Juliet Taylor

The Complexity of the cGAS-STING Pathway in CNS Pathologies

Amelia L Fryer, Amar Abdullah, Juliet M Taylor, Peter J Crack

Journal article  |  2021  |  FRONTIERS IN NEUROSCIENCE

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologie..

STING-Mediated Autophagy Is Protective against H2O2-Induced Cell Death

Amar Abdullah, Frank Mobilio, Peter J Crack, Juliet M Taylor

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stimulator of interferon genes (STING)-mediated type-I interferon signaling is a well characterized instigator of the innate immun..

Abrogation of type-I interferon signalling alters the microglial response to A beta(1-42)

Zachery Moore, Frank Mobilio, Frederick R Walker, Juliet M Taylor, Peter J Crack

Journal article  |  2020  |  SCIENTIFIC REPORTS

Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogene..

The use of bioactive matrices in regenerative therapies for traumatic brain injury

Hui X Tan, Mark P Del Borgo, Marie-Isabel Aguilar, John S Forsythe, Juliet M Taylor, Peter J Crack

Journal article  |  2020  |  ACTA BIOMATERIALIA

Functional deficits due to neuronal loss are a common theme across multiple neuropathologies, including traumatic brain injury (TB..

The involvement of microglia in Alzheimer's disease: a new dog in the fight

Zachery Moore, Juliet M Taylor, Peter J Crack

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

First described clinically in 1906, Alzheimer's disease (AD) is the most common neurodegenerative disease and form of dementia wor..

Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astrocytic Crosstalk

David PQ Clark, Victoria M Perreau, Sandy R Shultz, Rhys D Brady, Enie Lei, Shilpi Dixit, Juliet M Taylor, Philip M Beart, Wah Chin Boon

Journal article  |  2019  |  NEUROCHEMICAL RESEARCH

Traumatic brain injury triggers neuroinflammation that may contribute to progressive neurodegeneration. We investigated patterns o..

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

Amar Abdullah, Moses Zhang, Tony Frugier, Sammy Bedoui, Juliet M Taylor, Peter J Crack

Journal article  |  2018  |  JOURNAL OF NEUROINFLAMMATION

BACKGROUND: Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuroinflammati..

Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line

Sarah EM Stephenson, Timothy D Aumann, Juliet M Taylor, Jessica R Riseley, Ruili Li, Jeffrey R Mann, Doris Tomas, Paul J Lockhart

Journal article  |  2018  |  SCIENTIFIC REPORTS

Mutations in PARK2 (parkin) can result in Parkinson's disease (PD). Parkin shares a bidirectional promoter with parkin coregulated..

Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer's disease

Juliet M Taylor, Zachery Moore, Myles R Minter, Peter J Crack

Journal article  |  2018  |  JOURNAL OF NEURAL TRANSMISSION

Past research in Alzheimer's disease (AD) has largely been driven by the amyloid hypothesis; the accompanying neuroinflammation se..

Type-I interferon signalling through IFNAR1 plays a deleterious role in the outcome after stroke

Moses Zhang, Catherine E Downes, Connie HY Wong, Kate M Brody, Pedro L Guio-Agulair, Jodee Gould, Robert Ates, Paul J Hertzog, Juliet M Taylor, Peter J Crack

Journal article  |  2017  |  NEUROCHEMISTRY INTERNATIONAL