Alexandra Harvey

Acetoacetate and ?-hydroxybutyrate reduce mouse embryo viability via differential metabolic and epigenetic mechanisms

Emma G Whatley, Thi T Truong, Alexandra J Harvey, David K Gardner

Journal article  |  2023  |  REPRODUCTIVE BIOMEDICINE ONLINE

RESEARCH QUESTION: Does the ketone acetoacetate (AcAc) alone, or combined with β-hydroxybutyrate (βOHB), impact mouse embryo devel..

The Blastocyst Creates a Specialized Microenvironment to Promote Endometrial Receptivity and Implantation

Kathryn GURNER, Jemma EVANS, Alexandra J HARVEY, David K GARDNER

Journal article  |  2022  |  Fertility & Reproduction

Background: At the time of implantation, the blastocyst produces a significant amount of lactic acid (LA), creating a microenviron..

Short-Term Exposure with Long-Term Effects: The Ketone Body, Beta-Hydroxybutyrate, Alters Mouse Embryo Developmental Programming and Reduces Viability

Emma G WHATLEY, Alexandra J HARVEY, David K GARDNER

Journal article  |  2022  |  Fertility & Reproduction

Background: Diet-induced nutritional changes in the maternal reproductive tract stimulate embryonic adaptations to maintain growth..

beta-hydroxybutyrate reduces blastocyst viability via trophectoderm-mediated metabolic aberrations in mice

Emma G Whatley, Thi T Truong, Dagmar Wilhelm, Alexandra J Harvey, David K Gardner

Journal article  |  2022  |  HUMAN REPRODUCTION

STUDY QUESTION: What is the effect of the ketone β-hydroxybutyrate (βOHB) on preimplantation mouse embryo development, metabolism,..

Antioxidant supplementation of mouse embryo culture or vitrification media support more in-vivo-like gene expression post-transfer

Thi Truong, Alexandra J Harvey, David K Gardner

Journal article  |  2022  |  REPRODUCTIVE BIOMEDICINE ONLINE

RESEARCH QUESTION: What is the effect on mouse fetal gene expression of combined antioxidants (acetyl-L-carnitine, N-acetyl-L-cyst..

A microenvironment of high lactate and low pH created by the blastocyst promotes endometrial receptivity and implantation

Kathryn H Gurner, Jemma Evans, Jennifer C Hutchison, Alexandra J Harvey, David K Gardner

Journal article  |  2022  |  REPRODUCTIVE BIOMEDICINE ONLINE

RESEARCH QUESTION: Is the blastocyst's idiosyncratic metabolic production of lactate, and creation of a specialized microenvironme..

A pilot study investigating a novel particle-based growth factor delivery system for preimplantation embryo culture

Kathryn H Gurner, Joseph J Richardson, Alexandra J Harvey, David K Gardner

Journal article  |  2021  |  Human Reproduction

STUDY QUESTION: Can vascular endothelial growth factor (VEGF)-loaded silica supraparticles (V-SPs) be used as a novel mode of deli..

Neural differentiation medium for human pluripotent stem cells to model physiological glucose levels in human brain

Michal E Mor, Alexandra Harvey, Mary Familari, Mitchell St Clair-Glover, Serena Viventi, Robb U de Iongh, Fergus J Cameron, Mirella Dottori

Journal article  |  2021  |  BRAIN RESEARCH BULLETIN

Cortical neurospheres (NSPs) derived from human pluripotent stem cells (hPSC), have proven to be a successful platform to investig..

Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period

Mark P Green, Alexandra J Harvey, Bethany J Finger, Gerard A Tarulli

Journal article  |  2021  |  ENVIRONMENTAL RESEARCH

It is becoming increasingly difficult to avoid exposure to man-made endocrine disrupting chemicals (EDCs) and environmental toxica..

A combination of growth factors and cytokines alter preimplantation mouse embryo development, foetal development and gene expression profiles

Kathryn H Gurner, Thi T Truong, Alexandra J Harvey, David K Gardner

Journal article  |  2020  |  Molecular Human Reproduction

Within the maternal tract, the preimplantation embryo is exposed to an array of growth factors (GFs) and cytokines, most of which ..