Nicole Walsh

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs

SJ Gauci, SB Golub, L Tatarczuch, E Lee, D Chan, NC Walsh, CB Little, H Stanton, Z Lokmic, NA Sims, EJ Mackie, AJ Fosang

Journal article  |  2019  |  MATRIX BIOLOGY

Cartilage remodelling and chondrocyte differentiation are tightly linked to angiogenesis during bone development and endochondral ..

Abstract 5676: Patient-derived tumor xenografts in humanized NSG-SGM3 mice: An improved immuno-oncology platform

Li-Chin Yao, Mingshan Cheng, Ken-Edwin Aryee, Pooja Kumar, Nicole Walsh, Dale Greiner, Leonard Shultz, Edison T Liu, Michael Brehm, James G Keck

Conference Proceedings  |  2018  |  Cancer Research

Abstract The JAX® Onco-Hu® platform utilizes humanized mice engrafted with tumors to enable in vivo investigation o..

Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model.

Frederick R Roberts, Clinton Hupple, Elaine Norowski, Nicole C Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M Van Dessel, Agata Jurczyk, David M Harlan, Dale L Greiner, Rita Bortell, Chaoxing Yang

Journal article  |  2017  |  PLoS One

BACKGROUND/AIMS: Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type..

Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation.

MM Matzelle, AT Shaw, R Baum, Y Maeda, J Li, S Karmakar, CA Manning, NC Walsh, V Rosen, EM Gravallese

Journal article  |  2016  |  Scand J Rheumatol

OBJECTIVES: Inflammation in diseases such as rheumatoid arthritis (RA) stimulates osteoclast-mediated articular bone erosion and i..

Closed head experimental traumatic brain injury increases size and bone volume of callus in mice with concomitant tibial fracture

Rhys D Brady, Brian L Grills, Jarrod E Church, Nicole C Walsh, Aaron C McDonald, Denes V Agoston, Mujun Sun, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald

Journal article  |  2016  |  SCIENTIFIC REPORTS

Concomitant traumatic brain injury (TBI) and long bone fracture are commonly observed in multitrauma and polytrauma. Despite clini..

Mechanical properties of normal and osteoarthritic human articular cartilage

Dale L Robinson, Mariana E Kersh, Nicole C Walsh, David C Ackland, Richard N de Steiger, Marcus G Pandy

Journal article  |  2016  |  JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS

Isotropic hyperelastic models have been used to determine the material properties of normal human cartilage, but there remains an ..

Impaired muscle function in a mouse surgical model of post-traumatic osteoarthritis

C van der Poel, P Levinger, BA Tonkin, I Levinger, NC Walsh

Journal article  |  2016  |  OSTEOARTHRITIS AND CARTILAGE

OBJECTIVES: Using a mouse surgical model of post-traumatic osteoarthritis (OA), we sought to determine if muscle function is alter..

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection (vol 89, pg 581, 2015)

Weiqiang Chen, Suan-Sin Foo, Adam Taylor, Aleksei Lulla, Andres Merits, Linda Hueston, Mark R Forwood, Nicole C Walsh, Natalie A Sims, Lara J Herrero, Suresh Mahalingam

Journal article  |  2015  |  JOURNAL OF VIROLOGY

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

Emma K Baker, Scott Taylor, Ankita Gupte, Phillip P Sharp, Mannu Walia, Nicole C Walsh, Andrew CW Zannettino, Alistair M Chalk, Christopher J Burns, Carl R Walkley

Journal article  |  2015  |  SCIENTIFIC REPORTS

Osteosarcoma (OS) survival rates have plateaued in part due to a lack of new therapeutic options. Here we demonstrate that bromodo..

Myelosuppressive Therapies Significantly Increase ProInflammatory Cytokines and Directly Cause Bone Loss

Julie M Quach, Maria Askmyr, Tanja Jovic, Emma K Baker, Nicole C Walsh, Simon J Harrison, Paul Neeson, David Ritchie, Peter R Ebeling, Louise E Purton

Journal article  |  2015  |  JOURNAL OF BONE AND MINERAL RESEARCH

Skeletal-related events resulting from accelerated bone loss are common complications in patients treated for a range of cancers. ..