Christopher Burns

A constricted opening in Kir channels does not impede potassium conduction

Katrina A Black, Sitong He, Ruitao Jin, David M Miller, Jani R Bolla, Oliver B Clarke, Paul Johnson, Monique Windley, Christopher J Burns, Adam P Hill, Derek Laver, Carol Robinson, Brian J Smith, Jacqueline M Gulbis

Journal article  |  2020  |  Nature Communications

The canonical mechanistic model explaining potassium channel gating is of a conformational change that alternately dilates and con..

TBK1 and IKK epsilon Act Redundantly to Mediate STING-Induced NF-kappa B Responses in Myeloid Cells

Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan, Christopher J Burns, Ian P Wicks, Jonathan J Miner, Benjamin T Kile, Seth L Masters, Dominic De Nardo

Journal article  |  2020  |  Cell Reports

Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimm..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  Nature

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

Therapeutic Effects of a TANK-Binding Kinase 1 Inhibitor in Germinal Center-Driven Collagen-Induced Arthritis

Cynthia Louis, Devi Ngo, Damian B D'Silva, Jacinta Hansen, Louisa Phillipson, Helene Jousset, Patrizia Novello, David Segal, Kate E Lawlor, Christopher J Burns, Ian P Wicks

Journal article  |  2019  |  Arthritis & Rheumatology

OBJECTIVE: The production of class-switched high-affinity autoantibodies derived from organized germinal centers (GCs) is a hallma..

Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer.

Emily Chan, Rodney Luwor, Christopher Burns, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2018  |  Oncotarget

Despite a good initial response to front-line chemotherapy, majority of the ovarian cancer patients relapse with consecutive phase..

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Phillip P Sharp, Jean-Marc Garnier, Tamas Hatfaludi, Zhen Xu, David Segal, Kate E Jarman, Helene Jousset, Alexandra Garnham, John T Feutrill, Anthony Cuzzupe, Peter Hall, Scott Taylor, Carl R Walkley, Dean Tyler, Mark A Dawson, Peter Czabotar, Andrew F Wilks, Stefan Glaser, David CS Huang, Christopher J Burns

Journal article  |  2017  |  ACS Medicinal Chemistry Letters

A number of diazepines are known to inhibit bromo- and extra-terminal domain (BET) proteins. Their BET inhibitory activity derives..

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

Kate McArthur, Akshay A D'Cruz, David Segal, Kurt Lackovic, Andrew F Wilks, Joanne A O'Donnell, Cameron J Nowell, Motti Gerlic, David CS Huang, Christopher J Burns, Ben A Croker

Journal article  |  2017  |  Oncotarget

Neutropenia represents one of the major dose-limiting toxicities of many current cancer therapies. To circumvent the off-target ef..

Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma

Clare E Weeden, Aliaksei Z Holik, Richard J Young, Stephen B Ma, Jean-Marc Garnier, Stephen B Fox, Phillip Antippa, Louis B Irving, Daniel P Steinfort, Gavin M Wright, Prudence A Russell, Matthew E Ritchie, Christopher J Burns, Benjamin Solomon, Marie-Liesse Asselin-Labat

Journal article  |  2017  |  Molecular Cancer Therapeutics

Lung squamous cell carcinoma (SqCC) is a molecularly complex and genomically unstable disease. No targeted therapy is currently ap..

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  Diabetes

Recent advances in immunotherapeutics have not yet changed the routine management of autoimmune type 1 diabetes. There is an oppor..

Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1

Onisha Patel, Weiwen Dai, Mareike Mentzel, Michael DW Griffin, Juliette Serindoux, Yoann Gay, Stefanie Fischer, Shoukat Sterle, Ashleigh Kropp, Christopher J Burns, Matthias Ernst, Michael Buchert, Isabelle S Lucet

Journal article  |  2016  |  STRUCTURE

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that belongs to the family of microtubule-associated proteins. Ori..