Xiaowei Wang

Dynamic Solid-State Ultrasound Contrast Agent for Monitoring pH Fluctuations In Vivo.

Julia Ann-Therese Walker, Xiaowei Wang, Karlheinz Peter, Kristian Kempe, Simon R Corrie

Journal article  |  2020  |  ACS Sensors

The key challenge for in vivo biosensing is to design biomarker-responsive contrast agents that can be readily detected and monito..

The Choice of Targets and Ligands for Site-Specific Delivery of Nanomedicine to Atherosclerosis.

Adil Zia, Yuao Wu, Tuan Nguyen, Xiaowei Wang, Karlheinz Peter, Hang T Ta

Journal article  |  2020  |  Cardiovascular Research

As nanotechnologies advance into clinical medicine, novel methods for applying nanomedicine to cardiovascular diseases are emergin..

Successful renal denervation decreases the platelet activation status in hypertensive patients

Maria TK Zaldivia, Dagmara Hering, Petra Marusic, Yusuke Sata, Rebecca Lee, Murray D Esler, Nay M Htun, Jacqueline Duval, Louise Hammond, Ulrike Flierl, Xiaowei Wang, Grant R Drummond, Antony Walton, Elizabeth E Gardiner, Robert K Andrews, Markus P Schlaich, Karlheinz Peter

Journal article  |  2020  |  Cardiovascular Research

Prime time viewing of the ischaemic heart: new technologies allow imaging and flow assessment of the microvasculature in the beating heart

Laura A Bienvenu, Xiaowei Wang, Karlheinz Peter

Journal article  |  2019  |  Cardiovascular Research

alpha-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury

Maria Wallert, Melanie Ziegler, Xiaowei Wang, Ana Maluenda, Xiaoqiu Xu, May Lin Yap, Roman Witt, Corey Giles, Stefan Kluge, Marcus Hortmann, Jianxiang Zhang, Peter Meikle, Stefan Lorkowski, Karlheinz Peter

Journal article  |  2019  |  Redox Biology

OBJECTIVE: Myocardial infarction (MI) is a leading cause of mortality and morbidity worldwide and new treatment strategies are hig..

Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability

Philipp Diehl, Frederik Nienaber, Maria TK Zaldivia, Johannes Stamm, Patrick M Siegel, Natalie A Mellett, Marius Wessinger, Xiaowei Wang, James D McFadyen, Nicole Bassler, Gerhard Puetz, Nay M Htun, David Braig, Jonathon Habersberger, Thomas Helbing, Steffen U Eisenhardt, Maria Fuller, Christoph Bode, Peter J Meikle, Yung Chih Chen, et al.

Journal article  |  2019  |  Thrombosis and Haemostasis

Myocardial Infarction-From Atherosclerosis to Thrombosis Uncovering New Diagnostic and Therapeutic Approaches

Jathushan Palasubramaniam, Xiaowei Wang, Karlheinz Peter

Journal article  |  2019  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target

Melanie Ziegler, Xiaowei Wang, Karlheinz Peter

Journal article  |  2019  |  Cardiovascular Research

Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study

Tiago Granja, Andreas Koerner, Christian Gluck, Jan David Hohmann, Xiaowei Wang, David Koehler, Ariane Streissenberger, Harshal H Nandurkar, Valbona Mirakaj, Peter Rosenberger, Karlheinz Peter, Andreas Straub

Journal article  |  2019  |  Critical Care Medicine

OBJECTIVES: Sepsis is associated with a systemic inflammatory reaction, which can result in a life-endangering organ dysfunction. ..

Mending the failing heart

Xiaowei Wang, Karlheinz Peter

Journal article  |  2019  |  Aging

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Tatjana Michel, Antonia Link, Meike-Kristin Abraham, Christian Schlensak, Karlheinz Peter, Hans-Peter Wendel, Xiaowei Wang, Stefanie Krajewski

Journal article  |  2019  |  Journal of Visualized Experiments

The pulmonary microvasculature entraps induced vascular progenitor cells (iVPCs) systemically delivered after cardiac ischemia-reperfusion injury: Indication for preservation of heart function via paracrine effects beyond engraftment

Melanie Ziegler, Katharina Haigh, Nguyen Thao, Xiaowei Wang, Bock Lim, May Lin Yap, Eleanor M Eddy, Jody J Haigh, Karlheinz Peter

Journal article  |  2019  |  Microcirculation

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

May Lin Yap, James D McFadyen, Xiaowei Wang, Melanie Ziegler, Yung-Chih Chen, Abbey Willcox, Cameron J Nowell, Andrew M Scott, Erica K Sloan, P Mark Hogarth, Geoffrey A Pietersz, Karlheinz Peter

