Over the past decade, my laboratory, jointly headed with Professor Geoff Lindeman has made important contributions to breast cancer research, including:
- Identifying breast stem cells, which give rise to normal breast tissue.
- Defining how normal breast growth is regulated, and how errors lead to breast cancer.
- Identifying the breast cells that are predisposed to becoming cancerous in women with BRCA1 gene mutations.
- Discovering potential strategies to treat and prevent breast cancer.
Translation is an important focus of our laboratory and towards this end we have generated valuable preclinical models to study potentially novel treatments.
Find out more about Jane Visvader's experience
Jane Visvader's highlights
Jane Visvader's selected work
Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids
Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor po..
Displaying the 162 most recent scholarly works by Jane Visvader.
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
Caleb A Dawson, Bhupinder Pal, Francois Vaillant, Luke C Gandolfo, Zhaoyuan Liu, Camille Bleriot, Florent Ginhoux, Gordon K Smyth, Geoffrey J Lindeman, Scott N Mueller, Anne C Rios, Jane E Visvader
Journal article | 2020 | Nature Cell Biology
Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland functi..
Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids
Johanna F Dekkers, James R Whittle, Francois Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten H Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2020 | JNCI: Journal of the National Cancer Institute
Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..
Targeting triple-negative breast cancers with the Smac-mimetic birinapant
Najoua Lalaoui, Delphine Merino, Goknur Giner, Francois Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Grasel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Gordon K Smyth, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke
Journal article | 2020 | Cell Death & Differentiation
Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Her..
Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer.
James R Whittle, François Vaillant, Elliot Surgenor, Antonia N Policheni, Goknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2020 | Clinical Cancer Research
PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..
STEM CELLS AND THE DIFFERENTIATION HIERARCHY IN MAMMARY GLAND DEVELOPMENT
Nai Yang Fu, Emma Nolan, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2020 | Physiological Reviews
The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproduct..
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.
Journal article | 2020 | Nature Genetics
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..
Development and validation of a targeted gene sequencing panel for application to disparate cancers
Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.
Journal article | 2019 | Scientific Reports
Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.
Journal article | 2019 | npj Breast Cancer
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..
Lgr(5 ) pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis
Chow Hiang Ang, Shih Han Hsu, Fusheng Guo, Chong Teik Tan, Victor C Yu, Jane E Visvader, Pierce KH Chow, Nai Yang Fu
Journal article | 2019 | Proceedings of the National Academy of Sciences
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.
Anne C Rios, Bianca D Capaldo, François Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, undefined 3DTCLSM Group, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2019 | Cancer Cell
High-resolution 3D imaging of fixed and cleared organoids
Johanna F Dekkers, Maria Alieva, Lianne M Wellens, Hendrikus CR Ariese, Paul R Jamieson, Annelotte M Vonk, Gimano D Amatngalim, Huili Hu, Koen C Oost, Hugo JG Snippert, Jeffrey M Beekman, Ellen J Wehrens, Jane E Visvader, Hans Clevers, Anne C Rios
Journal article | 2019 | Nature Protocols
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging
Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.
Journal article | 2019 | Cancer Cell
A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer
Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.
Journal article | 2019 | Cancer Discovery
Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik
Journal article | 2019 | Nature Communications
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
Stefano Annunziato, Julian R de Ruiter, Linda Henneman, Chiara S Brambillasca, Catrin Lutz, Francois Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjorn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H van Miltenburg, Ivo J Huijbers, Marieke van de Ven, Jane E Visvader, Geoffrey J Lindeman, Lodewyk FA Wessels, Jos Jonkers
Journal article | 2019 | Nature Communications
Isolation and Propagation of Mammary Epithelial Stem and Progenitor Cells.
Julie M Sheridan, Jane E Visvader
Journal article | 2019 | Methods in molecular biology (Clifton, N.J.)
Several methods of mammary gland dissociation have been described that utilize a combined strategy of mechanical and enzymatic dis..
Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence
Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2018 | Developmental Cell
Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids
Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2018 | PLOS Biology
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
Reema Jain, Julie M Sheridan, Antonia Policheni, Melanie Heinlein, Luke C Gandolfo, Grant Dewson, Gordon K Smyth, Stephen N Sansom, Nai Yang Fu, Jane E Visvader, Georg A Hollander, Andreas Strasser, Daniel HD Gray
Journal article | 2017 | Blood
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
Bhupinder Pal, Yunshun Chen, Francois Vaillant, Paul Jamieson, Lavinia Gordon, Anne C Rios, Stephen Wilcox, Naiyang Fu, Kevin He Liu, Felicity C Jackling, Melissa J Davis, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2017 | Nature Communications
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.
