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MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3( )regulator..
Loss of NFKB1 Results in Expression of Tumor Necrosis Factor and Activation of STAT1 to Pr..
Displaying the 111 most recent scholarly works by Lorraine O'Reilly.
MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3( )regulatory T cells
Charis E Teh, Alissa K Robbins, Darren C Henstridge, Grant Dewson, Sarah T Diepstraten, Gemma Kelly, Mark A Febbraio, Sarah S Gabriel, Lorraine A O'Reilly, Andreas Strasser, Daniel HD Gray
Journal article | 2020 | Cell Death & Differentiation
FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related d..
Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice.
Yanhong Ni, Tami Yap, Natasha Silke, John Silke, Michael McCullough, Antonio Celentano, Lorraine A O'Reilly
Journal article | 2020 | Oral Diseases
Oral squamous cell carcinoma (OSCC) is a major subcategory of head and neck squamous cell carcinomas (HNSCC) and is currently the ..
Loss of NFKB1 Results in Expression of Tumor Necrosis Factor and Activation of STAT1 to Promote Gastric Tumorigenesis in Mice.
Jun T Low, Michael Christie, Matthias Ernst, Laure Dumoutier, Adele Preaudet, Yanhong Ni, Michael DW Griffin, Lisa A Mielke, Andreas Strasser, Tracy L Putoczki, Lorraine A O'Reilly
Journal article | 2020 | Gastroenterology
BACKGROUND & AIMS: Activity of NFkB transcription factors and signaling via STAT are frequently altered in gastric cancer cells. M..
Ptpn6 inhibits caspase-8-and Ripk3/Mlkl-dependent inflammation
Mary Speir, Cameron J Nowell, Alyce A Chen, Joanne A O'Donnell, Isaac S Shamie, Paul R Lakin, Akshay A D'Cruz, Roman O Braun, Jeff J Babon, Rowena S Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H Cengia, Anca I Stoica, Razq Hakem, Michelle A Kelliher, Lorraine A O'Reilly, Heather Patsiouras, Kate E Lawlor, et al.
Journal article | 2020 | Nature Immunology
Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-ind..
Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice
Prerak M Trivedi, Stacey Fynch, Lucy M Kennedy, Jonathan Chee, Balasubramanian Krishnamurthy, Lorraine A O'Reilly, Andreas Strasser, Thomas WH Kay, Helen E Thomas
Journal article | 2019 | Cell Death Discovery
CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two main effector pathways to kill ..
CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3( ) regulatory T cells
Antonia Polichen, Keisuke Horikawa, Liz Milla, Jennifer Kofler, Philippe Bouillet, Gabrielle T Belz, Lorraine A O'Reilly, Christopher C Goodnow, Andreas Strasser, Daniel HD Gray
Journal article | 2019 | Immunology & Cell Biology
FOXP3+ regulatory T (Treg) cells are essential for immunological tolerance and immune homeostasis. Despite a great deal of interes..
BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals
Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O'Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, et al.
Journal article | 2019 | Proceedings of the National Academy of Sciences
BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK, a multidomain BCL-2 family protein, is generally believed..
Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development
Brandon J Aubrey, Ana Janic, Yunshun Chen, Catherine Chang, Elizabeth C Lieschke, Sarah T Diepstraten, Andrew J Kueh, Jonathan P Bernardini, Grant Dewson, Lorraine A O'Reilly, Lachlan Whitehead, Anne K Voss, Gordon K Smyth, Andreas Strasser, Gemma L Kelly
Journal article | 2018 | Genes & Development
Loss of NF-kappa B1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner
Lorraine A O'Reilly, Tracy L Putoczki, Lisa A Mielke, Jun T Low, Ann Lin, Adele Preaudet, Marco J Herold, Kelvin Yaprianto, Lin Tai, Andrew Kueh, Guido Pacini, Richard L Ferrero, Raffi Gugasyan, Yifang Hu, Michael Christie, Stephen Wilcox, Raelene Grumont, Michael DW Griffin, Liam O'Connor, Gordon K Smyth, et al.
