Marie-Liesse Asselin-Labat

Heterogeneity of tumour mutational burden in metastatic NSCLC demonstrated by endobronchial ultrasound sampling

Tracy L Leong, Christian Aloe, Savreet Aujla, Hao Wang, Velimir Gayevskiy, Marie-Liesse Asselin-Labat, Lesley-Ann Gray, Daniel Steinfort, Steven Bozinovski

Journal article  |  2023  |  Frontiers in Oncology

IntroductionTumour mutational burden (TMB) is an important emerging biomarker for immune checkpoint inhibitors (ICI). The stabilit..

Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance

Adithya Balasubramanian, Thomas John, Marie-Liesse Asselin-Labat

Journal article  |  2022  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Evading immune destruction is one of the hallmarks of cancer. A key mechanism of immune evasion deployed by tumour cells is to red..

Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

Michael Dominic Stutz, Cody Charles Allison, Samar Ojaimi, Simon Peter Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan Whitehead, Stefanie M Bader, Daniel Batey, Marie-Liesse Asselin-Labat, Marco J Herold, Andreas Strasser, Nicholas P West, Marc Pellegrini

Journal article  |  2021  |  IMMUNITY

Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche..

Spatial omics and multiplexed imaging to explore cancer biology

Sabrina M Lewis, Marie-Liesse Asselin-Labat, Nguyen Quan, Jean Berthelet, Xiao Tan, Verena C Wimmer, Delphine Merino, Kelly L Rogers, Shalin H Naik

Journal article  |  2021  |  NATURE METHODS

Understanding intratumoral heterogeneity-the molecular variation among cells within a tumor-promises to address outstanding questi..

A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells

Casey Ah-Cann, Verena C Wimmer, Clare E Weeden, Claire Marceaux, Charity W Law, Laura Galvis, Caitlin E Filby, Joy Liu, Kelsey Breslin, Tracy Willson, Matthew E Ritchie, Marnie E Blewitt, Marie-Liesse Asselin-Labat

Journal article  |  2021  |  DEVELOPMENT

Development of a branching tree in the embryonic lung is crucial for the formation of a fully mature functional lung at birth. Sox..

Holding our breath: the promise of tissue-resident memory T cells in lung cancer

Claire Marceaux, Clare E Weeden, Claire L Gordon, Marie-Liesse Asselin-Labat

Journal article  |  2021  |  TRANSLATIONAL LUNG CANCER RESEARCH

T cell memory is critical in controlling infection and plays an important role in anti-tumor responses in solid cancers. While eff..

Thermal ablation in non-small cell lung cancer: a review of treatment modalities and the evidence for combination with immune checkpoint inhibitors

Kanishka Rangamuwa, Tracy Leong, Clare Weeden, Marie-Liesse Asselin-Labat, Steven Bozinovski, Michael Christie, Tom John, Phillip Antippa, Louis Irving, Daniel Steinfort

Journal article  |  2021  |  TRANSLATIONAL LUNG CANCER RESEARCH

Lung cancer is the leading cause of cancer death worldwide, with approximately 1.6 million cancer related deaths each year. Progno..

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chueh, Judy Doherty, Francois Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, et al.

Journal article  |  2021  |  CELL DEATH & DISEASE

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limita..

Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer

Adam Pennycuick, Vitor H Teixeira, Khalid AbdulJabbar, Shan E Ahmed Raza, Tom Lund, Ayse U Akarca, Rachel Rosenthal, Lukas Kalinke, Deepak P Chandrasekharan, Christodoulos P Pipinikas, Henry Lee-Six, Robert E Hynds, Kate HC Gowers, Jake Y Henry, Fraser R Millar, Yeman B Hagos, Celine Denais, Mary Falzon, David A Moore, Sophia Antoniou, et al.

Journal article  |  2020  |  CANCER DISCOVERY

Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know..

Covering all your bases: incorporating intron signal from RNA-seq data

Stuart Lee, Albert Y Zhang, Shian Su, Ashley P Ng, Aliaksei Z Holik, Marie-Liesse Asselin-Labat, Matthew E Ritchie, Charity W Law

Journal article  |  2020  |  NAR GENOMICS AND BIOINFORMATICS

RNA-seq datasets can contain millions of intron reads per library that are typically removed from downstream analysis. Only reads ..