Journal article | 2017 | Science Translational Medicine
Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer
Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman
Journal article | 2017 | Science translational medicine
Safety and efficacy of the BCL2 inhibitor venetoclax in estrogen receptor (ER) and BCL2-positive metastatic breast cancer: The mBEP study.
Geoffrey John Lindeman, Sheau Wen Lok, Alice Ruth Bergin, James Richard Whittle, Kylie Shackleton, Peter Sherman, Sarah-Jane Dawson, Jayesh Desai, Danny Liew, Bruce Mann, Anand Murugasu, Andrew Warwick Roberts, Mark Rosenthal, Jane Visvader
Conference Proceedings | 2017 | Journal of Clinical Oncology
Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression
Justin Grassmeyer, Malini Muldierjee, Jennifer deRiso, Casey Hettinger, Monica Bailey, Satrajit Sinha, Jane E Visvader, Haotian Zhao, Eric Fogarty, Kameswaran Surendran
Journal article | 2017 | Developmental Biology
Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Nai Yang Fu, Anne C Rios, Bhupinder Pal, Charity W Law, Paul Jamieson, Ruijie Liu, Francois Vaillant, Felicity Jackling, Kevin He Liu, Gordon K Smyth, Geoffrey J Lindeman, Matthew E Ritchie, Jane E Visvader
Journal article | 2017 | Nature Cell Biology
New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells
Carmel M O'Brien, Hun S Chy, Qi Zhou, Shiri Blumenfeld, Jack W Lambshead, Xiaodong Liu, Joshua Kie, Bianca D Capaldo, Tung-Liang Chung, Timothy E Adams, Phan Tram, John D Bentley, William J McKinstry, Karen Oliva, Paul J McMurrick, Yu-Chieh Wang, Fernando J Rossello, Geoffrey J Lindeman, Di Chen, Thierry Jarde, et al.
Journal article | 2017 | STEM CELLS
RANK ligand as a target for breast cancer prevention in BRCA1 mutation carriers
GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader
Conference Proceedings | 2017 | General Session Abstracts
Differential methylation analysis of reduced representation bisulfite sequencing experiments using edgeR.
Yunshun Chen, Bhupinder Pal, Jane E Visvader, Gordon K Smyth
Journal article | 2017 | F1000Research
Cytosine methylation is an important DNA epigenetic modification. In vertebrates, methylation occurs at CpG sites, which are dinuc..
Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Lacey E Dobrolecki, Susie D Airhart, Denis G Alferez, Samuel Aparicio, Fariba Behbod, Mohamed Bentires-Alj, Cathrin Brisken, Carol J Bult, Shirong Cai, Robert B Clarke, Heidi Dowst, Matthew J Ellis, Eva Gonzalez-Suarez, Richard D Iggo, Peter Kabos, Shunqiang Li, Geoffrey J Lindeman, Elisabetta Marangoni, Aaron McCoy, Funda Meric-Bernstam, et al.
