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Jonathan Gooi's selected work
Targeting Osteocytic Sphingosine-1-Phosphate Signalling To Promote Load-Induced Bone Forma..
Internal Research Grant
IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-..
Displaying the 2 most recent projects by Jonathan Gooi.
Displaying the 36 most recent scholarly works by Jonathan Gooi.
Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes
Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims
Journal article | 2020 | eLife
Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, ..
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis
Luke A Miles, Stefan J Hermans, Gabriela AN Crespi, Jonathan H Gooi, Larissa Doughty, Tracy L Nero, Jasmina Markulic, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andres A Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C Hancock, Michael W Parker
Journal article | 2019 | ISCIENCE
Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of ..
IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis
Narelle E McGregor, Melissa Murat, Jeevithan Elango, Ingrid J Poulton, Emma C Walker, Blessing Crimeen-Irwin, Patricia WM Ho, Jonathan H Gooi, T John Martin, Natalie A Sims
Journal article | 2019 | Journal of Biological Chemistry
Isolation, Purification, Generation, and Culture of Osteocytes.
Jonathan H Gooi, Ling Yeong Chia, Christina Vrahnas, Natalie A Sims
Journal article | 2019 | Methods in molecular biology (Clifton, N.J.)
Osteocytes reside within bone matrix and produce both paracrine and endocrine factors that influence the skeleton and other tissue..
Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein
Niloufar Ansari, Patricia WM Ho, Blessing Crimeen-Irwin, Ingrid J Poulton, Athena R Brunt, Mark R Forwood, Paola Divieti Pajevic, Jonathan H Gooi, T John Martin, Natalie A Sims
Journal article | 2018 | Journal of Bone and Mineral Research
Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments
Rose Crossin, Zane B Andrews, Natalie A Sims, Terence Pang, Michael Mathai, Jonathan H Gooi, Aneta Stefanidis, Brian J Oldfield, Andrew J Lawrence, Jhodie R Duncan
Journal article | 2018 | Neuroendocrinology
Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
Dae-Chul Cho, Holly J Brennan, Rachelle W Johnson, Ingrid J Poulton, Jonathan H Gooi, Brett A Tonkin, Narelle E McGregor, Emma C Walker, David J Handelsman, TJ Martin, Natalie A Sims
Journal article | 2017 | NATURE COMMUNICATIONS
High dose dietary vitamin D3 increases bone mass and strength in mice.
Liam Williamson, Alan Hayes, Erik D Hanson, Peter Pivonka, Natalie A Sims, Jonathan H Gooi
Journal article | 2017 | Bone Rep
Vitamin D plays a critical role in skeletal homeostasis. Vitamin D supplementation is used worldwide to maintain optimal bone heal..
The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro
Jordan M Spatz, Marc N Wein, Jonathan H Gooi, Yili Qu, Jenna L Garr, Shawn Liu, Kevin J Barry, Yuhei Uda, Forest Lai, Christopher Dedic, Mercedes Balcells-Camps, Henry M Kronenberg, Philip Babij, Paola Divieti Pajevic
Journal article | 2015 | Journal of Biological Chemistry
Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin- mediated relaxation after in vivo serelaxin treatment
Maria Jelinic, Chen-Huei Leo, Emiel D Post Uiterweer, Shaun L Sandow, Jonathan H Gooi, Mary E Wlodek, Kirk P Conrad, Helena Parkington, Marianne Tare, Laura J Parry
Journal article | 2014 | FASEB Journal
Reversing LRP5-Dependent Osteoporosis and SOST Deficiency-Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
Ming-Kang Chang, Ina Kramer, Hansjoerg Keller, Jonathan H Gooi, Corinne Collett, David Jenkins, Seth A Ettenberg, Feng Cong, Christine Halleux, Michaela Kneissel
Journal article | 2014 | JOURNAL OF BONE AND MINERAL RESEARCH
Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes
JH Gooi, S Pompolo, MA Karsdal, NH Kulkarni, I Kalajzic, SHM McAhren, B Han, JE Onyia, PWM Ho, MT Gillespie, NC Walsh, LY Chia, JMW Quinn, TJ Martin, NA Sims
Journal article | 2010 | BONE
Parathyroid hormone exposure to human articular osteoarthritic chondrocytes results in collagen and proteoglycan synthesis: May parathyroid hormone be a possible anabolic treatment opportunity for osteoarthritis?
B Sondergaard, SH Madsen, A Bay-Jensen, T Christensen, C Chrtiansen, N Schultz, NA Sims, JH Gooi, MA Karsdal
Conference Proceedings | 2009 | Bone
EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts
Elizabeth H Allan, Karl D Hausler, Tao Wei, Jonathan H Gooi, Julian MW Quinn, Blessing Crimeen-Irwin, Sueli Pompolo, Natalie A Sims, Matthew T Gillespie, Jude E Onyia, T John Martin
Journal article | 2008 | Journal of Bone and Mineral Research
Honours, Awards and Fellowships
Plenary Poster Prize
Roger Melick Young Investigator Award
AMGEN Outstanding Abstract Award
Research Week Student Poster: First Prize - Animal Models
Biochemistry And Molecular Biology
Australian & New Zealand Bone & Mineral Society
Doctor Of Philosophy
University of Melbourne
Bachelor of Science (Hons)
University of Melbourne
Bachelor of Biomedical Science
University of Melbourne