Marco Herold

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, Nenad Sejic, Laura CA Galbraith, Chathura D Suraweera, Deborah Croom-Carter, Grant Dewson, Rosemary J Tierney, Andrew Bell, Clare Shannon-Lowe, Marco J Herold, Alan B Rickinson, Peter M Colman, David CS Huang, Andreas Strasser, Marc Kvansakul, Martin Rowe, Gemma L Kelly

Journal article  |  2020  |  Cell Death & Differentiation

Epstein-Barr virus (EBV), which is ubiquitous in the adult population, is causally associated with human malignancies. Like many i..

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Ladina Di Rago, Craig D Hyland, Eugenio Morelli, Jai Rautela, Nicholas D Huntington, Andreas Strasser, Warren S Alexander, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

The miR17~92 cluster plays important roles in haematopoiesis. However, it is not clear at what stage of differentiation and throug..

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids.

Johanna F Dekkers, James R Whittle, François Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten H Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2020  |  JNCI: Journal of the National Cancer Institute

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer.

James R Whittle, François Vaillant, Elliot Surgenor, Antonia N Policheni, Goknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2020  |  Oncogene

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

Andrew J Kueh, Samantha Eccles, Leonie Tang, Alexandra L Garnham, Rose E May, Marco J Herold, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2020  |  Molecular and Cellular Biology

HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replica..

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Najoua Lalaoui, Steven E Boyden, Hirotsugu Oda, Geryl M Wood, Deborah L Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E Lawlor, Kristien JM Zaal, Patrycja M Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, et al.

Journal article  |  2020  |  Nature

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post..

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

Rochelle Tixeira, Kha Phan Thanh, Sarah Caruso, Bo Shi, Georgia K Atkin-Smith, Christina Nedeva, Jenny DY Chow, Hamsa Puthalakath, Mark D Hulett, Marco J Herold, Ivan KH Poon

Journal article  |  2020  |  Cell Death & Differentiation

An Erg driven transcriptional program controls B-lymphopoiesis

Ashley Ng, Hannah Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy Johanson, Michael Sze Yuan Low, Charles Bell, Omer Gilan, Yih-Chih Chan, Andrew Kueh, Thomas Boudier, Ladina DiRago, Craig Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark Dawson, Rhys Allan, Marco Herold, et al.

Journal article  |  2019

Summary/Abstract B-cell development is initiated by the stepwise differentiation of hematopoietic stem cells into lineage committe..

Single-Cell Transcriptomics Identifies the Adaptation of Scart1( )V gamma 6( ) T Cells to Skin Residency as Activated Effector Cells

Likai Tan, Inga Sandrock, Ivan Odak, Yuval Aizenbud, Anneke Wilharm, Joana Barros-Martins, Yaara Tabib, Alina Borchers, Tiago Amado, Lahiru Gangoda, Marco J Herold, Marc Schmidt-Supprian, Jan Kisielow, Bruno Silva-Santos, Christian Koenecke, Avi-Hai Hovav, Christian Krebs, Immo Prinz, Sarina Ravens

Journal article  |  2019  |  Cell Reports

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

Ranja Salvamoser, Kerstin Brinkmann, Lorraine A O'Reilly, Lachlan Whitehead, Andreas Strasser, Marco J Herold

Journal article  |  2019  |  Cell Death & Differentiation

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

Loic Lionnard, Pauline Duc, Margs S Brennan, Andrew J Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stephan Mora, Irena Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J Herold, Solange Desagher, Jerome Kucharczak

Journal article  |  2019  |  Cell Death & Differentiation

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Erinna F Lee, Tiffany J Harris, Sharon Tran, Marco Evangelista, Surein Arulananda, Thomas John, Celeste Ramnac, Chloe Hobbs, Haoran Zhu, Gency Gunasingh, David Segal, Andreas Behren, Jonathan Cebon, Alexander Dobrovic, John M Mariadason, Andreas Strasser, Leona Rohrbeck, Nikolas K Haass, Marco J Herold, W Douglas Fairlie

Journal article  |  2019  |  Cell Death & Disease

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  Cell Reports

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt

Journal article  |  2019  |  Immunity

Unexpected overlapping roles of multiple caspases and programmed cell death pathways in the response to bacterial infection