Journal article | 2018 | Immunity
Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C Lucchini, Remy Denzler, Muriel C Fisser, Tenagne D Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A O'Reilly, Markus Stoffel, Johan Auwerx, Daniel Konrad
Journal article | 2017 | Nature Communications
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.
Journal article | 2016 | NATURE COMMUNICATIONS
Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice
Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O'Reilly, Cody Allison, Marc Pellegrini, Richard S Hotchkiss, Hamsa Puthalakath
Journal article | 2016 | Scientific Reports
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser
Journal article | 2016 | Immunity
NF kappa B1 suppresses intestinal-type gastric cancer development by preventing chronic inflammation in the stomach
LA O'Reilly, TP Putoczki, L Mielke, A Lin, A Preaudet, JT Low, MJ Herold, L Tai, R Ferrero, Y Hu, R Grumont, G Smyth, M Ernst, P Waring, S Gerondakis, A Strasser
Conference Proceedings | 2016 | EUROPEAN JOURNAL OF IMMUNOLOGY
The NF-kappa B transcription factor RelA is required for the tolerogenic function of Foxp3( ) regulatory T cells
Nicole Messina, Thomas Fulford, Lorraine O'Reilly, Wen Xian Loh, Jessica M Motyer, Darcy Ellis, Catriona McLean, Haroon Naeem, Ann Lin, Raffi Gugasyan, Robyn M Slattery, Raelene J Grumont, Steve Gerondakis
Journal article | 2016 | Journal of Autoimmunity
NF kappa B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells
Elisha de Valle, George Grigoriadis, Lorraine A O'Reilly, Simon N Willis, Mhairi J Maxwell, Lynn M Corcoran, Evelyn Tsantikos, Jasper KS Cornish, Kirsten A Fairfax, Ajithkumar Vasanthakumar, Mark A Febbraio, Margaret L Hibbs, Marc Pellegrini, Ashish Banerjee, Philip D Hodgkin, Axel Kallies, Fabienne Mackay, Andreas Strasser, Steve Gerondakis, Raffi Gugasyan
Journal article | 2016 | Journal of Experimental Medicine
Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis
Mary Speir, Kate E Lawlor, Stefan P Glaser, Gilu Abraham, Seong Chow, Adam Vogrin, Keith E Schulze, Ralf Schuelein, Lorraine A O'Reilly, Kylie Mason, Elizabeth L Hartland, Trevor Lithgow, Andreas Strasser, Guillaume Lessene, David CS Huang, James E Vince, Thomas Naderer
Journal article | 2016 | Nature Microbiology
Erratum:Platelets induce apoptosis via membrane-bound FasL (Blood (2015) 126:12 (1483-1493))
RI Schleicher, F Reichenbach, P Kraft, A Kumar, M Lescan, F Todt, K Göbel, I Hilgendorf, T Geisler, A Bauer, M Olbrich, M Schaller, S Wesselborg, L O'Reilly, SG Meuth, K Schulze-Osthoff, M Gawaz, X Li, C Kleinschnitz, F Edlich, et al.
Journal article | 2016 | Blood
Platelets induce apoptosis via membrane-bound FasL.
Rebecca I Schleicher, Frank Reichenbach, Peter Kraft, Anil Kumar, Mario Lescan, Franziska Todt, Kerstin Göbel, Ingo Hilgendorf, Tobias Geisler, Axel Bauer, Marcus Olbrich, Martin Schaller, Sebastian Wesselborg, Lorraine O'Reilly, Sven G Meuth, Klaus Schulze-Osthoff, Meinrad Gawaz, Xuri Li, Christoph Kleinschnitz, Frank Edlich, et al.
