Alex Andrianopoulos

Adaptation to Industrial Stressors Through Genomic and Transcriptional Plasticity in a Bioethanol Producing Fission Yeast Isolate

Dane Vassiliadis, Koon Ho Wong, Jo Blinco, Geoff Dumsday, Alex Andrianopoulos, Brendon Monahan

Journal article  |  2020  |  G3: Genes|Genomes|Genetics

Schizosaccharomyces pombe is a model unicellular eukaryote with ties to the basic research, oenology and industrial biotechnology ..

Calcineurin A Is Essential in the Regulation of Asexual Development, Stress Responses and Pathogenesis in Talaromyces marneffei

Yan-Qing Zheng, Kai-Su Pan, Jean-Paul Latge, Alex Andrianopoulos, Hong Luo, Ru-Fan Yan, Jin-Ying Wei, Chun-Yang Huang, Cun-Wei Cao

Journal article  |  2020  |  Frontiers in Microbiology

Laboratory Maintenance and Growth of Talaromyces marneffei.

Alex Andrianopoulos

Journal article  |  2020  |  Current Protocols in Microbiology

Talaromyces marneffei is an important opportunistic human pathogen endemic to Southeast Asia. It is one of a number of pathogenic ..

beta-glucan-dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment

Vahid Pazhakh, Felix Ellett, Ben A Croker, Joanne A O'Donnell, Luke Pase, Keith E Schulze, R Stefan Greulich, Aakash Gupta, Constantino Carlos Reyes-Aldasoro, Alex Andrianopoulos, Graham J Lieschke

Journal article  |  2019  |  PLOS Biology

The initial host response to fungal pathogen invasion is critical to infection establishment and outcome. However, the diversity o..

In Vitro Susceptibility of Berberine Combined with Antifungal Agents Against the Yeast Form of Talaromyces marneffei

Hong Luo, Kai-su Pan, Xiao-lu Luo, Dong-yan Zheng, Alex Andrianopoulos, Le-min Wen, Yan-qing Zheng, Jing Guo, Chun-yang Huang, Xiu-ying Li, Rong Hu, Yu-jiao Li, Tian-min Li, Justin Joseph, Cun-wei Cao, Gang Liang

Journal article  |  2019  |  Mycopathologia

A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe

Dane Vassiliadis, Koon Ho Wong, Alex Andrianopoulos, Brendon J Monahan

Journal article  |  2019  |  BMC Genomics

A unique aspartyl protease gene expansion in Talaromyces marneffei plays a role in growth inside host phagocytes

Michael Payne, Harshini Weerasinghe, Irma Tedja, Alex Andrianopoulos

Journal article  |  2019  |  Virulence

Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo

Felix Ellett, Vahid Pazhakh, Luke Pase, Erica L Benard, Harshini Weerasinghe, Denis Azabdaftari, Sultan Alasmari, Alex Andrianopoulos, Graham J Lieschke

Journal article  |  2018  |  PLOS Pathogens

Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages

Kylie J Boyce, David P De Souza, Saravanan Dayalan, Shivani Pasricha, Dedreia Tull, Malcolm J McConville, Alex Andrianopoulos

Journal article  |  2018  |  mSphere

Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei

Shivani Pasricha, James I MacRae, Hwa H Chua, Jenny Chambers, Kylie J Boyce, Malcolm J McConville, Alex Andrianopoulos

Journal article  |  2017  |  Frontiers in Cellular and Infection Microbiology

Differentially regulated high-affinity iron assimilation systems support growth of the various cell types in the dimorphic pathogen Talaromyces marneffei

Shivani Pasricha, Lukas Schafferer, Herbert Lindner, Kylie Joanne Boyce, Hubertus Haas, Alex Andrianopoulos

Journal article  |  2016  |  Molecular Microbiology

A Plastic Vegetative Growth Threshold Governs Reproductive Capacity in Aspergillus nidulans

Luke M Noble, Linda M Holland, Alisha J McLauchlan, Alex Andrianopoulos

Journal article  |  2016  |  Genetics

Talaromyces marneffei laccase modifies THP-1 macrophage responses

Ariya Sapmak, Jutikul Kaewmalakul, Joshua D Nosanchuk, Nongnuch Vanittanakom, Alex Andrianopoulos, Kritsada Pruksaphon, Sirida Youngchim

