Shiang Lim

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells.

Tu Nguyen, Daniel Urrutia-Cabrera, Luozixian Wang, Jarmon G Lees, Jiang-Hui Wang, Sandy SC Hung, Alex W Hewitt, Thomas L Edwards, Sam McLenachan, Fred K Chen, Shiang Y Lim, Chi D Luu, Robyn Guymer, Raymond CB Wong

Journal article  |  2023  |  Aging (Albany NY)

Genetic and epidemiologic studies have significantly advanced our understanding of the genetic factors contributing to age-related..

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes.

Jiang-Hui Wang, Daniel Urrutia-Cabrera, Jarmon G Lees, Santiago Mesa Mora, Tu Nguyen, Sandy SC Hung, Alex W Hewitt, Shiang Y Lim, Thomas L Edwards, Raymond CB Wong

Journal article  |  2023  |  Int J Mol Sci

Age-related macular degeneration (AMD) is a blinding disease characterised by dysfunction of the retinal pigmented epithelium (RPE..

A novel small molecule inhibitor of human Drp1.

Ayeshah A Rosdah, Belinda M Abbott, Christopher G Langendorf, Yali Deng, Jia Q Truong, Helen MM Waddell, Naomi XY Ling, William J Smiles, Lea MD Delbridge, Guei-Sheung Liu, Jonathan S Oakhill, Shiang Y Lim, Jessica K Holien

Journal article  |  2022  |  Sci Rep

Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an impor..

A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly

Quanxia Lyu, Shu Gong, Jarmon G Lees, Jialiang Yin, Lim Wei Yap, Anne M Kong, Qianqian Shi, Runfang Fu, Qiang Zhu, Ash Dyer, Jennifer M Dyson, Shiang Y Lim, Wenlong Cheng

Journal article  |  2022  |  NATURE COMMUNICATIONS

Time-lapse mechanical properties of stem cell derived cardiac organoids are important biological cues for understanding contractio..

Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair

Jonathan Lozano, Alin Rai, Jarmon G Lees, Haoyun Fang, Bethany Claridge, Shiang Y Lim, David W Greening

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to repair injured cardiac tissues and re..

Mitochondrial Dynamin-Related Protein Drp1: a New Player in Cardio-oncology

Yali Deng, Doan TM Ngo, Jessica K Holien, Jarmon G Lees, Shiang Y Lim

Journal article  |  2022  |  CURRENT ONCOLOGY REPORTS

PURPOSE OF REVIEW: This study is aimed at reviewing the recent progress in Drp1 inhibition as a novel approach for reducing doxoru..

Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma.

Maciej Daniszewski, Anne Senabouth, Helena H Liang, Xikun Han, Grace E Lidgerwood, Damián Hernández, Priyadharshini Sivakumaran, Jordan E Clarke, Shiang Y Lim, Jarmon G Lees, Louise Rooney, Lerna Gulluyan, Emmanuelle Souzeau, Stuart L Graham, Chia-Ling Chan, Uyen Nguyen, Nona Farbehi, Vikkitharan Gnanasambandapillai, Rachael A McCloy, Linda Clarke, et al.

Journal article  |  2022  |  Cell Genom

To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glauc..

Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy

Ren Jie Phang, Rebecca H Ritchie, Derek J Hausenloy, Jarmon G Lees, Shiang Y Lim

Journal article  |  2022  |  CARDIOVASCULAR RESEARCH

Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac phenotype known as diabetic cardiomyopathy...

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

Siavash Beikoghli Kalkhoran, Janos Kriston-Vizi, Sauri Hernandez-Resendiz, Gustavo E Crespo-Avilan, Ayeshah A Rosdah, Jarmon G Lees, Joana Rodrigues Simoes Da Costa, Naomi XY Ling, Jessica K Holien, Parisa Samangouei, Kroekkiat Chinda, En Ping Yap, Jaime A Riquelme, Robin Ketteler, Derek M Yellon, Shiang Y Lim, Derek J Hausenloy

Journal article  |  2022  |  CARDIOVASCULAR RESEARCH

AIMS: Genetic and pharmacological inhibition of mitochondrial fission induced by acute myocardial ischaemia/reperfusion injury (IR..

Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart

Darnel Prakoso, Shiang Y Lim, Jeffrey R Erickson, Rachel S Wallace, Jarmon G Lees, Mitchel Tate, Helen Kiriazis, Daniel G Donner, Darren C Henstridge, Jonathan R Davey, Hongwei Qian, Minh Deo, Laura J Parry, Amy J Davidoff, Paul Gregorevic, John C Chatham, Miles J De Blasio, Rebecca H Ritchie

Journal article  |  2022  |  CARDIOVASCULAR RESEARCH

AIMS: The glucose-driven enzymatic modification of myocardial proteins by the sugar moiety, β-N-acetylglucosamine (O-GlcNAc), is i..