Jock Campbell

Impact of access to novel therapies on the initial management of castrate-resistant prostate cancer: an Australian multicentre study

Edmond M Kwan, Marie C Semira, Alice RT Bergin, Christine Muttiah, Sophie Beck, Angelyn Anton, David Campbell, Shirley Wong, Mark Rosenthal, Peter Gibbs, Ben Tran

Journal article  |  2019  |  Internal Medicine Journal

BACKGROUND: The impact of regulatory approvals of new therapies for castration-resistant prostate cancer (CRPC) in Australia is un..

Threshold body mass index and sex-specific waist circumference for increased risk of heart failure with preserved ejection fraction

Duncan J Campbell, Fei Fei Gong, Michael Jelinek, Julian M Castro, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior

Journal article  |  2019  |  European Journal of Preventive Cardiology

BACKGROUND: Body mass index †Deceased. (BMI) is a risk factor for heart failure with preserved ejection fraction (HFpEF). DESIGN: ..

Age-specific diastolic dysfunction improves prediction of symptomatic heart failure by Stage B heart failure

Jennifer M Coller, Fei Fei Gong, Michele McGrady, Michael Jelinek, Julian M Castro, Umberto Boffa, Louise Shiel, Danny Liew, Simon Stewart, Henry Krum, Christopher M Reid, David L Prior, Duncan J Campbell

Journal article  |  2019  |  ESC Heart Failure

AIMS: We investigated whether addition of diastolic dysfunction (DD) and longitudinal strain (LS) to Stage B heart failure (SBHF) ..

Prediction of incident heart failure by serum amino-terminal pro-B-type natriuretic peptide level in a community-based cohort

Duncan J Campbell, Fei Fei Gong, Michael Jelinek, Julian M Castro, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Bing H Wang, Danny Liew, Rory Wolfe, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior

Journal article  |  2019  |  European Journal of Heart Failure

Neprilysin Inhibitors and Bradykinin

Duncan J Campbell

Journal article  |  2018  |  Frontiers in Medicine

Risk factors for incident heart failure with preserved or reduced ejection fraction, and valvular heart failure, in a community-based cohort

Fei Fei Gong, Michael Jelinek, Julian M Castro, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior, Duncan J Campbell

Journal article  |  2018  |  Open Heart

Risk factor management in a contemporary Australian population at increased cardiovascular disease risk

Duncan J Campbell, Jennifer M Coller, Fei Fei Gong, Michele McGrady, David L Prior, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Alice J Owen, Henry Krum, Christopher M Reid

Journal article  |  2018  |  Internal Medicine Journal

Noninvasive Cardiac Imaging and the Prediction of Heart Failure Progression in Preclinical Stage A/B Subjects

Fei Fei Gong, Duncan J Campbell, David L Prior

Journal article  |  2017  |  JACC: Cardiovascular Imaging

Letter by Campbell Regarding Article, ''gamma(delta) T Cells Mediate Angiotensin II-Induced Hypertension and Vascular Injury"

Duncan J Campbell

Journal article  |  2017  |  Circulation

The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury

Veena Roberts, Duncan J Campbell, Bo Lu, Joanne Chia, Peter J Cowan, Karen M Dwyer

Journal article  |  2017  |  Transplantation

Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial

James Winearls, Martin Wullschleger, Elizabeth Wake, Catherine Hurn, Jeremy Furyk, Glenn Ryan, Melita Trout, James Walsham, Anthony Holley, Jeremy Cohen, Megan Shuttleworth, Wayne Dyer, Gerben Keijzers, John F Fraser, Jeffrey Presneill, Don Campbell

Journal article  |  2017  |  Trials

Long-term neprilysin inhibition - implications for ARNIs

Duncan J Campbell

Journal article  |  2017  |  Nature Reviews Cardiology

SCReening Evaluation of the Evolution of New Heart Failure Study (SCREEN-HF): early detection of chronic heart failure in the workplace

Umberto Boffa, Michele McGrady, Christopher M Reid, Louise Shiel, Rory Wolfe, Danny Liew, Duncan J Campbell, Simon Stewart, Henry Krum

Journal article  |  2017  |  Australian Health Review

Therapeutic modulation of tissue kallikrein expression

Duncan J Campbell

Journal article  |  2016  |  Biological Chemistry

Can cardiovascular disease guidelines that advise treatment decisions based on absolute risk be improved?