Ranja Salvamoser, Paul G Whitney, Marcel Doerflinger, Sammy Bedoui, Andreas Strasser, Clare Bryant, Marco J Herold

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

Targeting Mcl-1 is a promising strategy to kill mantle cell lymphoma cells

Michael A Dengler, Charis E Teh, Marco J Herold, Andrew W Roberts, Jerry M Adams

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

CRISPR/Cas9 screens identify novel Mycobacterium tuberculosis host cell death restriction factors as potential drug targets for treatment of Tuberculosis

M Doerflinger, M Stutz, L Milla, MJ Herold, M Pellegrini

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2018  |  Developmental Cell

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Victoria Y Ling, William Godfrey, Sebastien Jacquelin, Jasmin Straube, Leanne T Cooper, Claudia Bruedigam, Siok-Keen Tey, Lars Bullinger, Marco J Herold, Megan Bywater, Steven W Lane

Conference Proceedings  |  2018  |  Blood

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  Nature Communications

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Margs S Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas Strasser, Grant Dewson, Gemma L Kelly, Marco J Herold

Journal article  |  2018  |  Blood

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

Li Sun, Jai Rautela, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Emma M Carrington, Robyn L Schenk, Marco J Herold, Nicholas D Huntington, Andrew M Lew, Yuekang Xu, Yifan Zhan

Journal article  |  2018  |  Frontiers in Immunology

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

Stephanie Trezise, Alexander Karnowski, Pasquale L Fedele, Sridurga Mithraprabhu, Yang Liao, Kathy D'Costa, Andrew J Kueh, Matthew P Hardy, Catherine M Owczarek, Marco J Herold, Andrew Spencer, Wei Shi, Simon N Willis, Stephen L Nutt, Lynn M Corcoran

Journal article  |  2018  |  International Journal of Molecular Sciences

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

Kayla R Wilson, Haiyin Liu, Geraldine Healey, Vivian Vuong, Satoshi Ishido, Marco J Herold, Jose A Villadangos, Justine D Mintern

Journal article  |  2018  |  PLOS ONE

DNA repair processes are critical mediators of p53-dependent tumor suppression

Ana Janic, Liz J Valente, Matthew J Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J Vandenberg, Andrew J Kueh, Shinsuke Mizutani, Margs S Brennan, Robyn L Schenk, Lisa M Lindqvist, Anthony T Papenfuss, Liam O'Connor, Andreas Strasser, Marco J Herold

Journal article  |  2018  |  Nature Medicine

miR17~92 is essential for the survival of hematopoietic stem and progenitor cells by restraining pro-apoptotic BIM

Kerstin Brinkmann, Craig Hyland, Carolyn de Graaf, Andreas Strasser, Warren Alexander, Marco Herold

Journal article  |  2018

Summary The micro RNA cluster miR17~92 , also known as oncomiR-1, impacts diverse cellular processes, such as cell survival and pr..

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

Margs Brennan, Catherine Chang, Grant Dewson, Lin Tai, Guillaume Lessene, Andreas Strasser, Gemma Kelly, Marco Herold

Journal article  |  2018

SUMMARY MCL-1 is a pro-survival BCL-2 protein required for the sustained growth of many cancers. Recently a highly specific MCL-1-..

CRISPR/Cas9: A tool for immunological research

Katharina Hochheiser, Andrew J Kueh, Thomas Gebhardt, Marco J Herold

Journal article  |  2018  |  European Journal of Immunology

Loss of NF-kappa B1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

Lorraine A O'Reilly, Tracy L Putoczki, Lisa A Mielke, Jun T Low, Ann Lin, Adele Preaudet, Marco J Herold, Kelvin Yaprianto, Lin Tai, Andrew Kueh, Guido Pacini, Richard L Ferrero, Raffi Gugasyan, Yifang Hu, Michael Christie, Stephen Wilcox, Raelene Grumont, Michael DW Griffin, Liam O'Connor, Gordon K Smyth, et al.