Journal article | 2015 | Blood
After tissue injury, both wound sealing and apoptosis contribute to restoration of tissue integrity and functionality. Although th..
bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice
CA Duckworth, AA Abuderman, MD Burkitt, JM Williams, LA O'Reilly, DM Pritchard
Journal article | 2015 | American Journal of Physiology-Gastrointestinal and Liver Physiology
Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis
Derek Lacey, Peter Hickey, Benedicta D Arhatari, Lorraine A O'Reilly, Leona Rohrbeck, Helen Kiriazis, Xiao-Jun Du, Philippe Bouillet
Journal article | 2015 | Proceedings of the National Academy of Sciences
NF-B1, NF-B2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice
Michael D Burkitt, Abdalla F Hanedi, Carrie A Duckworth, Jonathan M Williams, Joseph M Tang, Lorraine A O'Reilly, Tracy L Putoczki, Steve Gerondakis, Rod Dimaline, Jorge H Caamano, D Mark Pritchard
Journal article | 2015 | The Journal of Pathology
FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production
Danyal Butt, Tyani D Chan, Katherine Bourne, Jana R Hermes, Akira Nguyen, Aaron Statham, Lorraine A O'Reilly, Andreas Strasser, Susan Price, Peter Schofield, Daniel Christ, Antony Basten, Cindy S Ma, Stuart G Tangye, Giang Phan Tri, V Koneti Rao, Robert Brink
Journal article | 2015 | Immunity
Fas regulates neutrophil lifespan during viral and bacterial infection
Joanne A O'Donnell, Catherine L Kennedy, Marc Pellegrini, Cameron J Nowell, Jian-Guo Zhang, Lorraine A O'Reilly, Louise Cengia, Stuart Dias, Seth L Masters, Elizabeth L Hartland, Andrew W Roberts, Motti Gerlic, Ben A Croker
Journal article | 2015 | Journal of Leukocyte Biology
TRAIL( ) NK Cells Control CD4( ) T Cell Responses during Chronic Viral Infection to Limit Autoimmunity
Iona S Schuster, Matthew E Wikstrom, Geraldine Brizard, Jerome D Coudert, Marie J Estcourt, Mitali Manzur, Lorraine A O'Reilly, Mark J Smyth, Joseph A Trapani, Geoffrey R Hill, Christopher E Andoniou, Mariapia A Degli-Esposti
Journal article | 2014 | Immunity
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi-Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, James E Vince
Journal article | 2014 | EMBO reports
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner
W Wei-Lynn Wong, James E Vince, Najoua Lalaoui, Kate E Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O'Reilly, Philipp J Jost, James M Murphy, Warren S Alexander, Andreas Strasser, David L Vaux, John Silke
Journal article | 2014 | Blood
Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas
Shoukat Afshar-Sterle, Dimitra Zotos, Nicholas J Bernard, Anna K Scherger, Lisa Roedling, Amber E Alsop, Jennifer Walker, Frederick Masson, Gabrielle T Belz, Lynn M Corcoran, Lorraine A O'Reilly, Andreas Strasser, Mark J Smyth, Ricky Johnstone, David M Tarlinton, Stephen L Nutt, Axel Kallies
Journal article | 2014 | Nature Medicine
Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways
Emma C Josefsson, Deborah L Burnett, Marion Lebois, Marlyse A Debrincat, Michael J White, Katya J Henley, Rachael M Lane, Diane Moujalled, Simon P Preston, Lorraine A O'Reilly, Marc Pellegrini, Donald Metcalf, Andreas Strasser, Benjamin T Kile
Journal article | 2014 | Nature Communications
The TACI Receptor Regulates T-Cell-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death
William A Figgett, Kirsten Fairfax, Fabien B Vincent, Melanie A Le Page, Indzi Katik, Devy Deliyanti, Shie Quah Pin, Pali Verma, Raelene Grumont, Steve Gerondakis, Paul Hertzog, Lorraine A O'Reilly, Andreas Strasser, Fabienne Mackay
Journal article | 2013 | Immunity
A type III effector antagonizes death receptor signalling during bacterial gut infection
Jaclyn S Pearson, Cristina Giogha, Sze Ying Ong, Catherine L Kennedy, Michelle Kelly, Keith S Robinson, Tania Wong Fok Lung, Ashley Mansell, Patrice Riedmaier, Clare VL Oates, Ali Zaid, Sabrina Muehlen, Valerie F Crepin, Olivier Marches, Ching-Seng Ang, Nicholas A Williamson, Lorraine A O'Reilly, Aleksandra Bankovacki, Ueli Nachbur, Giuseppe Infusini, et al.
