Susanne Heinzel

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

Isabella Y Kong, Joel S Rimes, Amanda Light, Izabela Todorovski, Sarah Jones, Eric Morand, Deborah A Knight, Ylva E Bergman, Simon J Hogg, Hendrik Falk, Brendon J Monahan, Paul A Stupple, Ian P Street, Susanne Heinzel, Philippe Bouillet, Ricky W Johnstone, Philip D Hodgkin, Stephin J Vervoort, Edwin D Hawkins

Journal article  |  2020  |  Cell Reports

JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to..

Chromosome social distancing and crowd control: the dual role of Ki67

Alan Bruce Lyons, Susanne Heinzel

Journal article  |  2020  |  Immunology & Cell Biology

Speculations on the evolution of humoral adaptive immunity

Miles B Horton, Edwin D Hawkins, Susanne Heinzel, Philip D Hodgkin

Journal article  |  2020  |  Immunology and Cell Biology

The protection of a multicellular organism from infection, at both a cell and humoral level has been a tremendous driver of gene s..

Differential expansion of T central memory precursor and effector subsets is regulated by division speed

Lorenz Kretschmer, Michael Flossdorf, Jonas Mir, Yi-Li Cho, Marten Plambeck, Irina Treise, Albulena Toska, Susanne Heinzel, Matthias Schiemann, Dirk H Busch, Veit R Buchholz

Journal article  |  2020  |  Nature Communications

While antigen-primed T cells proliferate at speeds close to the physiologic maximum of mammalian cells, T cell memory is maintaine..

Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny

Mark R Dowling, Andrey Kan, Susanne Heinzel, Julia M Marchingo, Philip D Hodgkin, Edwin D Hawkins

Journal article  |  2018  |  Frontiers in Immunology

Multiplexed Division Tracking Dyes for Proliferation-Based Clonal Lineage Tracing

Miles B Horton, Giulio Prevedello, Julia M Marchingo, Jie HS Zhou, Ken R Duffy, Susanne Heinzel, Philip D Hodgkin

Journal article  |  2018  |  The Journal of Immunology

The regulation of lymphocyte activation and proliferation

Susanne Heinzel, Julia M Marchingo, Miles B Horton, Philip D Hodgkin

Journal article  |  2018  |  Current Opinion in Immunology

Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

M Waibel, SJ Vervoort, IY Kong, S Heinzel, KM Ramsbottom, BP Martin, ED Hawkins, RW Johnstone

Journal article  |  2018  |  Leukemia

Life and Death of Activated T Cells: How Are They Different from Naive T Cells?

Yifan Zhan, Emma M Carrington, Yuxia Zhang, Susanne Heinzel, Andrew M Lew

Journal article  |  2017  |  Frontiers in Immunology

Cognate antigen engagement on parenchymal cells stimulates CD8( ) T cell proliferation in situ

Robyn M Sutherland, Sarah L Londrigan, Jamie L Brady, Emma M Carrington, Julia M Marchingo, Susanne Heinzel, Philip D Hodgkin, Kate L Graham, Thomas W Kay, Yifan Zhan, Andrew M Lew

Journal article  |  2017  |  Nature Communications