Nai Fu

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

Jicheng Yang, Fusheng Guo, Hui San Chin, Gao Bin Chen, Chow Hiang Ang, Qingsong Lin, Wanjin Hong, Nai Yang Fu

Journal article  |  2023  |  Cell Rep

Tetraspanins, a superfamily of membrane proteins, mediate diverse biological processes through tetraspanin-enriched microdomains i..

Fluid shear stress activates YAP to promote epithelial-mesenchymal transition in hepatocellular carcinoma.

Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Naiyang Fu, Yunbing Wang, Yang Shen, Xiaoheng Liu

Journal article  |  2021  |  Mol Oncol

Epithelial-mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor microenvironment plays an important role..

Physiological Functions of Mcl-1: Insights From Genetic Mouse Models.

Hui San Chin, Nai Yang Fu

Journal article  |  2021  |  Front Cell Dev Biol

The ability to regulate the survival and death of a cell is paramount throughout the lifespan of a multicellular organism. Apoptos..

MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.

Chong Teik Tan, Hao-Chun Chang, Qiling Zhou, Chundong Yu, Nai Yang Fu, Kanaga Sabapathy, Victor C Yu

Journal article  |  2021  |  EMBO Rep

Nrf2 signaling is vital for protecting cells against oxidative stress. However, its hyperactivation is frequently found in liver c..

STEM CELLS AND THE DIFFERENTIATION HIERARCHY IN MAMMARY GLAND DEVELOPMENT

Nai Yang Fu, Emma Nolan, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2020  |  PHYSIOLOGICAL REVIEWS

The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproduct..

Halting triple negative breast cancer by targeting PROCR

Nai Yang Fu, Jane E Visvader

Journal article  |  2019  |  CELL RESEARCH

Lgr(5 ) pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

Chow Hiang Ang, Shih Han Hsu, Fusheng Guo, Chong Teik Tan, Victor C Yu, Jane E Visvader, Pierce KH Chow, Nai Yang Fu

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging evidence suggests that hepatocytes are primarily maintained by self-renewal during normal liver homeostasis, as well as i..

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging (vol 35, pg 618, 2019)

Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2019  |  CANCER CELL

(Cancer Cell 35, 618–632.e1–e6; April 15, 2019) In the STAR Methods section of the originally published version of this article, t..

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.

Journal article  |  2019  |  CANCER CELL

Breast tumors are inherently heterogeneous, but the evolving cellular organization through neoplastic progression is poorly unders..

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2018  |  DEVELOPMENTAL CELL

Long-lived quiescent mammary stem cells (MaSCs) are presumed to coordinate the dramatic expansion of ductal epithelium that occurs..