Eugene Maraskovsky

Therapeutic ISCOMATRIX (TM) adjuvant vaccine elicits effective anti-tumor immunity in the TRAMP-C1 mouse model of prostate cancer

Adele M Barr, Anabel Silva, Sandro Prato, Gabrielle T Belz, Eugene Maraskovsky, Adriana Baz Morelli

Journal article  |  2020  |  Cancer Immunology, Immunotherapy

Cancer vaccine development has proven challenging with the exception of some virally induced cancers for which prophylactic vaccin..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products

Wojciech Jankowski, Yara Park, Joseph McGill, Eugene Maraskovsky, Marco Hofmann, Vincent P Diego, Bernadette W Luu, Tom E Howard, Roberta Kellerman, Nigel S Key, Zuben E Sauna

Journal article  |  2019  |  Blood Advances

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Shereen Oon, Katherine Monaghan, Milica Ng, Alberta Hoi, Eric Morand, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2019  |  Clinical & Translational Immunology

Objectives: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are majo..

Machine learning applied to whole-blood RNA-sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus

William A Figgett, Katherine Monaghan, Milica Ng, Monther Alhamdoosh, Eugene Maraskovsky, Nicholas J Wilson, Alberta Y Hoi, Eric F Morand, Fabienne Mackay

Journal article  |  2019  |  Clinical & Translational Immunology

The Role of II Human Leukocyte Antigens (cII-HLAs) in Determining the Immunogenic Potential of Therapeutic Factor VIII Proteins in Hemophilia Patients: The "Gate Keeper" Hypothesis

Vincent P Diego, Bernadette W Luu, Marco Hofmann, Marcio A Almeida, Jose Antonio G Hernandez, Juan Peralta, Joanne Curran, Jerry S Powell, Raja Rajalingam, Long V Dinh, Sarah Williams-Blangero, Miguel A Escobar, Eugene Maraskovsky, John Blangero, Tom E Howard

Conference Proceedings  |  2018  |  Blood

A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell Activation in vivo

Hannah E Scales, Gavin R Meehan, Alan J Hayes, Robert A Benson, Emma Watson, Anne Walters, Michio Tomura, Eugene Maraskovsky, Paul Garside, Adriana Baz Morelli, James M Brewer

Journal article  |  2018  |  Frontiers in Immunology

ANALYSIS OF HLACII PEPTIDOMES PRESENTED BY DENDRITIC CELLS (DCS) FROM HEALTHY DONORS AND HEMOPHILIA-A (HA) PATIENTS WITH OR WITHOUT FACTOR VIII (FVIII) INHIBITORS AFTER EX VIVO ADMINISTRATION OF DIFFERENT THERAPEUTIC FVIII PROTEINS (TFVIIIS)

Tom E Howard, Vincent P Diego, Marco Hofmann, Marcio Almeida, Bernadette W Luu, Long V Dinh, Raja Rajalingam, Miguel Escobar, Joanne Curran, Sarah Williams-Blangero, Jerry Powell, John Blangero, Eugene Maraskovsky, Nigel S Key, Zuben E Sauna

Conference Proceedings  |  2018  |  Human Immunology

A pilot study of peripheral blood BDCA-1 (CD1c) positive dendritic cells pulsed with NY-ESO-1 ISCOMATRIX™ adjuvant.

Ian D Davis, Juliet Quirk, Leone Morris, Lauren Seddon, Tsin Yee Tai, Genevieve Whitty, Tina Cavicchiolo, Lisa Ebert, Heather Jackson, Judy Browning, Duncan MacGregor, Frederick Wittke, Gregor Winkels, Regina Alex, Lena Miloradovic, Eugene Maraskovsky, Weisan Chen, Jonathan Cebon

Journal article  |  2017  |  Immunotherapy

AIM: Pilot clinical trial of NY-ESO-1 (ESO) protein in ISCOMATRIX™ adjuvant pulsed onto peripheral blood dendritic cells (PBDC), t..

A cytotoxic anti-IL-3R alpha antibody targets key cells and cytokines implicated in systemic lupus erythematosus

Shereen Oon, Huy Huynh, Tsin Yee Tai, Milica Ng, Katherine Monaghan, Mark Biondo, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2016  |  JCI Insight

Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice Is Dependent on the Fc Portion and Independent of Sialylation or Basophils

Ian K Campbell, Sylvia Miescher, Donald R Branch, Patrick J Mott, Alan H Lazarus, Dongji Han, Eugene Maraskovsky, Adrian W Zuercher, Anton Neschadim, Danila Leontyev, Brent S McKenzie, Fabian Kaesermann

Journal article  |  2014  |  Journal of Immunology

Combination of adjuvants: the future of vaccine design

Adele Mount, Sandra Koernig, Anabel Silva, Debbie Drane, Eugene Maraskovsky, Adriana Baz Morelli

Journal article  |  2013  |  Expert Review of Vaccines

ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases

Adriana Baz Morelli, Dorit Becher, Sandra Koernig, Anabel Silva, Debbie Drane, Eugene Maraskovsky

Journal article  |  2012  |  Journal of Medical Microbiology

Development of prophylactic and therapeutic vaccines using the ISCOMATRIX adjuvant

Eugene Maraskovsky, Max Schnurr, Nick S Wilson, Neil C Robson, Jeff Boyle, Debbie Drane

Journal article  |  2009  |  Immunology and Cell Biology

Activin-A attenuates several human natural killer cell functions

Neil C Robson, Heng Wei, Tristan McAlpine, Naomi Kirkpatrick, Jonathan Cebon, Eugene Maraskovsky

Journal article  |  2009  |  Blood

Regulatory T-Cell - Mediated Attenuation of T-Cell Responses to the NY-ESO-1 ISCOMATRIX Vaccine in Patients with Advanced Malignant Melanoma

