Justin Boddey

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL -mediated Necroptosis From Contributing to Liver Pathologies

Simon P Preston, Michael D Stutz, Cody C Allison, Ueli Nachbur, Quentin Gouil, Manh Tran Bang, Valerie Duvivier, Philip Arandjelovic, James P Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, et al.

Journal article  |  2022  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury incl..

The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria

Manuel de Lera Ruiz, Paola Favuzza, Zhuyan Guo, Lianyun Zhao, Bin Hu, Zhiyu Lei, Dongmei Zhan, Nicholas Murgolo, Christopher W Boyce, Marissa Vavrek, Jennifer Thompson, Anna Ngo, Kate E Jarman, Johnathan Robbins, Justin Boddey, Brad E Sleebs, Kym N Lowes, Alan F Cowman, David B Olsen, John A McCauley

Journal article  |  2022  |  ACS MEDICINAL CHEMISTRY LETTERS

Drug resistance to first-line antimalarials-including artemisinin-is increasing, resulting in a critical need for the discovery of..

Editorial: Molecular Approaches to Malaria 2020.

Tania F de Koning-Ward, Justin A Boddey, Freya JI Fowkes

Journal article  |  2022  |  Int J Parasitol

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission (vol 13, 1400, 2022)

Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan WJ Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal article  |  2022  |  NATURE COMMUNICATIONS

The original version of this Article incorrectly cited reference 85 instead of reference 84 in the methods section ‘An. stephensi ..

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan WJ Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal article  |  2022  |  NATURE COMMUNICATIONS

Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmo..

Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive gamma delta T cell repertoire

Anouk von Borstel, Priyanka Chevour, Daniel Arsovski, Jelte MM Krol, Lauren J Howson, Andrea A Berry, Cheryl L Day, Paul Ogongo, Joel D Ernst, Effie YH Nomicos, Justin A Boddey, Edward M Giles, Jamie Rossjohn, Boubacar Traore, Kirsten E Lyke, Kim C Williamson, Peter D Crompton, Martin S Davey

Journal article  |  2021  |  SCIENCE TRANSLATIONAL MEDICINE

Repeated Plasmodium falciparum infections drive the development of clinical immunity to malaria in humans; however, the immunologi..

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites

Benjamin J Evert, Shuxiong Chen, Robyn McConville, Ryan WJ Steel, Julie Healer, Justin A Boddey, Lucas Huntimer, Bernd HA Rehm

Journal article  |  2021  |  NPJ VACCINES

The current Malaria RTS,S vaccine is based on virus-like particles (VLPs) comprising the NANP repetitive epitopes from the cicumsp..

Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity

Trent D Ashton, Anna Ngo, Paola Favuzza, Hayley E Bullen, Maria R Gancheva, Ornella Romeo, Molly Parkyn Schneider, Nghi Nguyen, Ryan WJ Steel, Sandra Duffy, Kym N Lowes, Helene Jousset Sabroux, Vicky M Avery, Justin A Boddey, Danny W Wilson, Alan F Cowman, Paul R Gilson, Brad E Sleebs

Journal article  |  2021  |  BIOORGANIC CHEMISTRY

Malaria is a devastating disease caused by Plasmodium parasites. Emerging resistance against current antimalarial therapeutics has..

Molecular approaches to Malaria 2020

Tania F de Koning-Ward, Justin A Boddey, Freya JI Fowkes

Journal article  |  2020  |  CELLULAR MICROBIOLOGY

Twenty years ago the Molecular Approaches to Malaria conference was conceived as a forum to present the very latest advances in ma..

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Paola Favuzza, Manuel de Lera Ruiz, Jennifer K Thompson, Tony Triglia, Anna Ngo, Ryan WJ Steel, Marissa Vavrek, Janni Christensen, Julie Healer, Christopher Boyce, Zhuyan Guo, Mengwei Hu, Tanweer Khan, Nicholas Murgolo, Lianyun Zhao, Jocelyn Sietsma Penington, Kitsanapong Reaksudsan, Kate Jarman, Melanie H Dietrich, Lachlan Richardson, et al.

Journal article  |  2020  |  CELL HOST & MICROBE

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmo..