Jane Visvader

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

Caleb A Dawson, Bhupinder Pal, Francois Vaillant, Luke C Gandolfo, Zhaoyuan Liu, Camille Bleriot, Florent Ginhoux, Gordon K Smyth, Geoffrey J Lindeman, Scott N Mueller, Anne C Rios, Jane E Visvader

Journal article  |  2020  |  Nature Cell Biology

Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland functi..

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Johanna F Dekkers, James R Whittle, Francois Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten H Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2020  |  JNCI: Journal of the National Cancer Institute

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Najoua Lalaoui, Delphine Merino, Goknur Giner, Francois Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Grasel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Gordon K Smyth, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke

Journal article  |  2020  |  Cell Death & Differentiation

Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Her..

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer.

James R Whittle, François Vaillant, Elliot Surgenor, Antonia N Policheni, Goknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..

STEM CELLS AND THE DIFFERENTIATION HIERARCHY IN MAMMARY GLAND DEVELOPMENT

Nai Yang Fu, Emma Nolan, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2020  |  Physiological Reviews

The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproduct..

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.

Journal article  |  2020  |  Nature Genetics

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..

Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

Halting triple negative breast cancer by targeting PROCR

Nai Yang Fu, Jane E Visvader

Journal article  |  2019  |  Cell Research

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.

Journal article  |  2019  |  npj Breast Cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..

Lgr(5 ) pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

Chow Hiang Ang, Shih Han Hsu, Fusheng Guo, Chong Teik Tan, Victor C Yu, Jane E Visvader, Pierce KH Chow, Nai Yang Fu

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.

Anne C Rios, Bianca D Capaldo, François Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, undefined 3DTCLSM Group, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2019  |  Cancer Cell

High-resolution 3D imaging of fixed and cleared organoids

Johanna F Dekkers, Maria Alieva, Lianne M Wellens, Hendrikus CR Ariese, Paul R Jamieson, Annelotte M Vonk, Gimano D Amatngalim, Huili Hu, Koen C Oost, Hugo JG Snippert, Jeffrey M Beekman, Ellen J Wehrens, Jane E Visvader, Hans Clevers, Anne C Rios

Journal article  |  2019  |  Nature Protocols

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.

Journal article  |  2019  |  Cancer Cell

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik

Journal article  |  2019  |  Nature Communications

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

Stefano Annunziato, Julian R de Ruiter, Linda Henneman, Chiara S Brambillasca, Catrin Lutz, Francois Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjorn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H van Miltenburg, Ivo J Huijbers, Marieke van de Ven, Jane E Visvader, Geoffrey J Lindeman, Lodewyk FA Wessels, Jos Jonkers

Journal article  |  2019  |  Nature Communications

Isolation and Propagation of Mammary Epithelial Stem and Progenitor Cells.

Julie M Sheridan, Jane E Visvader

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Several methods of mammary gland dissociation have been described that utilize a combined strategy of mechanical and enzymatic dis..

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2018  |  Developmental Cell

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2018  |  PLOS Biology

Sequence variability in plant viroid RNAs

PK Keese, JE Visvader, RH Symons

Book Chapter  |  2018

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Reema Jain, Julie M Sheridan, Antonia Policheni, Melanie Heinlein, Luke C Gandolfo, Grant Dewson, Gordon K Smyth, Stephen N Sansom, Nai Yang Fu, Jane E Visvader, Georg A Hollander, Andreas Strasser, Daniel HD Gray

Journal article  |  2017  |  Blood

Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

Bhupinder Pal, Yunshun Chen, Francois Vaillant, Paul Jamieson, Lavinia Gordon, Anne C Rios, Stephen Wilcox, Naiyang Fu, Kevin He Liu, Felicity C Jackling, Melissa J Davis, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2017  |  Nature Communications

RE: Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Emma Nolan, Francois Vaillant, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2017  |  JNCI: Journal of the National Cancer Institute

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman

Journal article  |  2017  |  Science translational medicine

Safety and efficacy of the BCL2 inhibitor venetoclax in estrogen receptor (ER) and BCL2-positive metastatic breast cancer: The mBEP study.

Geoffrey John Lindeman, Sheau Wen Lok, Alice Ruth Bergin, James Richard Whittle, Kylie Shackleton, Peter Sherman, Sarah-Jane Dawson, Jayesh Desai, Danny Liew, Bruce Mann, Anand Murugasu, Andrew Warwick Roberts, Mark Rosenthal, Jane Visvader

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression

Justin Grassmeyer, Malini Muldierjee, Jennifer deRiso, Casey Hettinger, Monica Bailey, Satrajit Sinha, Jane E Visvader, Haotian Zhao, Eric Fogarty, Kameswaran Surendran

Journal article  |  2017  |  Developmental Biology

Derivation of a robust mouse mammary organoid system for studying tissue dynamics

Paul R Jamieson, Johanna F Dekkers, Anne C Rios, Nai Yang Fu, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2017  |  Development

Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive

Nai Yang Fu, Anne C Rios, Bhupinder Pal, Charity W Law, Paul Jamieson, Ruijie Liu, Francois Vaillant, Felicity Jackling, Kevin He Liu, Gordon K Smyth, Geoffrey J Lindeman, Matthew E Ritchie, Jane E Visvader

Journal article  |  2017  |  Nature Cell Biology

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

Carmel M O'Brien, Hun S Chy, Qi Zhou, Shiri Blumenfeld, Jack W Lambshead, Xiaodong Liu, Joshua Kie, Bianca D Capaldo, Tung-Liang Chung, Timothy E Adams, Phan Tram, John D Bentley, William J McKinstry, Karen Oliva, Paul J McMurrick, Yu-Chieh Wang, Fernando J Rossello, Geoffrey J Lindeman, Di Chen, Thierry Jarde, et al.

Journal article  |  2017  |  STEM CELLS

Out-RANKing BRCA1 in Mutation Carriers

Emma Nolan, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2017  |  Cancer Research

RANK ligand as a target for breast cancer prevention in BRCA1 mutation carriers

GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader

Conference Proceedings  |  2017  |  General Session Abstracts

Differential methylation analysis of reduced representation bisulfite sequencing experiments using edgeR.

Yunshun Chen, Bhupinder Pal, Jane E Visvader, Gordon K Smyth

Journal article  |  2017  |  F1000Research

Cytosine methylation is an important DNA epigenetic modification. In vertebrates, methylation occurs at CpG sites, which are dinuc..

Lineage Tracing of Mammary Stem and Progenitor Cells

Anoeska AA van de Moosdijk, Nai Yang Fu, Anne C Rios, Jane E Visvader, Renee van Amerongen

Journal article  |  2017  |  Methods in molecular biology (Clifton, N.J.)

Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?

Ewa M Michalak, Jane E Visvader

Journal article  |  2016  |  Molecular Oncology

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

Lacey E Dobrolecki, Susie D Airhart, Denis G Alferez, Samuel Aparicio, Fariba Behbod, Mohamed Bentires-Alj, Cathrin Brisken, Carol J Bult, Shirong Cai, Robert B Clarke, Heidi Dowst, Matthew J Ellis, Eva Gonzalez-Suarez, Richard D Iggo, Peter Kabos, Shunqiang Li, Geoffrey J Lindeman, Elisabetta Marangoni, Aaron McCoy, Funda Meric-Bernstam, et al.

Journal article  |  2016  |  Cancer and Metastasis Reviews

The complexities and caveats of lineage tracing in the mammary gland

Anne C Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2016  |  Breast Cancer Research

Foreword by Jane Visvader

J Visvader

Book  |  2016

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

Emma Nolan, Francois Vaillant, Daniel Branstetter, Bhupinder Pal, Goeknur Giner, Lachlan Whitehead, Sheau W Lok, Gregory B Mann, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Gordon K Smyth, William C Dougall, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2016  |  Nature Medicine

Persistent Activation of NF-kappa B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage

Andrea Sau, Rosanna Lau, Miguel A Cabrita, Emma Nolan, Peter A Crooks, Jane E Visvader, MA Christine Pratt

Journal article  |  2016  |  Cell Stem Cell

RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity

Michael Chopin, Simon P Preston, Aaron TL Lun, Julie Tellier, Gordon K Smyth, Marc Pellegrini, Gabrielle T Belz, Lynn M Corcoran, Jane E Visvader, Li Wu, Stephen L Nutt

Journal article  |  2016  |  Cell Reports

Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer

D Merino, SW Lok, JE Visvader, GJ Lindeman

Journal article  |  2016  |  Oncogene

Tissue-specific designs of stem cell hierarchies

Jane E Visvader, Hans Clevers

Journal article  |  2016  |  Nature Cell Biology

Essential role for a novel population of binucleated mammary epithelial cells in lactation

Anne C Rios, Nai Yang Fu, Paul R Jamieson, Bhupinder Pal, Lachlan Whitehead, Kevin R Nicholas, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2016  |  Nature Communications

Corrigendum to "Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4" [Biochim. Biophys. Acta, 1853, 7, (2015), 1683-1692] Doi: 10.1016/j.bbamcr.2015.04.003

KD Baron, K Al-Zahrani, J Conway, C Labrèche, CJ Storbeck, JE Visvader, LA Sabourin

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Cellular Mechanisms Underlying Intertumoral Heterogeneity

Kate D Sutherland, Jane E Visvader

Journal article  |  2015  |  Trends in Cancer

Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4

Kyla D Baron, Khalid Al-Zahrani, Jillian Conway, Cedrik Labreche, Christopher J Storbeck, Jane E Visvader, Luc A Sabourin

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2

D Merino, SA Best, M-L Asselin-Labat, F Vaillant, B Pal, RA Dickins, RL Anderson, A Strasser, P Bouillet, GJ Lindeman, JE Visvader

Journal article  |  2015  |  Oncogene

Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits

Bhupinder Pal, Yunshun Chen, Andrew Bert, Yifang Hu, Julie M Sheridan, Tamara Beck, Wei Shi, Keith Satterley, Paul Jamieson, Gregory J Goodall, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2015  |  Breast Cancer Research

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1

Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, Francois Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2015  |  BMC Cancer

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

Nai Yang Fu, Anne C Rios, Bhupinder Pal, Rina Soetanto, Aaron TL Lun, Kevin Liu, Tamara Beck, Sarah A Best, Francois Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K Smyth, Rey J Lindeman, Jane E Visvader

Journal article  |  2015  |  Nature Cell Biology

Patient-derived xenograft models of breast cancer and their predictive power

James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2015  |  Breast Cancer Research

Runx2 Is a Novel Regulator of Mammary Epithelial Cell Fate in Development and Breast Cancer

Thomas W Owens, Renee L Rogers, Sarah A Best, Anita Ledger, Anne-Marie Mooney, Alison Ferguson, Paul Shore, Alexander Swarbrick, Christopher J Ormandy, Peter T Simpson, Jason S Carroll, Jane E Visvader, Matthew J Naylor

Journal article  |  2014  |  Cancer Research

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary

Sarah A Best, Karla J Hutt, Nai Yang Fu, Francois Vaillant, Seng H Liew, Lynne Hartley, Clare L Scott, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Development

Mammary stem cells and the differentiation hierarchy: current status and perspectives

Jane E Visvader, John Stingl

Journal article  |  2014  |  Genes & Development

Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

Nathan J Godde, Julie M Sheridan, Lorey K Smith, Helen B Pearson, Kara L Britt, Ryan C Galea, Laura L Yates, Jane E Visvader, Patrick O Humbert

Journal article  |  2014  |  PLoS Genetics

In situ identification of bipotent stem cells in the mammary gland

Anne C Rios, Nai Yang Fu, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Nature

The Mammary Stem Cell Hierarchy

Naiyang Fu, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Current topics in developmental biology

Distinct nuclear receptor expression in stroma adjacent to breast tumors

Kevin C Knower, Ashwini L Chand, Natalie Eriksson, Kiyoshi Takagi, Yasuhiro Miki, Hironobu Sasano, Jane E Visvader, Geoffrey J Lindeman, John W Funder, Peter J Fuller, Evan R Simpson, Wayne D Tilley, Peter J Leedman, J Dinny Graham, George EO Muscat, Christine L Clarke, Colin D Clyne

Journal article  |  2013  |  Breast Cancer Research and Treatment

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

Francois Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E Ritchie, Gordon K Smyth, Michael Christie, Louisa J Phillipson, Christopher J Burns, G Bruce Mann, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2013  |  Cancer Cell

Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8

PH Stokes, CW Liew, AH Kwan, P Foo, HE Barker, A Djamirze, V O'Reilly, JE Visvader, JP Mackay, JM Matthews

Journal article  |  2013  |  Journal of Molecular Biology

Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2

Bhupinder Pal, Toula Bouras, Wei Shi, Francois Vaillant, Julie M Sheridan, Naiyang Fu, Kelsey Breslin, Kun Jiang, Matthew E Ritchie, Matthew Young, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2013  |  Cell Reports

Remodeling of the Lymphatic Vasculature during Mouse Mammary Gland Morphogenesis Is Mediated via Epithelial-Derived Lymphangiogenic Stimuli

Kelly L Betterman, Sophie Paquet-Fifield, Marie-Liesse Asselin-Labat, Jane E Visvader, Lisa M Butler, Steven A Stacker, Marc G Achen, Natasha L Harvey

Journal article  |  2012  |  American Journal of Pathology

Cancer Stem Cells: Current Status and Evolving Complexities

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Cell Stem Cell

Isolation of Mouse Mammary Epithelial Subpopulations: A Comparison of Leading Methods

Matthew J Smalley, Howard Kendrick, Julie M Sheridan, Joseph L Regan, Michael D Prater, Geoffrey J Lindeman, Christine J Watson, Jane E Visvader, John Stingl

Journal article  |  2012  |  Journal of Mammary Gland Biology and Neoplasia

Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice

Margaret Czesak, Brice Le Francois, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Albert