Theo Nicholaou, Lisa M Ebert, Ian D Davis, Grant A McArthur, Heather Jackson, Nektaria Dimopoulos, Bee Tan, Eugene Maraskovsky, Lena Miloradovic, Wendie Hopkins, Linda Pan, Ralph Venhaus, Eric W Hoffman, Weisan Chen, Jonathan Cebon

Journal article  |  2009  |  Clinical Cancer Research

Priming of CD4( ) and CD8( ) T cell responses using a HCV core ISCOMATRIX (TM) vaccine A phase I study in healthy volunteers

Debbie Drane, Eugene Maraskovsky, Rebecca Gibson, Sue Mitchell, Megan Barnden, Alan Moskwa, David Shaw, Barbara Gervase, Stephen Coates, Michael Houghton, Russel Basser

Journal article  |  2009  |  Human Vaccines

ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II

Max Schnurr, Martin Orban, Neil C Robson, Amanda Shin, Hal Braley, Denise Airey, Jonathan Cebon, Eugene Maraskovsky, Stefan Endres

Journal article  |  2009  |  Journal of Immunology

Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery

M Schnurr, QY Chen, A Shin, WS Chen, T Toy, C Jenderek, S Green, L Miloradovic, D Drane, ID Davis, J Villadangos, K Shortman, E Maraskovsky, J Cebon

Journal article  |  2005  |  Blood

Characterization of antigen-specific CD8 T lymphocyte responses in skin and peripheral blood following intradermal peptide vaccination.

Qiyuan Chen, Heather Jackson, Mark Shackleton, Phillip Parente, Wendie Hopkins, Sue Sturrock, Duncan MacGregor, Eugene Maraskovsky, Tsin Yee Tai, Nektaria Dimopoulos, Kelly-Anne Masterman, Tina Luke, Ian D Davis, Weisan Chen, Jonathan Cebon

Journal article  |  2005  |  Cancer Immunity

Immune responses to cancer vaccines are commonly tested by measuring cutaneous reactions to intradermal (i.d.) antigen. When well-..

Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development

M O'Keeffe, TC Brodnicki, B Fancke, D Vremec, G Morahan, E Maraskovsky, R Steptoe, LC Harrison, K Shortman

Journal article  |  2005  |  International Immunology

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

M Schnurr, T Toy, A Shin, M Wagner, J Cebon, E Maraskovsky

Journal article  |  2005  |  Blood

Dendritic cell development

M SCHNURR, E MARASKOVSKY, JS CEBON

Book Chapter  |  2005

IDO production, adaptive immunity, and CTL killing

T Luft, E Maraskovsky, M Schnurr

Journal article  |  2005  |  Blood

Recombinant NY-ESO-1 cancer antigen: Production and purification under cGMP conditions

R Murphy, S Green, G Ritter, L Cohen, D Ryan, W Woods, M Rubira, J Cebon, ID Davis, A Sjolander, A Kypridis, H Kalnins, M McNamara, MB Moloney, J Ackland, G Cartwright, J Rood, G Dumsday, K Healey, D Maher, et al.

Journal article  |  2005  |  Preparative Biochemistry & Biotechnology

The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand.

Mark Shackleton, Ian D Davis, Wendie Hopkins, Heather Jackson, Nektaria Dimopoulos, Tsin Tai, Qiyuan Chen, Phillip Parente, Michael Jefford, Kelly-Anne Masterman, Dania Caron, Weisan Chen, Eugene Maraskovsky, Jonathan Cebon

Journal article  |  2004  |  Cancer Immunity

Dendritic cells (DCs) show promise as adjuvants in anticancer immunotherapeutic strategies. Flt3 ligand (FL) is a hematopoietic gr..

A robust human T-cell culture method suitable for monitoring CD8 and CD4 T-cell responses from cancer clinical trial samples

HM Jackson, N Dimopoulos, QY Chen, T Luke, TY Tai, E Maraskovsky, LJ Old, ID Davis, J Cebon, WS Chen

Journal article  |  2004  |  Journal of Immunological Methods

Immunodominant CD4( ) responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant

QY Chen, H Jackson, P Parente, T Luke, M Rizkalla, TY Tai, HC Zhu, NA Mifsud, N Dimopoulos, KA Masterman, W Hopkins, H Goldie, E Maraskovsky, S Green, L Miloradovic, J McCluskey, LJ Old, ID Davis, J Cebon, WS Chen

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

NY-ESO-1 Protein Formulated in ISCOMATRIX Adjuvant Is a Potent Anticancer Vaccine Inducing Both Humoral and CD8 T-Cell-Mediated Immunity and Protection against NY-ESO-1 Tumors

E Maraskovsky

Journal article  |  2004  |  Clinical Cancer Research

Exogenous peptides presented by transporter associated with antigen processing (TAP)-deficient and TAP-competent cells: Intracellular loading and kinetics of presentation

T Luft, M Rizkalla, TY Tai, QY Chen, RI MacFarlan, ID Davis, E Maraskovsky, J Cebon

Journal article  |  2001  |  Journal of Immunology

The use of dendritic cells in cancer therapy.

M Jefford, E Maraskovsky, J Cebon, ID Davis

Journal article  |  2001  |  Lancet Oncology

Although the immune system evolved to protect the host from infection, what fires the popular imagination is its potential to reco..

Dendritic cells as recipients of cytokine signals

JS CEBON, D DAVIS, T LUFT, E MARASKOVSKY

Book Chapter  |  2001

Modulating the immune response with dendritic cells and their growth factors

B Pulendran, E Maraskovsky, J Banchereau, C Maliszewski

Journal article  |  2001  |  Trends in Immunology (formerly Immunology Today)