Journal article  |  2018  |  Immunity

Anti-apoptotic A1 is not essential for lymphoma development in E mu-Myc mice but helps sustain transplanted E mu-Myc tumour cells

Mark Mensink, Natasha S Anstee, Mikara Robati, Robyn L Schenk, Marco J Herold, Suzanne Cory, Cassandra J Vandenberg

Journal article  |  2018  |  Cell Death & Differentiation

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter, Rosemary J Tierney, Marco J Herold, Andrew I Bell, Andreas Strasser, Gemma L Kelly, Martin Rowe

Journal article  |  2018  |  Cell Death & Differentiation

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold, Andreas Strasser

Journal article  |  2018  |  Cell Death & Differentiation

A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets

Francisca F Almeida, Sara Tognarelli, Antoine Marcais, Andrew J Kueh, Miriam E Friede, Yang Liao, Simon N Willis, Kylie Luong, Fabrice Faure, Francois E Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zoeller, et al.

Journal article  |  2018  |  OncoImmunology

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

Kerstin Brinkmann, Stephanie Grabow, Craig D Hyland, Charis E Teh, Warren S Alexander, Marco J Herold, Andreas Strasser

Journal article  |  2017  |  Cell Death & Differentiation

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunger

Journal article  |  2017  |  Nature Communications

An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles

Andrew J Kueh, Martin Pal, Lin Tai, Yang Liao, Gordon K Smyth, Wei Shi, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

Synergistic targeting of breast cancer stem-like cells by human gamma delta T cells and CD8( ) T cells

Hung-Chang Chen, Noemie Joalland, John S Bridgeman, Fouad S Alchami, Ulrich Jarry, Mohd Wajid A Khan, Luke Piggott, Yasmin Shanneik, Jianqiang Li, Marco J Herold, Thomas Herrmann, David A Price, Awen M Gallimore, Richard W Clarkson, Emmanuel Scotet, Bernhard Moser, Matthias Eberl

Journal article  |  2017  |  Immunology and Cell Biology

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti, Hamsa Puthalakath

Journal article  |  2017  |  Cell Death & Differentiation

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew

Journal article  |  2017  |  Cell Death & Differentiation

MDM4 is a rational target for treating breast cancers with mutant p53

Panimaya Jeffreena Miranda, Daniel Buckley, Dinesh Raghu, Jia-Min B Pang, Elena A Takano, Reshma Vijayakumaran, Amina FAS Teunisse, Atara Posner, Tahlia Procter, Marco J Herold, Cristina Gamell, Jean-Christophe Marine, Stephen B Fox, Aart Jochemsen, Sue Haupt, Ygal Haupt

Journal article  |  2017  |  The Journal of Pathology

A non-canonical function of Ezh2 preserves immune homeostasis

Ajithkumar Vasanthakumar, Dakang Xu, Aaron TL Lun, Andrew J Kueh, Klaas PJM van Gisbergen, Nadia Iannarella, Xiaofang Li, Liang Yu, Die Wang, Bryan RG Williams, Stanley CW Lee, Ian J Majewski, Dale I Godfrey, Gordon K Smyth, Warren S Alexander, Marco J Herold, Axel Kallies, Stephen L Nutt, Rhys S Allan

Journal article  |  2017  |  EMBO reports

Combination of IAP antagonist and IFN gamma activates novel caspase-10-and RIPK1-dependent cell death pathways

Maria C Tanzer, Nufail Khan, James A Rickard, Nima Etemadi, Najoua Lalaoui, Sukhdeep Kaur Spall, Joanne M Hildebrand, David Segal, Maria Miasari, Diep Chau, WendyWei-Lynn Wong, Mark McKinlay, Srinivas K Chunduru, Christopher A Benetatos, Stephen M Condon, James E Vince, Marco J Herold, John Silke

Journal article  |  2017  |  Cell Death & Differentiation

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment

Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Charis E Teh, Daniel H Gray, Lin Tai, Andrew M Lew, Andreas Villunger, Andreas Strasser, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection

Selma Tuzlak, Robyn L Schenk, Ajithkumar Vasanthakumar, Simon P Preston, Manuel D Haschka, Dimitra Zotos, Axel Kallies, Andreas Strasser, Andreas Villunger, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