Journal article  |  2012  |  Journal of Biological Chemistry

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Aldehyde Dehydrogenase Activity Is a Biomarker of Primitive Normal Human Mammary Luminal Cells

Peter Eirew, Nagarajan Kannan, David JHF Knapp, Francois Vaillant, Joanne T Emerman, Geoffrey J Lindeman, Jane E Visvader, Connie J Eaves

Journal article  |  2012  |  Stem Cells

The unmasking of novel unipotent stem cells in the mammary gland

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2011  |  EMBO Journal

Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Molecular and Cellular Biology

Lineage Specific Methylation of the Elf5 Promoter in Mammary Epithelial Cells

Heather J Lee, Rebecca A Hinshelwood, Toula Bouras, David Gallego-Ortega, Fatima Valdes-Mora, Katrina Blazek, Jane E Visvader, Susan J Clark, Christopher J Ormandy

Journal article  |  2011  |  STEM CELLS

Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations

Hong Ji, Robert JA Goode, Francois Vaillant, Suresh Mathivanan, Eugene A Kapp, Rommel A Mathias, Geoffrey J Lindeman, Jane E Visvader, Richard J Simpson

Journal article  |  2011  |  Proteomics

Mammary stem cells and their regulation by steroid hormones.

Marie-Liesse Asselin-Labat, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Expert Review of Endocrinology & Metabolism

Sustained exposure to estrogen and progesterone is a well-established risk factor for breast cancer. These hormones play a central..

Hereditary Breast Cancer Genetics-From Clinical Curiosities to Mainstream Paradigms PREFACE

GJ Lindeman, JE Visvader

Journal article  |  2011  |  Journal of Mammary Gland Biology and Neoplasia

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

CE Smart, A Wronski, JD French, SL Edwards, M-L Asselin-Labat, N Waddell, K Peters, BL Brewster, K Brooks, K Simpson, N Manning, SR Lakhani, S Grimmond, GJ Lindeman, JE Visvader, MA Brown

Journal article  |  2011  |  Oncogene

Murine mammary epithelial stem cells: discovery, function, and current status.

Jane E Visvader, Gilbert H Smith

Journal article  |  2011  |  Cold Spring Harbor perspectives in biology

An entire mammary epithelial outgrowth, capable of full secretory differentiation, may comprise the progeny of a single cellular a..

LMO4 expression in squamous cell carcinoma of the anterior tongue

Rhonda A Kwong, Christopher J Scarlett, Larry H Kalish, Ian E Cole, James G Kench, Eleanor YM Sum, Elizabeth A Musgrove, Susan M Henshall, Geoffrey J Lindeman, Andrew V Biankin, Jane E Visvader, Robert L Sutherland

Journal article  |  2011  |  Histopathology

Murine Mammary Epithelial Stem Cells: Discovery, Function, and Current Status

Jane E Visvader, Gilbert H Smith

Journal article  |  2011  |  Cold Spring Harbor Perspectives in Biology

Cells of origin in cancer

Jane E Visvader

Journal article  |  2011  |  Nature

Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Breast Cancer Research

Cell fate takes a slug in BRCA1-associated breast cancer

Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Breast Cancer Research

Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells

Marjorie E Montanez-Wiscovich, Melissa D Shelton, Darcie D Seachrist, Kristen L Lozada, Emhonta Johnson, John D Miedler, Fadi W Abdul-Karim, Jane E Visvader, Ruth A Keri

Journal article  |  2010  |  The Journal of Pathology

Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow

Chih-Wen Ni, Haiwei Qiu, Amir Rezvan, Kihwan Kwon, Douglas Nam, Dong Ju Son, Jane E Visvader, Hanjoong Jo

Journal article  |  2010  |  Blood

Stem cells and cancer - The promise and puzzles Preface

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2010  |  Molecular Oncology

ROAST: rotation gene set tests for complex microarray experiments

Di Wu, Elgene Lim, Francois Vaillant, Marie-Liesse Asselin-Labat, Jane E Visvader, Gordon K Smyth

Journal article  |  2010  |  Bioinformatics

FOXA1 is an essential determinant of ER alpha expression and mammary ductal morphogenesis

Gina M Bernardo, Kristen L Lozada, John D Miedler, Gwyndolen Harburg, Sylvia C Hewitt, Jonathan D Mosley, Andrew K Godwin, Kenneth S Korach, Jane E Visvader, Klaus H Kaestner, Fadi W Abdul-Karim, Monica M Montano, Ruth A Keri

Journal article  |  2010  |  Development

Control of mammary stem cell function by steroid hormone signalling

Marie-Liesse Asselin-Labat, Francois Vaillant, Julie M Sheridan, Bhupinder Pal, Di Wu, Evan R Simpson, Hisataka Yasuda, Gordon K Smyth, T John Martin, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2010  |  Nature

