Prof Kate Leslie

Find out more about Kate Leslie's experience

Kate Leslie's highlights

FEATURED Journal article

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery

Kate Leslie's selected work

Tranexamic Acid And Hypotension-Avoidance To Prevent Death And Major Complications After N..

Research Grant

Why are women ignored by medical research?

NEWS ARTICLE

Anaesthetic depth and complications after major surgery: an international, randomised cont..

Journal article

Reduction Of Chronic Post-Surgical Pain With Ketamine - Rocket Study

Research Grant

Health Check: why can you feel groggy days after an operation?

NEWS ARTICLE

Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperati..

Projects

Displaying the 4 most recent projects by Kate Leslie.

Tranexamic Acid And Hypotension-Avoidance To Prevent Death And Major Complications After Noncardiac Surgery (Perioperative Ischemic Evaluation-3 – The Poise-3 Trial)

Bleeding and low blood pressure are common and dangerous complications of anaesthesia and surgery. We propose a large international study to..

2019 - 2023

Active

Reduction Of Chronic Post-Surgical Pain With Ketamine - Rocket Study

Chronic post-surgical pain (CPSP) is a common complication of major surgery, and a significant burden on quality of life and ongoing health ..

2017 - 2021

Active

Reduction Of Chronic Post-Surgical Pain With Ketamine - Rocket Study

Chronic post-surgical pain (CPSP) is a common complication of major surgery, and a significant burden on quality of life and ongoing health ..

2017 - 2021

Active

Reduction Of Chronic Post-Surgical Pain With Ketamine - Rocket Study

Chronic post-surgical pain (CPSP) is a common complication of major surgery, and a significant burden on quality of life and ongoing health ..

2017 - 2021

Active

4

Projects

Project Types

Research Grant

Scholarly Works

Displaying the 189 most recent scholarly works by Kate Leslie.

Anaesthetic depth and complications after major surgery: an international, randomised controlled trial

Timothy G Short, Douglas Campbell, Christopher Frampton, Matthew TV Chan, Paul S Myles, Tomas B Corcoran, Daniel I Sessler, Gary H Mills, Juan P Cata, Thomas Painter, Kelly Byrne, Ruquan Han, Mandy HM Chu, Davina J McAllister, Kate Leslie

Journal article | 2019 | The Lancet

BACKGROUND: An association between increasing anaesthetic depth and decreased postoperative survival has been shown in observation..

Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study.

J Bartoszko, KE Thorpe, A Laupacis, DN Wijeysundera, undefined METS Study Investigators, undefined International and National Coordinators, undefined Central Project Office Operations Committee, undefined CPET Methods Committee, undefined Outcome Adjudication Committee, undefined International Steering Committee

Journal article | 2019 | British Journal of Anaesthesia

BACKGROUND: Preoperative anaemia is associated with elevated risks of postoperative complications. This association may be explain..

Chewing gum to treat postoperative nausea and emesis in female patients (CHEWY): rationale and design for a multicentre randomised trial

Jai Darvall, Britta Sylvia von Ungern-Sternberg, Sabine Braat, David Story, Andrew Davidson, Megan Allen, Tran-Duy An, Dana Middleton, Kate Leslie

Journal article | 2019 | BMJ OPEN

Patient willingness to try chewing gum to treat postoperative nausea and vomiting

Jai N Darvall, Edward McIlroy, Margaret Forbes, Kate Leslie

Journal article | 2019 | Anaesthesia and Intensive Care

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis

Jonathan Barnes, Jennifer Hunter, Steve Harris, Manu Shankar-Hari, Elisabeth Diouf, Ib Jammer, Cor Kalkman, Andrew A Klein, Tomas Corcoran, Stefan Dieleman, Michael PW Grocott, Michael G Mythen

Journal article | 2019 | British Journal of Anaesthesia

Pounds of Prevention but Only Ounces of Cure The Need for More Research on the Treatment of Postoperative Nausea and Vomiting

Jai N Darvall, Kate Leslie

Journal article | 2019 | Anesthesiology

Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial

W Scott Beattie, Duminda N Wijeysundera, Matthew TV Chan, Philip J Peyton, Kate Leslie, Michael J Paech, Daniel I Sessler, Sophie Wallace, Paul S Myles

