Annabel Chee

Mechanisms of chemotherapy‐induced muscle wasting in mice with cancer cachexia

Kate T Murphy, Kristy Swiderski, James G Ryall, Jonathan R Davey, Hongwei Qian, Séverine Lamon, Victoria C Foletta, Jennifer Trieu, Annabel Chee, Suzannah J Read, Timur Naim, Paul Gregorevic, Gordon S Lynch

Journal article  |  2022  |  JCSM Rapid Communications

Phosphorylation of ERK and dystrophin S3059 protects against inflammation-associated C2C12 myotube atrophy

Kristy Swiderski, Christopher J Brock, Jennifer Trieu, Annabel Chee, Savant S Thakur, Dale M Baum, Paul Gregorevic, Kate T Murphy, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The dystrophin-glycoprotein complex (DGC) is a multiprotein structure required to maintain muscle fiber membrane integrity, transm..

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

Hon Yan K Yip, Annabel Chee, Ching-Seng Ang, Sung-Young Shin, Lisa M Ooms, Zainab Mohammadi, Wayne A Phillips, Roger J Daly, Timothy J Cole, Roderick T Bronson, Lan K Nguyen, Tony Tiganis, Robin M Hobbs, Catriona A McLean, Christina A Mitchell, Antonella Papa

Journal article  |  2020  |  MOLECULAR CELL

The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of..

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice

Daniel J Ham, Anastasia Gardner, Tahnee L Kennedy, Jennifer Trieu, Timur Naim, Annabel Chee, Francesca M Alves, Marissa K Caldow, Gordon S Lynch, Rene Koopman

Journal article  |  2019  |  SCIENTIFIC REPORTS

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and prem..

Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury

Kristy Swiderski, Marissa K Caldow, Timur Naim, Jennifer Trieu, Annabel Chee, Rene Koopman, Gordon S Lynch

Journal article  |  2019  |  PLOS ONE

Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a persistent inflammatory response. ..

Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer

Kate T Murphy, Mohammed I Hossain, Kristy Swiderski, Annabel Chee, Timur Naim, Jennifer Trieu, Vanessa Haynes, Suzannah J Read, David I Stapleton, Sarah M Judge, Jose G Trevino, Andrew R Judge, Gordon S Lynch

Journal article  |  2019  |  CANCER RESEARCH

Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass associated with significa..

Muscle-specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation

MK Caldow, DJ Ham, A Chee, J Trieu, T Naim, DI Stapleton, K Swiderski, GS Lynch, R Koopman

Journal article  |  2017  |  CYTOKINE

Excessive inflammation reduces skeletal muscle protein synthesis leading to wasting and weakness. The janus kinase/signal transduc..

Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury

Kristy Swiderski, Savant S Thakur, Timur Naim, Jennifer Trieu, Annabel Chee, David I Stapleton, Rene Koopman, Gordon S Lynch

Journal article  |  2016  |  SKELETAL MUSCLE

BACKGROUND: Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circul..

Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology

Kristy Swiderski, Karen Janet Bernice Martins, Annabel Chee, Jennifer Trieu, Timur Naim, Stefan Martin Gehrig, Dale Michael Baum, Julia Brenmoehl, Luong Chau, Rene Koopman, Paul Gregorevic, Friedrich Metzger, Andreas Hoeflich, Gordon Stuart Lynch

Journal article  |  2016  |  GROWTH HORMONE & IGF RESEARCH

OBJECTIVE: The insulin-like growth factor binding proteins (IGFBPs) are thought to modulate cell size and homeostasis via IGF-I-de..

Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice

Marissa K Caldow, Daniel J Ham, Daniel P Godeassi, Annabel Chee, Gordon S Lynch, Rene Koopman

Journal article  |  2016  |  CLINICAL NUTRITION

BACKGROUND & AIM: Calorie restriction (CR) reduces co-morbidities associated with obesity, but also reduces lean mass thereby pred..