Deb Colville

KCTD1 and Scalp-Ear-Nipple ('Finlay-Marks') syndrome may be associated with myopia and Thin basement membrane nephropathy through an effect on the collagen IV alpha 3 and alpha 4 chains

Dongmao Wang, Paul Trevillian, Stephen May, Peter Diakumis, Yanyan Wang, Deb Colville, Melanie Bahlo, Una Greferath, Erica Fletcher, Barbara Young, Heather G Mack, Judy Savige

Journal article  |  2022  |  OPHTHALMIC GENETICS

INTRODUCTION: Scalp-Ear-Nipple syndrome is caused by pathogenic KCTD1 variants and characterised by a scalp defect, prominent ears..

Increased retinal drusen in IgA glomerulonephritis are further evidence for complement activation in disease pathogenesis.

P Harraka, Tony Wightman, Sarah Akom, Kieran Sandhu, Deb Colville, Andrew Catran, David Langsford, Timothy Pianta, David Barit, Frank Ierino, Alison Skene, Heather Mack, Judy Savige

Journal article  |  2022  |  Sci Rep

Drusen are retinal deposits comprising cell debris, immune material and complement that are characteristic of macular degeneration..

Obstructive sleep apnea, chronic obstructive pulmonary disease and hypertensive microvascular disease: a cross-sectional observational cohort study.

Sky Chew, Deb Colville, Anastasia Hutchinson, Piers Canty, Lauren Hodgson, Judy Savige

Journal article  |  2022  |  Sci Rep

Hypertensive microvascular disease is associated with an increased risk of diastolic heart failure, vascular dementia and progress..

Retinal small vessel dilatation in the systemic inflammatory response to surgery.

Alexander Grogan, Karen Barclay, Deb Colville, Lauren Hodgson, Judy Savige

Journal article  |  2022  |  Sci Rep

Retinal microvascular calibre has been proposed as a predictor of cardiac events. Surgery is a major stimulus for inflammation whi..

Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis.

E Nicklason, Y Ham, D Ng, S Glance, K Abel, P Harraka, H Mack, D Colville, J Savige

Journal article  |  2022  |  Sci Rep

Retinal drusen are deposits of inflammatory proteins that are found in macular degeneration and glomerulonephritis and result, in ..

Taking a broader view of the health care needs of people with chronic kidney disease

Heather G Mack, Deborah J Colville, Judith A Savige

Journal article  |  2022  |  MEDICAL JOURNAL OF AUSTRALIA

Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis

P Harraka, H Mack, D Colville, D Barit, D Langsford, T Pianta, F Ierino, Judy Savige

Journal article  |  2022  |  SCIENTIFIC REPORTS

Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropat..

Retinal Drusen Are More Common and Larger in Systemic Lupus Erythematosus With Renal Impairment

Ye Ji Ham, Eleanor Nicklason, Tony Wightman, Sarah Akom, Kieran Sandhu, Philip Harraka, Deb Colville, Andrew Catran, David Barit, David Langsford, Tim Pianta, Andrew Foote, Russell Buchanan, Heather Mack, Judy Savige

Journal article  |  2022  |  KIDNEY INTERNATIONAL REPORTS

INTRODUCTION: Complement has been implicated in systemic lupus erythematosus (SLE) pathogenesis on the basis of the associations w..

Retinal findings in glomerulonephritis

Heather G Mack, Deborah J Colville, Phillip Harraka, Judith Anne Savige, Alessandro Invernizzi, Samantha Fraser-Bell

Journal article  |  2021  |  CLINICAL AND EXPERIMENTAL OPTOMETRY

The complement system is part of the innate immune system activated by three distinct pathways: classical, lectin and alternative...

Increased retinal venular calibre in acute infections

Cara Fitt, Vi Luong Thao, Damian Cresp, Anastasia Hutchinson, Karen Lim, Lauren Hodgson, Deb Colville, Judy Savige

Journal article  |  2021  |  SCIENTIFIC REPORTS

Population-based studies have demonstrated that increased retinal venular calibre is a risk factor for cardiac disease, cardiac ev..