Alexandra Harvey

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim

Journal article  |  2019  |  Stem Cells International

Metabolomic and Transcriptional Analyses Reveal Atmospheric Oxygen During Human Induced Pluripotent Stem Cell Generation Impairs Metabolic Reprogramming

James Spyrou, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  STEM CELLS

The transition to pluripotency invokes profound metabolic restructuring; however, reprogramming is accompanied by the retention of..

Metabolic Control of Stemness and Differentiation.

Viviana Moresi, Athanassia Sotiropoulos, Giuseppina Caretti, Alexandra Harvey

Journal article  |  2019  |  Stem Cells International

Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming

James Spyrou, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  Stem Cells International

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

Jarmon G Lees, Timothy S Cliff, Amanda Gammilonghi, James G Ryall, Stephen Dalton, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  Stem Cells International

Mitochondrial and glycolytic remodeling during nascent neural differentiation of human pluripotent stem cells

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2018  |  Development

Physiological oxygen culture reveals retention of metabolic memory in human induced pluripotent stem cells

Alexandra J Harvey, Carmel O'Brien, Jack Lambshead, John R Sheedy, Joy Rathjen, Andrew L Laslett, David K Gardner

Journal article  |  2018  |  PLOS ONE

Environmental factors to consider prior to conception

MP Green, AJ Harvey

Book Chapter  |  2018

Lactate availability affects preimplantation mouse embryo acetylation and viability.

Emma G Whatley, A Harvey, David K Gardner

Conference Proceedings  |  2018

Mitochondrial and glycolytic metabolism decreases during neural differentiation of human embryonic stem cells.

Jarmon G Lees, David Gardner, A Harvey

Conference Proceedings  |  2018

Transcriptomic and metabolic analyses reveal reprogramming conditions impact the human iPSC response to oxygen and identify retention of somatic cell metabolic memory.

James Spyrou, David Gardner, A Harvey

Conference Proceedings  |  2018

Oxygen and acetyl-CoA modulate blastocyst H3K9 and H3K27 acetylation.

Hannah M Burn, A Harvey, David Gardner

Conference Proceedings  |  2018

Interrogating the mechanisms underlying cognitive impairments in type 1 diabetes using human embryonic stem cells.

Michal Mor, Fergus Cameron, Mary Familari, Gurscharan Chana, A Harvey, Mirella Dottori

Conference Proceedings  |  2018

Physiological oxygen facilitates the acquisition of a more Embryonic Stem Cell-like metabolic response in human induced Pluripotent Stem Cells.

A Harvey, James Spyrou, David K Gardner

Conference Proceedings  |  2018

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2017  |  Stem Cells International

Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters

Boon Siang Nicholas Tan, Peter D Rathjen, Alexandra J Harvey, David K Gardner, Joy Rathjen

Journal article  |  2016  |  Mechanisms of Development

Bisphenol A affects early bovine embryo development and metabolism that is negated by an oestrogen receptor inhibitor

Bom-Ie Choi, Alexandra J Harvey, Mark P Green

Journal article  |  2016  |  Scientific Reports

Metaboloepigenetic Regulation of Pluripotent Stem Cells

Alexandra J Harvey, Joy Rathjen, David K Gardner

Journal article  |  2016  |  Stem Cells International

Malate-aspartate shuttle regulation and pluripotency in human embryonic stem cells.

Riley McMahon, A Harvey, David Gardner

Conference Proceedings  |  2016

Acute exposure to environmental concentrations of the endocrine disruptor atrazine affects preimplantation bovine embryo total cell count but not development or quality.

