Jeffrey Liddell

Transdermal Application of Soluble CuII(atsm) Increases Brain and Spinal Cord Uptake Compared to Gavage with an Insoluble Suspension

Sara Nikseresht, James BW Hilton, Jeffrey R Liddell, Kai Kysenius, Ashley I Bush, Scott Ayton, HuiJing Koay, Paul S Donnelly, Peter J Crouch

Journal article  |  2022  |  NEUROSCIENCE

CuII(atsm) is a blood-brain barrier permeant copper(II) compound that is under investigation in human clinical trials for the trea..

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex

Xin Yi Choo, Lachlan E McInnes, Alexandra Grubman, Joanna M Wasielewska, Irina Belaya, Emma Burrows, Hazel Quek, Jorge Canas Martin, Sanna Loppi, Annika Sorvari, Dzhessi Rait, Andrew Powell, Clare Duncan, Jeffrey R Liddell, Heikki Tanila, Jose M Polo, Tarja Malm, Katja M Kanninen, Paul S Donnelly, Anthony R White

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroinflammation has a major role in several brain disorders including Alzheimer's disease (AD), yet at present there are no effe..

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease.

Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R Liddell, Dzhessi Rait, Mikko T Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, Andrii Domanskyi, Riikka H Hämäläinen, Gundars Goldsteins, Jari Koistinaho, Tarja Malm, et al.

Journal article  |  2022  |  Neurobiol Dis

Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy..

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients.

Riikka Lampinen, Veronika Górová, Simone Avesani, Jeffrey R Liddell, Elina Penttilä, Táňa Závodná, Zdeněk Krejčík, Juha-Matti Lehtola, Toni Saari, Juho Kalapudas, Sanna Hannonen, Heikki Löppönen, Jan Topinka, Anne M Koivisto, Anthony R White, Rosalba Giugno, Katja M Kanninen

Journal article  |  2022  |  Int J Mol Sci

Olfactory function, orchestrated by the cells of the olfactory mucosa at the rooftop of the nasal cavity, is disturbed early in th..

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Irina Belaya, Nina Kucharikova, Veronika Gorova, Kai Kysenius, Dominic J Hare, Peter J Crouch, Tarja Malm, Mustafa Atalay, Anthony R White, Jeffrey R Liddell, Katja M Kanninen

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulation of brain iron metabolism is one of the pathological features of aging and Alzheimer's disease (AD), a neurodegenerat..

Molecular mechanisms of cell death in neurological diseases

Diane Moujalled, Andreas Strasser, Jeffrey R Liddell

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and tem..

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

Sara Nikseresht, James BW Hilton, Kai Kysenius, Jeffrey R Liddell, Peter J Crouch

Journal article  |  2020  |  LIFE-BASEL

The blood-brain barrier permeant, copper-containing compound, CuII(atsm), has successfully progressed from fundamental research ou..

Disrupted copper availability in sporadic ALS: Implications for CuII(atsm) as a treatment option

James BW Hilton, Kai Kysenius, Jeffrey Liddell, Carsten Rautengarten, Stephen Mercer, Bence Paul, Joseph Beckman, Catriona McLean, Anthony White, Paul Donnelly, Ashley Bush, Dominic Hare, Blaine Roberts, Peter Crouch

Journal article  |  2020

ABSTRACT Objective The copper compound Cu II (atsm) is in phase 2/3 testing for treatment of the neurodegenerative disease amyotro..

A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples

Kai Kysenius, Bence Paul, James B Hilton, Jeffrey R Liddell, Dominic J Hare, Peter J Crouch

Journal article  |  2019  |  ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analysis of μ-droplets is becoming an attractive alternati..

Cu-II(atsm) Attenuates Neuroinflammation

Xin Yi Choo, Jeffrey R Liddell, Mikko T Huuskonen, Alexandra Grubman, Diane Moujalled, Jessica Roberts, Kai Kysenius, Lauren Patten, Hazel Quek, Lotta E Oikari, Clare Duncan, Simon A James, Lachlan E McInnes, David J Hayne, Paul S Donnelly, Eveliina Pollari, Suvi Vahatalo, Katarina Lejavova, Mikko Kettunen, Tarja Malm, et al.

Journal article  |  2018  |  FRONTIERS IN NEUROSCIENCE

Background: Neuroinflammation and biometal dyshomeostasis are key pathological features of several neurodegenerative diseases, inc..