Journal article  |  2016  |  Virulence

Organism-wide studies into pathogenicity and morphogenesis in Talaromyces marneffei

Harshini Weerasinghe, Michael Payne, Sally Beard, Alex Andrianopoulos

Journal article  |  2016  |  Future Microbiology

Two-Component Signaling Regulates Osmotic Stress Adaptation via SskA and the High-Osmolarity Glycerol MAPK Pathway in the Human Pathogen Talaromyces marneffei

Kylie J Boyce, Cunwei Cao, Alex Andrianopoulos

Journal article  |  2016  |  mSphere

Fungal dimorphism: the switch from hyphae to yeast is a specialized morphogenetic adaptation allowing colonization of a host

Kylie J Boyce, Alex Andrianopoulos

Journal article  |  2015  |  FEMS Microbiology Reviews

Thermally Dimorphic Human Fungal Pathogens-Polyphyletic Pathogens with a Convergent Pathogenicity Trait

Anita Sil, Alex Andrianopoulos

Journal article  |  2015  |  Cold Spring Harbor Perspectives in Medicine

KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans

Agnieszka Gacek-Matthews, Luke M Noble, Clemens Gruber, Harald Berger, Michael Sulyok, Ana T Marcos, Joseph Strauss, Alex Andrianopoulos

Journal article  |  2015  |  Molecular Microbiology

Morphogenesis and pathogenesis: control of cell identity in a dimorphic pathogen

Hayley E Bugeja, Alex Andrianopoulos

Journal article  |  2015  |  Microbiology Australia

The pbrB Gene Encodes a Laccase Required for DHN-Melanin Synthesis in Conidia of Talaromyces (Penicillium) marneffei

Ariya Sapmak, Kylie J Boyce, Alex Andrianopoulos, Nongnuch Vanittanakom

Journal article  |  2015  |  PLOS ONE

Intracellular Growth Is Dependent on Tyrosine Catabolism in the Dimorphic Fungal Pathogen Penicillium marneffei

Kylie J Boyce, Alisha McLauchlan, Lena Schreider, Alex Andrianopoulos

Journal article  |  2015  |  PLOS PATHOGENS

Genome Sequence of the AIDS-Associated Pathogen Penicillium marneffei (ATCC18224) and Its Near Taxonomic Relative Talaromyces stipitatus (ATCC10500)

William C Nierman, Natalie D Fedorova-Abrams, Alex Andrianopoulos

Journal article  |  2015  |  MICROBIOLOGY RESOURCE ANNOUNCEMENTS

Cell-Type-Specific Transcriptional Profiles of the Dimorphic Pathogen Penicillium marneffei Reflect Distinct Reproductive, Morphological, and Environmental Demands

Shivani Pasricha, Michael Payne, David Canovas, Luke Pase, Nathamon Ngaosuwankul, Sally Beard, Alicia Oshlack, Gordon K Smyth, Sansanee C Chaiyaroj, Kylie J Boyce, Alex Andrianopoulos

Journal article  |  2013  |  G3: Genes, Genomes, Genetics

Reproductive competence: a recurrent logic module in eukaryotic development

Luke M Noble, Alex Andrianopoulos

Journal article  |  2013  |  Proceedings of the Royal Society B: Biological Sciences

HgrA is necessary and sufficient to drive hyphal growth in the dimorphic pathogen Penicillium marneffei

Hayley E Bugeja, Michael J Hynes, Alex Andrianopoulos

Journal article  |  2013  |  Molecular Microbiology

Morphogenetic Circuitry Regulating Growth and Development in the Dimorphic Pathogen Penicillium marneffei

Kylie J Boyce, Alex Andrianopoulos

Journal article  |  2013  |  Eukaryotic Cell

Fungal Genes in Context: Genome Architecture Reflects Regulatory Complexity and Function

Luke M Noble, Alex Andrianopoulos

Journal article  |  2013  |  Genome Biology & Evolution

Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability

Vinita Joardar, Natalie F Abrams, Jessica Hostetler, Paul J Paukstelis, Suchitra Pakala, Suman B Pakala, Nikhat Zafar, Olukemi O Abolude, Gary Payne, Alex Andrianopoulos, David W Denning, William C Nierman

