Amanda Lee

Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes

Deepak N Subramanian, Magnus Zethoven, Simone McInerny, James A Morgan, Simone M Rowley, Jue Er Amanda Lee, Na Li, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2020  |  NATURE COMMUNICATIONS

High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, approximately half of which cannot be explaine..

Combined Tumor Sequencing and Case-Control Analyses of RAD51C in Breast Cancer

Na Li, Simone McInerny, Magnus Zethoven, Dane Cheasley, Belle WX Lim, Simone M Rowley, Lisa Devereux, Norah Grewal, Somayeh Ahmadloo, David Byrne, Jue Er Amanda Lee, Jason Li, Stephen B Fox, Thomas John, Yoland Antill, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2019  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: Loss-of-function variants in RAD51C are associated with familial ovarian cancer, but its role in hereditary breast can..

Population-based genetic testing of asymptomatic women for breast and ovarian cancer susceptibility

Simone M Rowley, Lyon Mascarenhas, Lisa Devereux, Na Li, Kaushalya C Amarasinghe, Magnus Zethoven, Jue Er Amanda Lee, Alexandra Lewis, James A Morgan, Sharpe Limb, Mary-Anne Young, Paul A James, Alison H Trainer, Ian G Campbell

Journal article  |  2019  |  GENETICS IN MEDICINE

PURPOSE: The identification of carriers of hereditary breast and ovarian cancer (HBOC) gene variants through family cancer history..

Mutations in RECQL are not associated with breast cancer risk in an Australian population

Na Li, Simone M Rowley, David L Goode, Kaushalya C Amarasinghe, Simone McInerny, Lisa Devereux, Michelle W Wong-Brown, Richard Lupat, Jue Er Amanda Lee, Siobhan Hughes, Ella R Thompson, Magnus Zethoven, Jason Li, Alison H Trainer, Kylie L Gorringe, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2018  |  NATURE GENETICS

Molecular analysis of PALB2-associated breast cancers

Jue Er Amanda Lee, Na Li, Simone M Rowley, Dane Cheasley, Magnus Zethoven, Simone McInerny, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2018  |  JOURNAL OF PATHOLOGY

PALB2 is established as the most clinically important moderate to high penetrance breast cancer predisposition gene after BRCA1 an..

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

Linna Guo, Olga Zaysteva, Zuqin Nie, Naomi C Mitchell, Jue Er Amanda Lee, Thomas Ware, Linda Parsons, Rodney Luwor, Gretchen Poortinga, Ross D Hannan, David L Levens, Leonie M Quinn

Journal article  |  2016  |  NUCLEIC ACIDS RESEARCH

Despite two decades of research, the major function of FBP-family KH domain proteins during animal development remains controversi..

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

Naomi C Mitchell, Elissaveta B Tchoubrieva, Arjun Chahal, Simone Woods, Amanda Lee, Jane I Lin, Linda Parsons, Katarzyna Jastrzebski, Gretchen Poortinga, Katherine M Hannan, Richard B Pearson, Ross D Hannan, Leonie M Quinn

Journal article  |  2015  |  CELLULAR SIGNALLING

Increased rates of ribosome biogenesis and biomass accumulation are fundamental properties of rapidly growing and dividing maligna..

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models

Jue Er Amanda Lee, Naomi C Mitchell, Olga Zaytseva, Arjun Chahal, Peter Mendis, Amandine Cartier-Michaud, Linda M Parsons, Gretchen Poortinga, David L Levens, Ross D Hannan, Leonie M Quinn

Journal article  |  2015  |  NATURE COMMUNICATIONS

Nucleotide excision DNA repair (NER) pathway mutations cause neurodegenerative and progeroid disorders (xeroderma pigmentosum (XP)..

The Ecdysone receptor constrains wingless expression to pattern cell cycle across the Drosophila wing margin in a cyclin B-dependent manner

Naomi C Mitchell, Jane I Lin, Olga Zaytseva, Nicola Cranna, Amanda Lee, Leonie M Quinn

Journal article  |  2013  |  BMC DEVELOPMENTAL BIOLOGY

BACKGROUND: Ecdysone triggers transcriptional changes via the ecdysone receptor (EcR) to coordinate developmental programs of apop..

Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner

Naomi C Mitchell, Timothy M Johanson, Nicola J Cranna, Amanda Lee Jue Er, Helena E Richardson, Ross D Hannan, Leonie M Quinn

Journal article  |  2010  |  DEVELOPMENT

An unresolved question regarding the RNA-recognition motif (RRM) protein Half pint (Hfp) has been whether its tumour suppressor be..