Ashleigh Henderson, Bethany Finger, A Harvey, Mark Green

Conference Proceedings  |  2016

The effects of 2,4-dinitrophenol and d-glucose concentration on the development, sex ratio, and interferon-tau (IFNT) production of bovine blastocysts

Mark P Green, Alexandra J Harvey, Lee D Spate, Koji Kimura, Jeremy G Thompson, R Michael Roberts

Journal article  |  2016  |  Molecular Reproduction and Development

Oxygen modulates human embryonic stem cell metabolism in the absence of changes in self-renewal

Alexandra J Harvey, Joy Rathjen, Lijia Jackie Yu, David K Gardner

Journal article  |  2016  |  Reproduction, Fertility and Development

Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen

Jarmon G Lees, Joy Rathjen, John R Sheedy, David K Gardner, Alexandra J Harvey

Journal article  |  2015  |  REPRODUCTION

Combined parental obesity negatively impacts preimplantation mouse embryo development, kinetics, morphology and metabolism

Bethany J Finger, Alexandra J Harvey, Mark P Green, David K Gardner

Journal article  |  2015  |  Human Reproduction

Fathers That Are Born Small Program Alterations in the Next-Generation Preimplantation Rat Embryos

Jordanna S Master, George A Thouas, Alexandra J Harvey, John R Sheedy, Natalie J Hannan, David K Gardner, Mary E Wlodek

Journal article  |  2015  |  The Journal of Nutrition

Low female birth weight and advanced maternal age programme alterations in next-generation blastocyst development

Jordanna S Master, George A Thouas, Alexandra J Harvey, John R Sheedy, Natalie J Hannan, David K Gardner, Mary E Wlodek

Journal article  |  2015  |  REPRODUCTION

Cellular outcomes of regulating malate-aspartate shuttle in human embryonic stem cells

Riley McMahon, A Harvey, David Gardner

Conference Proceedings  |  2015

Mesendoderm differentiation is delayed in metabolically aberrant human ES cells.

Jarmon Lees, Joy RATHJEN, John SHEEDY, David Gardner, A Harvey

Conference Proceedings  |  2015

Blastocyst metabolism

David K Gardner, Alexandra J Harvey

Journal article  |  2015  |  Reproduction, Fertility and Development

Distinct metabolic profiles identify metabolic dysfunction in human pluripotent stem cells.

A Harvey, Carmel O'Brien, Jarmon Lees, Joy RATHJEN, Jack Lambshead, John SHEEDY, Andrew Laslett, David Gardner

Conference Proceedings  |  2014

Nutrient utilization distinguishes between human embryonic stem cell lines.

Jarmon Lees, Joy RATHJEN, John SHEEDY, David Gardner, A Harvey

Conference Proceedings  |  2014

Brief exposure to physiological concentrations of Bisphenol A (BPA) affects early embryo metabolism and quality

Bom Ie Choi, A Harvey, Mark Green

Conference Proceedings  |  2014

Combined parental obesity negatively affects mouse preimplantation embryo kinetics and quality.

Bethany Finger, A Harvey, Mark Green, David Gardner

Conference Proceedings  |  2014

Combined parental obesity negatively affects mouse preimplantation embryo kinetics and quality

Bethany Finger, A Harvey, Mark Green, David Gardner

Conference Proceedings  |  2014

Distinct metabolic profiles identify metabolic dysfunction in human pluripotent stem cells.

A Harvey, Carmel O'Brien, Jarmon Lees, Joy RATHJEN, Jack Lambshead, John SHEEDY, Andrew Laslett, David Gardner

Conference Proceedings  |  2014

Regulation of human embryonic stem cell metabolism by oxygen.

A Harvey, Jarmon Lees, Joy RATHJEN, Lijia Yu, John SHEEDY, David Gardner

Conference Proceedings  |  2013

The metabolic framework of pluripotent stem cells and potential mechanisms of regulation

Alexandra J Harvey, Joy Rathjen, David K Gardner

Book Chapter  |  2013

Oxygen regulates human embryonic stem cell mitochondrial biogenesis

Jarmon Lees, David Gardner, A Harvey

Conference Proceedings  |  2013

Activation of AMPK regulates mouse embryo development and glucose metabolism.