Journal article  |  2012  |  BMC Genomics

Clonality Despite Sex: The Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffei

Daniel A Henk, Revital Shahar-Golan, Khuraijam Ranjana Devi, Kylie J Boyce, Nengyong Zhan, Natalie D Fedorova, William C Nierman, Po-Ren Hsueh, Kwok-Yung Yuen, Tran PM Sieu, Van Kinh Nguyen, Heiman Wertheim, Stephen G Baker, Jeremy N Day, Nongnuch Vanittanakom, Elaine M Bignell, Alex Andrianopoulos, Matthew C Fisher

Journal article  |  2012  |  PLoS Pathogens

Tools for high efficiency genetic manipulation of the human pathogen Penicillium marneffei

Hayley E Bugeja, Kylie J Boyce, Harshini Weerasinghe, Sally Beard, Anne Jeziorowski, Shivani Pasricha, Michael Payne, Lena Schreider, Alex Andrianopoulos

Journal article  |  2012  |  Fungal Genetics and Biology

Macrophage infection by fungi

KJ Boyce, A Andrianopoulos

Journal article  |  2012  |  Bio-Protocol

Strategies for the molecular genetic manipulation and visualization of the human fungal pathogen Penicillium marneffei

KJ Boyce, HE Bugeja, HC Weerasinghe, MJ Payne, L Schreider, C Park, T WOODWARD, A Andrianopoulos

Journal article  |  2012  |  Fungal Genetics Reports

AreA controls nitrogen source utilisation during both growth programs of the dimorphic fungus Penicillium marneffei

Hayley E Bugeja, Michael J Hynes, Alex Andrianopoulos

Journal article  |  2012  |  Fungal Biology

The two-component histidine kinases DrkA and SlnA are required for in vivo growth in the human pathogen Penicillium marneffei

Kylie J Boyce, Lena Schreider, Leonie Kirszenblat, Alex Andrianopoulos

Journal article  |  2011  |  Molecular Microbiology

Ste20-related kinases: effectors of signaling and morphogenesis in fungi

Kylie J Boyce, Alex Andrianopoulos

Journal article  |  2011  |  Trends in Microbiology

Role of Carnitine Acetyltransferases in Acetyl Coenzyme A Metabolism in Aspergillus nidulans

Michael J Hynes, Sandra L Murray, Alex Andrianopoulos, Meryl A Davis

Journal article  |  2011  |  Eukaryotic Cell

The Fungal Type II Myosin in Penicillium marneffei, MyoB, Is Essential for Chitin Deposition at Nascent Septation Sites but Not Actin Localization

David Canovas, Kylie J Boyce, Alex Andrianopoulos

Journal article  |  2011  |  Eukaryotic Cell

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

Felix Ellett, Luke Pase, John W Hayman, Alex Andrianopoulos, Graham J Lieschke

Journal article  |  2011  |  Blood

The RFX Protein RfxA Is an Essential Regulator of Growth and Morphogenesis in Penicillium marneffei

Hayley E Bugeja, Michael J Hynes, Alex Andrianopoulos

Journal article  |  2010  |  Eukaryotic Cell

In Vivo Yeast Cell Morphogenesis Is Regulated by a p21-Activated Kinase in the Human Pathogen Penicillium marneffei

Kylie J Boyce, Lena Schreider, Alex Andrianopoulos

Journal article  |  2009  |  PLoS Pathogens

A p21-activated kinase is required for conidial germination in Penicillium marneffei.

Kylie J Boyce, Alex Andrianopoulos

Journal article  |  2007  |  PLoS pathogens

Asexual spores (conidia) are the infectious propagules of many pathogenic fungi, and the capacity to sense the host environment an..

Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Drosophila melanogaster insecticide resistance gene Cyp6g1

Henry Chung, Michael R Bogwitz, Caroline McCart, Alex Andrianopoulos, Richard H ffrench-Constant, Philip Batterham, Phillip J Daborn

Journal article  |  2007  |  Genetics

Regulating the transition between the two major fungal cell types; yeast cells and filamentous hyphal cells

A ANDRIANOPOULOS

Journal article  |  2007  |  Microbiology Australia

The biology of the thermally dimorphic fungal pathogen Penicillium marneffei

D Cánovas, A Andrianopoulos

Book Chapter  |  2007

Developmental regulation of the glyoxylate cycle in the human pathogen Penicillium marneffei

David Canovas, Alex Andrianopoulos

Journal article  |  2006  |  Molecular Microbiology

The Aspergillus nidulans rcoA gene is required for veA-dependent sexual development

Richard B Todd, Michael J Hynes, Alex Andrianopoulos

Journal article  |  2006  |  Genetics

Signaling Pathways in the Dimorphic Human Fungal Pathogen Penicillium marneffei

Alex Andrianopoulos, Sophie Zuber

Book Chapter  |  2006

Morphogenesis:Control of cell types and shape

K BOYCE, A ANDRIANOPOULOS

Book Chapter  |  2006

Conditional lethal disruption of TATA-binding protein gene in Penicillium marneffei

S Pongsunk, A Andrianopoulos, SC Chaiyaroj

Journal article  |  2005  |  Fungal Genetics and Biology

The Ras and Rho GTPases genetically interact to co-ordinately regulate cell polarity during development in Penicillium marneffei

KJ Boyce, MJ Hynes, A Andrianopoulos

Journal article  |  2005  |  Molecular Microbiology

The G-protein alpha-subunit GasC plays a major role in germination in the dimorphic fungus Penicillium marneffei

S Zuber, MJ Hynes, A Andrianopoulos

Journal article  |  2003  |  Genetics

Control of morphogenesis and actin localization by the Penicillium marneffei RAC homolog

KJ Boyce, MJ Hynes, A Andrianopoulos

Journal article  |  2003  |  Journal of Cell Science

TupA, the Penicillium marneffei Tup1p homologue, represses both yeast and spore development

RB Todd, JR Greenhalgh, MJ Hynes, A Andrianopoulos

Journal article  |  2003  |  Molecular Microbiology

Control of morphogenesis in the human fungal pathogen Penicillium marneffei

A Andrianopoulos

Journal article  |  2002  |  International Journal of Medical Microbiology

G-protein signaling mediates asexual development at 25 degrees C but has no effect on yeast-like growth at 37 degrees C in the dimorphic fungus Penicillium marneffei

S Zuber, MJ Hynes, A Andrianopoulos

Journal article  |  2002  |  Eukaryotic Cell

A basic helix-loop-helix protein with similarity to the fungal morphological regulators, Phd1p, Efg1p and StuA, controls conidiation but not dimorphic growth in Penicillium marneffei

AR Borneman, MJ Hynes, A Andrianopoulos

Journal article  |  2002  |  Molecular Microbiology

A single gene produces mitochondrial, cytoplasmic, and peroxisomal NADP-dependent isocitrate dehydrogenase in Aspergillus nidulans

E Szewczyk, A Andrianopoulos, MA Davis, MJ Hynes

Journal article  |  2001  |  Journal of Biological Chemistry

The CDC42 homolog of the dimorphic fungus Penicillium marneffei is required for correct cell polarization during growth but not development

KJ Boyce, MJ Hynes, A Andrianopoulos

Journal article  |  2001  |  Journal of Bacteriology

An STE12 homolog from the asexual, dimorphic fungus Penicillium marneffei complements the defect in sexual development of an Aspergillus nidulans steA mutant

AR Borneman, MJ Hynes, A Andrianopoulos

Journal article  |  2001  |  Genetics

The abaA homologue of Penicillium marneffei participates in two developmental programmes: conidiation and dimorphic growth.

AR Borneman, MJ Hynes, A Andrianopoulos

Journal article  |  2000  |  Molecular Microbiology

Penicillium marneffei is the only known species of its genus that is dimorphic. At 25 degrees C, P. marneffei exhibits true filame..

HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology.

AA Brakhage, A Andrianopoulos, M Kato, S Steidl, MA Davis, N Tsukagoshi, MJ Hynes

Journal article  |  1999  |  Fungal Genetics and Biology

Regulatory CCAAT boxes are found frequently in eukaryotic promoter regions. They are bound by different CCAAT-binding factors. Unt..

AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR.

S Steidl, P Papagiannopoulos, O Litzka, A Andrianopoulos, MA Davis, AA Brakhage, MJ Hynes

Journal article  |  1999  |  Molecular and Cellular Biology

CCAAT binding factors (CBFs) positively regulating the expression of the amdS gene (encoding acetamidase) and two penicillin biosy..

Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression.

A Andrianopoulos, S Kourambas, JA Sharp, MA Davis, MJ Hynes

Journal article  |  1998  |  Journal of Bacteriology

The gene nmrA of Aspergillus nidulans has been isolated and found to be a homolog of the Neurospora crassa gene nmr-1, involved in..

FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences.

RB Todd, A Andrianopoulos, MA Davis, MJ Hynes

Journal article  |  1998  |  The EMBO Journal

The facB gene is required for acetate induction of acetamidase (amdS) and the acetate utilization enzymes acetyl-CoA synthase (fac..

Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif.

RB Todd, A Andrianopoulos

Journal article  |  1997  |  Fungal Genetics and Biology

The coevolution of DNA binding proteins and their cognate binding sites is essential for the maintenance of function. As a result,..

Identification of amdX, a new Cys-2-His-2 (C2H2) zinc-finger gene involved in the regulation of the amdS gene of Aspergillus nidulans.

RL Murphy, A Andrianopoulos, MA Davis, MJ Hynes

Journal article  |  1997  |  Molecular Microbiology

The acetamidase-encoding amdS gene of Aspergillus nidulans has been shown to be controlled by multiple regulatory genes. A new gen..

The amdA regulatory gene of Aspergillus nidulans: characterization of gain-of-function mutations and identification of binding sites for the gene product.

A Andrianopoulos, J Brons, MA Davis, MJ Hynes

Journal article  |  1997  |  Fungal Genetics and Biology

Genetic evidence suggests that the amdA gene of Aspergillus nidulans encodes a protein which controls the expression of the amdS a..

The hapC gene of Aspergillus nidulans is involved in the expression of CCAAT-containing promoters.

P Papagiannopoulos, A Andrianopoulos, JA Sharp, MA Davis, MJ Hynes

Journal article  |  1996  |  Molecular and General Genetics MGG

The 5' regulatory region of the amdS gene of Aspergillus nidulans, which encodes an acetamidase required for growth on acetamide a..

Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth.

V Gavrias, A Andrianopoulos, CJ Gimeno, WE Timberlake

Journal article  |  1996  |  Molecular Microbiology

Diverse eukaryotic organisms share developmental transcription factors with homologous DNA-binding domains. We showed that the dev..

The

Peter Papagiannopoulos, Alex Andrianopoulos, Julie A Sharp, Meryl A Davis, MJ Hynes

Journal article  |  1996  |  MGG Molecular & General Genetics

The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development.

A Andrianopoulos, WE Timberlake

Journal article  |  1994  |  Molecular and Cellular Biology

The Aspergillus nidulans abaA gene encodes a protein containing an ATTS DNA-binding motif and is required for the terminal stages ..

ATTS, a new and conserved DNA binding domain.

A Andrianopoulos, WE Timberlake

Journal article  |  1991  |  The Plant Cell

Sequence and functional analysis of the positively acting regulatory gene amdR from Aspergillus nidulans.

A Andrianopoulos, MJ Hynes

Journal article  |  1990  |  Molecular and Cellular Biology

The positively acting regulatory gene amdR of Aspergillus nidulans coordinately regulates the expression of five structural genes ..

Cloning and analysis of the positively acting regulatory gene amdR from Aspergillus nidulans.

A Andrianopoulos, MJ Hynes

Journal article  |  1988  |  Molecular and Cellular Biology

The positively acting regulatory gene amdR of Aspergillus nidulans coordinately regulates the expression of four unlinked structur..

The novel Dbl homology/BAR domain protein, MsgA, of Talaromyces marneffei regulates yeast morphogenesis during growth inside host cells

Harshini Weerasinghe, Hayley E Bugeja, Alex Andrianopoulos

Journal article

AbstractMicrobial pathogens have evolved many strategies to evade recognition by the host immune system, including the use of phag..