M Doerflinger, W Forsyth, G Ebert, M Pellegrini, MJ Herold

Journal article  |  2017  |  Cellular Microbiology

Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

Brandon J Aubrey, Ana Janic, Yunshun Chen, Gordon K Smyth, Andrew J Kueh, Stephen Wilcox, Margs S Brennan, Lin Tai, Daniel HD Gray, Charis Teh, Ann Lin, Catherine Chang, Lorraine A O'Reilly, Marco J Herold, Andreas Strasser, Gemma L Kelly

Conference Proceedings  |  2016  |  Blood

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability

Casey Ah-Cann, Maximilien Tailler, Andrew J Kueh, Marco J Herold, Joseph T Opferman, Marie-Liesse Asselin-Labat, Philippe Bouillet

Journal article  |  2016  |  Cell Death & Disease

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

Leona Rohrbeck, Jia-Nan Gong, Erinna F Lee, Andrew J Kueh, Andreas Behren, Lin Tai, Guillaume Lessene, David CS Huang, Walter D Fairlie, Andreas Strasser, Marco J Herold

Journal article  |  2016  |  Cell Death & Differentiation

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, A-L Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

Journal article  |  2016  |  Oncogene

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Gamier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Baker

Journal article  |  2016  |  eLife

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy, Zoltan Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaetane Le Toumelin-Braizat, Maia Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Marton C Sekei, Attila Paczal, Zoltan B Szabo, Szabolcs Sipos, Gabor Radics, Agnes Proszenyak, Balazs Balint, Levente Ondi, Gabor Blasko, et al.

Journal article  |  2016  |  Nature

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris D Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J Herold, Andrew W Roberts, David CS Huang

Journal article  |  2016  |  Blood

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

Alex RD Delbridge, Swee Heng Milon Pang, Cassandra J Vandenberg, Stephanie Grabow, Brandon J Aubrey, Lin Tai, Marco J Herold, Andreas Strasser

Journal article  |  2016  |  The Journal of Experimental Medicine

NF kappa B1 suppresses intestinal-type gastric cancer development by preventing chronic inflammation in the stomach

LA O'Reilly, TP Putoczki, L Mielke, A Lin, A Preaudet, JT Low, MJ Herold, L Tai, R Ferrero, Y Hu, R Grumont, G Smyth, M Ernst, P Waring, S Gerondakis, A Strasser

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells

Z Xu, PP Sharp, Y Yao, D Segal, CH Ang, SL Khaw, BJ Aubrey, J Gong, GL Kelly, MJ Herold, A Strasser, AW Roberts, WS Alexander, CJ Burns, DCS Huang, SP Glaser

Journal article  |  2016  |  Leukemia

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival

M Sochalska, E Ottina, S Tuzlak, S Herzog, M Herold, A Villunger

Journal article  |  2016  |  Cell Death & Differentiation

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David CS Huang, Lyubomir T Vassilev, Andreas Strasser

Journal article  |  2016  |  Cell Reports

The new editor-targeted genome engineering in the absence of homology-directed repair

AJ Kueh, MJ Herold

Journal article  |  2016  |  Cell Death Discovery

Using CRISPR/Cas9 Technology for Manipulating Cell Death Regulators.

Andrew J Kueh, Marco J Herold

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

Clustered, regularly interspaced, short palindromic repeats (CRISPR)/Cas9 technology has been demonstrated to be a useful tool for..

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Paul J Baker, Dave Boucher, Damien Bierschenk, Christina Tebartz, Paul G Whitney, Damian B D'Silva, Maria C Tanzer, Mercedes Monteleone, Avril AB Robertson, Matthew A Cooper, Silvia Alvarez-Diaz, Marco J Herold, Sammy Bedoui, Kate Schroder, Seth L Masters

Journal article  |  2015  |  European Journal of Immunology

Targeting Mdmx to treat breast cancers with wild-type p53

S Haupt, D Buckley, J-MB Pang, J Panimaya, PJ Paul, C Gamell, EA Takano, Y Ying Lee, S Hiddingh, T-M Rogers, AFAS Teunisse, MJ Herold, J-C Marine, SB Fox, A Jochemsen, Y Haupt

