Shiang Lim

Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction.

Andrew R Kompa, David W Greening, Anne M Kong, Paul J McMillan, Haoyun Fang, Ritika Saxena, Raymond CB Wong, Jarmon G Lees, Priyadharshini Sivakumaran, Andrew E Newcomb, Bakhos A Tannous, Cameron Kos, Lina Mariana, Thomas Loudovaris, Derek J Hausenloy, Shiang Y Lim

Journal article  |  2021  |  Cardiovascular Research

AIMS: To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells..

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Ayeshah A Rosdah, William J Smiles, Jonathan S Oakhill, John W Scott, Christopher G Langendorf, Lea MD Delbridge, Jessica K Holien, Shiang Y Lim

Journal article  |  2020  |  Pharmacology & Therapeutics

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochond..

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Omar Lozano, Christian Silva-Platas, Hector Chapoy-Villanueva, Baruc E Perez, Jarmon G Lees, Chrishan JA Ramachandra, Flavio F Contreras-Torres, Anay Lazaro-Alfaro, Estefania Luna-Figueroa, Judith Bernal-Ramirez, Aldemar Gordillo-Galeano, Alfredo Benitez, Yuriana Oropeza-Almazan, Elena C Castillo, Poh Ling Koh, Derek J Hausenloy, Shiang Y Lim, Gerardo Garcia-Rivas

Journal article  |  2020  |  Particle and Fibre Toxicology

BACKGROUND: Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such a..

Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems

Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell

Journal article  |  2019  |  American Journal of Physiology - Cell Physiology

Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel anti-arrhythmi..

Generation of a nitric oxide signaling pathway in mesenchymal stem cells promotes endothelial lineage commitment

Nadeeka Bandara, Saliya Gurusinghe, Anne Kong, Geraldine Mitchell, Le-Xin Wang, Shiang Y Lim, Padraig Strappe

Journal article  |  2019  |  Journal of Cellular Physiology

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim

Journal article  |  2019  |  Stem Cells International

Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle

Anne M Kong, Kiryu K Yap, Shiang Y Lim, Diego Marre, Alice Pebay, Yi-wen Gerrand, Jarmon G Lees, Jason A Palmer, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2019  |  Acta Biomaterialia

Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a ..

A Simple Cloning-free Method to Efficiently Induce Gene Expression Using CRISPR/Cas9

Lyujie Fang, Sandy SC Hung, Jennifer Yek, Layal El Wazan, Nguyen Tu, Shahnaz Khan, Shiang Y Lim, Alex W Hewitt, Raymond CB Wong

Journal article  |  2019  |  Molecular Therapy : Nucleic Acids

Methods for Assessing Scaffold Vascularization In Vivo

Jiang-Hui Wang, Jinying Chen, Shyh-Ming Kuo, Geraldine M Mitchell, Shiang Y Lim, Guei-Sheung Liu

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

The success of tissue engineering hinges on the rapid and sufficient vascularization of the neotissue. For efficient vascular netw..

Mitochondrial Assays Using Cardiac Stem Cells.

Ayeshah A Rosdah, Lea MD Delbridge, Shiang Y Lim

Book Chapter  |  2019  |  Methods in Molecular Biology

Ischemic heart disease is the leading cause of death worldwide. Stem cell therapy to repair and regenerate the infarcted myocardiu..