Duncan J Campbell

Journal article  |  2016  |  BMC Cardiovascular Disorders

Letter by Campbell Regarding Article, "Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects"

Duncan J Campbell

Journal article  |  2016  |  Circulation

The clinical utility curve: a proposal to improve the translation of information provided by prediction models to clinicians.

Duncan J Campbell

Journal article  |  2016  |  BMC Research Notes

BACKGROUND: Prediction models are essential to the development of prediction rules that guide decision-making, and comparison of p..

Letter by Campbell Regarding Article, "Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction"

Duncan J Campbell

Journal article  |  2015  |  Circulation

Calibrated integrated backscatter and myocardial fibrosis in patients undergoing cardiac surgery

David L Prior, Jithendra B Somaratne, Alicia J Jenkins, Michael Yii, Andrew E Newcomb, Casper G Schalkwijk, Mary J Black, Darren J Kelly, Duncan J Campbell

Journal article  |  2015  |  Open Heart

Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia

Tong Zhu, Antonia G Miller, Devy Deliyanti, David R Berka, Alex Agrotis, Duncan J Campbell, Jennifer L Wilkinson-Berka

Journal article  |  2015  |  Clinical and Experimental Pharmacology and Physiology

Meditation on medical practice.

D Campbell

Journal article  |  2014  |  The Medical journal of Australia

Amino-terminal-pro-B-type natriuretic peptide levels and low diastolic blood pressure: potential relevance to the diastolic J-curve

Duncan J Campbell, Michele McGrady, David L Prior, Jennifer M Coller, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Simon Stewart, Christopher M Reid, Henry Krum

Journal article  |  2014  |  Journal of Hypertension

The undivided patient: a retrospective cohort analysis of specialty referrals made from inpatient general medical units comparing regional to metropolitan practice

MG Brown, D Campbell, BW Maydom

Journal article  |  2014  |  Internal Medicine Journal

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

Sean L McGee, Courtney Swinton, Shona Morrison, Vidhi Gaur, Duncan E Campbell, Sebastian B Jorgensen, Bruce E Kemp, Keith Baar, Gregory R Steinberg, M Hargreaves

Journal article  |  2014  |  The FASEB Journal

A Pilot Study for a Prospective, Randomized, --DoubleBlind Trial of the Influence of Anesthetic Depth on Long- Term Outcome

Timothy G Short, Kate Leslie, Douglas Campbell, Matthew TV Chan, Tomas Corcoran, Edward O'Loughlin, Chris Frampton, Paul Myles

Journal article  |  2014  |  Anesthesia & Analgesia

Aliskiren Reduces Myocardial Ischemia-Reperfusion Injury by a Bradykinin B-2 Receptor- and Angiotensin AT(2) Receptor-Mediated Mechanism

Suang Suang Koid, James Ziogas, Duncan John Campbell

Journal article  |  2014  |  Hypertension

The Operating Surgeon Is an Independent Predictor of Chest Tube Drainage Following Cardiac Surgery

Barry Dixon, David Reid, Marnie Collins, Andrew E Newcomb, Alexander Rosalion, Cheng-Hon Yap, John D Santamaria, Duncan J Campbell

Journal article  |  2014  |  Journal of Cardiothoracic and Vascular Anesthesia

Primary prevention of cardiovascular disease: new guidelines, technologies and therapies

Duncan J Campbell

Journal article  |  2014  |  The Medical Journal of Australia

Clinical relevance of local renin angiotensin systems

Duncan J Campbell

Journal article  |  2014  |  Frontiers in Endocrinology

Obesity Is Associated with Lower Coronary Microvascular Density

Duncan J Campbell, Jithendra B Somaratne, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Darren J Kelly, Mary Jane Black

Journal article  |  2013  |  PLoS One

Reduced microvascular density in non-ischemic myocardium of patients with recent non-ST-segment-elevation myocardial infarction

Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Darren J Kelly, Mary Jane Black

Journal article  |  2013  |  International Journal of Cardiology

Do intravenous and subcutaneous angiotensin II increase blood pressure by different mechanisms?

