Robyn Sutherland

CIS controls the functional polarization of GM-CSF-derived macrophages

Shengbo Zhang, Jai Rautela, Naiara G Bediaga, Tatiana B Kolesnik, Yue You, Junli Nie, Laura F Dagley, Justin Bedo, Hanqing Wang, Li Sun, Robyn Sutherland, Elliot Surgenor, Nadia Iannarella, Rhys Allan, Fernando Souza-Fonseca-Guimaraes, Yi Xie, Qike Wang, Yuxia Zhang, Yuekang Xu, Stephen L Nutt, et al.

Journal article  |  2022  |  CELLULAR & MOLECULAR IMMUNOLOGY

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macr..

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Emma M Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R Keenan, Nadia Iannarella, Rhys S Allan, Ahmad Z Wardak, Peter E Czabotar, Marco J Herold, Robyn L Schenk, Christine A White, Damian D'Silva, Yuyan Yang, Wesley Wong, Huon Wong, Vanessa L Bryant, Nicholas D Huntington, Jai Rautela, Robyn M Sutherland, et al.

Journal article  |  2021  |  BLOOD ADVANCES

Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged n..

Prevention of Islet Inflammatory Stress with JAK1/JAK2 Inhibitors

Eleanor Watson, Michaela Waibel, Prerak Trivedi, Evan Pappas, Stacey Fynch, Robyn Sutherland, Thomas Kay, Helen Thomas

Conference Proceedings  |  2018  |  TRANSPLANTATION

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  DIABETES

Recent advances in immunotherapeutics have not yet changed the routine management of autoimmune type 1 diabetes. There is an oppor..

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew

Journal article  |  2017  |  CELL DEATH AND DIFFERENTIATION

Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family m..

Cognate antigen engagement on parenchymal cells stimulates CD8( ) T cell proliferation in situ

Robyn M Sutherland, Sarah L Londrigan, Jamie L Brady, Emma M Carrington, Julia M Marchingo, Susanne Heinzel, Philip D Hodgkin, Kate L Graham, Thomas W Kay, Yifan Zhan, Andrew M Lew

Journal article  |  2017  |  NATURE COMMUNICATIONS

T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then..

Heterogeneity, functional specialization and differentiation of monocyte-derived dendritic cells

Kevin V Chow, Robyn M Sutherland, Yifan Zhan, Andrew M Lew

Journal article  |  2017  |  IMMUNOLOGY AND CELL BIOLOGY

Dendritic cells (DCs) are professional antigen-presenting cells that consist of functionally and phenotypically heterogeneous popu..

Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation

Kevin V Chow, Emma M Carrington, Yifan Zhan, Andrew M Lew, Robyn M Sutherland

Journal article  |  2017  |  CELL TRANSPLANTATION

Islet transplantation can cure type 1 diabetes but is limited by lack of donor organs and early graft dysfunction, such that many ..

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

Kevin V Chow, Rebecca B Delconte, Nicholas D Huntington, David M Tarlinton, Robyn M Sutherland, Yifan Zhan, Andrew M Lew

Journal article  |  2016  |  JOURNAL OF IMMUNOLOGY

Although the mechanisms governing the innate recognition of pathogen-associated molecular patterns have been well defined, how all..

Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation

Kevin V Chow, Andrew M Lew, Robyn M Sutherland, Yifan Zhan

Journal article  |  2016  |  JOURNAL OF IMMUNOLOGY

Monocyte-derived dendritic cells (moDCs) dramatically increase in numbers upon infection and inflammation; accordingly, we found t..