A Harvey, Natalie K Binder, David Gardner

Conference Proceedings  |  2013

Transcriptional Differences between Rhesus Embryonic Stem Cells Generated from In Vitro and In Vivo Derived Embryos

Alexandra J Harvey, Shihong Mao, Claudia Lalancette, Stephen A Krawetz, Carol A Brenner

Journal article  |  2012  |  PLoS ONE

Expression profiles of cohesins, shugoshins and spindle assembly checkpoint genes in rhesus macaque oocytes predict their susceptibility for aneuploidy during embryonic development

Catherine Dupont, Alexandra J Harvey, D Randall Armant, Mary B Zelinski, Carol A Brenner

Journal article  |  2012  |  Cell Cycle

Dynamic regulation of mitochondrial function in preimplantation embryos and embryonic stem cells

Alexandra Harvey, Tiffini Gibson, Thomas Lonergan, Carol Brenner

Journal article  |  2011  |  Mitochondrion

Long-distance transportation of primate embryos developing in culture: a preliminary study

Stephanie Nichols, Alexandra Harvey, Lynette Gierbolini, Janis Gonzalez-Martinez, Carol Brenner, Barry Bavister

Journal article  |  2010  |  Reproductive BioMedicine Online

Inner Cell Mass Localization of NANOG Precedes OCT3/4 in Rhesus Monkey Blastocysts

AJ Harvey, DR Armant, BD Bavister, SM Nichols, CA Brenner

Journal article  |  2009  |  Stem Cells and Development

Inner cell mass localization of Nanog precedes Oct3/4 in rhesus monkey blastocysts

AJ Harvey, undefined Armant, undefined Nichols, undefined Bavister, undefined Brenner

Journal article  |  2009  |  Stem Cells and Development

Molecular control of mitochondrial function in developing rhesus monkey oocytes and preimplantation-stage embryos

NR Mtango, AJ Harvey, KE Latham, CA Brenner

Journal article  |  2008  |  Reproduction, Fertility and Development

Active mitochondria are present in mouse and monkey embryonic stem cell lines

undefined Lonergan, AJ Harvey, undefined Zhao, undefined Bavister, undefined Brenner

Conference Proceedings  |  2008  |  Reproduction, Fertility and Development

Regulation of gene expression in bovine Blastocysts in response to oxygen and the iron chelator desferrioxamine

AJ Harvey, KL Kind, JG Thompson

Journal article  |  2007  |  Biology of Reproduction

The role of oxygen in ruminant preimplantation embryo development and metabolism

AJ Harvey

Journal article  |  2007  |  Animal Reproduction Science

Differential expression of oxygen-regulated genes in bovine blastocysts

AJ Harvey, A Navarrete Santos, M Kirstein, KL Kind, B Fischer, JG Thompson

Journal article  |  2007  |  Molecular Reproduction and Development

Impact of assisted reproductive technologies: A mitochondrial perspective of cytoplasmic transplantation

AJ Harvey, TC Gibson, TM Quebedeaux, CA Brenner

Journal article  |  2007  |  Current Topics in Developmental Biology

Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst

KL Kind, RA Collett, AJ Harvey, JG Thompson

Journal article  |  2005  |  Molecular Reproduction and Development

Typical HIF1-regulated genes are unaltered by oxygen in bovine blastocysts

AJ Harvey, undefined Kind, undefined Thompson

Conference Proceedings  |  2005  |  Reproduction, Fertility and Development

Oxygen-regulated gene expression in bovine blastocysts

AJ Harvey, KL Kind, M Pantaleon, DT Armstrong, JG Thompson

Journal article  |  2004  |  Biology of Reproduction

Effect of the oxidative phosphorylation uncoupler 2,4-dinitrophenol on hypoxia-inducible factor-regulated gene expression in bovine blastocysts

AJ Harvey, KL Kind, JG Thompson

Journal article  |  2004  |  Reproduction Fertility and Development

REDOX regulation of early embryo development

AJ Harvey, KL Kind, JG Thompson

Journal article  |  2002  |  Reproduction