Journal article | 2016 | Cancer and Metastasis Reviews
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers
Emma Nolan, Francois Vaillant, Daniel Branstetter, Bhupinder Pal, Goeknur Giner, Lachlan Whitehead, Sheau W Lok, Gregory B Mann, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Gordon K Smyth, William C Dougall, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2016 | Nature Medicine
RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity
Michael Chopin, Simon P Preston, Aaron TL Lun, Julie Tellier, Gordon K Smyth, Marc Pellegrini, Gabrielle T Belz, Lynn M Corcoran, Jane E Visvader, Li Wu, Stephen L Nutt
Journal article | 2016 | Cell Reports
Corrigendum to "Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4" [Biochim. Biophys. Acta, 1853, 7, (2015), 1683-1692] Doi: 10.1016/j.bbamcr.2015.04.003
KD Baron, K Al-Zahrani, J Conway, C Labrèche, CJ Storbeck, JE Visvader, LA Sabourin
Journal article | 2015 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4
Kyla D Baron, Khalid Al-Zahrani, Jillian Conway, Cedrik Labreche, Christopher J Storbeck, Jane E Visvader, Luc A Sabourin
Journal article | 2015 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits
Bhupinder Pal, Yunshun Chen, Andrew Bert, Yifang Hu, Julie M Sheridan, Tamara Beck, Wei Shi, Keith Satterley, Paul Jamieson, Gregory J Goodall, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2015 | Breast Cancer Research
A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1
Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, Francois Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2015 | BMC Cancer
EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
Nai Yang Fu, Anne C Rios, Bhupinder Pal, Rina Soetanto, Aaron TL Lun, Kevin Liu, Tamara Beck, Sarah A Best, Francois Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K Smyth, Rey J Lindeman, Jane E Visvader
Journal article | 2015 | Nature Cell Biology
Runx2 Is a Novel Regulator of Mammary Epithelial Cell Fate in Development and Breast Cancer
Thomas W Owens, Renee L Rogers, Sarah A Best, Anita Ledger, Anne-Marie Mooney, Alison Ferguson, Paul Shore, Alexander Swarbrick, Christopher J Ormandy, Peter T Simpson, Jason S Carroll, Jane E Visvader, Matthew J Naylor
Journal article | 2014 | Cancer Research
Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland
Nathan J Godde, Julie M Sheridan, Lorey K Smith, Helen B Pearson, Kara L Britt, Ryan C Galea, Laura L Yates, Jane E Visvader, Patrick O Humbert
Journal article | 2014 | PLoS Genetics
Distinct nuclear receptor expression in stroma adjacent to breast tumors
Kevin C Knower, Ashwini L Chand, Natalie Eriksson, Kiyoshi Takagi, Yasuhiro Miki, Hironobu Sasano, Jane E Visvader, Geoffrey J Lindeman, John W Funder, Peter J Fuller, Evan R Simpson, Wayne D Tilley, Peter J Leedman, J Dinny Graham, George EO Muscat, Christine L Clarke, Colin D Clyne
Journal article | 2013 | Breast Cancer Research and Treatment
Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
Francois Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E Ritchie, Gordon K Smyth, Michael Christie, Louisa J Phillipson, Christopher J Burns, G Bruce Mann, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2013 | Cancer Cell
Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2
Bhupinder Pal, Toula Bouras, Wei Shi, Francois Vaillant, Julie M Sheridan, Naiyang Fu, Kelsey Breslin, Kun Jiang, Matthew E Ritchie, Matthew Young, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2013 | Cell Reports
Remodeling of the Lymphatic Vasculature during Mouse Mammary Gland Morphogenesis Is Mediated via Epithelial-Derived Lymphangiogenic Stimuli
Kelly L Betterman, Sophie Paquet-Fifield, Marie-Liesse Asselin-Labat, Jane E Visvader, Lisa M Butler, Steven A Stacker, Marc G Achen, Natasha L Harvey
Journal article | 2012 | American Journal of Pathology
Isolation of Mouse Mammary Epithelial Subpopulations: A Comparison of Leading Methods
Matthew J Smalley, Howard Kendrick, Julie M Sheridan, Joseph L Regan, Michael D Prater, Geoffrey J Lindeman, Christine J Watson, Jane E Visvader, John Stingl
Journal article | 2012 | Journal of Mammary Gland Biology and Neoplasia
Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice
Margaret Czesak, Brice Le Francois, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Albert
Journal article | 2012 | Journal of Biological Chemistry
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2012 | Proceedings of the National Academy of Sciences of the United States of America
Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14
Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2011 | Molecular and Cellular Biology
Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations
Hong Ji, Robert JA Goode, Francois Vaillant, Suresh Mathivanan, Eugene A Kapp, Rommel A Mathias, Geoffrey J Lindeman, Jane E Visvader, Richard J Simpson
Journal article | 2011 | Proteomics
Mammary stem cells and their regulation by steroid hormones.
Marie-Liesse Asselin-Labat, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2011 | Expert Review of Endocrinology & Metabolism
Sustained exposure to estrogen and progesterone is a well-established risk factor for breast cancer. These hormones play a central..
Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit
CE Smart, A Wronski, JD French, SL Edwards, M-L Asselin-Labat, N Waddell, K Peters, BL Brewster, K Brooks, K Simpson, N Manning, SR Lakhani, S Grimmond, GJ Lindeman, JE Visvader, MA Brown
Journal article | 2011 | Oncogene
Murine mammary epithelial stem cells: discovery, function, and current status.
Jane E Visvader, Gilbert H Smith
Journal article | 2011 | Cold Spring Harbor perspectives in biology
An entire mammary epithelial outgrowth, capable of full secretory differentiation, may comprise the progeny of a single cellular a..
LMO4 expression in squamous cell carcinoma of the anterior tongue
Rhonda A Kwong, Christopher J Scarlett, Larry H Kalish, Ian E Cole, James G Kench, Eleanor YM Sum, Elizabeth A Musgrove, Susan M Henshall, Geoffrey J Lindeman, Andrew V Biankin, Jane E Visvader, Robert L Sutherland
Journal article | 2011 | Histopathology
Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells
Marjorie E Montanez-Wiscovich, Melissa D Shelton, Darcie D Seachrist, Kristen L Lozada, Emhonta Johnson, John D Miedler, Fadi W Abdul-Karim, Jane E Visvader, Ruth A Keri
Journal article | 2010 | The Journal of Pathology
FOXA1 is an essential determinant of ER alpha expression and mammary ductal morphogenesis
Gina M Bernardo, Kristen L Lozada, John D Miedler, Gwyndolen Harburg, Sylvia C Hewitt, Jonathan D Mosley, Andrew K Godwin, Kenneth S Korach, Jane E Visvader, Klaus H Kaestner, Fadi W Abdul-Karim, Monica M Montano, Ruth A Keri
Journal article | 2010 | Development
Loss of STARD 10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status
Niamh C Murphy, Andrew V Biankin, Ewan KA Millar, Catriona M McNeil, Sandra A O'Toole, Davendra Segara, Paul Crea, Monilola A Olayioye, C Soon Lee, Stephen B Fox, Adrienne L Morey, Michael Christie, Elizabeth A Musgrove, Roger J Daly, Geoffrey J Lindeman, Susan M Henshall, Jane E Visvader, Robert L Sutherland
Journal article | 2010 | International Journal of Cancer
Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors
Jeremy M Arnold, David YH Choong, Ella R Thompson, Nic Waddell, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell, Georgia Chenevix-Trench
Journal article | 2010 | Breast Cancer Research and Treatment
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, Francois Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2010 | Breast Cancer Research
Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers
Renea A Taylor, Hong Wang, Sarah E Wilkinson, Michelle G Richards, Kara L Britt, Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader, Gerald R Cunha, Justin St John, Gail P Risbridger
Journal article | 2009 | Stem Cells
Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer
Andrew V Biankin, James G Kench, Emily K Colvin, Davendra Segara, Christopher J Scarlett, Nam Q Nguyen, David K Chang, Adrienne L Morey, C-Soon Lee, Mark Pinese, Samuel CL Kuo, Johana M Susanto, Peter H Cosman, Geoffrey J Lindeman, Jane E Visvader, Tuan V Nguyen, Neil D Merrett, Janindra Warusavitarne, Elizabeth A Musgrove, Susan M Henshall, et al.
Journal article | 2009 | Gastroenterology
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim, Francois Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2009 | Nature Medicine
The Ets transcription factor Elf5 specifies mammary alveolar cell fate
Samantha R Oakes, Matthew J Naylor, Marie-Liesse Asselin-Labat, Katrina D Blazek, Margaret Gardiner-Garden, Heidi N Hilton, Michael Kazlauskas, Melanie A Pritchard, Lewis A Chodosh, Peter L Pfeffer, Geoffrey J Lindeman, Jane E Visvader, Christopher J Ormandy
Journal article | 2008 | Genes & Development
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3
Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2006 | The EMBO Journal
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
Michael F Clarke, John E Dick, Peter B Dirks, Connie J Eaves, Catriona HM Jamieson, D Leanne Jones, Jane Visvader, Irving L Weissman, Geoffrey M Wahl
Conference Proceedings | 2006 | Cancer Research
Identification of the key LMO2-binding determinants on Ldb1
Daniel P Ryan, Margaret Sunde, Ann H-Y Kwan, Neelan J Marianayagam, Amy L Nancarrow, Rachel N vanden Hoven, Lyndal S Thompson, Manuel Baca, Joel P Mackay, Jane E Visvader, Jacqueline M Matthews
Journal article | 2006 | Journal of Molecular Biology
Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants
PK Lovelock, S Healey, W Au, EYM Sum, A Tesoriero, EM Wong, S Hinson, R Brinkworth, A Bekessy, O Diez, L Izatt, E Solomon, M Jenkins, H Renard, J Hopper, P Waring, SV Tavtigian, D Goldgar, GJ Lindeman, JE Visvader, et al.
