Marco Herold

CRISPR base editing applications for identifying cancer-driving mutations.

Martin Pal, Marco J Herold

Journal article  |  2021  |  Biochemical Society Transactions

CRISPR base editing technology is a promising genome editing tool as (i) it does not require a DNA template to introduce mutations..

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

Margaret A Potts, Jackson A McDonald, Kate D Sutherland, Marco J Herold

Journal article  |  2020  |  European Journal of Immunology

The mutational landscape of human cancers is highly complex. While next generation sequencing aims to comprehensively catalogue so..

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser

Journal article  |  2020  |  The EMBO Journal

Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis. However, lit..

Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Donia M Moujalled, Fiona C Brown, Giovanna Pomilio, Natasha S Anstee, Veronique Litalien, Ella R Thompson, Thomas Morley, Sarah MacRaild, Chong C Chua, SéBastien Banquet, Maia Chanrion, Ana-Leticia Maragno, Marie Schoumacher, Marco J Herold, Guillaume Lessene, Olivier Geneste, David CS Huang, Andrew W Roberts, Piers Blombery, Andrew Wei

Journal article  |  2020  |  Blood

Background: Recent randomized trials have demonstrated improvements in overall survival (OS) for the BCL-2 inhibito..

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

Pasquale L Fedele, Yang Liao, Jia-nan Gong, Yuan Yao, Mark F van Delft, Michael SY Low, Lin Tai, Marco J Herold, Jacob T Jackson, Charis E Teh, Tania Tan, Lorraine A O'Reilly, Julie Tellier, George Grigoriadis, David CS Huang, Wei Shi, Stephen L Nutt, Simon N Willis

Journal article  |  2020  |  Leukemia

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

Sarah A Best, Cassandra J Vandenberg, Etna Abad, Lachlan Whitehead, Laia Guiu, Sheryl Ding, Margs S Brennan, Andreas Strasser, Marco J Herold, Kate D Sutherland, Ana Janic

Journal article  |  2020  |  Cell Death and Disease

TP53 is a critical tumor suppressor that is mutated in approximately 50% of human cancers. Unveiling the downstream target genes o..

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

Christina Nedeva, Joseph Menassa, Mubing Duan, Chuanxin Liu, Marcel Doerflinger, Andrew J Kueh, Marco J Herold, Pamali Fonseka, Thanh Kha Phan, Pierre Faou, Harinda Rajapaksha, Weisan Chen, Mark D Hulett, Hamsa Puthalakath

Journal article  |  2020  |  Nature Immunology

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui, Marco J Herold, Andreas Strasser

Journal article  |  2020  |  Nature Reviews Molecular Cell Biology

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathway..

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Susanna S Ng, Fabian De Labastida Rivera, Juming Yan, Dillon Corvino, Indrajit Das, Ping Zhang, Rachel Kuns, Shashi Bhushan Chauhan, Jiajie Hou, Xian-Yang Li, Teija CM Frame, Benjamin A McEnroe, Eilish Moore, Jinrui Na, Jessica A Engel, Megan SF Soon, Bhawana Singh, Andrew J Kueh, Marco J Herold, Marcela Montes de Oca, et al.

Journal article  |  2020  |  Nature Immunology