Jane Visvader

Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB.

Holly Holliday, Daniel Roden, Simon Junankar, Sunny Z Wu, Laura A Baker, Christoph Krisp, Chia-Ling Chan, Andrea McFarland, Joanna N Skhinas, Thomas R Cox, Bhupinder Pal, Nicholas D Huntington, Christopher J Ormandy, Jason S Carroll, Jane Visvader, Mark P Molloy, Alexander Swarbrick

Journal article  |  2021  |  iScience

Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of linea..

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  American Journal of Human Genetics

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer.

James R Whittle, François Vaillant, Elliot Surgenor, Antonia N Policheni, Göknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

Caleb A Dawson, Bhupinder Pal, Francois Vaillant, Luke C Gandolfo, Zhaoyuan Liu, Camille Bleriot, Florent Ginhoux, Gordon K Smyth, Geoffrey J Lindeman, Scott N Mueller, Anne C Rios, Jane E Visvader

Journal article  |  2020  |  Nature Cell Biology

Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland functi..

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Johanna F Dekkers, James R Whittle, Francois Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten H Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2020  |  Journal of the National Cancer Institute

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Najoua Lalaoui, Delphine Merino, Goknur Giner, Francois Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Grasel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Gordon K Smyth, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke

Journal article  |  2020  |  Cell Death and Differentiation

Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Her..

STEM CELLS AND THE DIFFERENTIATION HIERARCHY IN MAMMARY GLAND DEVELOPMENT

Nai Yang Fu, Emma Nolan, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2020  |  Physiological Reviews

The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproduct..

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.

Journal article  |  2020  |  Nature Genetics

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..

Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

Halting triple negative breast cancer by targeting PROCR

Nai Yang Fu, Jane E Visvader

Journal article  |  2019  |  Cell Research