Insights into the cell of origin in breast cancer and breast cancer stem cells

Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2010  |  Asia-Pacific Journal of Clinical Oncology

Loss of STARD 10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status

Niamh C Murphy, Andrew V Biankin, Ewan KA Millar, Catriona M McNeil, Sandra A O'Toole, Davendra Segara, Paul Crea, Monilola A Olayioye, C Soon Lee, Stephen B Fox, Adrienne L Morey, Michael Christie, Elizabeth A Musgrove, Roger J Daly, Geoffrey J Lindeman, Susan M Henshall, Jane E Visvader, Robert L Sutherland

Journal article  |  2010  |  International Journal of Cancer

Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors

Jeremy M Arnold, David YH Choong, Ella R Thompson, Nic Waddell, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell, Georgia Chenevix-Trench

Journal article  |  2010  |  Breast Cancer Research and Treatment

Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, Francois Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2010  |  Breast Cancer Research

Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers

Renea A Taylor, Hong Wang, Sarah E Wilkinson, Michelle G Richards, Kara L Britt, Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader, Gerald R Cunha, Justin St John, Gail P Risbridger

Journal article  |  2009  |  Stem Cells

Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis.

Jane E Visvader

Journal article  |  2009  |  Genes & Development

The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic morphogenetic changes during puberty, pr..

LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression

ME Montanez-Wiscovich, DD Seachrist, MD Landis, J Visvader, B Andersen, RA Keri

Journal article  |  2009  |  Oncogene

Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer

Andrew V Biankin, James G Kench, Emily K Colvin, Davendra Segara, Christopher J Scarlett, Nam Q Nguyen, David K Chang, Adrienne L Morey, C-Soon Lee, Mark Pinese, Samuel CL Kuo, Johana M Susanto, Peter H Cosman, Geoffrey J Lindeman, Jane E Visvader, Tuan V Nguyen, Neil D Merrett, Janindra Warusavitarne, Elizabeth A Musgrove, Susan M Henshall, et al.

Journal article  |  2009  |  Gastroenterology

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Elgene Lim, Francois Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Nature Medicine

Impaired Lactation in Mice Expressing Dominant-Negative FADD in Mammary Epithelium

Mark Shackleton, Lorraine A O'Reilly, Kate D Sutherland, Mary L Bath, Sarah Ellis, Andreas Strasser, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Developmental Dynamics

Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control

Zhenyong Huang, Yoko Lawase-Koga, Shuqun Zhang, Jane Visvader, Miklos Toth, Christopher A Walsh, Tao Sun

Journal article  |  2009  |  Developmental Biology

EpCAM and solid tumour fractionation

JE Visvader, GJ Lindeman

Journal article  |  2009  |  Nature Reviews Cancer

Breast cancer risk and the BRCA1 interacting protein CTIP

Kylie L Gorringe, David YH Choong, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell

Journal article  |  2008  |  Breast Cancer Research and Treatment

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

Toula Bouras, Bhupinder Pal, Francois Vaillant, Gwyndolen Harburg, Marie-Liesse Asselin-Labat, Samantha R Oakes, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  CELL STEM CELL

Deaf-I regulates epithelial cell proliferation and side-branching in the mammary gland

Holly E Barker, Gordon K Smyth, James Wettenhall, Teresa A Ward, Mary L Bath, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  BMC Developmental Biology

BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer

Kylie L Gorringe, David YH Choong, Jane E Visvader, Geoffrey J Lindeman, Ian G Campbell

Journal article  |  2008  |  Breast Cancer Research and Treatment

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2008  |  Nature Reviews Cancer

The mammary progenitor marker CD61/beta 3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis

Francois Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Natasha C Forrest, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  CANCER RESEARCH

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

Samantha R Oakes, Matthew J Naylor, Marie-Liesse Asselin-Labat, Katrina D Blazek, Margaret Gardiner-Garden, Heidi N Hilton, Michael Kazlauskas, Melanie A Pritchard, Lewis A Chodosh, Peter L Pfeffer, Geoffrey J Lindeman, Jane E Visvader, Christopher J Ormandy

Journal article  |  2008  |  Genes & Development

Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma

NC Murphy, CJ Scarlett, JG Kench, EYM Sum, D Segara, EK Colvin, J Susanto, PH Cosman, C-S Lee, EA Musgrove, RL Sutherland, GJ Lindeman, SM Henshall, JE Visvader, AV Biankin