Journal article | 2018 | Anesthesia & Analgesia

Out of Africa: three generalisable lessons about clinical research

K Leslie, DA Story, E Diouf

Journal article | 2018 | British Journal of Anaesthesia

Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes

DJ Buggy, J Freeman, MZ Johnson, K Leslie, B Riedel, DI Sessler, A Kurz, V Gottumukkala, T Short, N Pace, PM Myles

Journal article | 2018 | British Journal of Anaesthesia

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery

PS Myles, R Bellomo, T Corcoran, A Forbes, P Peyton, D Story, C Christophi, K Leslie, S McGuinness, R Parke, J Serpell, MTV Chan, T Painter, S McCluskey, G Minto, S Wallace

Journal article | 2018 | New England Journal of Medicine

Reporting of sex and gender in human studies published in anaesthesia journals.

K Leslie, C Edgley, AC-Y Lee, A Sellar, J Sgroi, R Toh

Journal article | 2018 | British Journal of Anaesthesia

Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery

Michelle M Graham, Daniel I Sessler, Joel L Parlow, Bruce M Biccard, Gordon Guyatt, Kate Leslie, Matthew TV Chan, Christian S Meyhoff, Denis Xavier, Alben Sigamani, Priya A Kumar, Marko Mrkobrada, Deborah J Cook, Vikas Tandon, Jesus Alvarez-Garcia, Juan Carlos Villar, Thomas W Painter, Giovanni Landoni, Edith Fleischmann, Andre Lamy, et al.

Journal article | 2018 | Annals of Internal Medicine

Feasibility and pilot studies: small steps before giant leaps

DA Story, K Leslie, C French

Journal article | 2018 | Anaesthesia and Intensive Care

Growing the next generation of anaesthesia research leaders.

K Leslie

Conference Proceedings | 2017 | British Journal of Anaesthesia

Complications and unplanned admissions in nonoperating room procedures

Kate Leslie, Benjamin Kave

Journal article | 2017 | Current Opinion in Anaesthesiology

Awareness during general anaesthesia in the first 4,000 incidents reported to webAIRS.

K Leslie, MD Culwick, H Reynolds, JA Hannam, AF Merry

Journal article | 2017 | Anaesthesia and Intensive Care

The aim of this study was to analyse the incidents related to awareness during general anaesthesia in the first 4,000 cases report..

Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries.

Brennan C Kahan, Desponia Koulenti, Kostoula Arvaniti, Vanessa Beavis, Douglas Campbell, Matthew Chan, Rui Moreno, Rupert M Pearse, undefined International Surgical Outcomes Study (ISOS) group

Journal article | 2017 | Intensive Care Medicine

PURPOSE: As global initiatives increase patient access to surgical treatments, there is a need to define optimal levels of periope..

The effect of a perioperative ketamine infusion on the incidence of chronic postsurgical pain-a pilot study

PJ Peyton, C Wu, T Jacobson, M Hogg, F Zia, K Leslie

Journal article | 2017 | Anaesthesia and Intensive Care

Women, Minorities, and Leadership in Anesthesiology: Take the Pledge

Kate Leslie, Harriet W Hopf, Patricia Houston, Ellen O'Sullivan

Journal article | 2017 | Anesthesia & Analgesia

Survey of research capability at Australian and New Zealand College of Anaesthetists accredited training sites

KR Goulding, RJ Peyton, DA Story, A Parker, K Leslie

Journal article | 2017 | Anaesthesia and Intensive Care

Intraoperative dexamethasone does not increase the risk of postoperative wound infection: a propensity score-matched post hoc analysis of the ENIGMA-II trial (EnDEX).

T Corcoran, J Kasza, TG Short, E O'Loughlin, MTV Chan, K Leslie, A Forbes, M Paech, P Myles, undefined ENIGMA-II investigators

Journal article | 2017 | British Journal of Anaesthesia

BACKGROUND: In a post hoc analysis of the ENIGMA-II trial, we sought to determine whether intraoperative dexamethasone was associa..

