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Dr

Shiang Lim

Honorary
Surgery - St Vincent'S Hospital
myocardial infarction
science & technology
life sciences & biomedicine
animals
humans
cell biology
mice
male
cell & tissue engineering
Shiang Lim's Profile Picture
Dr

Shiang Lim

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Heart disease
Shiang Lim's Profile Picture
Dr

Shiang Lim

 
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Shiang's  Short Profile
 

After completing a PhD from University of Strathclyde (UK) in 2005, Dr Lim spent 4 years post-doc research at The Hatter Cardiovascular Institute (University College London, UK) focused on cardioprotection research, in particular the role of the mitochondria permeability transition pore and the translational value of ischemic conditioning. In June 2010, he joined the O’Brien Institute (Melbourne) and was appointed as the leader of the Cardiac Regeneration team in 2012.

His group focuses on combining stem cell technology and tissue engineering approach to repair and regenerate damaged heart

Projects

Displaying the 1 most recent project by Shiang Lim.

Project icon

Towards growing large pieces of human heart from stem cells

Stem cell therapies to repair heart muscle are experimental methods which promise future clinical treatments. Our tissue engineering chamber..

2012 - 2015
Completed

1

Projects

Project Types

1

Research Grant

Additional Information

2014: The CASS Foundation. (Lim). Cardiac repair and regeneration with novel human cardiac resident stem cells. AUD$50,000.

2014: St Vincent’s Hospital Research Endowment Fund. (Lim, Mitchell, Liu, Newcomb). Constructing a vascularized human heart muscle graft using a 3D collagen scaffold. AUD

7,500.

2013: St Vincent’s Hospital Research Endowment Fund. (Lim, Dusting, Newcomb). Human resident cardiac stem cells for cardiac tissue engineering. AUD
5,000.

2013-14: Friedreich Ataxia Research Association. (Pébay, Lim, Trounce, Needham). Differentiating Friedreich ataxia-induced pluripotent stem cells for disease modelling. AUD$257,400.

2013-14: Australia National Heart Foundation (Dusting, Peshavariya, Lim). Boosting oxidant signalling in endothelial progenitor cells to improve cardiac repair after infarction. AUD
30,000; G12M6726

2012-14: Australia National Health and Medical Research Council project grant (Dusting, Dilley, Pébay, Lim, Shepherd). Upscaling cardiac tissue engineering: Differentiation of iPS cells, enrichment and bionic approaches. AUD $685,710; 1024817

2012-14: UK Medical Research Council project grant (Hausenloy, Lim, Yellon). DJ-1 as a novel target for cardioprotection. £372,796; MR/J003530/1

2012-13: Australia National Heart Foundation (Dusting, Lim, Peshavariya). Cardioprotection in ischaemic heart failure by prostacyclin and oxidant signaling. AUD
30,000; G11M5836

Scholarly Works

Displaying the 10 most recent scholarly works by Shiang Lim.

Scholarly works icon

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Ayeshah A Rosdah, William J Smiles, Jonathan S Oakhill, John W Scott, Christopher G Langendorf, Lea MD Delbridge, Jessica K Holien, Shiang Y Lim

Journal article  |  2020  |  Pharmacology & Therapeutics

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochond..

Scholarly works icon

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Omar Lozano, Christian Silva-Platas, Hector Chapoy-Villanueva, Baruc E Perez, Jarmon G Lees, Chrishan JA Ramachandra, Flavio F Contreras-Torres, Anay Lazaro-Alfaro, Estefania Luna-Figueroa, Judith Bernal-Ramirez, Aldemar Gordillo-Galeano, Alfredo Benitez, Yuriana Oropeza-Almazan, Elena C Castillo, Poh Ling Koh, Derek J Hausenloy, Shiang Y Lim, Gerardo Garcia-Rivas

Journal article  |  2020  |  Particle and Fibre Toxicology

BACKGROUND: Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such a..

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Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction.

Andrew R Kompa, David W Greening, Anne M Kong, Paul J McMillan, Haoyun Fang, Ritika Saxena, Raymond CB Wong, Jarmon G Lees, Priyadharshini Sivakumaran, Andrew E Newcomb, Bakhos A Tannous, Cameron Kos, Lina Mariana, Thomas Loudovaris, Derek J Hausenloy, Shiang Y Lim

Journal article  |  2020  |  Cardiovascular Research

AIMS: To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells..

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Generation of a nitric oxide signaling pathway in mesenchymal stem cells promotes endothelial lineage commitment

Nadeeka Bandara, Saliya Gurusinghe, Anne Kong, Geraldine Mitchell, Le-Xin Wang, Shiang Y Lim, Padraig Strappe

Journal article  |  2019  |  Journal of Cellular Physiology

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Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim

Journal article  |  2019  |  Stem Cells International

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Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle

Anne M Kong, Kiryu K Yap, Shiang Y Lim, Diego Marre, Alice Pebay, Yi-wen Gerrand, Jarmon G Lees, Jason A Palmer, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2019  |  Acta Biomaterialia

Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a ..

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A Simple Cloning-free Method to Efficiently Induce Gene Expression Using CRISPR/Cas9

Lyujie Fang, Sandy SC Hung, Jennifer Yek, Layal El Wazan, Nguyen Tu, Shahnaz Khan, Shiang Y Lim, Alex W Hewitt, Raymond CB Wong

Journal article  |  2019  |  Molecular Therapy - Nucleic Acids

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Methods for Assessing Scaffold Vascularization In Vivo

Jiang-Hui Wang, Jinying Chen, Shyh-Ming Kuo, Geraldine M Mitchell, Shiang Y Lim, Guei-Sheung Liu

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

The success of tissue engineering hinges on the rapid and sufficient vascularization of the neotissue. For efficient vascular netw..

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Mitochondrial Assays Using Cardiac Stem Cells.

Ayeshah A Rosdah, Lea MD Delbridge, Shiang Y Lim

Book Chapter  |  2019  |  Methods in Molecular Biology

Ischemic heart disease is the leading cause of death worldwide. Stem cell therapy to repair and regenerate the infarcted myocardiu..

Scholarly works icon

Does osteogenic potential of clonal human bone marrow mesenchymal stem/stromal cells correlate with their vascular supportive ability?

Alison T Merryweather-Clarke, David Cook, Barbara Joo Lara, Peng Hua, Emmanouela Repapi, Neil Ashley, Shiang Y Lim, Suzanne M Watt

Journal article  |  2018  |  Stem Cell Research & Therapy

60

Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Biochemistry and Cell Biology
Cardiovascular Medicine and Haematology
Expanding Knowledge
Medical Biotechnology
Other Health
Medical Physiology
Clinical Sciences
Ophthalmology and Optometry
Biomedical Engineering

Honours, Awards and Fellowships

2012

Asia Pacific Society of Hypertension
2012

Young Investigator Award

High Blood Pressure Research Council of Australia

2

Awards

Credentials

Positions

Positions

Honorary

Surgery - St Vincent'S Hospital

Member

Tissue Engineering International & Regenerative Medicine Society

Member

High Blood Pressure Research Council of Australia

Member

International Society of Heart Research

Education

Education

Physiology and Pharmacology

University of Strathclyde

Pharmacy

University of Strathclyde