Journal article  |  2008  |  British Journal of Cancer

Delineating the Epithelial Hierarchy in the Mouse Mammary Gland

M-L Asselin-Labat, F Vaillant, M Shackleton, T Bouras, GJ Lindeman, JE Visvader

Journal article  |  2008  |  Cold Spring Harbor Symposia on Quantitative Biology

The future of mammary stem cell biology: the power of in vivo transplants

Geoffrey J Lindeman, Jane E Visvader, Matthew J Smalley, Connie J Eaves

Journal article  |  2008  |  Breast Cancer Research

The emerging picture of the mouse mammary stem cell

Francois Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Stem Cell Reviews

c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3

Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2006  |  The EMBO Journal

Mammary stem cells and mammopoiesis

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2006  |  Cancer Research

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

Michael F Clarke, John E Dick, Peter B Dirks, Connie J Eaves, Catriona HM Jamieson, D Leanne Jones, Jane Visvader, Irving L Weissman, Geoffrey M Wahl

Conference Proceedings  |  2006  |  Cancer Research

Steroid hormone receptor status of mouse mammary stem cells

Marie-Liesse Asselin-Labat, Mark Shackleton, John Stingl, Francois Vaillant, Natasha C Forrest, Connie J Eaves, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2006  |  JOURNAL OF THE NATIONAL CANCER INSTITUTE

Identification of the key LMO2-binding determinants on Ldb1

Daniel P Ryan, Margaret Sunde, Ann H-Y Kwan, Neelan J Marianayagam, Amy L Nancarrow, Rachel N vanden Hoven, Lyndal S Thompson, Manuel Baca, Joel P Mackay, Jane E Visvader, Jacqueline M Matthews

Journal article  |  2006  |  Journal of Molecular Biology

Socs2 and Elf5 mediate prolactin-induced mammary gland development

J Harris, PM Stanford, K Sutherland, SR Oakes, MJ Naylor, FG Robertson, KD Blazek, M Kazlauskas, HN Hilton, S Wittlin, WS Alexander, GJ Lindeman, JE Visvader, CJ Ormandy

Journal article  |  2006  |  Molecular Endocrinology

Generation of a functional mammary gland from a single stem cell

M Shackleton, F Vaillant, KJ Simpson, J Stingl, GK Smyth, ML Asselin-Labat, L Wu, GJ Lindeman, JE Visvader

Journal article  |  2006  |  Nature

Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants

PK Lovelock, S Healey, W Au, EYM Sum, A Tesoriero, EM Wong, S Hinson, R Brinkworth, A Bekessy, O Diez, L Izatt, E Solomon, M Jenkins, H Renard, J Hopper, P Waring, SV Tavtigian, D Goldgar, GJ Lindeman, JE Visvader, et al.

Journal article  |  2006  |  Journal of Medical Genetics

Early asymmetry of gene transcription in embryonic human left and right cerebral cortex

T Sun, C Patoine, A Abu-Khalil, J Visvader, E Sum, TJ Cherry, SH Orkin, DH Geschwind, CA Walsh

Journal article  |  2005  |  Science

A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3

RJY Simpson, SHY Lee, N Bartle, EY Sum, JE Visvader, JM Matthews, JP Mackay, M Crossley

Journal article  |  2004  |  Journal of Biological Chemistry

Tandem LIM domains provide synergistic binding in the LMO4 : Ldb1 complex

JE Deane, DP Ryan, M Sunde, MJ Maher, JM Guss, JE Visvader, JM Matthews

Journal article  |  2004  |  The EMBO Journal

LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins

JM Matthews, JE Visvader

Journal article  |  2003  |  EMBO reports

Two promoters within the human LMO4 gene contribute to its overexpression in breast cancer cells

S Wittlin, EYM Sum, NK Jonas, GJ Lindeman, JE Visvader

Journal article  |  2003  |  Genomics

Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex

JE Deane, MJ Maher, DB Langley, SC Graham, JE Visvader, JM Guss, JM Matthews

Journal article  |  2003  |  Acta Crystallographica Section D Biological Crystallography

Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.

Janet E Deane, Joel P Mackay, Ann HY Kwan, Eleanor YM Sum, Jane E Visvader, Jacqueline M Matthews

Journal article  |  2003  |  The EMBO Journal

LMO2 and LMO4 are members of a small family of nuclear transcriptional regulators that are important for both normal development a..

