Michael Goddard

Putative Causal Variants Are Enriched in Annotated Functional Regions From Six Bovine Tissues

Claire P Prowse-Wilkins, Jianghui Wang, Ruidong Xiang, Josie B Garner, Michael E Goddard, Amanda J Chamberlain

Journal article  |  2021  |  FRONTIERS IN GENETICS

Genetic variants which affect complex traits (causal variants) are thought to be found in functional regions of the genome. Identi..

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

Valentin Hivert, Julia Sidorenko, Florian Rohart, Michael E Goddard, Jian Yang, Naomi R Wray, Loic Yengo, Peter M Visscher

Journal article  |  2021  |  AMERICAN JOURNAL OF HUMAN GENETICS

Non-additive genetic variance for complex traits is traditionally estimated from data on relatives. It is notoriously difficult to..

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.

Valentin Hivert, Julia Sidorenko, Florian Rohart, Michael E Goddard, Jian Yang, Naomi R Wray, Loic Yengo, Peter M Visscher

Journal article  |  2021  |  Am J Hum Genet

(The American Journal of Human Genetics 108, 786–798; May 6, 2021) In this paper, the mean estimates of SNP-based heritability and..

Quantifying genetic heterogeneity between continental populations for human height and body mass index

Jing Guo, Andrew Bakshi, Ying Wang, Longda Jiang, Loic Yengo, Michael E Goddard, Peter M Visscher, Jian Yang

Journal article  |  2021  |  SCIENTIFIC REPORTS

Genome-wide association studies (GWAS) in samples of European ancestry have identified thousands of genetic variants associated wi..

On the use of whole-genome sequence data for across-breed genomic prediction and fine-scale mapping of QTL

Theo Meuwissen, Irene van den Berg, Mike Goddard

Journal article  |  2021  |  GENETICS SELECTION EVOLUTION

BACKGROUND: Whole-genome sequence (WGS) data are increasingly available on large numbers of individuals in animal and plant breedi..

Genetic parameters for methane emission traits in Australian dairy cows

CM Richardson, TTT Nguyen, M Abdelsayed, PJ Moate, SRO Williams, TCS Chud, FS Schenkel, ME Goddard, I van den Berg, BG Cocks, LC Marett, WJ Wales, JE Pryce

Journal article  |  2021  |  JOURNAL OF DAIRY SCIENCE

Methane is a greenhouse gas of high interest to the dairy industry, with 57% of Australia's dairy emissions attributed to enteric ..

Improving Genomic Prediction of Crossbred and Purebred Dairy Cattle

Majid Khansefid, Michael E Goddard, Mekonnen Haile-Mariam, Kon Konstantinov, Chris Schrooten, Gerben de Jong, Erica G Jewell, Erin O'Connor, Jennie E Pryce, Hans D Daetwyler, Iona M MacLeod

Journal article  |  2020  |  FRONTIERS IN GENETICS

This study assessed the accuracy and bias of genomic prediction (GP) in purebred Holstein (H) and Jersey (J) as well as crossbred ..

Application of multivariate single-step SNP best linear unbiased predictor model and revised SNP list for genomic evaluation of dairy cattle in Australia

KV Konstantinov, ME Goddard

Journal article  |  2020  |  JOURNAL OF DAIRY SCIENCE

The objectives of this study were (1) to evaluate the computational feasibility of the multitrait test-day single-step SNP-BLUP (s..

Meta-analysis for milk fat and protein percentage using imputed sequence variant genotypes in 94,321 cattle from eight cattle breeds

Irene van den Berg, Ruidong Xiang, Janez Jenko, Hubert Pausch, Mekki Boussaha, Chris Schrooten, Thierry Tribout, Arne B Gjuvsland, Didier Boichard, Oyvind Nordbo, Marie-Pierre Sanchez, Mike E Goddard

Journal article  |  2020  |  GENETICS SELECTION EVOLUTION

BACKGROUND: Sequence-based genome-wide association studies (GWAS) provide high statistical power to identify candidate causal muta..

Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal

Ruidong Xiang, Irene van den Berg, Iona M MacLeod, Hans D Daetwyler, Michael E Goddard

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

In genome-wide association studies (GWAS), variants showing consistent effect directions across populations are considered as true..