Journal article | 2013 | Nature
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
Kylie D Mason, Ann Lin, Lorraine Robb, Emma C Josefsson, Katya J Henley, Daniel HD Gray, Benjamin T Kile, Andrew W Roberts, Andreas Strasser, David CS Huang, Paul Waring, Lorraine A O'Reilly
Journal article | 2013 | Proceedings of the National Academy of Sciences of the United States of America
The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments
Jian-Guo Zhang, Peter E Czabotar, Antonia N Policheni, Irina Caminschi, Soo San Wan, Susie Kitsoulis, Kirsteen M Tullett, Adeline Y Robin, Rajini Brammananth, Mark F van Delft, Jinhua Lu, Lorraine A O'Reilly, Emma C Josefsson, Benjamin T Kile, Wei Jin Chin, Justine D Mintern, Maya A Olshina, Wilson Wong, Jake Baum, Mark D Wright, et al.
Journal article | 2012 | IMMUNITY
Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
James E Vince, W Wei-Lynn Wong, Ian Gentle, Kate E Lawlor, Ramanjaneyulu Allam, Lorraine O'Reilly, Kylie Mason, Olaf Gross, Stephen Ma, Greta Guarda, Holly Anderton, Rosa Castillo, Georg Haecker, John Silke, Juerg Tschopp
Journal article | 2012 | Immunity
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
Emma C Josefsson, Chloe James, Katya J Henley, Marlyse A Debrincat, Kelly L Rogers, Mark R Dowling, Michael J White, Elizabeth A Kruse, Rachael M Lane, Sarah Ellis, Paquita Nurden, Kylie D Mason, Lorraine A O'Reilly, Andrew W Roberts, Donald Metcalf, David CS Huang, Benjamin T Kile
Journal article | 2011 | Journal of Experimental Medicine
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1
Ben A Croker, Joanne A O'Donnell, Cameron J Nowell, Donald Metcalf, Grant Dewson, Kirsteen J Campbell, Kelly L Rogers, Yifang Hu, Gordon K Smyth, Jian-Guo Zhang, Michael White, Kurt Lackovic, Louise H Cengia, Lorraine A O'Reilly, Philippe Bouillet, Suzanne Cory, Andreas Strasser, Andrew W Roberts
Journal article | 2011 | Proceedings of the National Academy of Sciences of the United States of America
Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells
Edwina Naik, Lorraine A O'Reilly, Marie-Liesse Asselin-Labat, Delphine Merino, Ann Lin, Michele Cook, Leigh Coultas, Philippe Bouillet, Jerry M Adams, Andreas Strasser
Journal article | 2011 | Journal of Experimental Medicine
Type I Interferon Drives Dendritic Cell Apoptosis via Multiple BH3-Only Proteins following Activation by PolyIC In Vivo
Silvia A Fuertes Marraco, Clare L Scott, Philippe Bouillet, Annette Ives, Slavica Masina, David Vremec, Elisa S Jansen, Lorraine A O'Reilly, Pascal Schneider, Nicolas Fasel, Ken Shortman, Andreas Strasser, Hans Acha-Orbea
Journal article | 2011 | PLoS One
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
Simone M Schoenwaelder, Yuping Yuan, Emma C Josefsson, Michael J White, Yu Yao, Kylie D Mason, Lorraine A O'Reilly, Katya J Henley, Akiko Ono, Sarah Hsiao, Abbey Willcox, Andrew W Roberts, David CS Huang, Hatem H Salem, Benjamin T Kile, Shaun P Jackson
Journal article | 2009 | Blood
Intrahepatic murine CD8 T-Cell activation associates with a distinct phenotype leading to Bim-dependent death
Lauren E Holz, Volker Benseler, David G Bowen, Philippe Bouillet, Andreas Strasser, Lorraine O'Reilly, William MH D'Avigdor, Alex G Bishop, Geoffrey W McCaughan, Patrick Bertolino
Journal article | 2008 | Gastroenterology
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
Verena Labi, Miriam Erlacher, Stephan Kiessling, Claudia Manzl, Anna Frenzel, Lorraine O'Reilly, Andreas Strasser, Andreas Villunger
Journal article | 2008 | J. Exp. Med.
Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia
J Kuroda, S Kimura, A Strasser, M Andreeff, LA O'Reilly, E Ashihara, Y Kamitsuji, A Yokota, E Kawata, M Takeuchi, R Tanaka, Y Tabe, M Taniwaki, T Maekawa
Journal article | 2007 | Cell Death Differ.
ER stress triggers apoptosis by activating BH3-only protein Bim
Hamsa Puthalakath, Lorraine A O'Reilly, Priscilla Gunn, Lily Lee, Priscilla N Kelly, Nicholas D Huntington, Peter D Hughes, Ewa M Michalak, Jennifer McKimm-Breschkin, Noburo Motoyama, Tomomi Gotoh, Shizuo Akira, Philippe Bouillet, Andreas Strasser
Journal article | 2007 | Cell
Patients with chronic pancreatitis have islet progenitor cells in their ducts, but reversal of overt diabetes in NOD mice by anti-CD3 shows no evidence for islet regeneration.
Jenny M Phillips, Lorraine O'Reilly, Chris Bland, Alan K Foulis, Anne Cooke
Journal article | 2007 | Diabetes
Monoclonal antibodies to T-cell coreceptors have been shown to tolerise autoreactive T-cells and prevent or even reverse autoimmun..
Subversion of the Bcl-2 life/death switch in cancer development and therapy
JM Adams, DCS Huang, A Strasser, S Willis, L Chen, A Wei, M Van Delft, JI Fletcher, H Puthalakath, J Kuroda, EM Michalak, PN Kelly, P Bouillet, A Villunger, L O'Reilly, ML Bath, DP Smith, A Egle, AW Harris, M Hinds, et al.
Journal article | 2005 | Cold Spring Harbor Symp. Quant. Biol.
Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim
A Liston, S Lesage, DHD Gray, LA O'Reilly, A Strasser, AM Fahrer, RL Boyd, J Wilson, AG Baxter, EM Gallo, GR Crabtree, KM Peng, SR Wilson, CC Goodnow
Journal article | 2004 | Immunity
Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine
DM Pritchard, C Print, L O'Reilly, JM Adams, CS Potten, JA Hickman
Journal article | 2000 | Oncogene
The potential role of the bcl-2 relative bcl-w as a physiological regulator of apoptosis in intestinal epithelia has been investig..
Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins
JM Adams, DCS Huang, H Puthalakath, P Bouillet, G Vairo, K Moriishi, G Hausmann, L O'Reilly, K Newton, S Ogilvy, ML Bath, CG Print, AW Harris, A Strasser, S Cory
Conference Proceedings | 1999 | Cold Spring Harbor Symposia on Quantitative Biology
B lymphocytes differentially use the Rel and nuclear factor kappa B1 (NF-kappa B1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
RJ Grumont, IJ Rourke, LA O'Reilly, A Strasser, K Miyake, W Sha, S Gerondakis
Journal article | 1998 | Journal of Experimental Medicine
Lessons from bcl-2 transgenic mice for immunology, cancer biology and cell death research.
