Emma Josefsson

Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes

Man KS Lee, Michael J Kraakman, Dragana Dragoljevic, Nordin MJ Hanssen, Michelle C Flynn, Annas Al-Sharea, Gopalkrishna Sreejit, Camilla Bertuzzo-Veiga, Olivia D Cooney, Fatima Baig, Elizabeth Morriss, Mark E Cooper, Emma C Josefsson, Benjamin T Kile, Prabhakara R Nagareddy, Andrew J Murphy

Journal article  |  2021  |  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

OBJECTIVE: People with diabetes are at a significantly higher risk of cardiovascular disease, in part, due to accelerated atherosc..

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S Alexander, Emma C Josefsson

Journal article  |  2021  |  CELL DEATH & DISEASE

Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). P..

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

Emma C Josefsson, William Vainchenker, Chloe James

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have al..

Membrane budding is a major mechanism of in vivo platelet biogenesis

Kathryn S Potts, Alison Farley, Caleb A Dawson, Joel Rimes, Christine Biben, Carolyn de Graaf, Margaret A Potts, Olivia J Stonehouse, Amandine Carmagnac, Pradnya Gangatirkar, Emma C Josefsson, Casey Anttila, Daniela Amann-Zalcenstein, Shalin Naik, Warren S Alexander, Douglas J Hilton, Edwin D Hawkins, Samir Taoudi

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

How platelets are produced by megakaryocytes in vivo remains controversial despite more than a century of investigation. Megakaryo..

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma

Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon, Warren S Alexander, Kate D Sutherland, Emma C Josefsson

Journal article  |  2020  |  Oncogene

Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimenta..

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a singl..

Platelets disrupt vasculogenic mimicry by cancer cells

Carmela Martini, Emma J Thompson, Stephanie R Hyslop, Michaelia P Cockshell, Brian J Dale, Lisa M Ebert, Anthony E Woods, Emma C Josefsson, Claudine S Bonder

Journal article  |  2020  |  SCIENTIFIC REPORTS

Tumour vasculature supports the growth and progression of solid cancers with both angiogenesis (endothelial cell proliferation) an..

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E Au, Rachael M Lane, Katya J Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E Jarman, Sarah Ellis, Donald Metcalf, Shaun P Jackson, Simone M Schoenwaelder, Benjamin T Kile, Emma C Josefsson

Journal article  |  2018  |  BLOOD

The circulating life span of blood platelets is regulated by the prosurvival protein BCL-XL It restrains the activity of BAK and B..

N-methyl-D-aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell lines

Tania Kamal, Taryn N Green, James Hearn, Emma C Josefsson, Marie-Christine Morel-Kopp, Christopher M Ward, Matthew J During, Maggie L Kalev-Zylinska

Journal article  |  2018  |  RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS

Background: N-methyl-d-aspartate receptors (NMDARs) contribute calcium influx in megakaryocytic cells but their roles remain uncle..

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

Amanda E Au, Marion Lebois, Starling A Sim, Ping Cannon, Jason Corbin, Pradnya Gangatirkar, Craig D Hyland, Diane Moujalled, Angelika Rutgersson, Fatme Yassinson, Benjamin T Kile, Kylie D Mason, Ashley P Ng, Warren S Alexander, Emma C Josefsson

Journal article  |  2017  |  SCIENTIFIC REPORTS

Thrombopoietin (TPO) is the master cytokine regulator of megakaryopoiesis. In addition to regulation of megakaryocyte and platelet..