Xiaowei Wang

Near-infrared light-responsive liposomes for protein delivery: Towards bleeding-free photothermally-assisted thrombolysis.

Ahmed Refaat, Blanca Del Rosal, Jathushan Palasubramaniam, Geoffrey Pietersz, Xiaowei Wang, Simon E Moulton, Karlheinz Peter

Journal article  |  2021  |  J Control Release

Smart drug delivery systems represent state-of-the-art approaches for targeted therapy of life-threatening diseases such as cancer..

P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells.

Patrick M Siegel, Laura Sander, Alba Fricke, Johannes Stamm, Xiaowei Wang, Prerna Sharma, Nicole Bassler, Ya-Lan Ying, Christoph B Olivier, Steffen U Eisenhardt, Christoph Bode, Ingo Ahrens, Philipp Diehl, Karlheinz Peter

Journal article  |  2021  |  Sci Rep

P2Y12 blockade improves patient outcomes after myocardial infarction. As well as antithrombotic effects, anti-inflammatory effects..

Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy

Melrine Pereira, Natasha Ting Lee, Jonathan Noonan, Abbey EH Willcox, Ilaria Calvello, Smitha Rose Georgy, Carly Selan, Joanne S Chia, Wayne Hauw, Xiaowei Wang, Karlheinz Peter, Simon C Robson, Harshal H Nandurkar, Maithili Sashindranath

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Allogenic hematopoietic stem cell transplant (allo-HSCT) can lead to sinusoidal obstruction syndrome (SOS) and graft-versus-host d..

Molecular imaging of arterial and venous thrombosis.

Xiaowei Wang, Melanie Ziegler, James D McFadyen, Karlheinz Peter

Journal article  |  2021  |  Br J Pharmacol

Thrombosis contributes to one in four deaths worldwide and is the cause of a large proportion of mortality and morbidity. A reliab..

Smart Delivery of Plasminogen Activators for Efficient Thrombolysis; Recent Trends and Future Perspectives

Ahmed Refaat, Blanca del Rosal, Jathushan Palasubramaniam, Geoffrey Pietersz, Xiaowei Wang, Karlheinz Peter, Simon E Moulton

Journal article  |  2021  |  ADVANCED THERAPEUTICS

Fibrinolytic drugs have been successfully used to manage acute thrombotic and thromboembolic conditions. However, their narrow adm..

Visions by Women in Molecular Imaging Network: Antiracism and Allyship in Action

Eman Akam, Carmen Azevedo, Aisling M Chaney, Savita Dhanvantari, Kimberly J Edwards, Kelly E Henry, Oluwatosin Y Ibhagui, Jenny N Ijoma, Oluwatayo F Ikotun, Kyeara N Mack, Veronica L Nagle, Patricia MR Pereira, Mona L Purcell, Vanessa A Sanders, Monica Shokeen, Xiaowei Wang

Journal article  |  2021  |  MOLECULAR IMAGING AND BIOLOGY

Recent events in America in 2020 have stimulated a worldwide movement to dismantle anti-Black racism in all facets of our lives. A..

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Patrick M Siegel, Istvan Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto-Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, et al.

Journal article  |  2021  |  BASIC RESEARCH IN CARDIOLOGY

The monocyte β2-integrin Mac-1 is crucial for leukocyte-endothelium interaction, rendering it an attractive therapeutic target for..

Platelets in Multiple Sclerosis: Early and Central Mediators of Inflammation and Neurodegeneration and Attractive Targets for Molecular Imaging and Site-Directed Therapy

Jacqueline M Orian, Claretta S D'Souza, Pece Kocovski, Guy Krippner, Matthew W Hale, Xiaowei Wang, Karlheinz Peter

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Platelets are clearly central to thrombosis and hemostasis. In addition, more recently, evidence has emerged for non-hemostatic ro..

Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction

Poonam Sharma, Xiaowei Wang, Clara Liu Chung Ming, Laura Vettori, Gemma Figtree, Andrew Boyle, Carmine Gentile

Journal article  |  2021  |  SMALL

Despite the latest advances in cardiovascular biology and medicine, myocardial infarction (MI) remains one of the major causes of ..

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

Laura A Bienvenu, Jonathan Noonan, Xiaowei Wang, Karlheinz Peter

Journal article  |  2020  |  CARDIOVASCULAR RESEARCH

The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the cor..