Journal article  |  2015  |  Cell Death & Disease

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Emma M Carrington, Jian-Guo Zhang, Robyn M Sutherland, Ingela B Vikstrom, Jamie L Brady, Priscilla Soo, David Vremec, Cody Allison, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet, Stephanie Grabow, Eleonora Ottina, Marco J Herold, Marc Pellegrini, David CS Huang, David M Tarlinton, Andreas Strasser, Andrew M Lew, Yifan Zhan

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Brandon J Aubrey, Gemma L Kelly, Andrew J Kueh, Margs S Brennan, Liam O'Connor, Liz Milla, Stephen Wilcox, Lin Tai, Andreas Strasser, Marco J Herold

Journal article  |  2015  |  Cell Reports

Myeloid-Derived Suppressor Activity Is Mediated by Monocytic Lineages Maintained by Continuous Inhibition of Extrinsic and Intrinsic Death Pathways

Jessica M Haverkamp, Amber M Smith, Ricardo Weinlich, Christopher P Dillon, Joseph E Qualls, Geoffrey Neale, Brian Koss, Young Kim, Vincenzo Bronte, Marco J Herold, Douglas R Green, Joseph T Opferman, Peter J Murray

Journal article  |  2014  |  Immunity

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

Michael J White, Kate McArthur, Donald Metcalf, Rachael M Lane, John C Cambier, Marco J Herold, Mark F van Delft, Sammy Bedoui, Guillaume Lessene, Matthew E Ritchie, David CS Huang, Benjamin T Kile

Journal article  |  2014  |  Cell

Characterisation of a novel A1-specific monoclonal antibody

MJ Lang, MS Brennan, LA O'Reilly, E Ottina, PE Czabotar, E Whitlock, WD Fairlie, L Tai, A Strasser, MJ Herold

Journal article  |  2014  |  Cell Death & Disease

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3

MN Koenig, E Naik, L Rohrbeck, MJ Herold, E Trounson, P Bouillet, T Thomas, AK Voss, A Strasser, L Coultas

Journal article  |  2014  |  Cell Death & Differentiation

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

MJ Herold, R Stuchbery, D Merino, T Willson, A Strasser, D Hildeman, P Bouillet

Journal article  |  2014  |  Cell Death & Disease

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA

MJ Herold, LA O'Reilly, A Lin, R Srivastava, M Doerflinger, P Bouillet, A Strasser, H Puthalakath

Journal article  |  2014  |  Cell Death & Disease

It's not over until the FAT lady sings

Marco J Herold, Andreas Strasser

Journal article  |  2014  |  EMBO Journal

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Gemma L Kelly, Stephanie Grabow, Stefan P Glaser, Leah Fitzsimmons, Brandon J Aubrey, Toru Okamoto, Liz J Valente, Mikara Robati, Lin Tai, W Douglas Fairlie, Erinna F Lee, Mikael S Lindstrom, Klas G Wiman, David CS Huang, Philippe Bouillet, Martin Rowe, Alan B Rickinson, Marco J Herold, Andreas Strasser

Journal article  |  2014  |  Genes & Development

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

Marco J Herold, Leona Rohrbeck, Mathias J Lang, Raelene Grumont, Steve Gerondakis, Lin Tai, Philippe Bouillet, Thomas Kaufmann, Andreas Strasser

Journal article  |  2013  |  EMBO Reports

Hoxb8 regulates expression of microRNAs to control cell death and differentiation

M Salmanidis, G Brumatti, N Narayan, BD Green, JA van den Bergen, JJ Sandow, AG Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, MJ Herold, GJ Goodall, AM Jabbour, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

MCl-1 is critically required for T-lymphocyte non-Hodgkin lymphoma cell survival

S Spinner, G Kelly, M Herold, K Pechloff, G Crispatzu, A Strasser, J Ruland, M Herling, C Peschel, P Jost

Conference Proceedings  |  2013  |  ONKOLOGIE

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3( ) regulatory T cells

Wim Pierson, Benedicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schonefeldt, Marco J Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A Freitas, Rita J Luther, Casey T Weaver, James Dooley, Daniel HD Gray, Adrian Liston

Journal article  |  2013  |  Nature Immunology

THE ROLE OF THE BCL-2 PROTEIN FAMILY TN TUMORIGENESIS AND CANCER THERAPY

Andreas Strasser, G Kelly, S Glaser, PN Kelly, S Grabow, A Delbridge, M Herold, JM Adams