Restrictive versus liberal fluid therapy in major abdominal surgery (RELIEF): rationale and design for a multicentre randomised trial

Paul Myles, Rinaldo Bellomo, Tomas Corcoran, Andrew Forbes, Sophie Wallace, Philip Peyton, Chris Christophi, David Story, Kate Leslie, Jonathan Serpell, Shay McGuinness, Rachel Parke

Journal article | 2017 | BMJ OPEN

Chewing gum for the treatment of postoperative nausea and vomiting: a pilot randomized controlled trial

JN Darvall, M Handscombe, K Leslie

Journal article | 2017 | British Journal of Anaesthesia

Safety of sedation for gastrointestinal endoscopy in a group of university-affiliated hospitals: a prospective cohort study

K Leslie, ML Allen, EC Hessian, PJ Peyton, J Kasza, A Courtney, PA Dhar, J Briedis, S Lee, AR Beeton, D Sayakkarage, S Palanivel, JK Taylor, AJ Haughton, CX O'Kane

Journal article | 2017 | British Journal of Anaesthesia

Perioperative Aspirin for Prevention of Venous Thromboembolism The PeriOperative ISchemia Evaluation-2 Trial and a Pooled Analysis of the Randomized Trials

John W Eikelboom, Clive Kearon, Gordon Guyatt, Daniel I Sessler, Salim Yusuf, Deborah Cook, James Douketis, Ameen Patel, Andrea Kurz, Rene Allard, Philip M Jones, Rodolfo J Dennis, Thomas W Painter, Sergio D Bergese, Kate Leslie, Duminda N Wijeysundera, Kumar Balasubramanian, Emmanuelle Duceppe, Scott Miller, Johan Diedericks, et al.

Journal article | 2016 | Anesthesiology

Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial

MTV Chan, PJ Peyton, PS Myles, K Leslie, N Buckley, J Kasza, MJ Paech, WS Beattie, DI Sessler, A Forbes, S Wallace, Y Chen, Y Tian, WKK Wu

Journal article | 2016 | British Journal of Anaesthesia

Comparative Plasma and Cerebrospinal Fluid Pharmacokinetics of Paracetamol After Intravenous and Oral Administration

Roger A Langford, Malcolm Hogg, Andrew R Bjorksten, Daryl L Williams, Kate Leslie, Kris Jamsen, Carl Kirkpatrick

Journal article | 2016 | Anesthesia & Analgesia

A randomized-controlled trial of high- or low-volume intravenous Plasma-Lyte((R)) to prevent hypotension during sedation for colonoscopy

Kate Leslie, Megan Allen, Austin Lee, Phillip Clarke

Journal article | 2016 | Canadian Journal of Anesthesia/Journal canadien d'anesthésie

Quality of recovery from sedation for endoscopy.

R Barber, ML Allen, K Leslie

Journal article | 2016 | Anaesthesia and Intensive Care

Survey of anaesthetists' practice of sedation for gastrointestinal endoscopy

K Leslie, ML Allen, E Hessian, AY-S Lee

Journal article | 2016 | Anaesthesia and Intensive Care

Prewarming neurosurgical patients to minimize hypotension on induction of anesthesia: a randomized trial

Jai Darvall, Rukman Vijayakumar, Kate Leslie

Journal article | 2016 | Canadian Journal of Anesthesia/Journal canadien d'anesthésie

Response of bispectral index to neuromuscular block in awake volunteers.

TG Short, D Campbell, K Leslie

Journal article | 2016 | British Journal of Anaesthesia

Severe Nausea and Vomiting in the Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia II Trial

Paul S Myles, Matthew TV Chan, Jessica Kasza, Michael J Paech, Kate Leslie, Philip J Peyton, Daniel I Sessler, Guy Haller, W Scott Beattie, Cameron Osborne, J Robert Sneyd, Andrew Forbes

Journal article | 2016 | Anesthesiology

Anesthetic depth and long-term survival: an update

Kate Leslie, Timothy G Short

Journal article | 2016 | Canadian Journal of Anesthesia/Journal canadien d'anesthésie

Neuraxial block and postoperative epidural analgesia: effects on outcomes in the POISE-2 trial

K Leslie, D McIlroy, J Kasza, A Forbes, A Kurz, J Khan, CS Meyhoff, R Allard, G Landoni, X Jara, G Lurati Buse, K Candiotti, H-S Lee, R Gupta, T VanHelder, W Purayil, S De Hert, T Treschan, PJ Devereaux

Journal article | 2016 | British Journal of Anaesthesia

Nitrous Oxide and Serious Long-term Morbidity and Mortality in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II Trial