Journal article | 2006 | Journal of Medical Genetics
Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.
Janet E Deane, Joel P Mackay, Ann HY Kwan, Eleanor YM Sum, Jane E Visvader, Jacqueline M Matthews
Journal article | 2003 | The EMBO Journal
LMO2 and LMO4 are members of a small family of nuclear transcriptional regulators that are important for both normal development a..
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.
LC Wang, W Swat, Y Fujiwara, L Davidson, J Visvader, F Kuo, FW Alt, DG Gilliland, TR Golub, SH Orkin
Journal article | 1998 | Genes & Development
The TEL (translocation-Ets-leukemia or ETV6) locus, which encodes an Ets family transcription factor, is frequently rearranged in ..
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.
JE Visvader, X Mao, Y Fujiwara, K Hahm, SH Orkin
Journal article | 1997 | Proceedings of the National Academy of Sciences
The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presum..
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.
AP Tsang, JE Visvader, CA Turner, Y Fujiwara, C Yu, MJ Weiss, M Crossley, SH Orkin
Journal article | 1997 | Cell
The hematopoietic transcription factor GATA-1 is essential for development of the erythroid and megakaryocytic lineages. Using the..
Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins.
LJ Ransone, J Visvader, P Sassone-Corsi, IM Verma
Journal article | 1989 | Genes & Development
Jun and Fos oncoproteins form a complex that regulates transcription from promoters containing AP-1 binding sites. The 'leucine zi..
Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.
J Visvader, IM Verma
Journal article | 1989 | Molecular and Cellular Biology
Structural analysis of the 5' end of the human c-fms gene revealed that a large intron of about 25 kilobases separates an upstream..
fos and jun interaction: the role of the leucine zipper.
LJ Ransone, J Visvader, WW Lamph, P Sassone-Corsi, IM Verma
Journal article | 1989 | International journal of cancer. Supplement = Journal international du cancer. Supplement
Jun and fos oncoproteins form a complex which regulates transcription from promoters containing AP-I binding sites. The "leucine z..
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
P Sassone-Corsi, J Visvader, L Ferland, PL Mellon, IM Verma
Journal article | 1988 | Genes & Development
Transcription of proto-oncogene fos is induced by elevated levels of intracellular cAMP. We report that human c-fos promoter recom..
Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes.
J Visvader, P Sassone-Corsi, IM Verma
Journal article | 1988 | Proceedings of the National Academy of Sciences
Protooncogene fos is rapidly and transiently induced by nerve growth factor (NGF) in rat pheochromocytoma PC12 cells. Two adjacent..
Self-cleavage of RNA in the replication of viroids and virusoids.
RH Symons, CJ Hutchins, AC Forster, PD Rathjen, P Keese, JE Visvader
Journal article | 1987 | Journal of Cell Science
Viroids are infectious, circular RNA molecules of 246 to 375 nucleotides found in plants. Virusoids are of similar size and struct..
Infectivity and in vitro mutagenesis of monomeric cDNA clones of citrus exocortis viroid indicates the site of processing of viroid precursors.
JE Visvader, AC Forster, RH Symons
Journal article | 1985 | Nucleic Acids Research
Monomeric cDNA clones of citrus exocortis viroid (CEV) were constructed in the plasmid vector pSP6-4 and the infectivity of the cl..
Eleven new sequence variants of citrus exocortis viroid and the correlation of sequence with pathogenicity.
JE Visvader, RH Symons
Journal article | 1985 | Nucleic Acids Research
Full-length double-stranded cDNA was prepared from purified circular RNA of two new Australian field isolates of citrus exocortis ..
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Honours, Awards and Fellowships
FAA - Fellow of the Australian Academy of Science
Medical Biology (W.E.H.I.)
Doctor of Philosophy