Jessica Holien

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Ayeshah A Rosdah, William J Smiles, Jonathan S Oakhill, John W Scott, Christopher G Langendorf, Lea MD Delbridge, Jessica K Holien, Shiang Y Lim

Journal article  |  2020  |  Pharmacology & Therapeutics

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochond..

Sequence comparisons of cytochrome P450 aromatases from Australian animals predict differences in enzymatic activity and/or efficiency

Anam Fatima, Jessica K Holien, Chandni Tiwari, Michael W Parker, Raymond J Rodgers, Lisandra L Martin

Journal article  |  2020  |  Biology of Reproduction

Aromatase (P450arom, CYP19A1) is the terminal enzyme in the synthesis of the steroid hormone family of estrogens. Not surprisingly..

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K Holien, Hassina Massudi, Daniel R Carter, Olivia C Ciampa, Mika Herath, Taylor Lim, Janith A Seneviratne, Giorgio Milazzo, Jayne E Murray, Joshua A McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W Stevenson, Michael A Gorman, Jessica L Bell, Larissa Doughty, Stefan Huettelmaier, Andre Oberthuer, et al.

Journal article  |  2019  |  Cancer Research

MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN pro..

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

Paul R Gilson, Rasika Kumarasingha, Jennifer Thompson, Xinxin Zhang, Jocelyn Sietsma Penington, Robabeh Kalhor, Hayley E Bullen, Adele M Lehane, Madeline G Dans, Tania F de Koning-Ward, Jessica K Holien, Tatiana P Soares da Costa, Mark D Hulett, Melissa J Buskes, Brendan S Crabb, Kiaran Kirk, Anthony T Papenfuss, Alan F Cowman, Belinda M Abbott

Journal article  |  2019  |  Scientific Reports

AMP and adenosine are both ligands for adenosine 2B receptor signaling

Jessica K Holien, Benjamin Seibt, Veena Roberts, Evelyn Salvaris, Michael W Parker, Peter J Cowan, Karen M Dwyer

Journal article  |  2018  |  Bioorganic & Medicinal Chemistry Letters

Computational Analysis of Amiloride Analogue Inhibitors of Coxsackievirus B3 RNA Polymerase.

Jessica K Holien, Elena V Gazina, Robert W Elliott, Bevyn Jarrott, Craig E Cameron, Spencer J Williams, Michael W Parker, Steven Petrou

Journal article  |  2014  |  Journal of Proteomics & Bioinformatics

Coxsackievirus B3 (CVB3) is a picornavirus that is responsible for a significant proportion of human myocarditis. However, no anti..