Frank Alford

A Prospective Study of Renal Transplant Recipients: A Fall in Insulin Secretion Underpins Dysglycemia After Renal Transplantation

David Langsford, Varuni Obeyesekere, Sara Vogrin, Jessie Teng, Richard J MacIsaac, Glenn Ward, Frank Alford, Karen M Dwyer

Journal article  |  2016  |  TRANSPLANTATION DIRECT

BACKGROUND: Dysglycemia (encompassing impaired glucose tolerance and diabetes mellitus) arising after renal transplantation is com..

A prospective study of renal transplant recipients: the interrelationship between insulin secretion and sensitivity underpins dysglycemia post following renal transplantation

Karen M Dwyer, David Langsford, Varuni Obeyesekere, Jessie Teng, Sara Vogrin, Richard MacIsaac, Glenn Ward, Frank Alford

Conference Proceedings  |  2016  |  TRANSPLANTATION

Endogenous Incretin Hormone Augmentation of Acute Insulin Secretion in Normoglycemic Relatives of Type 2 Diabetic Subjects: A 10-Year Retrospective Pathophysiological Study

Frank P Alford, Christian Rantzau, Jan-Erik Henriksen, Mette Brogaard Egede, Tina Trier Durck, Klaus Levin, Henning Beck-Nielsen

Journal article  |  2014  |  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

AIMS/HYPOTHESIS: The pathophysiological role of gut incretin hormone argumentation on acute insulin release in the genesis of type..

Glucose Effectiveness in Nondiabetic Relatives: Dysglycemia and beta-Cell Function at 10 Years

MB Egede, J-E Henriksen, TT Durck, K Levin, C Rantzau, G Ward, H Beck-Nielsen, FP Alford

Journal article  |  2014  |  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

AIMS: Reduced glucose effectiveness is a predictor of future glucose tolerance in individuals with a family history of type 2 diab..

The metabolic responses induced by acute dexamethasone predict glucose tolerance and insulin secretion over 10years in relatives of type 2 diabetic subjects

Tina Trier Durck, Jan Erik Henriksen, Mette Brogaard Egede, Klaus Levin, Christian Rantzau, Glenn Ward, Henning Beck-Nielsen, Frank P Alford

Journal article  |  2013  |  DIABETES-METABOLISM RESEARCH AND REVIEWS

BACKGROUND: This study aimed to compare the metabolic and insulin secretory responses to dexamethasone with the metabolic response..

Skeletal Muscle 11 beta HSD1 Activity of Nondiabetic Subjects is Unaltered in Central Obesity-associated Insulin Resistance

WJ Inder, VR Obeyesekere, FP Alford, C Jang

Journal article  |  2011  |  HORMONE AND METABOLIC RESEARCH

Local activation of glucocorticoids in insulin target tissues by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) has ..

Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1-implications for steroid-induced myopathy

Warrick J Inder, Christina Jang, Varuni R Obeyesekere, Frank P Alford

Journal article  |  2010  |  CLINICAL ENDOCRINOLOGY

CONTEXT: Glucocorticoids are a well-recognized cause of muscle weakness. The early effects of glucocorticoids on skeletal muscle (..

The 4-mg intravenous dexamethasone suppression test in the diagnosis of Cushing's syndrome

Caroline Jung, Frank P Alford, Duncan J Topliss, John R Burgess, Fiona Long, James J Gome, Jim R Stockigt, Warrick J Inder

Journal article  |  2010  |  CLINICAL ENDOCRINOLOGY

OBJECTIVE: Optimal diagnostic criteria for the 4-mg intravenous dexamethasone suppression test (IVDST) in patients with Cushing's ..

Skeletal muscle 11 beta hydroxysteroid dehydrogenase type 1 activity is upregulated following elective abdominal surgery

Christina Jang, Varuni R Obeyesekere, Frank P Alford, Warrick J Inder

Journal article  |  2009  |  EUROPEAN JOURNAL OF ENDOCRINOLOGY

OBJECTIVE: Cortisol has been traditionally implicated in the causation of peri-operative skeletal muscle (SkM) insulin resistance,..

Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone

Christina Jang, Warrick J Inder, Varuni R Obeyesekere, Frank P Alford

Journal article  |  2008  |  CLINICAL ENDOCRINOLOGY

OBJECTIVE: Skeletal muscle is a major site of adiponectin action and of glucocorticoid-induced insulin resistance. Little human da..