Samir Taoudi

Vaccine-induced immune thrombosis and thrombocytopenia syndrome following adenovirus-vectored severe acute respiratory syndrome coronavirus 2 vaccination: a novel hypothesis regarding mechanisms and implications for future vaccine development

Paul Monagle, Ashley P Ng, Matthew Linden, Vera Ignjatovic, Alison Farley, Samir Taoudi, Sant Rayn Pasricha, Joseph Torresi

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

We hypothesize that thrombosis with thrombocytopenia syndrome recently described after administration of adenovirus-vectored vacci..

Severe thrombocytopenia is sufficient for fetal and neonatal intracerebral hemorrhage to occur

Alison Farley, Sarah Lloyd, Merle Dayton, Christine Biben, Olivia Stonehouse, Samir Taoudi

Journal article  |  2021  |  BLOOD

Intracerebral hemorrhage (ICH) has a devastating impact on the neonatal population. Whether thrombocytopenia is sufficient to caus..

Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development

Dawn S Lin, Luyi Tian, Sara Tomei, Daniela Amann-Zalcenstein, Tracey M Baldwin, Tom S Weber, Jaring Schreuder, Olivia J Stonehouse, Jai Rautela, Nicholas D Huntington, Samir Taoudi, Matthew E Ritchie, Philip D Hodgkin, Ashley P Ng, Stephen L Nutt, Shalin H Naik

Journal article  |  2021  |  NATURE CELL BIOLOGY

Regulation of haematopoietic stem and progenitor cell (HSPC) fate is crucial during homeostasis and under stress conditions. Here ..

A new lymphoid-primed progenitor marked byDach1downregulation identified with single cell multi-omics

Daniela Amann-Zalcenstein, Luyi Tian, Jaring Schreuder, Sara Tomei, Dawn S Lin, Kirsten A Fairfax, Jessica E Bolden, Mark D McKenzie, Andrew Jarratt, Adrienne Hilton, Jacob T Jackson, Ladina Di Rago, Matthew P McCormack, Carolyn A de Graaf, Olivia Stonehouse, Samir Taoudi, Warren S Alexander, Stephen L Nutt, Matthew E Ritchie, Ashley P Ng, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-rest..

Membrane budding is a major mechanism of in vivo platelet biogenesis

Kathryn S Potts, Alison Farley, Caleb A Dawson, Joel Rimes, Christine Biben, Carolyn de Graaf, Margaret A Potts, Olivia J Stonehouse, Amandine Carmagnac, Pradnya Gangatirkar, Emma C Josefsson, Casey Anttila, Daniela Amann-Zalcenstein, Shalin Naik, Warren S Alexander, Douglas J Hilton, Edwin D Hawkins, Samir Taoudi

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

How platelets are produced by megakaryocytes in vivo remains controversial despite more than a century of investigation. Megakaryo..

Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo

Jennifer Easterbrook, Stanislav Rybtsov, Sabrina Gordon-Keylock, Andrejs Ivanovs, Samir Taoudi, Richard A Anderson, Alexander Medvinsky

Journal article  |  2019  |  STEM CELL REPORTS

Definitive hematopoietic stem cells (HSCs) first emerge in the aorta-gonad-mesonephros (AGM) region in both mice and humans. An ex..

NOTCHing down a win for megakaryocytes

Samir Taoudi

Journal article  |  2018  |  BLOOD

High-Jaking the blood: resistance is fetal

Samir Taoudi

Journal article  |  2016  |  BLOOD

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

Celine Souilhol, Christele Gonneau, Javier G Lendinez, Antoniana Batsivari, Stanislav Rybtsov, Heather Wilson, Lucia Morgado-Palacin, David Hills, Samir Taoudi, Jennifer Antonchuk, Suling Zhao, Alexander Medvinsky

Journal article  |  2016  |  NATURE COMMUNICATIONS

During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially in the ventral domain of the aorta in t..

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL

Kathryn S Potts, Tobias J Sargeant, Caleb A Dawson, Emma C Josefsson, Douglas J Hilton, Warren S Alexander, Samir Taoudi

Journal article  |  2015  |  BLOOD

The thrombopoietic environment of the neonate is established during prenatal life; therefore, a comprehensive understanding of pla..