Duncan J Campbell

Journal article  |  2013  |  Clinical and Experimental Pharmacology and Physiology

Evolving concepts of the renin-angiotensin system: Highlights from the pre-ISH 2012 satellite meeting

Suang S Koid, Duncan J Campbell

Journal article  |  2013  |  Journal of Renin-Angiotensin-Aldosterone System

Early Identification of Asymptomatic Subjects at Increased Risk of Heart Failure and Cardiovascular Events: Progress and Future Directions

JM Coller, DJ Campbell, H Krum, DL Prior

Journal article  |  2013  |  Heart, Lung and Circulation

Most individuals with treated blood pressures above target receive only one or two antihypertensive drug classes

DJ Campbell, M McGrady, DL Prior, JM Coller, U Boffa, L Shiel, D Liew, R Wolfe, S Stewart, CM Reid, H Krum

Journal article  |  2013  |  Internal Medicine Journal

The association of blood transfusion with mortality after cardiac surgery: cause or confounding? (CME)

Barry Dixon, John D Santamaria, David Reid, Marnie Collins, Thomas Rechnitzer, Andrew E Newcomb, Ian Nixon, Michael Yii, Alexander Rosalion, Duncan J Campbell

Journal article  |  2013  |  Transfusion

Transthoracic echocardiography findings Implications for clinical management

Jennifer Coller, Duncan Campbell, Henry Krum, David Prior

Journal article  |  2012  |  Australian Family Physician

Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels

Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Casper G Schalkwijk, Mary Jane Black, Darren J Kelly

Journal article  |  2012  |  PLoS One

Angiotensin II generation in vivo: does it involve enzymes other than renin and angiotensin-converting enzyme?

Duncan J Campbell

Journal article  |  2012  |  Journal of Renin-Angiotensin-Aldosterone System

Vaccination Against High Blood Pressure

Duncan J Campbell

Journal article  |  2012  |  Current Pharmaceutical Design

Increased Angiotensin II-Induced Hypertension and Inflammatory Cytokines in Mice Lacking Angiotensin-Converting Enzyme N Domain Activity

Frank S Ong, Chentao X Lin, Duncan J Campbell, Derick Okwan-Duodu, Xu Chen, Wendell-Lamar B Blackwell, Kandarp H Shah, Romer A Gonzalez-Villalobos, Xiao Z Shen, Sebastien Fuchs, Kenneth E Bernstein

Journal article  |  2012  |  Hypertension

Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat

JL Wilkinson-Berka, G Tan, KJ Binger, L Sutton, K McMaster, D Deliyanti, G Perera, DJ Campbell, AG Miller

Journal article  |  2011  |  Diabetologia

Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart

Duncan J Campbell, Yuan Zhang, Darren J Kelly, Richard E Gilbert, Davis J McCarthy, Wei Shi, Gordon K Smyth

Journal article  |  2011  |  Clinical and Experimental Pharmacology and Physiology

Aprotinin, but not tranexamic acid, is associated with increased pulmonary microvascular fibrin deposition after cardiac surgery

Barry Dixon, Ian Nixon, James Kenny, Andrew E Newcomb, Alexander Rosalion, Kenneth Opeskin, Georgia Stamaratis, Brendan S Silbert, S Said, John D Santamaria, Duncan J Campbell

Journal article  |  2011  |  Thrombosis Research

Differences in Myocardial Structure and Coronary Microvasculature Between Men and Women With Coronary Artery Disease

Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Darren J Kelly, Mary Jane Black

Journal article  |  2011  |  Hypertension

Pre-operative heparin reduces pulmonary microvascular fibrin deposition following cardiac surgery

Barry Dixon, Kenneth Opeskin, Georgia Stamaratis, Ian Nixon, Michael Yi, Andrew E Newcomb, Alexander Rosalion, Yuan Zhang, John D Santamaria, Duncan J Campbell

Journal article  |  2011  |  Thrombosis Research

Whole Body Deletion of AMP-activated Protein Kinase beta 2 Reduces Muscle AMPK Activity and Exercise Capacity

Gregory R Steinberg, Hayley M O'Neill, Nicolas L Dzamko, Sandra Galic, Tim Naim, Rene Koopman, Sebastian B Jorgensen, Jane Honeyman, Kimberly Hewitt, Zhi-Ping Chen, Jonathan D Schertzer, John W Scott, Frank Koentgen, Gordon S Lynch, Matthew J Watt, Bryce JW van denderen, Duncan J Campbell, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease

Duncan J Campbell, Habib Karam, Patrick Bruneval, John J Mullins, Joel Menard

Journal article  |  2010  |  Journal of Hypertension

RILLKKMPSV Influences the Vasculature, Neurons and Glia, and (Pro)Renin Receptor Expression in the Retina