Letter to the editor: H-1, N-15 and C-13 assignments of FLIN4, an intramolecular LMO4 : ldb1 complex

JE Deane, JE Visvader, JP Mackay, JM Matthews

Journal article  |  2002  |  Journal of Biomolecular NMR

Letter to the Editor: H-1, N-15 and C-13 assignments of FLIN2, an intramolecular LMO2 : ldb1 complex

JM Matthews, JE Visvader, JP Mackay

Journal article  |  2001  |  Journal of Biomolecular NMR

SUO SAS radio intra-networking architecture

C Li, CJ Yoon, J Visvader, P Kolodzy

Conference Proceedings  |  2001  |  Proceedings - IEEE Military Communications Conference MILCOM

A potential role for protein kinase C-epsilon in regulating megakaryocytic lineage commitment

FK Racke, DY Wang, Z Zaidi, J Kelley, J Visvader, JW Soh, AN Goldfarb

Journal article  |  2001  |  Journal of Biological Chemistry

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

LA O'Reilly, L Cullen, J Visvader, GJ Lindeman, C Print, ML Bath, DCS Huang, A Strasser

Journal article  |  2000  |  The American Journal of Pathology

11th Lorne Cancer Conference, Lorne, Victoria, Australia, 11-14th February 1999.

GJ Lindeman, JE Visvader

Journal article  |  1999  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Intersections between blood cell development and leukemia genes.

SH Orkin, C Porcher, Y Fujiwara, J Visvader, LC Wang

Conference Proceedings  |  1999  |  Cancer Research

Hematopoietic development is regulated in large part by transcription factors that control cell fate decisions and cellular differ..

Ken's problem: Environmental activism in an age of deconstructionist biology

J Visvader

Journal article  |  1998  |  Human Ecology Review

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.

LC Wang, W Swat, Y Fujiwara, L Davidson, J Visvader, F Kuo, FW Alt, DG Gilliland, TR Golub, SH Orkin

Journal article  |  1998  |  Genes & Development

The TEL (translocation-Ets-leukemia or ETV6) locus, which encodes an Ets family transcription factor, is frequently rearranged in ..

Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.

JE Visvader, Y Fujiwara, SH Orkin

Journal article  |  1998  |  Genes & Development

The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, S..

Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment

S Ogilvy, AG Elefanty, J Visvader, ML Bath, AW Harris, JM Adams

Journal article  |  1998  |  Blood

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.

JE Visvader, X Mao, Y Fujiwara, K Hahm, SH Orkin

Journal article  |  1997  |  Proceedings of the National Academy of Sciences

The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presum..

FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.

AP Tsang, JE Visvader, CA Turner, Y Fujiwara, C Yu, MJ Weiss, M Crossley, SH Orkin

Journal article  |  1997  |  Cell

The hematopoietic transcription factor GATA-1 is essential for development of the erythroid and megakaryocytic lineages. Using the..

THE C-TERMINAL ZINC-FINGER OF GATA-1 OR GATA-2 IS SUFFICIENT TO INDUCE MEGAKARYOCYTIC DIFFERENTIATION OF AN EARLY MYELOID CELL-LINE

JE VISVADER, M CROSSLEY, J HILL, SH ORKIN, JM ADAMS

Journal article  |  1995  |  Molecular and Cellular Biology

STRUCTURE OF THE GENE ENCODING THE MURINE SCL PROTEIN

CG BEGLEY, L ROBB, S ROCKMAN, J VISVADER, EO BOCKAMP, YS CHAN, AR GREEN

Journal article  |  1994  |  Gene

MEGAKARYOCYTIC DIFFERENTIATION-INDUCED IN 416B MYELOID CELLS BY GATA-2 AND GATA-3 TRANSGENES OR 5-AZACYTIDINE IS TIGHTLY COUPLED TO GATA-1 EXPRESSION

J VISVADER, JM ADAMS

Journal article  |  1993  |  Blood

GATA-1 BUT NOT SCL INDUCES MEGAKARYOCYTIC DIFFERENTIATION IN AN EARLY MYELOID LINE

JE VISVADER, AG ELEFANTY, A STRASSER, JM ADAMS

Journal article  |  1992  |  The EMBO Journal

SCL IS COEXPRESSED WITH GATA-1 IN HEMATOPOIETIC-CELLS BUT IS ALSO EXPRESSED IN DEVELOPING BRAIN

AR GREEN, T LINTS, J VISVADER, R HARVEY, CG BEGLEY

Journal article  |  1992  |  Oncogene

HELIX-LOOP-HELIX GENES TRANSLOCATED IN LYMPHOID LEUKEMIA

J VISVADER, CG BEGLEY

Journal article  |  1991  |  Trends in Biochemical Sciences

MOLECULAR-CLONING AND CHROMOSOMAL LOCALIZATION OF THE MURINE HOMOLOG OF THE HUMAN HELIX-LOOP-HELIX GENE SCL

CG BEGLEY, J VISVADER, AR GREEN, PD APLAN, D METCALF, IR KIRSCH, NM GOUGH

Journal article  |  1991  |  Proceedings of the National Academy of Sciences

DIFFERENTIAL EXPRESSION OF THE LYL, SCL AND E2A HELIX-LOOP-HELIX GENES WITHIN THE HEMATOPOIETIC SYSTEM

J VISVADER, CG BEGLEY, JM ADAMS

Journal article  |  1991  |  Oncogene

HOMEOBOX GENE-EXPRESSION PLUS AUTOCRINE GROWTH-FACTOR PRODUCTION ELICITS MYELOID-LEUKEMIA

A PERKINS, K KONGSUWAN, J VISVADER, JM ADAMS, S CORY

Journal article  |  1990  |  Proceedings of the National Academy of Sciences

Trans-dominant negative mutants of Fos and Jun.