Journal article  |  2019  |  Theranostics

Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis

Donny Hanjaya-Putra, Carolyn Haller, Xiaowei Wang, Erbin Dai, Bock Lim, Liying Liu, Patrick Jaminet, Joy Yao, Amy Searle, Thomas Bonnard, Christoph E Hagemeyer, Karlheinz Peter, Elliot L Chaikof

Journal article  |  2018  |  JCI Insight

NANOLIPOSOMES FOR SAFE AND EFFICIENT THERAPEUTIC CD39 MRNA DELIVERY: PREVENTION AND TREATMENT OF INFLAMMATORY AND CARDIOVASCULAR DISEASES

Xiaowei Wang, Meike-Kristin Abraham, Karlheinz Peter, Tatjana Michel, Hans Wendel, Stefanie Krajewski

Conference Proceedings  |  2018  |  ATHEROSCLEROSIS SUPPLEMENTS

SHINING A LIGHT ON PLAQUE INSTABILITY: NEAR INFRARED AUTOFLUORESCENCE AS CHARACTERISTIC OF UNSTABLE, HIGH RISK ATHEROSCLEROTIC PLAQUES

Yung-Chih Chen, Nay M Htun, Ghassan J Maghzal, Hans Schneider, Roland Stocker, Karlheinz Peter, Xiaowei Wang

Conference Proceedings  |  2018  |  Atherosclerosis Supplements

TARGETED MICROBUBBLES LOADED WITH MICRORNA FOR A THERANOSTIC APPROACH OF ABDOMINAL AORTIC ANEURYSMS

Xiaowei Wang, Amy K Searle, Yung-Chih Chen, Karlheinz Peter

Conference Proceedings  |  2018  |  Atherosclerosis Supplements

Boost of vitamin E metabolism as a novel treatment strategy for myocardial infarction

Maria Wallert, Melanie Ziegler, Xiaowei Wang, Ana Maluenda, Stefan Lorkowski, Karlheinz Peter

Conference Proceedings  |  2018  |  Free Radical Biology and Medicine

Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development

Xiaowei Wang, Amy Kate Searle, Jan David Hohmann, Ao Leo Liu, Meike-Kristin Abraham, Jathushan Palasubramaniam, Bock Lim, Yu Yao, Maria Wallert, Eefang Yu, Yung-Chih Chen, Karlheinz Peter

Journal article  |  2018  |  Molecular Therapy

A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury

Melanie Ziegler, Jan David Hohmann, Amy Kate Searle, Meike-Kristin Abraham, Harshal H Nandurkar, Xiaowei Wang, Karlheinz Peter

Journal article  |  2018  |  European Heart Journal

Aims: CD39 is a cell membrane NTPase with anti-inflammatory and anti-platelet effects. However, its clinical use is limited by its..

Mesoscale Nanoparticles: An Unexpected Means for Selective Therapeutic Targeting of Kidney Diseases!

May Lin Yap, Xiaowei Wang, Geoffrey A Pietersz, Karlheinz Peter

Journal article  |  2018  |  Hypertension

Mesoscale Nanoparticles: An Unexpected Means for Selective Therapeutic Targeting of Kidney Diseases!

May Lin Yap, Xiaowei Wang, Geoffrey A Pietersz, Karlheinz Peter

Journal article  |  2018  |  Hypertension

Platelet-Derived Microvesicles in Cardiovascular Diseases

Maria TK Zaldivia, James D McFadyen, Bock Lim, Xiaowei Wang, Karlheinz Peter

Journal article  |  2017  |  Frontiers in Cardiovascular Medicine

Intranasal application of glucocorticoid alleviates olfactory dysfunction in mice with allergic rhinitis

Xiaowei Wang, Yingying Zhu, Daofeng Ni, Wei Lv, Zhiqiang Gao, Fang Qi

Journal article  |  2017  |  Experimental and Therapeutic Medicine

Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications

Tatjana Michel, Daniel Luft, Meike-Kristin Abraham, Sabrina Reinhardt, Martha L Salinas Medina, Julia Kurz, Martin Schaller, Meltem Avci-Adali, Christian Schlensak, Karlheinz Peter, Hans Peter Wendel, Xiaowei Wang, Stefanie Krajewski

Journal article  |  2017  |  Molecular Therapy - Nucleic Acids

Therapeutic targeting in nanomedicine: the future lies in recombinant antibodies

Geoffrey A Pietersz, Xiaowei Wang, May Lin Yap, Bock Lim, Karlheinz Peter

Journal article  |  2017  |  Nanomedicine

Molecular imaging of activated platelets via antibody-targeted ultrasmall iron oxide nanoparticles displaying unique dual MRI contrast

Hang T Ta, Zhen Li, Christoph E Hagemeyer, Gary Cowin, Shaohua Zhang, Jathushan Palasubramaniam, Karen Alt, Xiaowei Wang, Karlheinz Peter, Andrew K Whittaker

