Alexandra Harvey

Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2020  |  Stem Cells

Nicotinamide adenine dinucleotide (NAD+ ) and its precursor metabolites are emerging as important regulators of both cell metaboli..

Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance.

Alexandra Harvey, Giuseppina Caretti, Viviana Moresi, Alessandra Renzini, Sergio Adamo

Journal article  |  2019  |  Stem Cell Reports

The environment surrounding stem cells has the ability to elicit profound, heritable epigenetic changes orchestrated by multiple e..

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim

Journal article  |  2019  |  Stem Cells International

Acute in vitro exposure to environmentally relevant atrazine levels perturbs bovine preimplantation embryo metabolism and cell number

Ashleigh J Henderson, Bethany J Finger, Alexander W Scott, Alexandra J Harvey, Mark P Green

Journal article  |  2019  |  Reproductive Toxicology

Atrazine is a widely used herbicide known to negatively alter endocrine systems and perturb metabolism. Preimplantation exposure t..

Metabolomic and Transcriptional Analyses Reveal Atmospheric Oxygen During Human Induced Pluripotent Stem Cell Generation Impairs Metabolic Reprogramming

James Spyrou, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  Stem Cells

The transition to pluripotency invokes profound metabolic restructuring; however, reprogramming is accompanied by the retention of..

Mitochondria in early development: linking the microenvironment, metabolism and the epigenome

Alexandra J Harvey

Journal article  |  2019  |  Reproduction

Metabolic Control of Stemness and Differentiation.

Viviana Moresi, Athanassia Sotiropoulos, Giuseppina Caretti, Alexandra Harvey

Journal article  |  2019  |  Stem Cells International

Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming

James Spyrou, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  Stem Cells International

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

Jarmon G Lees, Timothy S Cliff, Amanda Gammilonghi, James G Ryall, Stephen Dalton, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  Stem Cells International

Mitochondrial and glycolytic remodeling during nascent neural differentiation of human pluripotent stem cells

Jarmon G Lees, David K Gardner, Alexandra J Harvey

Journal article  |  2018  |  Development