Stuart Mannering

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

James G Bedford, Melanie Heinlein, Alexandra L Garnham, Thi HO Nguyen, Tom Loudovaris, Chenghao Ge, Stuart Mannering, Michael Elliott, Stuart G Tangye, Katherine Kedzierska, Daniel HD Gray, William R Heath, Linda M Wakim

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

The nasal-associated lymphoid tissues (NALTs) are mucosal-associated lymphoid organs embedded in the submucosa of the nasal passag..

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8( )T cells

Sneha Sant, Sergio M Quinones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2020  |  PLOS PATHOGENS

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell ..

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes

Kriti Joshi, Colleen Elso, Ali Motazedian, Tanya Labonne, Jacqueline V Schiesser, Fergus Cameron, Stuart I Mannering, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2019  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. ..

Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer capable of activating or repressing gene transcription i..

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  NATURE IMMUNOLOGY

Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the m..

Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes.

Stuart I Mannering, Anthony R Di Carluccio, Colleen M Elso

Journal article  |  2019  |  Diabetologia

Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of pancreatic insulin-producing beta cells. The epi..

Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

BACKGROUND: Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in dis..

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Colleen M Elso, Nicholas A Scott, Lina Mariana, Emma I Masterman, Andrew PR Sutherland, Helen E Thomas, Stuart I Mannering

Journal article  |  2019  |  PLoS One

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-o..

IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4( ) T Cell Migration

Nicholas A Scott, Yuxing Zhao, Balasubramanian Krishnamurthy, Stuart I Mannering, Thomas WH Kay, Helen E Thomas

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Diabetogenic T cells infiltrate the pancreatic islets by transmigrating across the microcapillaries residing close to, or within, ..