Elaine Sanij

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.

Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J Deans, Kum Kum Khanna, et al.

Journal article  |  2020  |  Nature Communications

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cance..

A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson

Journal article  |  2020  |  Cell Death & Differentiation

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

Shunfei Yan, Piyush Madhamshettiwar, Kaylene Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen Sheppard, Katherine Hannan, Ross Hannan, Elaine Sanij, Richard Pearson, Keefe Chan

Journal article  |  2019

Abstract Limited effective therapeutic options are available for patients with recurrent high-grade serous carcinoma (HGSC), the m..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, KT Chan, DP De Souza, MJ McConville, GA McArthur, G Thomas, E Sanij, G Poortinga, RD Hannan, KM Hannan, J Kang, RB Pearson

Journal article  |  2019  |  bioRxiv

Abstract Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-i..

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt, et al.

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery, Ella R Thompson, Andrew Fellowes, Karen E Sheppard, Grant A McArthur, Richard B Pearson, Ross D Hannan, Gretchen Poortinga, Simon J Harrison

Journal article  |  2019  |  Cancer Discovery

RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and it..

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Elaine Sanij, Katherine Hannan, Shunfei Yan, Jiachen Xuan, Jessica Ahern, Keefe Chan, Jinbae Son, Olga Kondrashova, Elizabeth Lieschke, Matthew Wakefield, Anna Trigos, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Kum Kum Khanna, Linda Mileshkin, Grant McArthur, et al.

Journal article  |  2019

Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.

Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers, Richard B Pearson, Grant A McArthur, Austen RD Ganley, Justin M O'Sullivan, Ross D Hannan, Gretchen Poortinga

Journal article  |  2019  |  Communications biology

The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associat..

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers, Richard B Pearson, Grant A McArthur, Austen RD Ganley, Justin M O'Sullivan, Ross D Hannan, Gretchen Poortinga

Journal article  |  2019  |  Communications Biology

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria Harrell, Giada Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B Pearson, John J Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J Hutt, Scott H Kaufmann, et al.

Journal article  |  2018  |  Nature Communications

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naive melanoma but not after the development of BRAF inhibitor resistance

Claire A Martin, Carleen Cullinane, Laura Kirby, Shatha Abuhammad, Emily J Lelliott, Kelly Waldeck, Richard J Young, Natalie Brajanovski, Donald P Cameron, Rachael Walker, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Richard B Pearson, Rodney J Hicks, Grant A McArthur, Karen E Sheppard

Journal article  |  2018  |  International Journal of Cancer

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Maheshi Udugama, Elaine Sanij, Hsiao PJ Voon, Jinbae Son, Linda Hii, Jeremy D Henson, F Lyn Chan, Fiona TM Chang, Yumei Liu, Richard B Pearson, Paul Kalitsis, Jeffrey R Mann, Philippe Collas, Ross D Hannan, Lee H Wong

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

Genevieve Pepin, Charlotte Nejad, Jonathan Ferrand, Belinda J Thomas, H James Stunden, Elaine Sanij, Chwan-Hong Foo, Cameron R Stewart, Jason E Cain, Philip G Bardin, Bryan RG Williams, Michael P Gantier

Journal article  |  2017  |  mBio

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario, et al.

Journal article  |  2017  |  Blood

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Sandy S Hung, Analia Lesmana, Abigail Peck, Rachel Lee, Elly Tchoubrieva, Katherine M Hannan, Jane Lin, Karen E Sheppard, Katarzyna Jastrzebski, Leonie M Quinn, Lawrence I Rothblum, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2017  |  Gene

A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Shunfei Yan, Keefe T Chan, Kaylene J Simpson, Elaine Sanij, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Richard B Pearson

Conference Proceedings  |  2017  |  Synthetic Lethality and Viability

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

Shunfei Yan, Daniel Frank, Jinbae Son, Katherine M Hannan, Ross D Hannan, Keefe T Chan, Richard B Pearson, Elaine Sanij

Journal article  |  2017  |  International Journal of Molecular Sciences

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Jian Kang, Eric P Kusnadi, Allison J Ogden, Rodney J Hicks, Lukas Bammert, Ulrike Kutay, Sandy Hung, Elaine Sanij, Ross D Hannan, Katherine M Hannan, Richard B Pearson

Journal article  |  2016  |  Oncotarget

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan

Journal article  |  2016  |  Oncotarget

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O'Brien, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2016  |  Cancer Discovery

Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence

Sharon Brookes, Sladjana Gagrica, Elaine Sanij, Janice Rowe, Fiona J Gregory, Eiji Hara, Gordon Peters

Journal article  |  2015  |  Cell Cycle

Cellular senescence, the stable cell cycle arrest elicited by various forms of stress, is an important facet of tumor suppression...