A Strasser, L O'Connor, DC Huang, LA O'Reilly, ML Stanley, ML Bath, JM Adams, S Cory, AW Harris
Journal article | 1996 | Behring Institute Mitteilungen
The protein product of the proto-oncogene bcl-2, originally discovered by virtue of its chromosomal translocation in human follicu..
The role of infiltrating macrophages in islet destruction and regrowth in a transgenic model.
D Gu, L O'Reilly, L Molony, A Cooke, N Sarvetnick
Journal article | 1995 | Journal of Autoimmunity
The expression of interferon-gamma (IFN-gamma) in pancreatic beta cells leads to a complex pathology that represents the processes..
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus.
R Quartey-Papafio, T Lund, P Chandler, J Picard, P Ozegbe, S Day, PR Hutchings, L O'Reilly, D Kioussis, E Simpson
Journal article | 1995 | Journal of Immunology
MHC class II genes have been shown to influence the development of the autoimmune disease insulin-dependent diabetes mellitus (IDD..
Tolerance induction as a therapeutic strategy for the control of autoimmune endocrine disease in mouse models.
NM Parish, PR Hutchings, L O'Reilly, R Quartey-Papafio, D Healey, P Ozegbe, A Cooke
Journal article | 1995 | Immunological Reviews
This chapter aims to describe ways in which autoimmunity can be prevented or reversed and 'self-tolerance' re-established. To this..
Non-diabetogenic insulitis in NODB10.GD allophenic mice in spite of permissive class I MHC antigens.
F Colucci, U Dahl, L O'Reilly, A Cooke, P Chandler, E Simpson, T Matsunaga
Journal article | 1994 | Scandinavian Journal of Immunology
Allophenic mice (embryo aggregation mouse chimeras) enable us to dissect the process of spontaneous autoimmunity under physiologic..
Studies on the thymus of non-obese diabetic (NOD) mice: effect of transgene expression.
LA O'Reilly, D Healey, E Simpson, P Chandler, T Lund, MA Ritter, A Cooke
Journal article | 1994 | Immunology
The non-obese diabetic (NOD) mouse is a good model of insulin-dependent diabetes mellitus. Autoreactive T cells may play a fundame..
Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism.
SD Husbands, G Schönrich, B Arnold, PR Chandler, E Simpson, KL Philpott, P Tomlinson, L O'Reilly, A Cooke, AL Mellor
Journal article | 1992 | European Journal of Immunology
Transgenic CBA (H-2k haplotype) mice expressing the H-2 Kb major histocompatibility complex (MHC) class I gene under control of tr..
Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression.
LA O'Reilly, PR Hutchings, PR Crocker, E Simpson, T Lund, D Kioussis, F Takei, J Baird, A Cooke
Journal article | 1991 | European Journal of Immunology
Insulin-dependent diabetes mellitus can be transferred into young irradiated non-obese diabetic (NOD) mice by spleen cells from a ..
Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages.
P Hutchings, H Rosen, L O'Reilly, E Simpson, S Gordon, A Cooke
Journal article | 1990 | Nature
Insulin-dependent diabetes mellitus (IDDM) is a disease with an autoimmune aetiology. The non-obese diabetic mouse is a good spont..
Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain.
T Lund, L O'Reilly, P Hutchings, O Kanagawa, E Simpson, R Gravely, P Chandler, J Dyson, JK Picard, A Edwards
Journal article | 1990 | Nature
Insulin-dependent diabetes mellitus (IDDM) is a disease with an autoimmune aetiology. The inbred non-obese diabetic (NOD) mouse st..
The involvement of Ly2 T cells in beta cell destruction.
PR Hutchings, E Simpson, LA O'Reilly, T Lund, H Waldmann, A Cooke
Journal article | 1990 | Journal of Autoimmunity
The non-obese diabetic (NOD) mouse is considered to be a good model of human Type I diabetes mellitus. Both sexes develop insuliti..
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Medical Biology (W.E.H.I.)