Frederic Hollande

Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin

Jean Berthelet, Momeneh Foroutan, Dharmesh D Bhuva, Holly J Whitfield, Farrah El-Saafin, Joseph Cursons, Antonin Serrano, Michal Merdas, Elgene Lim, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Matthias Ernst, Frederic Hollande, Robin L Anderson, Bhupinder Pal, Belinda Yeo, Melissa J Davis, Delphine Merino

Journal article  |  2022  |  CANCERS

The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast can..

Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy

Lucile Bansard, Oceane Bouvet, Elisa Moutin, Gaetan Le Gall, Alessandro Giammona, Elodie Pothin, Marion Bacou, Cedric Hassen-Khodja, Benoit Bordignon, Jean Francois Bourgaux, Michel Prudhomme, Frederic Hollande, Julie Pannequin, Jean Marc Pascussi, Chris Planque

Journal article  |  2022  |  STEM CELL REPORTS

Tumor recurrence is often attributed to cancer stem cells (CSCs). We previously demonstrated that down-regulation of Pregnane X Re..

Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models

Carolyn Shembrey, Jai Smith, Melodie Grandin, Nathalia Williams, Hyun-Jung Cho, Christina Molck, Corina Behrenbruch, Benjamin NJ Thomson, Alexander G Heriot, Delphine Merino, Frederic Hollande

Journal article  |  2022  |  CANCERS

Geno- and phenotypic heterogeneity amongst cancer cell subpopulations are established drivers of treatment resistance and tumour r..

CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM

Guillaume Belthier, Zeinab Homayed, Fanny Grillet, Christophe Duperray, Julie Vendrell, Ilona Krol, Sophie Bravo, Jean-Christophe Boyer, Olivia Villeronce, Jihane Vitre-Boubaker, Diana Heaug-Wane, Francoise Macari-Fine, Jai Smith, Matthieu Merlot, Gerald Lossaint, Thibault Mazard, Fabienne Portales, Jerome Solassol, Marc Ychou, Nicola Aceto, et al.

Journal article  |  2021  |  CANCERS

Circulating tumor cells (CTCs) are promising diagnostic and prognostic tools for clinical use. In several cancers, including color..

The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids

Ronnie Ren Jie Low, Wei Wen Lim, Paul M Nguyen, Belinda Lee, Michael Christie, Antony W Burgess, Peter Gibbs, Sean M Grimmond, Frederic Hollande, Tracy L Putoczki

Journal article  |  2021  |  CANCERS

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. While immortalized cancer cell lines and gen..

Dependence receptors: new targets for cancer therapy

Morgan Brisset, Melodie Grandin, Agnes Bernet, Patrick Mehlen, Frederic Hollande

Journal article  |  2021  |  EMBO MOLECULAR MEDICINE

Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation wh..

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

Jean Berthelet, Verena C Wimmer, Holly J Whitfield, Antonin Serrano, Thomas Boudier, Stefano Mangiola, Michal Merdas, Farrah El-Saafin, David Baloyan, Jordan Wilcox, Steven Wilcox, Adam C Parslow, Anthony T Papenfuss, Belinda Yeo, Matthias Ernst, Bhupinder Pal, Robin L Anderson, Melissa J Davis, Kelly L Rogers, Frederic Hollande, et al.

Journal article  |  2021  |  SCIENCE ADVANCES

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in ..

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

Anderly C Chueh, Gahana Advani, Momeneh Foroutan, Jai Smith, Nadia Ng, Harshal Nandurkar, Daisy S Lio, Hong-Jian Zhu, Yuh-Ping Chong, Heather Verkade, Donald J Fujita, Jeffrey Bjorge, Faiza Basheer, Jet Phey Lim, Ian Luk, Amardeep Dhillon, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver Sieber, Frederic Hollande, et al.

Journal article  |  2021  |  ONCOGENE

Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC..

Survival benefit of neoadjuvant chemotherapy and surgery versus surgery first for resectable colorectal liver metastases: a cohort study

Corina Behrenbruch, Sowmya Prabhakaran, Dilshan Udayasiri, Frederic Hollande, Michael Michael, Ian Hayes, Alexander Heriot, Brett Knowles, Benjamin Thomson

Journal article  |  2021  |  ANZ JOURNAL OF SURGERY

BACKGROUND: There is continued debate about the survival benefit of neoadjuvant chemotherapy (neoCT) in patients with resectable c..

Progastrin production transitions from Bmi1( )/Prox1( ) to Lgr5(high) cells during early intestinal tumorigenesis

J Giraud, M Foroutan, J Boubaker-Vitre, F Grillet, Z Homayed, U Jadhav, P Crespy, C Breuker, J-F Bourgaux, J Hazerbroucq, C Pignodel, B Brulin, RA Shivdasani, P Jay, F Hollande, J Pannequin

Journal article  |  2021  |  TRANSLATIONAL ONCOLOGY

Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expr..