Julie Ralton

Evolution and function of carbohydrate reserve biosynthesis in parasitic protists

Julie E Ralton, M Fleur Sernee, Malcolm J McConville

Journal article  |  2021  |  TRENDS IN PARASITOLOGY

Nearly all eukaryotic cells synthesize carbohydrate reserves, such as glycogen, starch, or low-molecular-weight oligosaccharides. ..

Metabolic stringent response in intracellular stages of Leishmania

Eleanor C Saunders, Marijke F Sernee, Julie E Ralton, Malcolm J McConville

Journal article  |  2021  |  CURRENT OPINION IN MICROBIOLOGY

Leishmania are unusual in being able to survive long-term in the mature phagolysosome compartment of macrophages and other phagocy..

The Structure and Biosynthesis of Glycans in the Parasitic Protists

MF Sernee, JE Ralton, MJ McConville

Book Chapter  |  2021

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Marcel A Vieira-Lara, Simon A Cobbold, Lauren Stanton, Douglas EV Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M Bastidas, Phillip L van der Peet, Michael W Parker, David B Ascher, Spencer J Williams, Gideon J Davies, Malcolm J McConville

Journal article  |  2019  |  CELL HOST & MICROBE

Parasitic protists belonging to the genus Leishmania synthesize the non-canonical carbohydrate reserve, mannogen, which is compose..

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell

Srinivasan Ramakrishnan, Melissa D Docampo, James I MacRae, Julie E Ralton, Thusitha Rupasinghe, Malcolm J McConville, Boris Striepen

Journal article  |  2015  |  MOLECULAR MICROBIOLOGY

Apicomplexa are parasitic protozoa that cause important human diseases including malaria, cryptosporidiosis and toxoplasmosis. The..

Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae

Yoshiki Yamaryo-Botte, Arek K Rainczuk, David J Lea-Smith, Rajini Brammananth, Phillip L van der Peet, Peter Meikle, Julie E Ralton, Thusita WT Rupasinghe, Spencer J Williams, Ross L Coppel, Paul K Crellin, Malcolm J McConville

Journal article  |  2015  |  ACS CHEMICAL BIOLOGY

Pathogenic species of Mycobacteria and Corynebacteria, including Mycobacterium tuberculosis and Corynebacterium diphtheriae, synth..

Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence

Fiona M Sansom, Julie E Ralton, M Fleur Sernee, Alice M Cohen, David J Hooker, Elizabeth L Hartland, Thomas Naderer, Malcolm J McConville

Journal article  |  2014  |  PLOS NEGLECTED TROPICAL DISEASES

Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate di..

Synthesis, Structural Elucidation, And Biochemical Analysis of Immunoactive Glucuronosyl Diacylglycerides of Mycobacteria and Corynebacteria

Benjamin Cao, Xingqiang Chen, Yoshiki Yamaryo-Botte, Mark B Richardson, Kirstee L Martin, George N Khairallah, Thusita WT Rupasinghe, Roisin M O'Flaherty, Richard AJ O'Hair, Julie E Ralton, Paul K Crellin, Ross L Coppel, Malcolm J McConville, Spencer J Williams

Journal article  |  2013  |  JOURNAL OF ORGANIC CHEMISTRY

Glucuronosyl diacylglycerides (GlcAGroAc2) are functionally important glycolipids and membrane anchors for cell wall lipoglycans i..

Leishmania major Methionine Sulfoxide Reductase A Is Required for Resistance to Oxidative Stress and Efficient Replication in Macrophages

Fiona M Sansom, Leonie Tang, Julie E Ralton, Eleanor C Saunders, Thomas Naderer, Malcolm J McConville

Journal article  |  2013  |  PLOS ONE

Leishmania are protozoan parasites that proliferate within the phagolysome of mammalian macrophages. While a number of anti-oxidan..

Discovery of Inhibitors of Leishmania beta-1,2-Mannosyltransferases Using a Click-Chemistry-Derived Guanosine Monophosphate Library

Phillip van der Peet, Julie E Ralton, Malcolm J McConville, Spencer J Williams

Journal article  |  2012  |  PLOS ONE

Leishmania spp. are a medically important group of protozoan parasites that synthesize a novel intracellular carbohydrate reserve ..