Elizabeth Tudor

Effect of the p38MAPKinhibitor doramapimod on the systemic inflammatory response to intravenous lipopolysaccharide in horses

Jennifer Bauquier, Elizabeth Tudor, Simon Bailey

Journal article  |  2020  |  JOURNAL OF VETERINARY INTERNAL MEDICINE

BACKGROUND: Doramapimod, a p38 MAPK inhibitor, is a potent anti-inflammatory drug that decreases inflammatory cytokine production ..

Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

Andrea Strakova, Thomas J Nicholls, Adrian Baez-Ortega, Maire Ni Leathlobhair, Alexander T Sampson, Katherine Hughes, Isobelle AG Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Clara L Arnold, Leontine Bansse-Issa, Thinlay N Bhutia, Jocelyn L Bisson, Kelli Blank, Cristobal Briceno, Artemio Castillo Domracheva, Anne M Corrigan, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emer..

Validation of canine uterine and testicular arteries for the functional characterisation of receptor-mediated contraction as a replacement for laboratory animal tissues in teaching

Louise Mulcahy, Elizabeth Tudor, Simon R Bailey

Journal article  |  2020  |  PLOS ONE

Teaching practicals for receptor physiology/pharmacology in medical and veterinary schools have involved the use of in vitro exper..

Anti-inflammatory effects of a p38 MAP kinase inhibitor, doramapimod, against bacterial cell wall toxins in equine whole blood.

Jennifer R Bauquier, Brett S Tennent-Brown, Elizabeth Tudor, Simon R Bailey

Journal article  |  2020  |  Veterinary Immunology and Immunopathology

Doramapimod (BIRB-796-BS), is an anti-inflammatory compound, acting through p38 MAPK inhibition, but its anti-inflammatory effects..

Somatic evolution and global expansion of an ancient transmissible cancer lineage

Adrian Baez-Ortega, Kevin Gori, Andrea Strakova, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Thinlay N Bhutia, Jocelyn L Bisson, Cristobal Briceno, Artemio Castillo Domracheva, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Eric Davis, Karina F de Castro, Andrigo B de Nardi, Anna P de Vos, Laura Delgadillo Keenan, Edward M Donelan, Adela R Espinoza Huerta, et al.

Journal article  |  2019  |  SCIENCE

The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing..

A controlled randomized clinical trial to assess postoperative analgesia after thiopental-isoflurane anaesthesia or total intravenous anaesthesia with alfaxalone in dogs

Paula M Bennell, Ted Whittem, Elizabeth Tudor

Journal article  |  2019  |  JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Alfaxalone, a synthetic neuroactive steroid, has been attributed with properties including sedation, anaesthesia and analgesia. Th..

Implementing the Flipped Classroom in a Veterinary Pre-clinical Science Course: Student Engagement, Performance, and Satisfaction

Laura M Dooley, Sarah Frankland, Elise Boller, Elizabeth Tudor

Journal article  |  2018  |  JOURNAL OF VETERINARY MEDICAL EDUCATION

There has been a recent move toward active learning pedagogies in veterinary education, with increasing use of a blended approach ..

Effects of polymyxin-B on TNF-alpha production in equine whole blood stimulated with three different bacterial toxins

JR Bauquier, BS Tennent-Brown, E Tudor, SR Bailey

Journal article  |  2018  |  JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Polymyxin-B is used to treat equine systemic inflammation. Bacterial toxins other than lipopolysaccharide (LPS) contribute to syst..

Collaborative Learning

L Dooley

Book Chapter  |  2017

Written by an international group of leading veterinary educators, the book offers a thorough examination of veterinary medical ed..

The flipped classroom in veterinary pre-clinical sciences: student engagement, performance and satisfaction

Sarah Frankland, Laura DOOLEY, Elizabeth Tudor

Conference Proceedings  |  2017