Jonathan Gooi

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2020  |  eLife

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, ..

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis

Luke A Miles, Stefan J Hermans, Gabriela AN Crespi, Jonathan H Gooi, Larissa Doughty, Tracy L Nero, Jasmina Markulic, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andres A Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C Hancock, Michael W Parker

Journal article  |  2019  |  ISCIENCE

Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of ..

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Narelle E McGregor, Melissa Murat, Jeevithan Elango, Ingrid J Poulton, Emma C Walker, Blessing Crimeen-Irwin, Patricia WM Ho, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2019  |  Journal of Biological Chemistry

Isolation, Purification, Generation, and Culture of Osteocytes.

Jonathan H Gooi, Ling Yeong Chia, Christina Vrahnas, Natalie A Sims

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Osteocytes reside within bone matrix and produce both paracrine and endocrine factors that influence the skeleton and other tissue..

Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein

Niloufar Ansari, Patricia WM Ho, Blessing Crimeen-Irwin, Ingrid J Poulton, Athena R Brunt, Mark R Forwood, Paola Divieti Pajevic, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2018  |  Journal of Bone and Mineral Research

Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments

Rose Crossin, Zane B Andrews, Natalie A Sims, Terence Pang, Michael Mathai, Jonathan H Gooi, Aneta Stefanidis, Brian J Oldfield, Andrew J Lawrence, Jhodie R Duncan

Journal article  |  2018  |  Neuroendocrinology

Increased sphingosine-1-phosphate production in response to osteocyte mechanotransduction.

Cale Dobrosak, Jonathan H Gooi

Journal article  |  2017  |  Bone Reports

Over the past few years interest has greatly increased in how the lipid mediator sphingosine-1-phosphate (S1P) influences bone hom..

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Dae-Chul Cho, Holly J Brennan, Rachelle W Johnson, Ingrid J Poulton, Jonathan H Gooi, Brett A Tonkin, Narelle E McGregor, Emma C Walker, David J Handelsman, TJ Martin, Natalie A Sims

Journal article  |  2017  |  NATURE COMMUNICATIONS

High dose dietary vitamin D3 increases bone mass and strength in mice.

Liam Williamson, Alan Hayes, Erik D Hanson, Peter Pivonka, Natalie A Sims, Jonathan H Gooi

Journal article  |  2017  |  Bone Rep

Vitamin D plays a critical role in skeletal homeostasis. Vitamin D supplementation is used worldwide to maintain optimal bone heal..

Osteocyte secreted factors inhibit skeletal muscle differentiation.

Charles L Wood, Paola Divieti Pajevic, Jonathan H Gooi

Journal article  |  2017  |  Bone Reports

It is generally accepted that bone and muscle possess the capacity to act in an autocrine, paracrine, or endocrine manner, with a ..

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro

Jordan M Spatz, Marc N Wein, Jonathan H Gooi, Yili Qu, Jenna L Garr, Shawn Liu, Kevin J Barry, Yuhei Uda, Forest Lai, Christopher Dedic, Mercedes Balcells-Camps, Henry M Kronenberg, Philip Babij, Paola Divieti Pajevic

Journal article  |  2015  |  Journal of Biological Chemistry

A Vasoactive Role for Endogenous Relaxin in Mesenteric Arteries of Male Mice

Chen Huei Leo, Maria Jelinic, Jon H Gooi, Marianne Tare, Laura J Parry

Journal article  |  2014  |  PLOS ONE

Decline in calcitonin receptor expression in osteocytes with age

Jonathan H Gooi, Ling Yeong Chia, Nicole C Walsh, Morten A Karsdal, Julian MW Quinn, T John Martin, Natalie A Sims

Journal article  |  2014  |  JOURNAL OF ENDOCRINOLOGY

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin- mediated relaxation after in vivo serelaxin treatment

Maria Jelinic, Chen-Huei Leo, Emiel D Post Uiterweer, Shaun L Sandow, Jonathan H Gooi, Mary E Wlodek, Kirk P Conrad, Helena Parkington, Marianne Tare, Laura J Parry

Journal article  |  2014  |  FASEB Journal

Reversing LRP5-Dependent Osteoporosis and SOST Deficiency-Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity

Ming-Kang Chang, Ina Kramer, Hansjoerg Keller, Jonathan H Gooi, Corinne Collett, David Jenkins, Seth A Ettenberg, Feng Cong, Christine Halleux, Michaela Kneissel

Journal article  |  2014  |  JOURNAL OF BONE AND MINERAL RESEARCH

Impaired effect of relaxin on vasoconstrictor reactivity in spontaneous hypertensive rats

Joris van Drongelen, Arianne van Koppen, Jeanne Pertijs, Jonathan H Gooi, Fred CGJ Sweep, Fred K Lotgering, Marc EA Spaanderman, Paul Smits

Journal article  |  2013  |  Peptides

Enhanced Uterine Artery Stiffness in Aged Pregnant Relaxin Mutant Mice Is Reversed with Exogenous Relaxin Treatment

Jonathan H Gooi, Meghan L Richardson, Maria Jelinic, Jane E Girling, Mary E Wlodek, Marianne Tare, Laura J Parry

Journal article  |  2013  |  Biology of Reproduction

Impaired vascular responses to relaxin in diet-induced overweight female rats

Joris van Drongelen, Arianne van Koppen, Jeanne Pertijs, Jonathan H Gooi, Laura J Parry, Fred CGJ Sweep, Frederik K Lotgering, Paul Smits, Marc EA Spaanderman

