Trent Perry

Dual nicotinic acetylcholine receptor subunit gene knockouts reveal limits to functional redundancy.

Wei Chen, Xinyue Gu, Ying Ting Yang, Philip Batterham, Trent Perry

Journal article  |  2022  |  Pestic Biochem Physiol

The nicotinic acetylcholine receptor (nAChR) subunit gene family consists of ten members in Drosophila melanogaster. The mature nA..

Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies

Felipe Martelli, Natalia H Hernandes, Zhongyuan Zuo, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusita Rupasinghe, Charles Robin, Kartik Venkatachalam, Trent Perry, Philip Batterham, Hugo J Bellen

Journal article  |  2022  |  ELIFE

Large-scale insecticide application is a primary weapon in the control of insect pests in agriculture. However, a growing body of ..

Genomic knockout of hsp23 both decreases and increases fitness under opposing thermal extremes in Drosophila melanogaster

Xinyue Gu, Wei Chen, Trent Perry, Philip Batterham, Ary A Hoffmann

Journal article  |  2021  |  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Under exposure to harmful environmental stresses, organisms exhibit a general stress response involving upregulation of the expres..

Loss of the D beta 1 nicotinic acetylcholine receptor subunit disrupts bursicon-driven wing expansion and diminishes adult viability in Drosophila melanogaster

Danielle Christesen, Ying Ting Yang, Wei Chen, Philip Batterham, Trent Perry

Journal article  |  2021  |  GENETICS

Cholinergic signaling dominates the insect central nervous system, contributing to numerous fundamental pathways and behavioral ci..

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Trent Perry, Wei Chen, Razi Ghazali, Ying Ting Yang, Danielle Christesen, Felipe Martelli, Chris Lumb, Hang Ngoc Bao Luong, Judith Mitchell, Jessica K Holien, Michael W Parker, Thomas C Sparks, Philip Batterham

Journal article  |  2021  |  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insecticides remain valuable tools for the control of insect pests that significantly impact human health and agriculture. A deepe..

Inhibiting the proteasome reduces molecular and biological impacts of the natural product insecticide, spinosad

Joseph Nguyen, Razi Ghazali, Philip Batterham, Trent Perry

Journal article  |  2021  |  PEST MANAGEMENT SCIENCE

BACKGROUND: Insecticide targets are often identified by mutations that confer resistance, but the intricacies of insecticide bindi..

Low doses of the organic insecticide spinosad trigger lysosomal defects, ROS driven lipid dysregulation and neurodegeneration in flies

Felipe Martelli, Zuo Zhongyuan, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusitha Rupasinghe, Kartik Venkatachalam, Trent Perry, Philip Batterham, Hugo J Bellen

Journal article  |  2021

AbstractThe plight of insect populations around the world and the threats it poses to agriculture and ecosystems has thrown insect..

Major SCP/TAPS protein expansion in Lucilia cuprina is associated with novel tandem array organisation and domain architecture

Yair DJ Prawer, Andreas J Stroehlein, Neil D Young, Shilpa Kapoor, Ross S Hall, Razi Ghazali, Phillip Batterham, Robin B Gasser, Trent Perry, Clare A Anstead

Journal article  |  2020  |  PARASITES & VECTORS

Background Larvae of the Australian sheep blowfly, Lucilia cuprina, parasitise sheep by feeding on skin excretions, dermal tissue ..

Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila

Felipe Martelli, Zhongyuan Zuo, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusitha Rupasinghe, Kartik Venkatachalam, Trent Perry, Hugo J Bellen, Philip Batterham

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Declining insect population sizes are provoking grave concern around the world as insects play essential roles in food production ..

Functional characterization and fitness cost of spinosad-resistant alleles in Ceratitis capitata

Ana Guillem-Amat, Enric Urena, Elena Lopez-Errasquin, Vicente Navarro-Llopis, Philip Batterham, Lucas Sanchez, Trent Perry, Pedro Hernandez-Crespo, Felix Ortego

Journal article  |  2020  |  JOURNAL OF PEST SCIENCE

The sustainability of control programs for the Mediterranean fruit fly, Ceratitis capitata, for citrus crops in Spain has been thr..