Mike Goddard

Putative Causal Variants Are Enriched in Annotated Functional Regions From Six Bovine Tissues (vol 12,& nbsp;664379, 2021)

Claire P Prowse-Wilkins, Jianghui Wang, Ruidong Xiang, Josie B Garner, Michael E Goddard, Amanda J Chamberlain

Journal article  |  2021  |  FRONTIERS IN GENETICS

[This corrects the article DOI: 10.3389/fgene.2021.664379.].

Genomic partitioning of inbreeding depression in humans.

Loic Yengo, Jian Yang, Matthew C Keller, Michael E Goddard, Naomi R Wray, Peter M Visscher

Journal article  |  2021  |  Am J Hum Genet

Across species, offspring of related individuals often exhibit significant reduction in fitness-related traits, known as inbreedin..

Phantom epistasis between unlinked loci.

Gibran Hemani, Joseph E Powell, Huanwei Wang, Konstantin Shakhbazov, Harm-Jan Westra, Tonu Esko, Anjali K Henders, Allan F McRae, Nicholas G Martin, Andres Metspalu, Lude Franke, Grant W Montgomery, Michael E Goddard, Greg Gibson, Jian Yang, Peter M Visscher

Journal article  |  2021  |  Nature

Bayesian genome-wide analysis of cattle traits using variants with functional and evolutionary significance

Ruidong Xiang, Ed J Breen, Claire P Prowse-Wilkins, Amanda J Chamberlain, Michael E Goddard

Journal article  |  2021  |  ANIMAL PRODUCTION SCIENCE

Context: Functional genomics studies have highlighted genomic regions with regulatory and evolutionary significance. Such informat..

Putative Causal Variants Are Enriched in Annotated Functional Regions From Six Bovine Tissues

Claire P Prowse-Wilkins, Jianghui Wang, Ruidong Xiang, Josie B Garner, Michael E Goddard, Amanda J Chamberlain

Journal article  |  2021  |  FRONTIERS IN GENETICS

Genetic variants which affect complex traits (causal variants) are thought to be found in functional regions of the genome. Identi..

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.

Valentin Hivert, Julia Sidorenko, Florian Rohart, Michael E Goddard, Jian Yang, Naomi R Wray, Loic Yengo, Peter M Visscher

Journal article  |  2021  |  Am J Hum Genet

(The American Journal of Human Genetics 108, 786–798; May 6, 2021) In this paper, the mean estimates of SNP-based heritability and..

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

Valentin Hivert, Julia Sidorenko, Florian Rohart, Michael E Goddard, Jian Yang, Naomi R Wray, Loic Yengo, Peter M Visscher

Journal article  |  2021  |  AMERICAN JOURNAL OF HUMAN GENETICS

Non-additive genetic variance for complex traits is traditionally estimated from data on relatives. It is notoriously difficult to..

Quantifying genetic heterogeneity between continental populations for human height and body mass index

Jing Guo, Andrew Bakshi, Ying Wang, Longda Jiang, Loic Yengo, Michael E Goddard, Peter M Visscher, Jian Yang

Journal article  |  2021  |  SCIENTIFIC REPORTS

Genome-wide association studies (GWAS) in samples of European ancestry have identified thousands of genetic variants associated wi..

On the use of whole-genome sequence data for across-breed genomic prediction and fine-scale mapping of QTL

Theo Meuwissen, Irene van den Berg, Mike Goddard

Journal article  |  2021  |  GENETICS SELECTION EVOLUTION

BACKGROUND: Whole-genome sequence (WGS) data are increasingly available on large numbers of individuals in animal and plant breedi..

Widespread signatures of natural selection across human complex traits and functional genomic categories

Jian Zeng, Angli Xue, Longda Jiang, Luke R Lloyd-Jones, Yang Wu, Huanwei Wang, Zhili Zheng, Loic Yengo, Kathryn E Kemper, Michael E Goddard, Naomi R Wray, Peter M Visscher, Jian Yang

Journal article  |  2021  |  NATURE COMMUNICATIONS

Understanding how natural selection has shaped genetic architecture of complex traits is of importance in medical and evolutionary..