Kate Leslie, Paul S Myles, Jessica Kasza, Andrew Forbes, Philip J Peyton, Matthew TV Chan, Michael J Paech, Daniel I Sessler, W Scott Beattie, PJ Devereaux, Sophie Wallace

Journal article | 2015 | Anesthesiology

A randomized controlled trial of light versus deep propofol sedation for elective outpatient colonoscopy: recall, procedural conditions, and recovery

Megan Allen, Kate Leslie, Geoffrey Hebbard, Ian Jones, Tejinder Mettho, Paul Maruff

Journal article | 2015 | Canadian Journal of Anesthesia/Journal canadien d'anesthésie

Rationale and Design of the Balanced Anesthesia Study: A Prospective Randomized Clinical Trial of Two Levels of Anesthetic Depth on Patient Outcome After Major Surgery

Timothy G Short, Kate Leslie, Matthew TV Chan, Douglas Campbell, Christopher Frampton, Paul Myles

Journal article | 2015 | Anesthesia & Analgesia

Cardiac Surgery: All for One and One for All

Kate Leslie, Alan F Merry

Journal article | 2015 | Anesthesia & Analgesia

Dexamethasone-an effective antiemetic, but is it safe?

TG Short, K Leslie

Journal article | 2015 | Anaesthesia and Intensive Care

Nitrous oxide in general anaesthesia reply

Paul S Myles, Phillip Peyton, Matthew TV Chan, Kate Leslie

Journal article | 2015 | The Lancet

Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury A Randomized Clinical Trial

Amit X Garg, Andrea Kurz, Daniel I Sessler, Meaghan Cuerden, Andrea Robinson, Marko Mrkobrada, Chirag R Parikh, Richard Mizera, Philip M Jones, Maria Tiboni, Adria Font, Virginia Cegarra, Maria Fernanda Rojas Gomez, Christian S Meyhoff, Tomas VanHelder, Matthew TV Chan, David Torres, Joel Parlow, Miriam de Nadal Clanchet, Mohammed Amir, et al.

Journal article | 2014 | JAMA

'Known unknowns and unknown unknowns': electroencephalographic burst suppression and mortality

TG Short, K Leslie

Journal article | 2014 | British Journal of Anaesthesia

The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial

Paul S Myles, Kate Leslie, Matthew TV Chan, Andrew Forbes, Philip J Peyton, Michael J Paech, W Scott Beattie, Daniel I Sessler, PJ Devereaux, Brendan Silbert, Thomas Schricker, Sophie Wallace

Journal article | 2014 | The Lancet

Sedation Depth and Mortality: A Large Randomized Trial Is Required

Kate Leslie, Timothy G Short

Journal article | 2014 | Anesthesia & Analgesia

Loss of chance in medical negligence

K Leslie, D Bramley, M Shulman, E Kennedy

Journal article | 2014 | Anaesthesia and Intensive Care

A Pilot Study for a Prospective, Randomized, --DoubleBlind Trial of the Influence of Anesthetic Depth on Long- Term Outcome

Timothy G Short, Kate Leslie, Douglas Campbell, Matthew TV Chan, Tomas Corcoran, Edward O'Loughlin, Chris Frampton, Paul Myles

Journal article | 2014 | Anesthesia & Analgesia

Aspirin in Patients Undergoing Noncardiac Surgery

PJ Devereaux, M Mrkobrada, DI Sessler, K Leslie, P Alonso-Coello, A Kurz, JC Villar, A Sigamani, BM Biccard, CS Meyhoff, JL Parlow, G Guyatt, A Robinson, AX Garg, RN Rodseth, F Botto, G Lurati Buse, D Xavier, MTV Chan, M Tiboni, et al.

Journal article | 2014 | New England Journal of Medicine

Clonidine in Patients Undergoing Noncardiac Surgery

PJ Devereaux, DI Sessler, K Leslie, A Kurz, M Mrkobrada, P Alonso-Coello, JC Villar, A Sigamani, BM Biccard, CS Meyhoff, JL Parlow, G Guyatt, A Robinson, AX Garg, RN Rodseth, F Botto, G Lurati Buse, D Xavier, MTV Chan, M Tiboni, et al.

Journal article | 2014 | New England Journal of Medicine

Reply from the authors.