Genome wide mapping of UBF binding-sites in mouse and human cell lines

Jeannine Diesch, Ross D Hannan, Elaine Sanij

Journal article  |  2015  |  Genomics Data

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Elaine Sanij, Jeannine Diesch, Analia Lesmana, Gretchen Poortinga, Nadine Hein, Grace Lidgerwood, Donald P Cameron, Jason Ellul, Gregory J Goodall, Lee H Wong, Amardeep S Dhillon, Nourdine Hamdane, Lawrence I Rothblum, Richard B Pearson, Izhak Haviv, Tom Moss, Ross D Hannan

Journal article  |  2015  |  Genome Research

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

Jeannine Diesch, Ross D Hannan, Elaine Sanij

Journal article  |  2014  |  Cell & Bioscience

Conditional Inactivation of Upstream Binding Factor Reveals Its Epigenetic Functions and the Existence of a Somatic Nucleolar Precursor Body

Nourdine Hamdane, Victor Y Stefanovsky, Michel G Tremblay, Attila Nemeth, Eric Paquet, Frederic Lessard, Elaine Sanij, Ross Hannan, Tom Moss

Journal article  |  2014  |  PLoS Genetics

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells

Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon

Journal article  |  2014  |  PLoS One

The nucleolus: an emerging target for cancer therapy

Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan

Journal article  |  2013  |  Trends in Molecular Medicine

Dysregulation of RNA polymerase I transcription during disease

KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson

Journal article  |  2013  |  Biochimica et Biophysica Acta. Gene Regulatory Mechanisms

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes, Nanni Huser, Chris Proffitt, Joshua Bliesath, Mustapha Haddach, Michael K Schwaebe, David M Ryckman, William G Rice, Clemens Schmitt, Scott W Lowe, Ricky W Johnstone, et al.

Journal article  |  2012  |  Cancer Cell

The Nucleolus and Ribosomal Genes in Aging and Senescence

Nadine Hein, Elaine Sanij, Jaclyn Quin, Katherine M Hannan, Austen Ganley, Ross D Hannan

Book Chapter  |  2012

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

Gretchen Poortinga, Meaghan Wall, Elaine Sanij, Kasia Siwicki, Jason Ellul, Daniel Brown, Timothy P Holloway, Ross D Hannan, Grant A McArthur

Journal article  |  2011  |  Nucleic Acids Research

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

Denis Drygin, Amy Lin, Josh Bliesath, Caroline B Ho, Sean E O'Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K Schwaebe, Adam Siddiqui-Jain, Nicole Streiner, Jaclyn E Quin, Elaine Sanij, Megan J Bywater, Ross D Hannan, David Ryckman, Kenna Anderes, William G Rice

Journal article  |  2011  |  Cancer Research

Signaling to the Ribosome in Cancer-It Is More Than Just mTORC1

Katherine M Hannan, Elaine Sanij, Nadine Hein, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  IUBMB Life

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

Elaine Sanij, Ross D Hannan

Journal article  |  2009  |  EPIGENETICS

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin.

Elaine Sanij, Ross D Hannan

Journal article  |  2009  |  Epigenetics

Somatic cells have approximately 200 hundred copies of ribosomal RNA (rRNA) genes (rDNA) per haploid genome of which only a fracti..

UBF levels determine the number of active ribosomal RNA genes in mammals

Elaine Sanij, Gretchen Poortinga, Kerith Sharkey, Sandy Hung, Timothy P Holloway, Jaclyn Quin, Elysia Robb, Lee H Wong, Walter G Thomas, Victor Stefanovsky, Tom Moss, Lawrence Rothblum, Katherine M Hannan, Grant A McArthur, Richard B Pearson, Ross D Hannan

Journal article  |  2008  |  Journal of Cell Biology

Chromatin organization and expression.

Elaine Sanij, Ross D Hannan

Journal article  |  2008  |  Genome Biology

A report on the 29th Lorne Genome Conference on the Organization and Expression of the Genome, Lorne, Australia, 17-21 February 20..

Epstein-Barr virus LMP1 blocks p(16INK4a)-RB pathway by promoting nuclear export of E2F4/5

N Ohtani, P Brennan, S Gaubatz, E Sanij, P Hertzog, E Wolvetang, J Ghysdael, M Rowe, E Hara

Journal article  |  2003  |  Journal of Cell Biology

The p16INK4a-RB pathway plays a critical role in preventing inappropriate cell proliferation and is often targeted by viral oncopr..

Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein

E Sanij, B Scott, T Wilson, DK Xu, P Hertzog, E Wolvetang

Journal article  |  2003  |  Immunology Letters

ETS-2 is a member of the ETS family of transcription factors. ETS-2 was initially characterized as a nuclear oncogene and has been..

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

EJ Wolvetang, TJ Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, PJ Hertzog, I Kola

Journal article  |  2003  |  Human Molecular Genetics

ETS2 is a transcription factor encoded by a gene on human chromosome 21 and alterations in its expression have been implicated in ..

Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster

MP Hardy, E Sanij, PJ Hertzog, CM Owczarek

Journal article  |  2003  |  Mammalian Genome

The class II cytokine receptor (CIICR) genes Il10r2 and Ifnar1 are localized on mouse Chr 16 in a cluster that also contains the C..

Transformation induced by Ewing's sarcoma associated EWS/FLI-I is suppressed by KRAB/FLI-I

D Chan, TJ Wilson, D Xu, HE Cowdery, E Sanij, PJ Hertzog, I Kola

Journal article  |  2003  |  British Journal of Cancer

Ewing's sarcoma is a childhood bone tumour with poor prognosis, most commonly associated with a t(11;22)(q24;q12) reciprocal trans..

Erratum: Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for down's syndrome, (Biochemical and Biophysical Research Communications (2001) 287:4 (1003-1008))

E Sanij, T Hatzistavrou, P Hertzog, I Kola, EJ Wolvetang

Journal article  |  2002  |  Biochemical and Biophysical Research Communications

Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's syndrome

E Sanij, T Hatzistavrou, P Hertzog, I Kola, EJ Wolvetang

Journal article  |  2001  |  Biochemical and Biophysical Research Communications