Jessica Holien

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

Charlotte Hodson, Jason KK Low, Sylvie van Twest, Samuel E Jones, Paolo Swuec, Vincent Murphy, Kaima Tsukada, Matthew Fawkes, Rohan Bythell-Douglas, Adelina Davies, Jessica K Holien, Julienne J O'Rourke, Benjamin L Parker, Astrid Glaser, Michael W Parker, Joel P Mackay, Andrew N Blackford, Alessandro Costa, Andrew J Deans

Journal article  |  2022  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the "Bloom syndrome c..

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

Siavash Beikoghli Kalkhoran, Janos Kriston-Vizi, Sauri Hernandez-Resendiz, Gustavo E Crespo-Avilan, Ayeshah A Rosdah, Jarmon G Lees, Joana Rodrigues Simoes Da Costa, Naomi XY Ling, Jessica K Holien, Parisa Samangouei, Kroekkiat Chinda, En Ping Yap, Jaime A Riquelme, Robin Ketteler, Derek M Yellon, Shiang Y Lim, Derek J Hausenloy

Journal article  |  2022  |  CARDIOVASCULAR RESEARCH

AIMS: Genetic and pharmacological inhibition of mitochondrial fission induced by acute myocardial ischaemia/reperfusion injury (IR..

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Patrick M Siegel, Istvan Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto-Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, et al.

Journal article  |  2021  |  BASIC RESEARCH IN CARDIOLOGY

The monocyte β2-integrin Mac-1 is crucial for leukocyte-endothelium interaction, rendering it an attractive therapeutic target for..

A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Belamy B Cheung, Ane Kleynhans, Rituparna Mittra, Patrick Y Kim, Jessica K Holien, Zsuzsanna Nagy, Olivia C Ciampa, Janith A Seneviratne, Chelsea Mayoh, Mukesh Raipuria, Satyanarayana Gadde, Hassina Massudi, Iris Poh Ling Wong, Owen Tan, Andrew Gong, Aldwin Suryano, Sonya M Diakiw, Bing Liu, Greg M Arndt, Tao Liu, et al.

Journal article  |  2021  |  ONCOGENE

Histone deacetylase (HDAC) inhibitors are effective in MYCN-driven cancers, because of a unique need for HDAC recruitment by the M..

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Trent Perry, Wei Chen, Razi Ghazali, Ying Ting Yang, Danielle Christesen, Felipe Martelli, Chris Lumb, Hang Ngoc Bao Luong, Judith Mitchell, Jessica K Holien, Michael W Parker, Thomas C Sparks, Philip Batterham

Journal article  |  2021  |  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insecticides remain valuable tools for the control of insect pests that significantly impact human health and agriculture. A deepe..

A structural view of PA2G4 isoforms with opposing functions in cancer

Brendan W Stevenson, Michael A Gorman, Jessica Koach, Belamy B Cheung, Glenn M Marshall, Michael W Parker, Jessica K Holien

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The role of proliferation-associated protein 2G4 (PA2G4), alternatively known as ErbB3-binding protein 1 (EBP1), in cancer has bec..

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Ayeshah A Rosdah, William J Smiles, Jonathan S Oakhill, John W Scott, Christopher G Langendorf, Lea MD Delbridge, Jessica K Holien, Shiang Y Lim

Journal article  |  2020  |  PHARMACOLOGY & THERAPEUTICS

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochond..

Sequence comparisons of cytochrome P450 aromatases from Australian animals predict differences in enzymatic activity and/or efficiency

Anam Fatima, Jessica K Holien, Chandni Tiwari, Michael W Parker, Raymond J Rodgers, Lisandra L Martin

Journal article  |  2020  |  BIOLOGY OF REPRODUCTION

Aromatase (P450arom, CYP19A1) is the terminal enzyme in the synthesis of the steroid hormone family of estrogens. Not surprisingly..

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K Holien, Hassina Massudi, Daniel R Carter, Olivia C Ciampa, Mika Herath, Taylor Lim, Janith A Seneviratne, Giorgio Milazzo, Jayne E Murray, Joshua A McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W Stevenson, Michael A Gorman, Jessica L Bell, Larissa Doughty, Stefan Huettelmaier, Andre Oberthuer, et al.

Journal article  |  2019  |  CANCER RESEARCH

MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN pro..

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

Paul R Gilson, Rasika Kumarasingha, Jennifer Thompson, Xinxin Zhang, Jocelyn Sietsma Penington, Robabeh Kalhor, Hayley E Bullen, Adele M Lehane, Madeline G Dans, Tania F de Koning-Ward, Jessica K Holien, Tatiana P Soares da Costa, Mark D Hulett, Melissa J Buskes, Brendan S Crabb, Kiaran Kirk, Anthony T Papenfuss, Alan F Cowman, Belinda M Abbott

Journal article  |  2019  |  SCIENTIFIC REPORTS

We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved mod..