K Leslie, P Myles, P Devereaux, E Williamson, P Rao-Melancini, A Forbes, S Xu, P Foex, J Pogue, M Arrieta, G Bryson, J Paul, M Paech, R Merchant, P Choi, N Badner, P Peyton, J Sear, H Yang

Journal article | 2014 | British Journal of Anaesthesia

Neuraxial block, death, and serious cardiovascular morbidity in the POISE trial Reply

K Leslie

Journal article | 2014 | British Journal of Anaesthesia

Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation ( POISE) 2 randomised controlled trial

Amit X Garg, Andrea Kurz, Daniel I Sessler, Meaghan Cuerden, Andrea Robinson, Marko Mrkobrada, Chirag Parikh, Richard Mizera, Philip M Jones, Maria Tiboni, Raul Gonzalez Rodriguez, Ekaterina Popova, Maria Fernanda Rojas Gomez, Christian S Meyhoff, Tomas Vanhelder, Matthew TV Chan, David Torres, Joel Parlow, Miriam de Nadal Clanchet, Mohammed Amir, et al.

Journal article | 2014 | BMJ Open

Preparing patients for colonoscopy sedation.

K Leslie

Journal article | 2013 | Anaesthesia and Intensive Care

Neuraxial block, death and serious cardiovascular morbidity in the POISE trial

K Leslie, P Myles, P Devereaux, E Williamson, P Rao-Melancini, A Forbes, S Xu, P Foex, J Pogue, M Arrieta, G Bryson, J Paul, M Paech, R Merchant, P Choi, N Badner, P Peyton, J Sear, H Yang

Journal article | 2013 | British Journal of Anaesthesia

Measurement of quality of recovery using the QoR-40: a quantitative systematic review

BF Gornall, PS Myles, CL Smith, JA Burke, K Leslie, MJ Pereira, JE Bost, KB Kluivers, UG Nilsson, Y Tanaka, A Forbes

Journal article | 2013 | British Journal of Anaesthesia

Leukocyte DNA Damage and Wound Infection after Nitrous Oxide Administration A Randomized Controlled Trial

Yan Chen, Xiaodong Liu, Christopher HK Cheng, Tony Gin, Kate Leslie, Paul Myles, Matthew TV Chan

Journal article | 2013 | Anesthesiology

Nitrous Oxide and Serious Morbidity and Mortality in the POISE Trial

Kate Leslie, Paul Myles, Philip J Devereaux, Andrew Forbes, Purnima Rao-Melancini, Elizabeth Williamson, Shouchun Xu, Pierre Foex, Janice Pogue, Maribel Arrieta, Gregory L Bryson, James Paul, Michael J Paech, Richard N Merchant, Peter T Choi, Neal Badner, Philip Peyton, John W Sear, Homer Yang

Journal article | 2013 | Anesthesia and Analgesia

The sitting position and the patent foramen ovale. Commentary: "A streamlined protocol for the use of the semi-sitting position in neurosurgery"

Kate Leslie, Andrew H Kaye

Journal article | 2013 | Journal of Clinical Neuroscience

Beta-blocker management in high-risk patients presenting for non-cardiac surgery: before and after the POISE Trial

K Leslie, PS Myles, R Halliwell, MJ Paech, TG Short, S Walker

Journal article | 2012 | Anaesthesia and Intensive Care

The Sitting Position for Neurosurgery: Yet Another Case Series Confirming Safety

Andrew H Kaye, Kate Leslie

Journal article | 2012 | World Neurosurgery

Chronic postsurgical pain after nitrous oxide anesthesia

Matthew TV Chan, Alex CM Wan, Tony Gin, Kate Leslie, Paul S Myles

Journal article | 2011 | Pain

Audit of recall of propofol injection pain

Balvindar Kaur, Wai Leap Ng, Kate Leslie

Journal article | 2011 | Journal of Clinical Anesthesia

The Importance of Being Negative

Kate Leslie, Timothy G Short

Journal article | 2011 | Anesthesia and Analgesia

Low Bispectral Index Values and Death: The Unresolved Causality Dilemma

Kate Leslie, Timothy G Short

Journal article | 2011 | Anesthesia and Analgesia

Effect of intravenous parecoxib on post-craniotomy pain

DL Williams, E Pemberton, K Leslie

Journal article | 2011 | British Journal of Anaesthesia