Eugene Maraskovsky

Therapeutic ISCOMATRIX (TM) adjuvant vaccine elicits effective anti-tumor immunity in the TRAMP-C1 mouse model of prostate cancer

Adele M Barr, Anabel Silva, Sandro Prato, Gabrielle T Belz, Eugene Maraskovsky, Adriana Baz Morelli

Journal article  |  2020  |  Cancer Immunology Immunotherapy

Cancer vaccine development has proven challenging with the exception of some virally induced cancers for which prophylactic vaccin..

Butyrophilin molecules govern gamma delta T cell reactivity against phosphoantigens

Marc Rigau, Simone Ostrouska, Tom Fulford, Darryl Neil Johnson, Katherine Woods, Zheng Ruan, Hamish McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Hammet, Anne M Verhagen, Gino Vairo, Eugene Maraskovsky, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma

Jonathan S Cebon, Martin Gore, John F Thompson, Ian D Davis, Grant A McArthur, Euan Walpole, Mark Smithers, Vincenzo Cerundolo, P Rod Dunbar, Duncan MacGregor, Cyril Fisher, Michael Millward, Paul Nathan, Michael PN Findlay, Peter Hersey, TR Jeffry Evans, Christian Hermann Ottensmeier, Jeremy Marsden, Angus G Dalgleish, Pippa G Corrie, et al.

Journal article  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: To compare the clinical efficacy of New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) vaccine with ISCOMATRIX a..

Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A

Vincent P Diego, Bernadette W Luu, Marco Hofmann, Long V Dinh, Marcio Almeida, Jerry S Powell, Raja Rajalingam, Juan M Peralta, Satish Kumar, Joanne E Curran, Zuben E Sauna, Roberta Kellerman, Yara Park, Nigel S Key, Miguel A Escobar, Huynh Huy, Anne M Verhagen, Sarah Williams-Blangero, Paul V Lehmann, Eugene Maraskovsky, et al.

Journal article  |  2020  |  JOURNAL OF THROMBOSIS AND HAEMOSTASIS

BACKGROUND: Plasma-derived (pd) or recombinant (r) therapeutic factor VIII proteins (FVIIIs) are infused to arrest/prevent bleedin..

Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products

Wojciech Jankowski, Yara Park, Joseph McGill, Eugene Maraskovsky, Marco Hofmann, Vincent P Diego, Bernadette W Luu, Tom E Howard, Roberta Kellerman, Nigel S Key, Zuben E Sauna

Journal article  |  2019  |  BLOOD ADVANCES

The immunogenicity of protein therapeutics is an important safety and efficacy concern during drug development and regulation. Str..

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Shereen Oon, Katherine Monaghan, Milica Ng, Alberta Hoi, Eric Morand, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are majo..

Machine learning applied to whole-blood RNA-sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus

William A Figgett, Katherine Monaghan, Milica Ng, Monther Alhamdoosh, Eugene Maraskovsky, Nicholas J Wilson, Alberta Y Hoi, Eric F Morand, Fabienne Mackay

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that is difficult to treat. There is currentl..

The Role of II Human Leukocyte Antigens (cII-HLAs) in Determining the Immunogenic Potential of Therapeutic Factor VIII Proteins in Hemophilia Patients: The "Gate Keeper" Hypothesis

Vincent P Diego, Bernadette W Luu, Marco Hofmann, Marcio A Almeida, Jose Antonio G Hernandez, Juan Peralta, Joanne Curran, Jerry S Powell, Raja Rajalingam, Long V Dinh, Sarah Williams-Blangero, Miguel A Escobar, Eugene Maraskovsky, John Blangero, Tom E Howard

Conference Proceedings  |  2018  |  BLOOD

Abstract The development of neutralizing antibodies-termed "inhibitors"-to infused therapeutic (t) factor VIII prot..

A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell Activation in vivo

Hannah E Scales, Gavin R Meehan, Alan J Hayes, Robert A Benson, Emma Watson, Anne Walters, Michio Tomura, Eugene Maraskovsky, Paul Garside, Adriana Baz Morelli, James M Brewer

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the ce..