Rachel Burt

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.

Wei-Hsi Yeh, Olga Shubina-Oleinik, Jonathan M Levy, Bifeng Pan, Gregory A Newby, Michael Wornow, Rachel Burt, Jonathan C Chen, Jeffrey R Holt, David R Liu

Journal article  |  2020  |  Science Translational Medicine

Most genetic diseases arise from recessive point mutations that require correction, rather than disruption, of the pathogenic alle..

Exome sequencing in infants with congenital hearing impairment: a population-based cohort study

Lilian Downie, Jane Halliday, Rachel Burt, Sebastian Lunke, Elly Lynch, Melissa Martyn, Zeffie Poulakis, Clara Gaff, Valerie Sung, Melissa Wake, Matthew F Hunter, Kerryn Saunders, Elizabeth Rose, Sharon Lewis, Anna Jarmolowicz, Dean Phelan, Heidi L Rehm, David J Amor

Journal article  |  2020  |  European Journal of Human Genetics

Congenital hearing impairment (HI) is the most common sensory impairment and can be isolated or part of a syndrome. Diagnosis thro..

Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice

Jacqueline M Ogier, Paul J Lockhart, Rachel A Burt

Journal article  |  2020  |  Hearing Research

Many drugs on the World Health Organization's list of critical medicines are ototoxic, destroying sensory hair cells within the ea..

Data Resource Profile: The Victorian Childhood Hearing Impairment Longitudinal Databank (VicCHILD)

Valerie Sung, Libby Smith, Zeffie Poulakis, Rachel A Burt, Peter Carew, Sherryn Tobin, Melissa Wake

Journal article  |  2019  |  International Journal of Epidemiology

Prevalence of Childhood Hearing Loss and Secular Trends: A Systematic Review and Meta-Analysis

Jing Wang, Valerie Sung, Peter Carew, Rachel A Burt, Mengjiao Liu, Yichao Wang, Aflah Afandi, Melissa Wake

Journal article  |  2019  |  Academic Pediatrics

BACKGROUND: Better epidemiologic information on childhood hearing loss would inform research priorities and efforts to prevent its..

Effect of a pneumococcal whole cell vaccine on influenza A-induced pneumococcal otitis media in infant mice

Jayne Manning, Eileen M Dunne, Nancy Wang, John S Pedersen, Jacqueline M Ogier, Rachel A Burt, E Kim Mulholland, Roy M Robins-Browne, Richard Malley, Odilia L Wijburg, Catherine Satzke

Journal article  |  2019  |  Vaccine

The pneumococcus remains a common cause of otitis media (OM) despite the widespread introduction of pneumococcal conjugate vaccine..

Organotypic Culture of Neonatal Murine Inner Ear Explants

Jacqueline M Ogier, Rachel A Burt, Hannah R Drury, Rebecca Lim, Bryony A Nayagam

Journal article  |  2019  |  Frontiers in Cellular Neuroscience

The inner ear is a complex organ containing highly specialised cell types and structures that are critical for sensing sound and m..

High prevalence of slight and mild hearing loss across mid-life: a cross-sectional national Australian study

J Wang, V Sung, CMP le Clercq, RA Burt, P Carew, RS Liu, FK Mensah, L Gold, M Wake

Journal article  |  2019  |  Public Health

OBJECTIVES: Although presbycusis typically becomes symptomatic only in older age, slight and mild hearing loss may be detectable w..

Cross-sectional epidemiology of hearing loss in Australian children aged 11-12 years old and 25-year secular trends

Jing Wang, Carliin MP le Clercq, Valerie Sung, Peter Carew, Richard S Liu, Fiona K Mensah, Rachel A Burt, Lisa Gold, Melissa Wake

Journal article  |  2018  |  Archives of Disease in Childhood

OBJECTIVE: In a national study of Australian children aged 11-12 years old, we examined the (1) prevalence and characteristics of ..

An intronic mutation in Chd7 creates a cryptic splice site, causing aberrant splicing in a mouse model of CHARGE syndrome

Jacqueline M Ogier, Benedicta D Arhatari, Marina R Carpinelli, Bradley K McColl, Michael A Wilson, Rachel A Burt

Journal article  |  2018  |  Scientific Reports

Alternate splicing is a critical regulator of gene expression in eukaryotes, however genetic mutations can cause erroneous splicin..