Kevin Man

Unlocking autofluorescence in the era of full spectrum analysis: Implications for immunophenotype discovery projects

Vanta J Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K Mackay, Axel Kallies, Jose A Villadangos, Hamish EG McWilliam, Alexis Perez-Gonzalez

Journal article  |  2022  |  CYTOMETRY PART A

Understanding the complex elements affecting signal resolution in cytometry is key for quality experimental design and data. In th..

Resident and migratory adipose immune cells control systemic metabolism and thermogenesis (Feb, 10.1038/s41423-022-00844-7, 2022)

Kevin Man, Axel Kallies, Ajithkumar Vasanthakumar

Journal article  |  2022  |  CELLULAR & MOLECULAR IMMUNOLOGY

The article Resident and migratory adipose immune cells control systemic metabolism and thermogenesis, written by Kevin Man, Axel ..

Resident and migratory adipose immune cells control systemic metabolism and thermogenesis

Kevin Man, Axel Kallies, Ajithkumar Vasanthakumar

Journal article  |  2021  |  CELLULAR & MOLECULAR IMMUNOLOGY

Glucose is a vital source of energy for all mammals. The balance between glucose uptake, metabolism and storage determines the ene..

A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance

Kevin Man, Christopher Bowman, Kristina N Braverman, Veronica Escalante, Yuan Tian, Jordan E Bisanz, Kirthana Ganeshan, Biao Wang, Andrew Patterson, James R Bayrer, Peter J Turnbaugh, Ajay Chawla

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease tolerance, the capacity of tissues to withstand damage caused by a stimulus without a decline in host fitness, varies acro..

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article  |  2019  |  BLOOD

Somatically acquired mutations in PHF6 (plant homeodomain finger 6) frequently occur in hematopoietic malignancies and often coinc..

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla

Journal article  |  2019  |  CELL

Host defenses against pathogens are energetically expensive, leading ecological immunologists to postulate that they might partici..

Transcription Factor IRF4 Promotes CD8( ) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

Kevin Man, Sarah S Gabriel, Yang Liao, Renee Gloury, Simon Preston, Darren C Henstridge, Marc Pellegrini, Dietmar Zehn, Friederike Berberich-Siebelt, Mark A Febbraio, Wei Shi, Axel Kallies

Journal article  |  2017  |  IMMUNITY

During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by expression of inhibitory receptors, down-..

Tissue Immunometabolism: Development, Physiology, and Pathobiology

Kevin Man, Vassily I Kutyavin, Ajay Chawla

Journal article  |  2017  |  CELL METABOLISM

Evolution of metazoans resulted in the specialization of cellular and tissue function. This was accomplished by division of labor,..

Immunity around the clock

Kevin Man, Andrew Loudon, Ajay Chawla

Journal article  |  2016  |  SCIENCE

Immunity is a high-cost, high-benefit trait that defends against pathogens and noxious stimuli but whose overactivation can result..

CXCR5( ) follicular cytotoxic T cells control viral infection in B cell follicles

Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man, Claire Deleage, Martina Minnich, Benjamin J Meckiff, Yunbo Wei, Zhaohua Hou, Dimitra Zotos, Kevin A Fenix, Anurag Atnerkar, Simon Preston, Jeffrey G Chipman, Greg J Beilman, Cody C Allison, Lei Sun, Peng Wang, Jiawei Xu, et al.

Journal article  |  2016  |  NATURE IMMUNOLOGY

During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types..