Journal article  |  2017  |  Biomaterials

Molecular Imaging of Atherothrombotic Diseases Seeing Is Believing

Xiaowei Wang, Karlheinz Peter

Journal article  |  2017  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

David Braig, Tracy L Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R Thiele, Craig J Morton, Johannes Zeller, Jurij Kiefer, Lawrence A Potempa, Natalie A Mellett, Luke A Miles, Xiao-Jun Du, Peter J Meikle, Markus Huber-Lang, G Bjoern Stark, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt

Journal article  |  2017  |  NATURE COMMUNICATIONS

Targeting Activated Platelets: A Unique and Potentially Universal Approach for Cancer Imaging

May Lin Yap, James D McFadyen, Xiaowei Wang, Nicholas A Zia, Jan David Hohmann, Melanie Ziegler, Yu Yao, Alan Pham, Matthew Harris, Paul S Donnelly, P Mark Hogarth, Geoffrey A Pietersz, Bock Lim, Karlheinz Peter

Journal article  |  2017  |  Theranostics

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar, Traver Hart, Xiaowei Wang, Xiaoyu Zhang, Melanie Robitaille, Kevin R Browne, Sridevi Jaksani, Rene Overmeer, Sylvia F Boj, Jarrett Adams, James Pan, Hans Clevers, Sachdev Sidhu, Jason Moffat, Stephane Angers

Journal article  |  2017  |  Nature Medicine

Platelet-Targeted Delivery of Peripheral Blood Mononuclear Cells to the Ischemic Heart Restores Cardiac Function after Ischemia-Reperfusion Injury

Melanie Ziegler, Xiaowei Wang, Bock Lim, Ephraem Leitner, Franco Klingberg, Victoria Ching, Yu Yao, Dexing Huang, Xiao-Ming Gao, Helen Kiriazis, Xiao-Jun Du, Jody J Haigh, Alex Bobik, Christoph E Hagemeyer, Ingo Ahrens, Karlheinz Peter

Journal article  |  2017  |  Theranostics

Nanoliposomes for Safe and Efficient Therapeutic mRNA Delivery: A Step Toward Nanotheranostics in Inflammatory and Cardiovascular Diseases as well as Cancer.

Meike-Kristin Abraham, Karlheinz Peter, Tatjana Michel, Hans Peter Wendel, Stefanie Krajewski, Xiaowei Wang

Journal article  |  2017  |  Nanotheranostics

Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination r..

A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology

Bock Lim, Yu Yao, Alex Lin-i Huang, May Lin Yap, Ulrike Flierl, Jathushan Palasubramaniam, Maria TK Zaldivia, Xiaowei Wang, Karlheinz Peter

Journal article  |  2017  |  Theranostics

PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids

Yung Chih Chen, Jennifer Rivera, Melissa Fitzgerald, Christian Hausding, Ya-Lan Ying, Xiaowei Wang, Krassimira Todorova, Soren Hayrabedyan, Eytan R Barnea, Karlheinz Peter

Journal article  |  2016  |  Thrombosis and Haemostasis

Thrombus-Targeted Theranostic Microbubbles: A New Technology towards Concurrent Rapid Ultrasound Diagnosis and Bleeding-free Fibrinolytic Treatment of Thrombosis

Xiaowei Wang, Yannik Gkanatsas, Jathushan Palasubramaniam, Jan David Hohmann, Yung Chih Chen, Bock Lim, Christoph E Hagemeyer, Karlheinz Peter

Journal article  |  2016  |  Theranostics

Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide

J Guo, X Wang, DC Henstridge, JJ Richardson, J Cui, A Sharma, MA Febbraio, K Peter, JB de Haan, CE Hagemeyer, F Caruso

Journal article  |  2015  |  Advanced healthcare materials

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Sylvia T Gunawan, Kristian Kempe, Thomas Bonnard, Jiwei Cui, Karen Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina K Such, Karlheinz Peter, Christoph E Hagemeyer, Frank Caruso

Journal article  |  2015  |  ADVANCED MATERIALS

A Versatile Approach for the Site-Specific Modification of Recombinant Antibodies Using a Combination of Enzyme-Mediated Bioconjugation and Click Chemistry

Karen Alt, Brett M Paterson, Erik Westein, Stacey E Rudd, Stan S Poniger, Shweta Jagdale, Katie Ardipradja, Timothy U Connell, Guy Y Krippner, Ashish KN Nair, Xiaowei Wang, Henri J Tochon-Danguy, Paul S Donnelly, Karlheinz Peter, Christoph E Hagemeyer

Journal article  |  2015  |  Angewandte Chemie International Edition

Particle generation, functionalization and sortase A-mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use

Christoph E Hagemeyer, Karen Alt, Angus PR Johnston, Georgina K Such, Hang T Ta, Melissa KM Leung, Sandeep Prabhu, Xiaowei Wang, Frank Caruso, Karlheinz Peter