Jennifer L Wilkinson-Berka, Ronen Heine, Genevieve Tan, Mark E Cooper, Kate M Hatzopoulos, Erica L Fletcher, Katrina J Binger, Duncan J Campbell, Antonia G Miller

Journal article  |  2010  |  Hypertension

Increased tissue kallikrein levels in type 2 diabetes

DJ Campbell, A Kladis, Y Zhang, AJ Jenkins, DL Prior, M Yii, JF Kenny, MJ Black, DJ Kelly

Journal article  |  2010  |  Diabetologia

Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial

Barry Dixon, Marcus J Schultz, Roger Smith, James B Fink, John D Santamaria, Duncan J Campbell

Journal article  |  2010  |  Critical Care

AMPK beta 1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Nicolas Dzamko, Bryce JW van Denderen, Andrea L Hevener, Sebastian Beck Jorgensen, Jane Honeyman, Sandra Galic, Zhi-Ping Chen, Matthew J Watt, Duncan J Campbell, Gregory R Steinberg, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

Nebulized heparin reduces levels of pulmonary coagulation activation in acute lung injury

BD Dixon, undefined Schultz, undefined Hofstra, DJC Campbell, JDS Santamaria

Journal article  |  2010  |  Critical Care

Prorenin Contributes to Angiotensin Peptide Formation in Transgenic Rats With Rat Prorenin Expression Targeted to the Liver

Duncan J Campbell, Habib Karam, Joel Menard, Patrick Bruneval, John J Mullins

Journal article  |  2009  |  Hypertension

Renin inhibitors - Mechanisms of action

DJ Campbell

Journal article  |  2009  |  Australian Prescriber

Method of blood collection may explain the suppression of plasma renin concentration in prorenin transgenic mice.

Duncan John Campbell

Journal article  |  2009  |  Hypertension

(Pro)renin Receptor: A Treatment Target for Diabetic Retinopathy?

Jennifer L Wilkinson-Berka, Duncan J Campbell

Journal article  |  2009  |  Diabetes

Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

Duncan J Campbell, Juerg Nussberger, Michael Stowasser, AH Jan Danser, Alberto Morganti, Erik Frandsen, Joel Menard

Journal article  |  2009  |  Clinical Chemistry

Genetic models provide unique insight into angiotensin and bradykinin peptides in the extravascular compartment of the heart in vivo.

Duncan J Campbell, Hong D Xiao, Sebastien Fuchs, Kenneth E Bernstein

Journal article  |  2009  |  Clinical and Experimental Pharmacology and Physiology

1. There is continuing uncertainty about the tissue compartments where angiotensin and bradykinin peptide formation occurs. Mice w..

Angiotensin vaccination: what is the prospect of success?

Duncan J Campbell

Journal article  |  2009  |  Current Hypertension Reviews

Over many decades, several attempts have been made to treat hypertension using a vaccination strategy to inhibit the renin-angiote..

Aliskiren therapy will have minimal effect on intracellular renin of renin-producing cells.

Duncan John Campbell

Journal article  |  2009  |  Hypertension

Associations of proinflammatory cytokines with the risk of recurrent stroke

Paul Welsh, Gordon DO Lowe, John Chalmers, Duncan J Campbell, Ann Rumley, Bruce C Neal, Stephen W MacMahon, Mark Woodward

Journal article  |  2008  |  Stroke

Elevated pulmonary dead space and coagulation abnormalities suggest lung microvascular thrombosis in patients undergoing cardiac surgery

Barry Dixon, Duncan J Campbell, John D Santamaria

Journal article  |  2008  |  Intensive Care Medicine

Osmoregulatory fluid intake but not hypovolemic thirst is intact in mice lacking angiotensin

Michael J McKinley, Lesley L Walker, Theodora Alexiou, Andrew M Allen, Duncan J Campbell, Robert Di Nicolantonio, Brian J Oldfield, Derek A Denton

Journal article  |  2008  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins exretion in man.

Michel Azizi, Costanza Emanueli, Severine Peyrard, Paolo Maddedu, François Alhenc-Gelas, Duncan J Campbell

Journal article  |  2008  |  Journal of Hypertension

OBJECTIVES: Tissue kallikrein is a major kinin-forming enzyme involved in artery and kidney functions. Urinary tissue kallikrein a..

Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy.

