Stuart Mannering

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8( )T cells

Sneha Sant, Sergio M Quinones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2020  |  PLOS Pathogens

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell ..

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes

Kriti Joshi, Colleen Elso, Ali Motazedian, Tanya Labonne, Jacqueline V Schiesser, Fergus Cameron, Stuart I Mannering, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2019  |  Diabetologia

AIMS/HYPOTHESIS: Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. ..

Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

Journal article  |  2019  |  Immunology & Cell Biology

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  Nature Immunology

Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes.

Stuart I Mannering, Anthony R Di Carluccio, Colleen M Elso

Journal article  |  2019  |  Diabetologia

Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of pancreatic insulin-producing beta cells. The epi..

Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska

Journal article  |  2019  |  Clinical & Translational Immunology

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Colleen M Elso, Nicholas A Scott, Lina Mariana, Emma I Masterman, Andrew PR Sutherland, Helen E Thomas, Stuart I Mannering

Journal article  |  2019  |  PLOS ONE

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-o..

IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4( ) T Cell Migration

Nicholas A Scott, Yuxing Zhao, Balasubramanian Krishnamurthy, Stuart I Mannering, Thomas WH Kay, Helen E Thomas

Journal article  |  2018  |  Frontiers in Immunology

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

Michelle So, Colleen M Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M Wentworth, Leonard C Harrison, Balasubramanian Krishnamurthy, Helen E Thomas, Christine Rodda, Fergus J Cameron, Jacinta McMahon, Thomas WH Kay, Stuart I Mannering

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Single-Cell Approach to Influenza Specific CD8( ) T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

Sneha Sant, Ludiyine Grzelak, Zhongfang Wang, Angela Pizzollal, Manbs Koutsakos, Jane Crowe, Thomas Loudoyaris, Stuart I Mannering, Glen P Westall, Linda M Wakiml, Jamie Rossjohn, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G Thomas, Liyen Loh, Thi H Nguyen, Katherine Kedzierska

Journal article  |  2018  |  Frontiers in Immunology

Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nussing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi HO Nguyen, et al.

Journal article  |  2018  |  SCIENCE TRANSLATIONAL MEDICINE

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

Angela Pizzolla, Thi HO Nguyen, Sneha Sant, Jade Jaffar, Tom Loudovaris, Stuart I Mannering, Paul G Thomas, Glen P Westall, Katherine Kedzierska, Linda M Wakim

Journal article  |  2018  |  Journal of Clinical Investigation

Shuffling peptides to create T-cell epitopes: does the immune system play cards?

Stuart I Mannering, Michelle So, Colleen M Elso, Thomas WH Kay

Journal article  |  2018  |  Immunology and Cell Biology

Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime".

Sally C Kent, Stuart I Mannering, Aaron W Michels, Jenny Aurielle B Babon

Journal article  |  2017  |  Current Diabetes Reports

PURPOSE OF REVIEW: Autoimmune-mediated destruction of insulin-producing β-cells within the pancreas results in type 1 diabetes (T1..

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  Diabetes

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.

Thomas Delong, Timothy A Wiles, Rocky L Baker, Brenda Bradley, Gene Barbour, Richard Reisdorph, Michael Armstrong, Roger L Powell, Nichole Reisdorph, Nitesh Kumar, Colleen M Elso, Megan DeNicola, Rita Bottino, Alvin C Powers, David M Harlan, Sally C Kent, Stuart I Mannering, Kathryn Haskins

Journal article  |  2016  |  Science

T cell-mediated destruction of insulin-producing β cells in the pancreas causes type 1 diabetes (T1D). CD4 T cell responses play a..

The case for an autoimmune aetiology of type 1 diabetes

SI Mannering, V Pathiraja, TWH Kay

Journal article  |  2016  |  Clinical & Experimental Immunology

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Misty R Jenkins, Jesse A Rudd-Schmidt, Jamie A Lopez, Kelly M Ramsbottom, Stuart I Mannering, Daniel M Andrews, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2015  |  JOURNAL OF EXPERIMENTAL MEDICINE

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4( ) T Cells Infiltrate Islets in Type 1 Diabetes

Vimukthi Pathiraja, Janine P Kuehlich, Peter D Campbell, Balasubramanian Krishnamurthy, Thomas Loudovaris, P Toby H Coates, Thomas C Brodnicki, Philip J O'Connell, Katherine Kedzierska, Christine Rodda, Philip Bergman, Erin Hill, Anthony W Purcell, Nadine L Dudek, Helen E Thomas, Thomas WH Kay, Stuart I Mannering

Journal article  |  2015  |  Diabetes

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

Jamie A Lopez, Misty R Jenkins, Jesse A Rudd-Schmidt, Amelia J Brennan, Jillian C Danne, Stuart I Mannering, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2013  |  JOURNAL OF IMMUNOLOGY

Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease

Sophie E Broughton, Jan Petersen, Alex Theodossis, Stephen W Scally, Khai Lee Loh, Allan Thompson, Jeroen van Bergen, Yvonne Kooy-Winkelaar, Kate N Henderson, Travis Beddoe, Jason A Tye-Din, Stuart I Mannering, Anthony W Purcell, James McCluskey, Robert P Anderson, Frits Koning, Hugh H Reid, Jamie Rossjohn

Journal article  |  2012  |  Immunity

Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors

Max Joffe, Andra S Necula, Rochna Chand, Brett C McWhinney, Balasubramanian Krishnamurthy, Tom Loudovaris, David Goodman, Helen E Thomas, Thomas WH Kay, Stuart I Mannering

Journal article  |  2012  |  International Immunology

Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.

Kate L Graham, Robyn M Sutherland, Stuart I Mannering, Yuxing Zhao, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas, Andrew M Lew, Thomas WH Kay

Journal article  |  2012  |  The Review of Diabetic Studies

Recent advances in our understanding of the pathogenesis of type 1 diabetes have occurred in all steps of the disease. This review..

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

Diana Mittag, Anna I Proietto, Thomas Loudovaris, Stuart I Mannering, David Vremec, Ken Shortman, Li Wu, Leonard C Harrison

Journal article  |  2011  |  The Journal of Immunology

Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes

SI Mannering, FS Wong, I Durinovic-Bello, B Brooks-Worrell, TI Tree, CM Cilio, NC Schloot, R Mallone

Journal article  |  2010  |  Clinical and Experimental Immunology

A method for extracting tissue proteins for use in lymphocyte function assays

Hayley C Moon, Max Joffe, Helen E Thomas, Thomas WH Kay, Stuart I Mannering

Journal article  |  2010  |  Journal of Immunological Methods

TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death

YF Zhan, DP Funda, AL Every, P Fundova, JF Purton, DR Liddicoat, TJ Cole, DI Godfrey, JL Brady, SI Mannering, LC Harrison, AM Lew

Journal article  |  2004  |  INTERNATIONAL IMMUNOLOGY