Chad Bousman

Editorial: Precision psychiatry from a pharmacogenetics perspective

Lisa C Brown, Josiah D Allen, Harris A Eyre, Bernhard T Baune, Katherine J Aitchison, Chad A Bousman

Journal article  |  2023  |  Frontiers in Psychiatry

Pharmacogenomics-informed clozapine therapy.

Chad A Bousman

Journal article  |  2023  |  Lancet Psychiatry

Perturbed iron biology in the prefrontal cortex of people with schizophrenia

Amit Lotan, Sandra Luza, Carlos M Opazo, Scott Ayton, Darius JR Lane, Serafino Mancuso, Avril Pereira, Suresh Sundram, Cynthia Shannon Weickert, Chad Bousman, Christos Pantelis, Ian P Everall, Ashley I Bush

Journal article  |  2023  |  MOLECULAR PSYCHIATRY

Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, curr..

Delineating gene-environment effects using virtual twins of patients treated with clozapine.

Sam Mostafa, Thomas M Polasek, Chad Bousman, Amin Rostami-Hodjegan, Leslie J Sheffield, Ian Everall, Christos Pantelis, Carl MJ Kirkpatrick

Journal article  |  2023  |  CPT Pharmacometrics Syst Pharmacol

Studies that focus on individual covariates, while ignoring their interactions, may not be adequate for model-informed precision d..

Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia.

Bochao D Lin, Justo Pinzón-Espinosa, Elodie Blouzard, Marte Z van der Horst, Cynthia Okhuijsen-Pfeifer, Kristel R van Eijk, Sinan Guloksuz, Wouter J Peyrot, Jurjen J Luykx, undefined Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators

Journal article  |  2023  |  JAMA Psychiatry

IMPORTANCE: Predictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum diso..

Effects of clozapine treatment on the improvement of substance use disorders other than nicotine in individuals with schizophrenia spectrum disorders: A systematic review and meta-analysis.

Reza Rafizadeh, Marlon Danilewitz, Chad A Bousman, Nickie Mathew, Randall F White, Anees Bahji, William G Honer, Christian G Schütz

Journal article  |  2023  |  J Psychopharmacol

BACKGROUND: Antipsychotic medications are the mainstay of treatment for schizophrenia and are associated with a reduction in psych..

ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-Analysis Including Results from the CAN-BIND-1 Study.

Leen Magarbeh, Claudia Hassel, Maximilian Choi, Farhana Islam, Victoria S Marshe, Clement C Zai, Rayyan Zuberi, Roseann S Gammal, Xiaoyu Men, Maike Scherf-Clavel, Dietmar Enko, Benicio N Frey, Roumen Milev, Claudio N Soares, Sagar V Parikh, Franca Placenza, Stephen C Strother, Stefanie Hassel, Valerie H Taylor, Francesco Leri, et al.

Journal article  |  2023  |  Clin Pharmacol Ther

The P-glycoprotein efflux pump, encoded by the ABCB1 gene, has been shown to alter concentrations of various antidepressants in th..

Sleep Quality and Duration in Children That Consume Caffeine: Impact of Dose and Genetic Variation in ADORA2A and CYP1A.

Chaten D Jessel, Ankita Narang, Rayyan Zuberi, Chad A Bousman

Journal article  |  2023  |  Genes (Basel)

Caffeine is the most consumed drug in the world, and it is commonly used by children. Despite being considered relatively safe, ca..

Experience, Knowledge, and Perceptions of Pharmacogenomics among Pharmacists and Nurse Practitioners in Alberta Hospitals

Meagan Hayashi, Chad A Bousman

Journal article  |  2022  |  PHARMACY

BACKGROUND: Despite evidence of clinical utility and the availability of prescription guidelines, pharmacogenomics (PGx) is not br..

Pharmacogenomic Testing and Depressive Symptom Remission: A Systematic Review and Meta-Analysis of Prospective, Controlled Clinical Trials

Lisa C Brown, Joseph D Stanton, Kanika Bharthi, Abdullah Al Maruf, Daniel J Muller, Chad A Bousman

Journal article  |  2022  |  CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenomic (PGx) testing has emerged as a compelling strategy that clinicians can use to inform antidepressant medication sel..