Hong D Xiao, Sebastien Fuchs, Ellen A Bernstein, Ping Li, Duncan J Campbell, Kenneth E Bernstein

Journal article  |  2008  |  American Journal of Physiology - Heart and Circulatory Physiology

In the heart, angiotensin II has been suggested to regulate cardiac remodeling and promote cardiac hypertrophy. To examine this, w..

A phase 1 trial of nebulised heparin in acute lung injury

Barry Dixon, John D Santamaria, Duncan J Campbell

Journal article  |  2008  |  Critical Care

Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease

Duncan J Campbell, Bruce C Neal, John R Chalmers, Samuel A Colman, Alicia J Jenkins, Bruce E Kemp, Anushka Patel, Stephen W MacMahon, Mark Woodward

Journal article  |  2007  |  European Journal of Cardiovascular Prevention & Rehabilitation

Putting blood pressure in its place.

Duncan J Campbell

Journal article  |  2007  |  Journal of Hypertension

The benefit of blood pressure-lowering therapy in individuals with normal blood pressure who are at high cardiovascular risk creat..

Perindopril-based blood pressure-lowering therapy reduces amino-terminal-pro-B-type natriuretic peptide in individuals with cerebrovascular disease

Duncan J Campbell, Mark Woodward, John P Chalmers, Samuel A Colman, Alicia J Jenkins, Bruce E Kemp, Bruce C Neal, Anushka Patel, Stephen W MacMahon

Journal article  |  2007  |  Journal of Hypertension

Carvedilol reduces aldosterone release in systolic heart failure.

Anuradha Aggarwal, James Wong, Duncan J Campbell

Journal article  |  2006  |  Heart, Lung & Circulation

BACKGROUND: Treatment of advanced systolic heart failure (HF) with the aldosterone antagonist spironolactone on the background of ..

AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in rats.

Xiao C Li, Duncan J Campbell, Mitsuru Ohishi, Shao Yuan, Jia L Zhuo

Journal article  |  2006  |  American Journal of Physiology: Renal Physiology

Angiotensin IV (ANG IV), an active ANG II fragment, has been shown to induce systemic and renal cortical effects by binding to ANG..

Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension

H Krum, E Lambert, E Windebank, DJ Campbell, M Esler

Journal article  |  2006  |  American Journal of Physiology - Heart and Circulatory Physiology

Chronic ethanol ingestion increases superoxide production and NADPH oxidase expression in the lung.

John A Polikandriotis, Heidi L Rupnow, Shawn C Elms, Roza E Clempus, Duncan J Campbell, Roy L Sutliff, Lou Ann S Brown, David M Guidot, C Michael Hart

Journal article  |  2006  |  American Journal of Respiratory Cell and Molecular Biology

Alcohol abuse increases the incidence of acute respiratory distress syndrome and causes oxidative stress and cellular dysfunction ..

A review of Perindopril in the reduction of cardiovascular events.

Duncan J Campbell

Journal article  |  2006  |  Vascular Health and Risk Management

BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEI) have a well-established role in the prevention of cardiovascular event..

L-NAME hypertension: trying to fit the pieces together.

Duncan J Campbell

Journal article  |  2006  |  Journal of Hypertension

Soluble vascular cell adhesion molecule 1 and N-terminal Pro-B-type natriuretic peptide in predicting ischemic stroke in patients with cerebrovascular disease

DJ Campbell, M Woodward, JP Chalmers, SA Colman, AJ Jenkins, BE Kemp, BC Neal, A Patel, SW MacMahon

Journal article  |  2006  |  Archives of Neurology

Associations of inflammatory and hemostatic variables with the risk of recurrent stroke

M Woodward, GDO Lowe, DJ Campbell, S Colman, A Rumley, J Chalmers, BC Neal, A Patel, AJ Jenkins, BE Kemp, SW MacMahon

Journal article  |  2005  |  Stroke

Angiotensin-(1-7) enhances anti-aggregatory effects of the nitric oxide donor sodium nitroprusside

S Rajendran, YY Chirkov, DJ Campbell, JD Horowitz

Journal article  |  2005  |  Journal of Cardiovascular Pharmacology

Fungiform papillary glossitis: atopic disease in the mouth?

