Rachel Buckley

Defining the lowest threshold for amyloid-PET to predict future cognitive decline and amyloid accumulation.

Michelle E Farrell, Shu Jiang, Aaron P Schultz, Michael J Properzi, Julie C Price, J Alex Becker, Heidi IL Jacobs, Bernard J Hanseeuw, Dorene M Rentz, Victor L Villemagne, Kathryn V Papp, Elizabeth C Mormino, Rebecca A Betensky, Keith A Johnson, Reisa A Sperling, Rachel F Buckley, undefined Alzheimer's disease Neuroimaging Initiative Harvard Aging Brain Study

Journal article  |  2020  |  Neurology

INTRODUCTION: As clinical trials move towards earlier intervention, we sought to redefine the Aβ-PET threshold based on the lowest..

Impact of APOE-epsilon 4 carriage on the onset and rates of neocortical A beta-amyloid deposition

Samantha C Burnham, Simon M Laws, Charley A Budgeon, Vincent Dore, Tenielle Porter, Pierrick Bourgeat, Rachel F Buckley, Kevin Murray, Kathryn A Ellis, Berwin A Turlach, Olivier Salvado, David Ames, Ralph N Martins, Dorene Rentz, Colin L Masters, Christopher C Rowe, Victor L Villemagne

Journal article  |  2020  |  Neurobiology of Aging

Neocortical Aβ-amyloid deposition, one of the hallmark pathologic features of Alzheimer's disease (AD), begins decades prior to th..

Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults

Matthew R Scott, Olivia L Hampton, Rachel F Buckley, Jasmeer P Chhatwal, Bernard J Hanseeuw, Heidi IL Jacobs, Michael J Properzi, Justin S Sanchez, Keith A Johnson, Reisa A Sperling, Aaron P Schultz

Journal article  |  2020  |  NeuroImage

Neurofibrillary tau tangles are a hallmark pathology of Alzheimer's disease (AD) and are more closely associated with AD-related c..

Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults

Jennifer S Rabin, Zahra Shirzadi, Walter Swardfager, Bradley J MacIntosh, Aaron Schultz, Hyun-Sik Yang, Rachel F Buckley, Jennifer R Gatchel, Dylan Kirn, Jeremy J Pruzin, Trey Hedden, Nir Lipsman, Dorene M Rentz, Sandra E Black, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal

Journal article  |  2020  |  Neurobiology of Aging

In the present study, we tested the hypothesis that higher amyloid-beta (Aβ) burden at baseline is associated with greater longitu..

Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline

Rachel F Buckley, Matthew R Scott, Heidi IL Jacobs, Aaron P Schultz, Michael J Properzi, Rebecca E Amariglio, Timothy J Hohman, Danielle V Mayblyum, Zoe B Rubinstein, Lyssa Manning, Bernard J Hanseeuw, Elizabeth C Mormino, Dorene M Rentz, Keith A Johnson, Reisa A Sperling

Journal article  |  2020  |  Annals of Neurology

OBJECTIVE: The goal of this study was to examine sex differences in tau distribution across the brain of older adults, using posit..

Age-Related Cognitive Decline Is Indicative of Neuropathology.

Rachel Buckley, Alvaro Pascual-Leone

Journal article  |  2020  |  Annals of Neurology

The characterisation of subjective cognitive decline

Frank Jessen, Rebecca E Amariglio, Rachel F Buckley, Wiesje M van der Flier, Ying Han, Jose Luis Molinuevo, Laura Rabin, Dorene M Rentz, Octavio Rodriguez-Gomez, Andrew J Saykin, Sietske AM Sikkes, Colette M Smart, Steffen Wolfsgruber, Michael Wagner

Journal article  |  2020  |  The Lancet Neurology

A growing awareness about brain health and Alzheimer's disease in the general population is leading to an increasing number of cog..

Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults

Federico d'Oleire Uquillas, Heidi IL Jacobs, Aaron P Schultz, Bernard J Hanseeuw, Rachel F Buckley, Jorge Sepulcre, Alvaro Pascual-Leone, Nancy J Donovan, Keith A Johnson, Reisa A Sperling, Patrizia Vannini

Journal article  |  2020  |  Cerebral Cortex

Judgments of learning (JOL) pertain to introspective metamemory processes evaluating how well information is learned. Using a func..

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD

Kathryn V Papp, Rachel Buckley, Elizabeth Mormino, Paul Maruff, Victor L Villemagne, Colin L Masters, Keith A Johnson, Dorene M Rentz, Reisa A Sperling, Rebecca E Amariglio

Journal article  |  2020  |  Alzheimer's & Dementia

INTRODUCTION: Demonstrating the "clinical meaningfulness" of slowing early cognitive decline in clinically normal (CN) older adult..

Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study

Rebecca E Amariglio, Rachel F Buckley, Jennifer S Rabin, Kathryn V Papp, Yakeel T Quiroz, Elizabeth C Mormino, Kathryn P Sparks, Keith A Johnson, Dorene M Rentz, Reisa A Sperling

Journal article  |  2020  |  Journal of Alzheimer's Disease

BACKGROUND: Black Americans are approximately twice as likely to develop dementia as compared to White Americans and the magnitude..