Marco Herold

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis.

Margaret A Potts, Shinsuke Mizutani, Alexandra L Garnham, Connie SN Li Wai Suen, Andrew J Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J Herold

Journal article  |  2023  |  Cell Death Differ

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of t..

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.

Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio, Natasha S Anstee, Veronique Litalien, Ella Thompson, Thomas Morley, Sarah MacRaild, Ing S Tiong, Rhiannon Morris, Karen Dun, Adrian Zordan, Jaynish Shah, Sebastien Banquet, Ensar Halilovic, Erick Morris, Marco J Herold, Guillaume Lessene, et al.

Journal article  |  2023  |  Blood

Randomized trials in acute myeloid leukemia (AML) have demonstrated improved survival by the BCL-2 inhibitor venetoclax combined w..

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1 beta release in X-linked inhibitor of apoptosis (XIAP) deficiency

Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, et al.

Journal article  |  2023  |  EMBO JOURNAL

Genetic lesions in X-linked inhibitor of apoptosis (XIAP) pre-dispose humans to cell death-associated inflammatory diseases, altho..

An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway.

Stephanie Trezise, Isabella Y Kong, Edwin D Hawkins, Marco J Herold, Simon N Willis, Stephen L Nutt

Journal article  |  2023  |  Front Immunol

BACKGROUND: Humoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropria..

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch, et al.

Journal article  |  2022  |  CELL METABOLISM

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

Generation of a CRISPR activationmouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (vol 13, 4739, 2022)

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

In this article the affiliation details for Amy Heidersbach were incorrectly given as ‘School of Dentistry and Medical Sciences, C..

Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goeknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been exploited in thi..

Last but not least: BFL-1 as an emerging target for anti-cancer therapies

Gaoyuan Wang, Sarah T Diepstraten, Marco J Herold

Journal article  |  2022  |  BIOCHEMICAL SOCIETY TRANSACTIONS

BFL-1 is an understudied pro-survival BCL-2 protein. The expression of BFL-1 is reported in many cancers, but it is yet to be clar..

Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Johannes Wichmann, Catherine Pitt, Samantha Eccles, Alexandra L Garnham, Connie SN Li-Wai-Suen, Rose May, Elizabeth Allan, Stephen Wilcox, Marco J Herold, Gordon K Smyth, Brendon J Monahan, Tim Thomas, Anne K Voss

Journal article  |  2022  |  CELL DEATH & DISEASE

Histone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysreg..

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Isabella Y Kong, Stephanie Trezise, Amanda Light, Izabela Todorovski, Gisela Mir Arnau, Sreeja Gadipally, David Yoannidis, Kaylene J Simpson, Xueyi Dong, Lachlan Whitehead, Jessica C Tempany, Anthony J Farchione, Amania A Sheikh, Joanna R Groom, Kelly L Rogers, Marco J Herold, Vanessa L Bryant, Matthew E Ritchie, Simon N Willis, Ricky W Johnstone, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell fu..