Jonathan Gooi

Dmp1Cre-directed knockdown of parathyroid hormone-related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny

Niloufar Ansari, Tsuyoshi Isojima, Blessing Crimeen-Irwin, Ingrid J Poulton, Narelle E McGregor, Patricia WM Ho, Mark R Forwood, Christopher S Kovacs, Evdokia Dimitriadis, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2021  |  JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid hormone-related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre-ta..

Interaction between osteocyte SOCS3-dependent signaling and the bone marrow microenvironment maintains cortical bone integrity

Tsuyoshi Isojima, Emma C Walker, Blessing Crimeen-Irwin, Ingrid J Poulton, Narelle E McGregor, Jonathan H Gooi, T John Martin, Natalie A Sims

Conference Proceedings  |  2020  |  JOURNAL OF BONE AND MINERAL RESEARCH

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2020  |  ELIFE

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, ..

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis

Luke A Miles, Stefan J Hermans, Gabriela AN Crespi, Jonathan H Gooi, Larissa Doughty, Tracy L Nero, Jasmina Markulic, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andres A Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C Hancock, Michael W Parker

Journal article  |  2019  |  ISCIENCE

Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of ..

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Narelle E McGregor, Melissa Murat, Jeevithan Elango, Ingrid J Poulton, Emma C Walker, Blessing Crimeen-Irwin, Patricia WM Ho, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bou..

Isolation, Purification, Generation, and Culture of Osteocytes

Jonathan H Gooi, Ling Yeong Chia, Christina Vrahnas, Natalie A Sims

Journal article  |  2019  |  BONE RESEARCH PROTOCOLS

Osteocytes reside within bone matrix and produce both paracrine and endocrine factors that influence the skeleton and other tissue..

Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein

Niloufar Ansari, Patricia WM Ho, Blessing Crimeen-Irwin, Ingrid J Poulton, Athena R Brunt, Mark R Forwood, Paola Divieti Pajevic, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2018  |  JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid hormone-related protein (PTHrP) and parathyroid hormone (PTH) have N-terminal domains that bind a common receptor, PTH..

Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments

Rose Crossin, Zane B Andrews, Natalie A Sims, Terence Pang, Michael Mathai, Jonathan H Gooi, Aneta Stefanidis, Brian J Oldfield, Andrew J Lawrence, Jhodie R Duncan

Journal article  |  2018  |  NEUROENDOCRINOLOGY

BACKGROUND/AIMS: Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with ..

Increased sphingosine-1-phosphate production in response to osteocyte mechanotransduction.

Cale Dobrosak, Jonathan H Gooi

Journal article  |  2017  |  Bone Rep

Over the past few years interest has greatly increased in how the lipid mediator sphingosine-1-phosphate (S1P) influences bone hom..

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Dae-Chul Cho, Holly J Brennan, Rachelle W Johnson, Ingrid J Poulton, Jonathan H Gooi, Brett A Tonkin, Narelle E McGregor, Emma C Walker, David J Handelsman, TJ Martin, Natalie A Sims

Journal article  |  2017  |  NATURE COMMUNICATIONS

Long bone strength is determined by its outer shell (cortical bone), which forms by coalescence of thin trabeculae at the metaphys..