Susanne Heinzel

Lineage tracing reveals B cell antibody class switching is stochastic, cell-autonomous, and tuneable

Miles B Horton, HoChan Cheon, Ken R Duffy, Daniel Brown, Shalin H Naik, Carolina Alvarado, Joanna R Groom, Susanne Heinzel, Philip D Hodgkin

Journal article  |  2022  |  IMMUNITY

To optimize immunity to pathogens, B lymphocytes generate plasma cells with functionally diverse antibody isotypes. By lineage tra..

Cyton2: A Model of Immune Cell Population Dynamics That Includes Familial Instructional Inheritance.

HoChan Cheon, Andrey Kan, Giulio Prevedello, Simone C Oostindie, Simon J Dovedi, Edwin D Hawkins, Julia M Marchingo, Susanne Heinzel, Ken R Duffy, Philip D Hodgkin

Journal article  |  2021  |  Front Bioinform

Lymphocytes are the central actors in adaptive immune responses. When challenged with antigen, a small number of B and T cells hav..

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

Isabella Y Kong, Joel S Rimes, Amanda Light, Izabela Todorovski, Sarah Jones, Eric Morand, Deborah A Knight, Ylva E Bergman, Simon J Hogg, Hendrik Falk, Brendon J Monahan, Paul A Stupple, Ian P Street, Susanne Heinzel, Philippe Bouillet, Ricky W Johnstone, Philip D Hodgkin, Stephin J Vervoort, Edwin D Hawkins

Journal article  |  2020  |  CELL REPORTS

JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to..

Chromosome social distancing and crowd control: the dual role of Ki67

Alan Bruce Lyons, Susanne Heinzel

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

The Ki67 protein is proposed to have two conformations; one which segregates chromosomes before anaphase, and the other which resu..

Speculations on the evolution of humoral adaptive immunity

Miles B Horton, Edwin D Hawkins, Susanne Heinzel, Philip D Hodgkin

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

The protection of a multicellular organism from infection, at both cell and humoral levels, has been a tremendous driver of gene s..

Differential expansion of T central memory precursor and effector subsets is regulated by division speed

Lorenz Kretschmer, Michael Flossdorf, Jonas Mir, Yi-Li Cho, Marten Plambeck, Irina Treise, Albulena Toska, Susanne Heinzel, Matthias Schiemann, Dirk H Busch, Veit R Buchholz

Journal article  |  2020  |  NATURE COMMUNICATIONS

While antigen-primed T cells proliferate at speeds close to the physiologic maximum of mammalian cells, T cell memory is maintaine..

Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny

Mark R Dowling, Andrey Kan, Susanne Heinzel, Julia M Marchingo, Philip D Hodgkin, Edwin D Hawkins

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Understanding how the strength of an effector T cell response is regulated is a fundamental problem in immunology with implication..

Multiplexed Division Tracking Dyes for Proliferation-Based Clonal Lineage Tracing

Miles B Horton, Giulio Prevedello, Julia M Marchingo, Jie HS Zhou, Ken R Duffy, Susanne Heinzel, Philip D Hodgkin

Journal article  |  2018  |  JOURNAL OF IMMUNOLOGY

The generation of cellular heterogeneity is an essential feature of immune responses. Understanding the heritability and asymmetry..

The regulation of lymphocyte activation and proliferation

Susanne Heinzel, Julia M Marchingo, Miles B Horton, Philip D Hodgkin

Journal article  |  2018  |  CURRENT OPINION IN IMMUNOLOGY

Activation induced proliferation and clonal expansion of antigen specific lymphocytes is a hallmark of the adaptive immune respons..

Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

M Waibel, SJ Vervoort, IY Kong, S Heinzel, KM Ramsbottom, BP Martin, ED Hawkins, RW Johnstone

Journal article  |  2018  |  LEUKEMIA