylase immunoreactivity in the preoptic hypothalamus of the ovariectomised ewe following injection of oestrogen: Evidence for increased noradrenaline release around the time of the oestrogen-induced surge in luteinizing hormone

IJ Clarke, CJ Scott, A Pereira, J Rawson

Journal article  |  1999  |  Journal of Neuroendocrinology

Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin

AJ Tilbrook, DM de Kretser, IJ Clarke

Conference Proceedings  |  1999  |  Journal of Endocrinology

Estrogen transiently increases delayed rectifier, voltage-dependent potassium currents in ovine gonadotropes

MA Cowley, C Chen, IJ Clarke

Journal article  |  1999  |  Neuroendocrinology

Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: Evidence for a dissociation of effects on appetite and neuroendocrine function

BA Henry, JW Goding, WS Alexander, AJ Tilbrook, BJ Canny, F Dunshea, A Rao, A Mansell, IJ Clarke

Journal article  |  1999  |  Endocrinology

Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function.

BA Henry, JW Goding, WS Alexander, AJ Tilbrook, BJ Canny, F Dunshea, A Rao, A Mansell, IJ Clarke

Journal article  |  1999  |  Endocrinology

We have studied the effect of leptin on food intake and neuroendocrine function in ovariectomized ewes. Groups (n = 5) received in..

Suppression of the secretion of luteinizing hormone due to isolation/restraint stress in gonadectomised rams and ewes is influenced by sex steroids

AJ Tilbrook, BJ Canny, MD Serapiglia, TJ Ambrose, IJ Clarke

Journal article  |  1999  |  Journal of Endocrinology

Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams

AJ Tilbrook, DM de Kretser, IJ Clarke

Journal article  |  1999  |  Journal of Endocrinology

Multilinear algebra for independent component analysis

JG McWhirter, IJ Clarke, G Spence

Conference Proceedings  |  1999  |  Advanced Signal Processing Algorithms, Architectures, and Implementations IX

Leptin and reproduction.

IJ Clarke, BA Henry

Journal article  |  1999  |  Reviews of Reproduction

In the few years since leptin was identified as a satiety factor in rodents, it has been implicated in the regulation of various p..

Effect of exogenous FSH on ovulation rate in homozygous carriers or noncarriers of the Booroola FecB gene after hypothalamic-pituitary disconnection or after treatment with a GnRH agonist

NL Hudson, AR O'Connell, L Shaw, IJ Clarke, KP McNatty

Journal article  |  1999  |  Domestic Animal Endocrinology

The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland

SG Roh, IJ Clarke, RW Xu, JW Goding, K Loneragan, C Chen

Journal article  |  1998  |  Neuroendocrinology

Evidence for differential regulation of multiple transcripts of the gonadotropin releasing hormone receptor in the ovine pituitary gland; effect of estrogen

MA Cowley, A Rao, PJ Wright, N Illing, RP Millar, IJ Clarke

Journal article  |  1998  |  Molecular and Cellular Endocrinology

Effects of estrogen and estrous cycle on glucocorticoid and catecholamine responses to stress in sheep.

PA Komesaroff, M Esler, IJ Clarke, MJ Fullerton, JW Funder

Journal article  |  1998  |  American Journal of Physiology-Endocrinology and Metabolism

There have been relatively few studies of the effects of estrogen on hormonal responses to stress. We therefore studied changes in..

Proopiomelanocortin mRNA levels in ovine hypothalamus are not reduced at the time of the preovulatory luteinising hormone surge

JP Walsh, A Rao, DM Simmons, IJ Clarke

Journal article  |  1998  |  Journal of Neuroendocrinology

Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells

C Chen, P Farnworth, S Petersenn, I Musgrave, BJ Canny, IJ Clarke

Journal article  |  1998  |  Endocrine

Sexual dimorphism of the somatotrophic axis

KL Gatford, AR Egan, IJ Clarke, PC Owens

Journal article  |  1998  |  Journal of Endocrinology

Angiotensin II- and phorbol ester-induced steroidogenesis by ovine adrenocortical cells: Effect of sex and the gonadal status of the donor animal

BJ Canny, KA O'Farrell, IJ Clarke, AJ Tilbrook

Journal article  |  1998  |  Clinical and Experimental Pharmacology and Physiology

Absence of photoperiodic modulation of gonadotrophin secretion in HPD rams following chronic pulsatile infusion of GnRH

GA Lincoln, IJ Clarke

Journal article  |  1998  |  Journal of Neuroendocrinology

Effect of growth hormone-releasing peptide-2 (GHRP-2) and GH-releasing hormone (GHRH) on the cAMP levels and GH release from cultured acromegalic tumours

C Chen, M Pullar, K Loneragan, J Zhang, IJ Clarke

Journal article  |  1998  |  Journal of Neuroendocrinology

Components of the neuronal exocytotic machinery in the anterior pituitary of the ovariectomised ewe and the effects of oestrogen in gonadotropes as studied with confocal microscopy

SG Thomas, M Takahashi, JD Neill, IJ Clarke

Journal article  |  1998  |  Neuroendocrinology

Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood

IJ Clarke, BW Brown, VV Tran, CJ Scott, R Fry, RP Millar, A Rao

Journal article  |  1998  |  Endocrinology

Blockade of the oestrogen-induced luteinizing hormone surge in ovariectomized ewes by a highly selective opioid mu-receptor agonist: Evidence for site of action

JP Walsh, IJ Clarke

Journal article  |  1998  |  Neuroendocrinology

The distribution of estrogen receptors in the brainstem of female sheep

CJ Scott, JA Rawson, AM Pereira, IJ Clarke

Journal article  |  1998  |  Neuroscience Letters

Paracrine interactions within the pituitary gland

J Schwartz, S Van De Pavert, I Clarke, A Rao, D Ray, K Vrana