Iain Clarke

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Giles SH Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M Koerperich, Mark D Ericson, Stephanie E Simonds, Courtney M Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clement, Michael A Cowley, Carrie Haskell-Luevano, Lex Van der Ploeg, Roger AH Adan

Journal article  |  2021  |  MOLECULAR METABOLISM

BACKGROUND: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-m..

Glucagon-like peptide-1 control of GnRH secretion in female sheep

Leila Arbabi, Qun Li, Belinda A Henry, Iain J Clarke

Journal article  |  2021  |  JOURNAL OF ENDOCRINOLOGY

The role of glucagon-like peptide-1 (GLP-1) on gonadotropin-releasing hormone (GnRH) secretion was investigated in ovariectomised ..

Comparative Assessment of Thermotolerance in Dorper and Second-Cross (Poll Dorset/Merino x Border Leicester) Lambs

Aleena Joy, Frank R Dunshea, Brian J Leury, Kristy DiGiacomo, Iain J Clarke, Minghao H Zhang, Archana Abhijith, Richard Osei-Amponsah, Surinder S Chauhan

Journal article  |  2020  |  ANIMALS

The objective of this study was to compare the thermotolerance of second-cross (SC; Poll Dorset × Merino × Border Leicester) and D..

Effect of sex and sex steroids on brown adipose tissue heat production in humans

John-Paul Fuller-Jackson, Aimee L Dordevic, Iain J Clarke, Belinda A Henry

Journal article  |  2020  |  EUROPEAN JOURNAL OF ENDOCRINOLOGY

Objective: Retrospective studies suggest that women have more active brown adipose tissue (BAT) than men, but little is known of t..

Resilience of Small Ruminants to Climate Change and Increased Environmental Temperature: A Review

Aleena Joy, Frank R Dunshea, Brian J Leury, Iain J Clarke, Kristy DiGiacomo, Surinder S Chauhan

Journal article  |  2020  |  ANIMALS

Climate change is a major global threat to the sustainability of livestock systems. Climatic factors such as ambient temperature, ..

The Effect of Heat Stress on Respiratory Alkalosis and Insulin Sensitivity in Cinnamon Supplemented Pigs

Jeremy J Cottrell, John B Furness, Udani A Wijesiriwardana, Mitchell Ringuet, Fan Liu, Kristy DiGiacomo, Brian J Leury, Iain J Clarke, Frank R Dunshea

Journal article  |  2020  |  ANIMALS

With increases in the frequency, intensity and duration of heat waves forecast plus expansion of tropical agriculture, heat stress..

Expression of genes for Kisspeptin (KISS1), Neurokinin B (TAC3), Prodynorphin (PDYN), and gonadotropin inhibitory hormone (RFRP) across natural puberty in ewes

Qun Li, Jeremy T Smith, Belinda Henry, Alexandra Rao, Alda Pereira, Iain J Clarke

Journal article  |  2020  |  PHYSIOLOGICAL REPORTS

Expression of particular genes in hypothami of ewes was measured across the natural pubertal transition by in situ hybridization. ..

Genetic Selection for Thermotolerance in Ruminants

Richard Osei-Amponsah, Surinder S Chauhan, Brian J Leury, Long Cheng, Brendan Cullen, Iain J Clarke, Frank R Dunshea

Journal article  |  2019  |  ANIMALS

Variations in climatic variables (temperature, humidity and solar radiation) negatively impact livestock growth, reproduction, and..

Perennial Ryegrass Alkaloids Increase Respiration Rate and Decrease Plasma Prolactin in Merino Sheep under Both Thermoneutral and Mild Heat Conditions

Michelle LE Henry, Stuart Kemp, Iain J Clarke, Frank R Dunshea, Brian J Leury

Journal article  |  2019  |  TOXINS

A study was undertaken to determine the effects of feeding two levels of perennial ryegrass alkaloids (nil vs. moderate) under two..

Lipopolysaccharide reduces gonadotrophin-releasing hormone (GnRH) gene expression: role of RFamide-related peptide-3 and kisspeptin

Chooi Yeng Lee, ShengYun Li, Xiao Feng Li, Daniel AE Stalker, Claire Cooke, Bei Shao, Haluk Kelestimur, Belinda A Henry, Gregory Conductier, Kevin T O'Byrne, Iain J Clarke

Journal article  |  2019  |  REPRODUCTION FERTILITY AND DEVELOPMENT

RFamide-related peptide (RFRP)-3 reduces luteinising hormone (LH) secretion in rodents. Stress has been shown to upregulate the ex..