Alexandra Harvey

A microenvironment of high lactate and low pH created by the blastocyst promotes endometrial receptivity and implantation.

Kathryn H Gurner, Jemma Evans, Jennifer C Hutchison, Alexandra J Harvey, David K Gardner

Journal article  |  2021  |  Reprod Biomed Online

RESEARCH QUESTION: Is the blastocyst's idiosyncratic metabolic production of lactate, and creation of a specialized microenvironme..

Neural differentiation medium for human pluripotent stem cells to model physiological glucose levels in human brain

Michal E Mor, Alexandra Harvey, Mary Familari, Mitchell St Clair-Glover, Serena Viventi, Robb U de Iongh, Fergus J Cameron, Mirella Dottori

Journal article  |  2021  |  BRAIN RESEARCH BULLETIN

Cortical neurospheres (NSPs) derived from human pluripotent stem cells (hPSC), have proven to be a successful platform to investig..

A pilot study investigating a novel particle-based growth factor delivery system for preimplantation embryo culture

Kathryn H Gurner, Joseph J Richardson, Alexandra J Harvey, David K Gardner

Journal article  |  2021  |  Human Reproduction

STUDY QUESTION: Can vascular endothelial growth factor (VEGF)-loaded silica supraparticles (V-SPs) be used as a novel mode of deli..

Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period

Mark P Green, Alexandra J Harvey, Bethany J Finger, Gerard A Tarulli

Journal article  |  2021  |  ENVIRONMENTAL RESEARCH

It is becoming increasingly difficult to avoid exposure to man-made endocrine disrupting chemicals (EDCs) and environmental toxica..

A combination of growth factors and cytokines alter preimplantation mouse embryo development, foetal development and gene expression profiles

Kathryn H Gurner, Thi T Truong, Alexandra J Harvey, David K Gardner

Journal article  |  2020  |  Molecular Human Reproduction

Within the maternal tract, the preimplantation embryo is exposed to an array of growth factors (GFs) and cytokines, most of which ..

Identification and Characterisation of cis-Regulatory Elements Upstream of the Human Receptor Tyrosine Kinase Gene MERTK

Alexander D Walsh, Laura J Johnson, Alexandra J Harvey, Trevor J Kilpatrick, Michele D Binder

Journal article  |  2020  |  Brain Plasticity

MERTK encodes a receptor tyrosine kinase that regulates immune homeostasis via phagocytosis of apoptotic cells and cytokine-mediat..

Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2020  |  STEM CELLS

Nicotinamide adenine dinucleotide (NAD+ ) and its precursor metabolites are emerging as important regulators of both cell metaboli..

Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance.

Alexandra Harvey, Giuseppina Caretti, Viviana Moresi, Alessandra Renzini, Sergio Adamo

Journal article  |  2019  |  Stem Cell Reports

The environment surrounding stem cells has the ability to elicit profound, heritable epigenetic changes orchestrated by multiple e..

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim

Journal article  |  2019  |  STEM CELLS INTERNATIONAL

Human induced pluripotent stem cells (iPSCs) can be differentiated in vitro into bona fide cardiomyocytes for disease modelling an..

Acute in vitro exposure to environmentally relevant atrazine levels perturbs bovine preimplantation embryo metabolism and cell number

Ashleigh J Henderson, Bethany J Finger, Alexander W Scott, Alexandra J Harvey, Mark P Green

Journal article  |  2019  |  REPRODUCTIVE TOXICOLOGY

Atrazine is a widely used herbicide known to negatively alter endocrine systems and perturb metabolism. Preimplantation exposure t..