Nick Wilson

G-CSFR antagonism reduces neutrophilic inflammation during pneumococcal and influenza respiratory infections without compromising clearance.

Hao Wang, Christian Aloe, Nick Wilson, Steven Bozinovski

Journal article  |  2019  |  Scientific Reports

Excessive neutrophilic inflammation can contribute to the pathogenesis of pneumonia. Whilst anti-inflammatory therapies such as co..

Anti-βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model.

Kwok Ho Yip, Nicholas J Wilson, Harshita Pant, Christopher L Brown, Samantha Busfield, Milica Ng, Monther Alhamdoosh, Naomi Woodman, Mark Schembri, Damon J Tumes, Gino Vairo, Angel F Lopez, Andrew D Nash, Michael J Wilson, Michele A Grimbaldeston, Catherine M Owczarek

Journal article  |  2019  |  Allergy

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  Nucleic Acids Research

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Shereen Oon, Katherine Monaghan, Milica Ng, Alberta Hoi, Eric Morand, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2019  |  Clinical & Translational Immunology

Objectives: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are majo..

Machine learning applied to whole-blood RNA-sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus

William A Figgett, Katherine Monaghan, Milica Ng, Monther Alhamdoosh, Eugene Maraskovsky, Nicholas J Wilson, Alberta Y Hoi, Eric F Morand, Fabienne Mackay

Journal article  |  2019  |  Clinical & Translational Immunology

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  Cold Spring Harbor Perspectives in Biology

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  Nature Communications

A neutralizing anti-G-CSFR antibody blocks G-CSF-induced neutrophilia without inducing neutropenia in nonhuman primates.

Karen Scalzo-Inguanti, Katherine Monaghan, Kirsten Edwards, Eva Herzog, Danijela Mirosa, Matthew Hardy, Vicki Sorto, Huy Huynh, Steven Rakar, Daria Kurtov, Hal Braley, Nick Wilson, Samantha Busfield, Andrew Nash, Arna Andrews

Journal article  |  2017  |  Journal of Leukocyte Biology

Neutrophils are the most abundant WBCs and have an essential role in the clearance of pathogens. Tight regulation of neutrophil nu..

Combining multiple tools outperforms individual methods in gene set enrichment analyses

Monther Alhamdoosh, Milica Ng, Nicholas J Wilson, Julie M Sheridan, Huy Huynh, Michael J Wilson, Matthew E Ritchie

Journal article  |  2017  |  Bioinformatics

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Gabrielle L Goldberg, Nicholas J Wilson, Karen Scalzo-Inguanti, Charley Mackenzie-Kludas, Kate E Lawlor, Ian P Wicks, Lorena E Brown, Adriana Baz Morelli, Con Panousis, Michael J Wilson, Andrew D Nash, Brent S McKenzie, Arna E Andrews

Journal article  |  2016  |  The Journal of Immunology

A cytotoxic anti-IL-3R alpha antibody targets key cells and cytokines implicated in systemic lupus erythematosus

Shereen Oon, Huy Huynh, Tsin Yee Tai, Milica Ng, Katherine Monaghan, Mark Biondo, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2016  |  JCI Insight

Targeted therapeutics in SLE: emerging strategies to modulate the interferon pathway

Shereen Oon, Nicholas J Wilson, Ian Wicks

Journal article  |  2016  |  Clinical & Translational Immunology

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors

Con Panousis, Urmi Dhagat, Kirsten M Edwards, Veronika Rayzman, Matthew P Hardy, Hal Braley, Gail M Gauvreau, Timothy R Hercus, Steven Smith, Roma Sehmi, Laura McMillan, Mara Dottore, Barbara J McClure, Louis J Fabri, Gino Vairo, Angel F Lopez, Michael W Parker, Andrew D Nash, Nicholas J Wilson, Michael J Wilson, et al.

Journal article  |  2016  |  mAbs

Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Timothy R Hercus, Sophie E Broughton, Matthew P Hardy, Tracy L Nero, Nicholas J Wilson, Michael W Parker, Angel F Lopez

Journal article  |  2014  |  Molecular & Cellular Oncology

CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subun..

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Sophie E Broughton, Timothy R Hercus, Matthew P Hardy, Barbara J McClure, Tracy L Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F Barry, Winnie L Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J Busfield, Catherine M Owczarek, Andrew D Nash, Nicholas J Wilson, Michael W Parker, Angel F Lopez

Journal article  |  2014  |  Cell Reports

Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays.

