Nicole Walsh

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs

SJ Gauci, SB Golub, L Tatarczuch, E Lee, D Chan, NC Walsh, CB Little, H Stanton, Z Lokmic, NA Sims, EJ Mackie, AJ Fosang

Journal article  |  2019  |  MATRIX BIOLOGY

Cartilage remodelling and chondrocyte differentiation are tightly linked to angiogenesis during bone development and endochondral ..

Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model.

Frederick R Roberts, Clinton Hupple, Elaine Norowski, Nicole C Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M Van Dessel, Agata Jurczyk, David M Harlan, Dale L Greiner, Rita Bortell, Chaoxing Yang

Journal article  |  2017  |  PLoS One

BACKGROUND/AIMS: Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type..

Mechanical properties of normal and osteoarthritic human articular cartilage

Dale L Robinson, Mariana E Kersh, Nicole C Walsh, David C Ackland, Richard N de Steiger, Marcus G Pandy

Journal article  |  2016  |  JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS

Isotropic hyperelastic models have been used to determine the material properties of normal human cartilage, but there remains an ..

Impaired muscle function in a mouse surgical model of post-traumatic osteoarthritis

C van der Poel, P Levinger, BA Tonkin, I Levinger, NC Walsh

Journal article  |  2016  |  OSTEOARTHRITIS AND CARTILAGE

OBJECTIVES: Using a mouse surgical model of post-traumatic osteoarthritis (OA), we sought to determine if muscle function is alter..

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

Emma K Baker, Scott Taylor, Ankita Gupte, Phillip P Sharp, Mannu Walia, Nicole C Walsh, Andrew CW Zannettino, Alistair M Chalk, Christopher J Burns, Carl R Walkley

Journal article  |  2015  |  SCIENTIFIC REPORTS

Osteosarcoma (OS) survival rates have plateaued in part due to a lack of new therapeutic options. Here we demonstrate that bromodo..

Myelosuppressive Therapies Significantly Increase ProInflammatory Cytokines and Directly Cause Bone Loss

Julie M Quach, Maria Askmyr, Tanja Jovic, Emma K Baker, Nicole C Walsh, Simon J Harrison, Paul Neeson, David Ritchie, Peter R Ebeling, Louise E Purton

Journal article  |  2015  |  JOURNAL OF BONE AND MINERAL RESEARCH

Skeletal-related events resulting from accelerated bone loss are common complications in patients treated for a range of cancers. ..

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

Alvin JM Ng, Mannu K Walia, Monique F Smeets, Anthony J Mutsaers, Natalie A Sims, Louise E Purton, Nicole C Walsh, T John Martin, Carl R Walkley

Journal article  |  2015  |  PLOS GENETICS

RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patien..

Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes

Ling Yeong Chia, Nicole C Walsh, T John Martin, Natalie A Sims

Journal article  |  2015  |  BONE

To define their gene expression and function, osteocytes are commonly isolated and purified by fluorescence-activated cell sorting..

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

Weiqiang Chen, Suan-Sin Foo, Adam Taylor, Aleksei Lulla, Andres Merits, Linda Hueston, Mark R Forwood, Nicole C Walsh, Natalie A Sims, Lara J Herrero, Suresh Mahalingam

Journal article  |  2015  |  JOURNAL OF VIROLOGY

UNLABELLED: The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urg..

Arthritogenic alphaviruses: new insights into arthritis and bone pathology.

Weiqiang Chen, Suan-Sin Foo, Natalie A Sims, Lara J Herrero, Nicole C Walsh, Suresh Mahalingam

Journal article  |  2015  |  Trends Microbiol

Arthritogenic alphaviral infection begins as a febrile illness and often progresses to joint pain and rheumatic symptoms that are ..