Journal article  |  2015  |  NATURE PROTOCOLS

Dual-Contrast Molecular Imaging Allows Noninvasive Characterization of Myocardial Ischemia/Reperfusion Injury After Coronary Vessel Occlusion in Mice by Magnetic Resonance Imaging

Dominik von Elverfeldt, Alexander Maier, Daniel Duerschmied, Moritz Braig, Thilo Witsch, Xiaowei Wang, Maximilian Mauler, Irene Neudorfer, Marius Menza, Marco Idzko, Andreas Zirlik, Timo Heidt, Peter Bronsert, Christoph Bode, Karlheinz Peter, Constantin von zur Muhlen

Journal article  |  2014  |  Circulation

Single-Chain Antibody Conjugated to a Cage Amine Chelator and Labeled with Positron-Emitting Copper-64 for Diagnostic Imaging of Activated Platelets

Karen Alt, Brett M Paterson, Katie Ardipradja, Christine Schieber, Gojko Buncic, Bock Lim, Stan S Poniger, Bjoern Jakoby, Xiaowei Wang, Graeme J O'Keefe, Henri J Tochon-Dansuy, Andrew M Scott, Uwe Ackermann, Karlheinz Peter, Paul S Donnelly, Christoph E Hagemeyer

Journal article  |  2014  |  Molecular Pharmaceutics

Towards Effective and Safe Thrombolysis and Thromboprophylaxis

Xiaowei Wang, Jathushan Palasubramaniam, Yannik Gkanatsas, Jan David Hohmann, Erik Westein, Ruchi Kanojia, Karen Alt, Dexing Huang, Fu Jia, Ingo Ahrens, Robert L Medcalf, Karlheinz Peter, Christoph E Hagemeyer

Journal article  |  2014  |  Circulation Research

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

Jan David Hohmann, Xiaowei Wang, Stefanie Krajewski, Carly Selan, Carolyn A Haller, Andreas Straub, Elliot L Chaikof, Harshal H Nandurkar, Christoph E Hagemeyer, Karlheinz Peter

Journal article  |  2013  |  Blood

Platelet-Targeted Microbubbles Allow Monitoring and Efficacy Testing of Thrombolytic Drugs in Molecular Ultrasound Imaging

Xiaowei Wang, Jan David Hohmann, Ephraem Leitner, Christoph E Hagemeyer, Kariheinz Peter

Conference Proceedings  |  2012  |  CIRCULATION

Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis Validation of a Unique Noninvasive Method for Rapid and Sensitive Detection of Thrombi and Monitoring of Success or Failure of Thrombolysis in Mice

Xiaowei Wang, Christoph E Hagemeyer, Jan David Hohmann, Ephraem Leitner, Paul C Armstrong, Fu Jia, Manfred Olschewski, Andrew Needles, Karlheinz Peter, Ingo Ahrens

Journal article  |  2012  |  Circulation

Amyloid Plaques Dissociate Pentameric to Monomeric C-Reactive Protein: A Novel Pathomechanism Driving Cortical Inflammation in Alzheimer's Disease?

Frederik Strang, Amelie Scheichl, Yung-Chih Chen, Xiaowei Wang, Nay-Min Htun, Nicole Bassler, Steffen U Eisenhardt, Jonathon Habersberger, Karlheinz Peter

Journal article  |  2012  |  Brain Pathology

A Novel Antibody-Targeted Recombinant Plasminogen Activator Directed to Activated Platelets Allows Efficient Antithrombotic Prophylaxis

Christoph E Hagemeyer, Xiaowei Wang, Jan-David Hohmann, Dexing Huang, Fu Jia, Karlheinz Peter

Conference Proceedings  |  2011  |  CIRCULATION

Clot-targeting Of CD39 Through Genetic Fusion To An Activated-platelet Specific Single-chain Antibody Provides Efficient Inhibition Of ADP Receptor-mediated Platelet Activation Without Systemic Platelet Inhibition

Jan David Hohmann, Stefanie Krajewski, Xiaowei Wang, Carly Selan, Andreas Straub, Harshal Nandurkar, Christoph Hagemeyer, Karlheinz Peter

Conference Proceedings  |  2011  |  CIRCULATION

Enzymatic Single-Chain Antibody Tagging A Universal Approach to Targeted Molecular Imaging and Cell Homing in Cardiovascular Disease

HT Ta, S Prabhu, E Leitner, F Jia, D von Elverfeldt, Katherine E Jackson, T Heidt, AKN Nair, H Pearce, C von zur Muhlen, X Wang, K Peter, CE Hagemeyer

Journal article  |  2011  |  Circulation Research

RATIONALE: Antibody-targeted delivery of imaging agents can enhance the sensitivity and accuracy of current imaging techniques. Si..