Kirsten M Edwards, Huy Huynh, Ranjeeta Prasad, Anne McDonald, Matthew P Hardy, Pierre Scotney, Catherine M Owczarek, Samantha J Busfield, Con Panousis, Nicholas J Wilson

Journal article  |  2014  |  Journal of Immunological Methods

Interleukin-13 (IL-13) is a cytokine implicated in airway diseases such as asthma and idiopathic pulmonary fibrosis. IL-13 signals..

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Urmi Dhagat, Catherine M Owczarek, Matthew P Hardy, Louis J Fabri, Pierre D Scotney, Andrew D Nash, Nicholas J Wilson, Angel F Lopez, Michael W Parker

Journal article  |  2014  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

The critical role of the colony-stimulating factor-1 receptor in the differentiation of myeloblastic leukemia cells

John A Hamilton, Genevieve Whitty, Paul Masendycz, Nicholas J Wilson, Jacob Jackson, Dominic De Nardo, Glen M Scholz

Journal article  |  2008  |  Molecular Cancer Research

Development, cytokine profile and function of human interleukin 17-producing helper T cells.

Nicholas J Wilson, Katia Boniface, Jason R Chan, Brent S McKenzie, Wendy M Blumenschein, Jeanine D Mattson, Beth Basham, Kathleen Smith, Taiying Chen, Franck Morel, Jean-Claude Lecron, Robert A Kastelein, Daniel J Cua, Terrill K McClanahan, Edward P Bowman, Rene de Waal Malefyt

Journal article  |  2007  |  Nature Immunology

T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitm..

cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation

NJ Wilson, M Cross, T Nguyen, JA Hamilton

Journal article  |  2005  |  The FEBS Journal

IL-12 and IL-23: master regulators of innate and adaptive immunity.

Claire L Langrish, Brent S McKenzie, Nicholas J Wilson, Rene de Waal Malefyt, Robert A Kastelein, Daniel J Cua

Journal article  |  2004  |  Immunological Reviews

Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in th..

A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling

M Cross, XF Csar, NJ Wilson, G Manes, TA Addona, DC Marks, GA Whitty, K Ashman, JA Hamilton

Journal article  |  2004  |  Biochemical Journal

Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity

KA McMahon, NJ Wilson, DC Marks, TL Beecroft, GA Whitty, JA Hamilton, XF Csar

Journal article  |  2001  |  Biochemical Journal

Proteomic analysis of macrophage differentiation - p46/52(Shc) tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation

XF Csar, NJ Wilson, KA McMahon, DC Marks, TL Beecroft, AC Ward, GA Whitty, V Kanangasundarum, JA Hamilton

Journal article  |  2001  |  Journal of Biological Chemistry

Copper/zinc superoxide dismutase is phosphorylated and modulated specifically by granulocyte-colony stimulating factor in myeloid cells

XF Csar, NJ Wilson, P Strike, L Sparrow, KA McMahon, AC Ward, JA Hamilton

Journal article  |  2001  |  Proteomics

Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells

KL Rickard, PR Gibson, NJ Wilson, JM Mariadason, WA Phillips

Journal article  |  2000  |  Journal of Cellular Physiology

Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal

A Jaworowski, NJ Wilson, E Christy, R Byrne, JA Hamilton

Journal article  |  1999  |  Journal of Biological Chemistry

Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation.

DC Marks, XF Csar, NJ Wilson, U Novak, AC Ward, V Kanagasundarum, BW Hoffmann, JA Hamilton

Journal article  |  1999  |  Molecular Cell Biology Research Communications

We have established two M1 myeloid cell lines, M1/WT cells overexpressing the wild-type CSF-1 receptor and M1/Y559F cells expressi..

Protein phosphatase 2A is expressed in response to colony-stimulating factor 1 in macrophages and is required for cell cycle progression independently of extracellular signal-regulated protein kinase activity

NJ Wilson, ST Moss, XF Csar, AC Ward, JA Hamilton

Journal article  |  1999  |  Biochemical Journal

cAMP enhances CSF-1-induced ERK activity and c-fos mRNA expression via a MEK-dependent and Ras-independent mechanism in macrophages

NJ Wilson, A Jaworowski, AC Ward, JA Hamilton

Journal article  |  1998  |  Biochemical and Biophysical Research Communications

Relationship of the antihypertensive effect of vasopressin withdrawal to sodium excretion in the Doca-salt hypertensive rat.

H Wang, N Wilson, JR McNeill

Journal article  |  1993  |  Clinical and Investigative Medicine

Arterial pressure, sodium excretion, urine output, and plasma atrial natriuretic peptide (ANP) concentrations were measured before..