LJ Ransone, J Visvader, P Wamsley, IM Verma

Journal article  |  1990  |  Proceedings of the National Academy of Sciences

Jun and Fos nuclear oncoproteins form a complex that regulates transcription from promoters containing activator protein AP-1 bind..

fos-jun conspiracy: implications for the cell.

IM Verma, LJ Ransone, J Visvader, P Sassone-Corsi, WW Lamph

Journal article  |  1990  |  Ciba Foundation symposium

Two nuclear oncoproteins, fos and jun (AP-1), cooperate in forming a very stable heterodimeric complex that binds to the AP-1 site..

Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins.

LJ Ransone, J Visvader, P Sassone-Corsi, IM Verma

Journal article  |  1989  |  Genes & Development

Jun and Fos oncoproteins form a complex that regulates transcription from promoters containing AP-1 binding sites. The 'leucine zi..

Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.

J Visvader, IM Verma

Journal article  |  1989  |  Molecular and Cellular Biology

Structural analysis of the 5' end of the human c-fms gene revealed that a large intron of about 25 kilobases separates an upstream..

fos and jun interaction: the role of the leucine zipper.

LJ Ransone, J Visvader, WW Lamph, P Sassone-Corsi, IM Verma

Journal article  |  1989  |  International journal of cancer. Supplement = Journal international du cancer. Supplement

Jun and fos oncoproteins form a complex which regulates transcription from promoters containing AP-I binding sites. The "leucine z..

fos and jun interaction: The role of the leucine zipper

LJ Ransone, J Visvader, WW Lamph, P Sassone‐Corsi, IM Verma

Journal article  |  1989  |  International Journal of Cancer

fos-jun Conspiracy: implications for the cell.

IM Verma, LJ Ransone, J Visvader, P Sassone-Corsi, WW Lamph

Journal article  |  1989  |  Princess Takamatsu symposia

Two nuclear oncoproteins, fos and jun (AP-1), cooperate in forming a very stable heterodimeric complex that binds to the AP-1 site..

Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

P Sassone-Corsi, J Visvader, L Ferland, PL Mellon, IM Verma

Journal article  |  1988  |  Genes & Development

Transcription of proto-oncogene fos is induced by elevated levels of intracellular cAMP. We report that human c-fos promoter recom..

Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes.

J Visvader, P Sassone-Corsi, IM Verma

Journal article  |  1988  |  Proceedings of the National Academy of Sciences

Protooncogene fos is rapidly and transiently induced by nerve growth factor (NGF) in rat pheochromocytoma PC12 cells. Two adjacent..

Self-cleavage of RNA in the replication of viroids and virusoids.

RH Symons, CJ Hutchins, AC Forster, PD Rathjen, P Keese, JE Visvader

Journal article  |  1987  |  Journal of Cell Science

Viroids are infectious, circular RNA molecules of 246 to 375 nucleotides found in plants. Virusoids are of similar size and struct..

Comparison of multimeric plus and minus forms of viroids and virusoids

CJ Hutchins, P Keese, JE Visvader, PD Rathjen, JL McInnes, RH Symons

Journal article  |  1985  |  Plant Molecular Biology

Infectivity and in vitro mutagenesis of monomeric cDNA clones of citrus exocortis viroid indicates the site of processing of viroid precursors.

JE Visvader, AC Forster, RH Symons

Journal article  |  1985  |  Nucleic Acids Research

Monomeric cDNA clones of citrus exocortis viroid (CEV) were constructed in the plasmid vector pSP6-4 and the infectivity of the cl..

Eleven new sequence variants of citrus exocortis viroid and the correlation of sequence with pathogenicity.

JE Visvader, RH Symons

Journal article  |  1985  |  Nucleic Acids Research

Full-length double-stranded cDNA was prepared from purified circular RNA of two new Australian field isolates of citrus exocortis ..

Comparative sequence and structure of different isolates of citrus exocortis viroid

JE Visvader, RH Symons

Journal article  |  1983  |  Virology

Citrus exocortis viroid: nucleotide sequence and secondary structure of an Australian isolate

JE Visvader, AR Gould, GE Bruening, RH Symons

Journal article  |  1982  |  FEBS Letters