Conference Proceedings  |  2013  |  Experimental Hematology

The transcription factor T-bet is essential for the development of NKp46( ) innate lymphocytes via the Notch pathway (vol 14, pg 389, 2013)

Lucille Rankin, Joanna R Groom, Michael Chopin, Marco J Herold, Jennifer A Walker, Lisa A Mielke, Andrew NJ McKenzie, Sebastian Carotta, Stephen L Nutt, Gabrielle T Belz

Journal article  |  2013  |  Nature Immunology

CD8( ) T cell help is required for efficient induction of EAE in Lewis rats

Monika Camara, Niklas Beyersdorf, Henrike J Fischer, Marco J Herold, Chi Wang Ip, Jens van den Brandt, Klaus V Toyka, Joel D Taurog, Thomas Huenig, Thomas Herrmann, Holger M Reichardt, Andreas Weishaupt, Thomas Kerkau

Journal article  |  2013  |  Journal of Neuroimmunology

CREB-binding protein (CBP) regulates beta-adrenoceptor (beta-AR) - mediated apoptosis

YY Lee, D Moujalled, M Doerflinger, L Gangoda, R Weston, A Rahimi, I de Alboran, M Herold, P Bouillet, Q Xu, X Gao, X-J Du, H Puthalakath

Journal article  |  2013  |  Cell Death & Differentiation

PEGylation of interferon alpha 2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases

Lisa M Kaminskas, David B Ascher, Victoria M McLeod, Marco J Herold, Caroline P Le, Erica K Sloan, Christopher JH Porter

Journal article  |  2013  |  Journal of Controlled Release

The transcription factor T-bet is essential for the development of NKp46( ) innate lymphocytes via the Notch pathway

Lucille C Rankin, Joanna R Groom, Michael Chopin, Marco J Herold, Jennifer A Walker, Lisa A Mielke, Andrew NJ McKenzie, Sebastian Carotta, Stephen L Nutt, Gabrielle T Belz

Journal article  |  2013  |  Nature Immunology

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Paul Koenen, Susanne Heinzel, Emma M Carrington, Lina Happo, Warren S Alexander, Jian-Guo Zhang, Marco J Herold, Clare L Scott, Andrew M Lew, Andreas Strasser, Philip D Hodgkin

Journal article  |  2013  |  Nature Communications

Glucocorticoid-Induced Apoptosis in Animal Models of Multiple Sclerosis

Marco J Herold, Holger M Reichardt

Journal article  |  2013  |  Critical Reviews in Immunology

The role of the anti-apoptotic Bcl-2 proteins Bcl-x(L) and Mcl-1 in survival of T-cell Non-Hodgkin's lymphoma

PJ Jost, S Spinner, G Kelly, M Herold, M Yabal, A Strasser, C Peschel

Conference Proceedings  |  2012  |  ONKOLOGIE

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens

Daniel HD Gray, Fiona Kupresanin, Stuart P Berzins, Marco J Herold, Lorraine A O'Reilly, Philippe Bouillet, Andreas Strasser

Journal article  |  2012  |  Immunity

A1/Bfl-1 in leukocyte development and cell death

Eleonora Ottina, Denise Tischner, Marco J Herold, Andreas Villunger

Journal article  |  2012  |  Experimental Cell Research

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

Eleonora Ottina, Francesca Grespi, Denise Tischner, Claudia Soratroi, Stephan Geley, Andreas Ploner, Holger M Reichardt, Andreas Villunger, Marco J Herold

Journal article  |  2012  |  Blood

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Stefan P Glaser, Erinna F Lee, Evelyn Trounson, Philippe Bouillet, Andrew Wei, W Douglas Fairlie, David J Izon, Johannes Zuber, Amy R Rappaport, Marco J Herold, Warren S Alexander, Scott W Lowe, Lorraine Robb, Andreas Strasser

Journal article  |  2012  |  Genes & Development

Acid Sphingomyelinase Is Required for Protection of Effector Memory T Cells against Glucocorticoid-Induced Cell Death

Denise Tischner, Jennifer Theiss, Anna Karabinskaya, Jens van den Brandt, Sybille D Reichardt, Ulrike Karow, Marco J Herold, Fred Luehder, Olaf Utermoehlen, Holger M Reichardt

Journal article  |  2011  |  The Journal of Immunology

Assessment of the near-Infrared Fluorescent Protein FP635 for Dynamic In Vivo Imaging in Models of Adaptive Immune Responses.