Journal article  |  2012  |  JOURNAL OF APPLIED PHYSIOLOGY

Aging attenuates the vasodilator response to relaxin

Joris van Drongelen, Ivo HJ Ploemen, Jeanne Pertijs, Jonathan H Gooi, Fred CGJ Sweep, Frederik K Lotgering, Marc EA Spaanderman, Paul Smits

Journal article  |  2011  |  American Journal of Physiology - Heart and Circulatory Physiology

Osteocyte Wnt/beta-Catenin Signaling Is Required for Normal Bone Homeostasis

Ina Kramer, Christine Halleux, Hansjoerg Keller, Marco Pegurri, Jonathan H Gooi, Patricia Brander Weber, Jian Q Feng, Lynda F Bonewald, Michaela Kneissel

Journal article  |  2010  |  Molecular and Cellular Biology

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

JH Gooi, S Pompolo, MA Karsdal, NH Kulkarni, I Kalajzic, SHM McAhren, B Han, JE Onyia, PWM Ho, MT Gillespie, NC Walsh, LY Chia, JMW Quinn, TJ Martin, NA Sims

Journal article  |  2010  |  BONE

Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage

TJ Martin, EH Allan, PWM Ho, JH Gooi, JMW Quinn, MT Gillespie, V Krasnoperov, NA Sims

Journal article  |  2010  |  Advances in Experimental Medicine and Biology

Parathyroid hormone exposure to human articular osteoarthritic chondrocytes results in collagen and proteoglycan synthesis: May parathyroid hormone be a possible anabolic treatment opportunity for osteoarthritis?

B Sondergaard, SH Madsen, A Bay-Jensen, T Christensen, C Chrtiansen, N Schultz, NA Sims, JH Gooi, MA Karsdal

Conference Proceedings  |  2009  |  Bone

Calcitonin attenuates the anabolic effect of PTH in young rats by rapid upregulation of sclerostin expression

JH Gooi, S Pompolo, M Karsdal, NH Kulkarni, SH McAhren, B Han, JE Onyia, PWM Ho, MT Gillespie, JMW Quinn, TJ Martin, NA Sims

Conference Proceedings  |  2009  |  Bone

The Chemokine Cxcl1 Is a Novel Target Gene of Parathyroid Hormone (PTH)/PTH-Related Protein in Committed Osteoblasts

Doene Onan, Elizabeth H Allan, Julian MW Quinn, Jonathan H Gooi, Sueli Pompolo, Natalie A Sims, Matthew T Gillespie, T John Martin

Journal article  |  2009  |  Endocrinology

Molecular Mechanisms in Coupling of Bone Formation to Resorption

T John Martin, Jonathan H Gooi, Natalie A Sims

Journal article  |  2009  |  Critical Reviews in Eukaryotic Gene Expression

The chemokine Cxcl1 is a novel target gene of PTH/PTHrP in committed osteoblasts

undefined Onan, EH Allan, JM Quinn, JH Gooi, undefined Pompolo, NA Sims, MT Gillespie, TJ Martin

Journal article  |  2009  |  Endocrinology

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

Natalie A Sims, Jonathan H Gooi

Journal article  |  2008  |  Seminars in Cell & Developmental Biology

Blockade of Ephrin/EphB4 Signaling within the Osteoblast Lineage Reduces Osteoblast Differentiation and Mineralization

EH Allan, S Pompolo, JH Gooi, MT Gillespie, NA Sims, V Krasnoperov, TJ Martin

Conference Proceedings  |  2008  |  JOURNAL OF BONE AND MINERAL RESEARCH

Calcitonin Attenuates the Anabolic Effect of PTH in vivo and Rapidly Upregulates Sclerostin Expression

JH Gooi, S Pompolo, NE McGregor, E Walker, MT Gillespie, JMW Quinn, TJ Martin, NA Sims

Conference Proceedings  |  2008  |  JOURNAL OF BONE AND MINERAL RESEARCH

PTH has Direct Anabolic Effects on Osteoarthritic Articular Cartilage in Vitro and in Vivo: Is PTH a New Treatment for Osteoarthritis?

BC Sondergaard, SH Madsen, AB Jensen, NA Sims, J Gooi, MA Karsdal

Conference Proceedings  |  2008  |  JOURNAL OF BONE AND MINERAL RESEARCH

EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts

Elizabeth H Allan, Karl D Hausler, Tao Wei, Jonathan H Gooi, Julian MW Quinn, Blessing Crimeen-Irwin, Sueli Pompolo, Natalie A Sims, Matthew T Gillespie, Jude E Onyia, T John Martin

Journal article  |  2008  |  Journal of Bone and Mineral Research

Potential involvement of ephrin b2 in the anabolic action of PTH in osteoblasts

EH Allan, KD Hausler, JMW Quinn, J Gooi, T Wei, JE Onyia, NA Sims, MT Gillespie, TJ Martin

Conference Proceedings  |  2007  |  JOURNAL OF BONE AND MINERAL RESEARCH

Active osteoclasts are required for PTH anabolic effects in young female rats

JH Gooi, JM Quinn, MT Gillespie, MA Karsdal, TJ Martin, NA Sims

Conference Proceedings  |  2007  |  BONE

Calcitonin directly modulates chondrocyte activity in vitro and abrogates collagen type II degradation in vivo.

MA Karsdal, BC Sondergaard, NA Sims, JH Gooi, P Qvist, C Christiansen

Conference Proceedings  |  2006  |  JOURNAL OF BONE AND MINERAL RESEARCH

Calcitonin attenuates the anabolic effect of PTH in young rats.

JH Gooi, JMW Quinn, MT Gillespie, MA Karsdal, TJ Martin, NA Sims

Conference Proceedings  |  2006  |  JOURNAL OF BONE AND MINERAL RESEARCH