Nick Wilson

Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways

Asres Berhan, Trudi Harris, Jade Jaffar, Fernando Jativa, Shenna Langenbach, Ingrid Loennstedt, Monther Alhamdoosh, Milica Ng, Peter Lee, Glen Westall, Nick Wilson, Michael Wilson, Alastair G Stewart

Journal article  |  2020  |  American Journal of Respiratory Cell and Molecular Biology

Pathological changes in the biomechanical environment are implicated in the progression of idiopathic pulmonary fibrosis (IPF). St..

Novel Therapies for Pneumonia-Associated Severe Asthma Phenotypes

Angelica Papanicolaou, Hao Wang, Catherine Satzke, Ross Vlahos, Nick Wilson, Steven Bozinovski

Journal article  |  2020  |  Trends in Molecular Medicine

Distinct asthma phenotypes are emerging from well-defined cohort studies and appear to be associated with a history of pneumonia. ..

Anti-βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model.

Kwok Ho Yip, Nicholas J Wilson, Harshita Pant, Christopher L Brown, Samantha Busfield, Milica Ng, Monther Alhamdoosh, Naomi Woodman, Mark Schembri, Damon J Tumes, Gino Vairo, Angel F Lopez, Andrew D Nash, Michael J Wilson, Michele A Grimbaldeston, Catherine M Owczarek

Journal article  |  2020  |  Allergy

G-CSFR antagonism reduces neutrophilic inflammation during pneumococcal and influenza respiratory infections without compromising clearance.

Hao Wang, Christian Aloe, Nick Wilson, Steven Bozinovski

Journal article  |  2019  |  Scientific Reports

Excessive neutrophilic inflammation can contribute to the pathogenesis of pneumonia. Whilst anti-inflammatory therapies such as co..

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  NUCLEIC ACIDS RESEARCH

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Shereen Oon, Katherine Monaghan, Milica Ng, Alberta Hoi, Eric Morand, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2019  |  Clinical and Translational Immunology

Objectives: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are majo..

Machine learning applied to whole-blood RNA-sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus

William A Figgett, Katherine Monaghan, Milica Ng, Monther Alhamdoosh, Eugene Maraskovsky, Nicholas J Wilson, Alberta Y Hoi, Eric F Morand, Fabienne Mackay

Journal article  |  2019  |  Clinical and Translational Immunology

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  Cold Spring Harbor Perspectives in Biology

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  NATURE COMMUNICATIONS

A neutralizing anti-G-CSFR antibody blocks G-CSF-induced neutrophilia without inducing neutropenia in nonhuman primates.

Karen Scalzo-Inguanti, Katherine Monaghan, Kirsten Edwards, Eva Herzog, Danijela Mirosa, Matthew Hardy, Vicki Sorto, Huy Huynh, Steven Rakar, Daria Kurtov, Hal Braley, Nick Wilson, Samantha Busfield, Andrew Nash, Arna Andrews

Journal article  |  2017  |  Journal of Leukocyte Biology

Neutrophils are the most abundant WBCs and have an essential role in the clearance of pathogens. Tight regulation of neutrophil nu..