Simone S Riedel, Marco Herold, Markus Hirschberg, Christian Brede, Carina A Baeuerlein, Ana-Laura Jordaan-Garrote, Carolin Kiesel, Miriam Ritz, Jeanette Baker, Robert S Negrin, Hermann Einsele, Andreas Beilhack

Conference Proceedings  |  2009  |  BLOOD

Clearance of Measles Virus from Persistently Infected Cells by Short Hairpin RNA

Michael Zinke, Sabine Kendl, Katrin Singethan, Markus Fehrholz, Dajana Reuter, Linda Rennick, Marco J Herold, Juergen Schneider-Schaulies

Journal article  |  2009  |  Journal of Virology

Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: Insight into neuroinflammatory disease

Denise Tischner, Jens van den Brandt, Andreas Weishaupt, Fred Luehder, Marco J Herold, Holger M Reichardt

Journal article  |  2009  |  European Journal of Immunology

Reduced Expression of the Mevalonate Pathway Enzyme Farnesyl Pyrophosphate Synthase Unveils Recognition of Tumor Cells by V gamma 9V delta 2 T Cells

Jianqiang Li, Marco J Herold, Brigitte Kimmel, Ingrid Mueller, Bladimiro Rincon-Orozco, Volker Kunzmann, Thomas Herrmann

Journal article  |  2009  |  The Journal of Immunology

Proliferation Arrest in B-Raf Mutant Melanoma Cell Lines upon MAPK Pathway Activation

Roland Houben, Sonja Ortmann, Astrid Drasche, Jakob Troppmair, Marco J Herold, Juergen C Becker

Journal article  |  2009  |  Journal of Investigative Dermatology

Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats

Marco J Herold, Jens van den Brandt, Jost Seibler, Holger M Reichardt

Journal article  |  2008  |  Proceedings of the National Academy of Sciences

Gene silencing in encephalitogenic T cells by RNAi allows new insight into glucocorticoid therapy of EAE

Denise Tischner, Jens van den Brandt, Marco Herold, Holger Reichardt

Conference Proceedings  |  2008  |  JOURNAL OF NEUROIMMUNOLOGY

Silencing of the mineralocorticoid receptor by ribonucleic acid interference in transgenic rats disrupts endocrine homeostasis

Hee-Young Lim, Jens van den Brandt, Martin Fassnacht, Bruno Allolio, Marco J Herold, Holger M Reichardt

Journal article  |  2008  |  Molecular Endocrinology

Activation of the MAP kinase pathway induces apoptosis in the merkel cell carcinoma cell line UISO

Roland Houben, Sonja Ortmann, David Schrama, Marco J Herold, Ingolf Berberich, Holger M Reichardt, Juergen C Becker

Journal article  |  2007  |  Journal of Investigative Dermatology

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

Hee-Young Lim, Nora Mueller, Marco J Herold, Jens van den Brandt, Holger M Reichardt

Journal article  |  2007  |  Immunology

Activation of the MAP kinase pathway induces apoptosis in Merkel cell carcinoma

S Ortmann, R Houben, D Schrama, MJ Herold, I Berberich, HM Reichardt, JC Becker

Conference Proceedings  |  2007  |  EXPERIMENTAL DERMATOLOGY

The stability and anti-apoptotic function of A1 are controlled by its C terminus

MJ Herold, J Zeitz, C Pelzer, C Kraus, A Peters, G Wohlleben, I Berberich

Journal article  |  2006  |  Journal of Biological Chemistry

Glucocorticoids in T cell apoptosis and function

MJ Herold, KG McPherson, HM Reichardt

Journal article  |  2006  |  Cellular and Molecular Life Sciences

Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells

MJ Herold, AW Kuss, C Kraus, I Berberich

Journal article  |  2002  |  The Journal of Immunology