R Marks, CE Scarff, LM Yap, V Verlinden, D Jolley, J Campbell

Journal article  |  2005  |  British Journal of Dermatology

Coagulation activation and organ dysfunction following cardiac surgery

B Dixon, J Santamaria, D Campbell

Journal article  |  2005  |  Chest

Angiotensinogen and angiotensin-converting enzyme gene copy number and angiotensin and bradykinin peptide levels in mice

T Alexiou, WM Boon, DA Denton, R Di Nicolantonio, LL Walker, MJ McKinley, DJ Campbell

Journal article  |  2005  |  Journal of Hypertension

Angiotensin II and norepinephrine release: interaction and effects on the heart.

Markus P Schlaich, David M Kaye, Elisabeth Lambert, Jacqui Hastings, Duncan J Campbell, Gavin Lambert, Murray D Esler

Journal article  |  2005  |  Journal of Hypertension

BACKGROUND: Angiotensin (Ang) II may enhance the influence of the sympathetic nervous system at various levels by facilitating nor..

Losartan increases bradykinin levels in hypertensive humans

DJ Campbell, H Krum, MD Esler

Journal article  |  2005  |  Circulation

Prediction of heart failure by amino terminal-pro-B-type natriuretic peptide and C-reactive protein in subjects with cerebrovascular disease

DJ Campbell, M Woodward, JP Chalmers, SA Colman, AJ Jenkins, BE Kemp, BC Neal, A Patel, SW MacMahon

Journal article  |  2005  |  Journal of Hypertension

Long-term renoprotection by perindopril or nifedipine in non-hypertensive patients with Type 2 diabetes and microalbuminuria

G Jerums, TJ Allen, DJ Campbell, ME Cooper, RE Gilbert, JJ Hammond, RC O'Brien, J Raffaele, C Tsalamandris

Journal article  |  2004  |  Diabetic Medicine

Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation

DJ Campbell, CJ Zeitz, MD Esler, JD Horowitz

Journal article  |  2004  |  Journal of Hypertension

AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females

GR Steinberg, AC Smith, BJW van Denderen, ZP Chen, S Murthy, DJ Campbell, GJF Heigenhauser, DJ Dyck, BE Kemp

Journal article  |  2004  |  Journal of Clinical Endocrinology & Metabolism

Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.

Hong D Xiao, Sebastien Fuchs, Duncan J Campbell, William Lewis, Samuel C Dudley, Vijaykumar S Kasi, Brian D Hoit, George Keshelava, Hui Zhao, Mario R Capecchi, Kenneth E Bernstein

Journal article  |  2004  |  American Journal of Pathology

To investigate the local effects of angiotensin II on the heart, we created a mouse model with 100-fold normal cardiac angiotensin..

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

KM Dwyer, SC Robson, HH Nandurkar, DJ Campbell, H Gock, LJ Murray-Segal, N Fisicaro, TB Mysore, E Kaczmarek, PJ Cowan, AJF d'Apice

Journal article  |  2004  |  Journal of Clinical Investigation

Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice

DJ Campbell, T Alexiou, HD Xiao, S Fuchs, MJ McKinley, P Corvol, KE Bernstein

Journal article  |  2004  |  Hypertension

Heart failure: how can we prevent the epidemic?

Matthew T Naughton, Darren R Mansfield, David M Kaye, Peter Bergin, Meroula Richardson

Journal article  |  2004  |  Medical Journal of Australia

Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and Angiotensin neuromodulation.

Markus P Schlaich, Elisabeth Lambert, David M Kaye, Zygmunt Krozowski, Duncan J Campbell, Gavin Lambert, Jacqui Hastings, Anuradha Aggarwal, Murray D Esler

Journal article  |  2004  |  Hypertension

There is growing evidence that essential hypertension is commonly neurogenic and is initiated and sustained by sympathetic nervous..

Hypertension in the (mRen-2)27 rat is not explained by enhanced kinetics of transgenic Ren-2 renin.

Pei Rong, Duncan J Campbell, Sandford L Skinner

Journal article  |  2003  |  Hypertension

Enhanced efficiency of the reaction between transgenic Ren-2 mouse renin and endogenous rat angiotensinogen has been suggested as ..

Protection of research subjects.

Jeffrey L Kaufman

Journal article  |  2003  |  New England Journal of Medicine

The renin-angiotensin and the kallikrein-kinin systems.

Duncan J Campbell

Journal article  |  2003  |  International Journal of Biochemistry and Cell Biology

The renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS) each encompasses a large number of molecules, with severa..

