Marco Herold

Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

Michael Dominic Stutz, Cody Charles Allison, Samar Ojaimi, Simon Peter Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan Whitehead, Stefanie M Bader, Daniel Batey, Marie-Liesse Asselin-Labat, Marco J Herold, Andreas Strasser, Nicholas P West, Marc Pellegrini

Journal article  |  2021  |  IMMUNITY

Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche..

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

Lahiru Gangoda, Robyn L Schenk, Sarah A Best, Christina Nedeva, Cynthia Louis, Damian B D'Silva, Kirsten Fairfax, Andrew G Jarnicki, Hamsa Puthalakath, Kate D Sutherland, Andreas Strasser, Marco J Herold

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Inflammation is a natural defence mechanism of the body to protect against pathogens. It is induced by immune cells, such as macro..

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Emma M Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R Keenan, Nadia Iannarella, Rhys S Allan, Ahmad Z Wardak, Peter E Czabotar, Marco J Herold, Robyn L Schenk, Christine A White, Damian D'Silva, Yuyan Yang, Wesley Wong, Huon Wong, Vanessa L Bryant, Nicholas D Huntington, Jai Rautela, Robyn M Sutherland, et al.

Journal article  |  2021  |  BLOOD ADVANCES

Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged n..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

The ubiquitylation of IL-1 beta limits its cleavage by caspase-1 and targets it for proteasomal degradation

Swarna L Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S Simpson, Gregor Ebert, Angelina Vince, Marco J Herold, Andrew Kueh, Jaclyn S Pearson, Laura F Dagley, James M Murphy, Andrew I Webb, Kate E Lawlor, James E Vince

Journal article  |  2021  |  NATURE COMMUNICATIONS

Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of o..

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

Bing Yao, Tao Gui, Xiangwei Zeng, Yexuan Deng, Zhi Wang, Ying Wang, Dongjun Yang, Qixiang Li, Peipei Xu, Ruifeng Hu, Xinyu Li, Bing Chen, Jin Wang, Ke Zen, Haitao Li, Melissa J Davis, Marco J Herold, Hua-Feng Pan, Zhi-Wei Jiang, David CS Huang, et al.

Journal article  |  2021  |  GENOME MEDICINE

BACKGROUND: Aberrant changes in epigenetic mechanisms such as histone modifications play an important role in cancer progression. ..

Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease

Camilla Bertuzzo Veiga, Erin M Lawrence, Andrew J Murphy, Marco J Herold, Dragana Dragoljevic

Journal article  |  2021  |  CANCERS

The development of myelodysplasia syndromes (MDS) is multiphasic and can be driven by a plethora of genetic mutations and/or abnor..

CRISPR base editing applications for identifying cancer-driving mutations

Martin Pal, Marco J Herold

Journal article  |  2021  |  BIOCHEMICAL SOCIETY TRANSACTIONS

CRISPR base editing technology is a promising genome editing tool as (i) it does not require a DNA template to introduce mutations..

A Hypomorphic Dars1(D367Y) Model Recapitulates Key Aspects of the Leukodystrophy HBSL

Dominik Frohlich, Marisa I Mendes, Andrew J Kueh, Andre Bongers, Marco J Herold, Gajja S Salomons, Gary D Housley, Matthias Klugmann

Journal article  |  2021  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL) is a leukodystrophy caused by missense mutat..

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser

Journal article  |  2020  |  The EMBO Journal

Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis. However, lit..