AMPK beta subunit targets metabolic stress sensing to glycogen

G Polekhina, A Gupta, BJ Michell, B van Denderen, S Murthy, SC Feil, IG Jennings, DJ Campbell, LA Witters, MW Parker, BE Kemp, D Stapleton

Journal article  |  2003  |  Current Biology

Plasminogen activator inhibitor activity is associated with raised lactate levels after cardiac surgery with cardiopulmonary bypass

B Dixon, JD Santamaria, DJ Campbell

Journal article  |  2003  |  Critical Care Medicine

Myocardial uptake and biochemical and hemodynamic effects of ACE inhibitors in humans

CJ Zeitz, DJ Campbell, JD Horowitz

Journal article  |  2003  |  Hypertension

Vasopeptidase inhibition: a double-edged sword?

Duncan John Campbell

Journal article  |  2003  |  Hypertension

The enormous benefits of inhibition of ACE demonstrate that manipulation of the metabolism of peptide hormones is a valuable thera..

AMP-activated protein kinase, super metabolic regulator

BE Kemp, D Stapleton, DJ Campbell, ZP Chen, S Murthy, M Walter, A Gupta, JJ Adams, F Katsis, B van Denderen, IG Jennings, T Iseli, BJ Michell, LA Witters

Journal article  |  2003  |  Biochemical Society Transactions

Heart failure: how can we prevent the epidemic?

DJ CAMPBELL

Journal article  |  2003  |  Medical Journal of Australia

Renin-angiotensin system inhibition: how much is too much of a good thing?

DJ Campbell

Journal article  |  2002  |  Internal Medicine Journal

Inhibitors of the renin-angiotensin system (RAS) are valuable therapeutic agents for a wide range of clinical conditions. Increasi..

Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat

JL Wilkinson-Berka, DJ Kelly, P Rong, DJ Campbell, SL Skinner

Journal article  |  2002  |  Molecular and Cellular Endocrinology

Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency.

Fiona E Mackie, Timothy W Meyer, Duncan J Campbell

Journal article  |  2002  |  Kidney International

BACKGROUND: Whereas angiotensin converting enzyme inhibitors and angiotensin type 1 receptor antagonists have beneficial effects i..

Valsartan in chronic heart failure

DJ CAMPBELL

Journal article  |  2002  |  New England Journal of Medicine

The kallikrein-kinin system in humans.

DJ Campbell

Journal article  |  2001  |  Clinical and Experimental Pharmacology and Physiology

1. Kinin peptides are implicated in many physiological and pathological processes, including the regulation of blood pressure and ..

beta-blockers, angiotensin II, and ACE inhibitors in patients with heart failure.

DJ Campbell, A Aggarwal, M Esler, D Kaye

Journal article  |  2001  |  The Lancet

Blood concentrations of angiotensin II are often raised in patients with heart failure, despite treatment with angiotensin-convert..

Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans

DJ Campbell, B Dixon, A Kladis, M Kemme, JD Santamaria

Journal article  |  2001  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Plasma amino-terminal pro-brain natriuretic peptide levels in subjects presenting to the Emergency Department with suspected acute coronary syndrome: possible role in selecting patients for follow up?

DJ Campbell, V Munir, OF Hennessy, AW Dent

Journal article  |  2001  |  Internal Medicine Journal

Long-term comparison between perindopril and nifedipine in normotensive patients with type 1 diabetes and microalbuminuria

G Jerums, TJ Allen, DJ Campbell, ME Cooper, RE Gilbert, JJ Hammond, J Raffaele, C Tsalamandris

Journal article  |  2001  |  American Journal of Kidney Diseases

The peripheral renin-angiotensin system is not involved in the hypertension of sheep exposed to prenatal dexamethasone

A Peers, DJ Campbell, EM Wintour, M Dodic

Journal article  |  2001  |  Clinical and Experimental Pharmacology and Physiology

Intrarenal angiotensin and bradykinin peptide levels in the remnant kidney model of renal insufficiency.

FE Mackie, DJ Campbell, TW Meyer

Journal article  |  2001  |  Kidney International

BACKGROUND: The remnant kidney model of renal failure is associated with normal or suppressed plasma renin and angiotensin (Ang) I..

Angiotensin-(1-7) in the ovine fetus

KM Moritz, DJ Campbell, EM Wintour

Journal article  |  2001  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Urinary levels of substance P and its metabolites are not increased in interstitial cystitis

DJ Campbell, N Tenis, A Rosamilia, JA Clements, PL Dwyer

Journal article  |  2001  |  BJU International