Lin Chen

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article  |  2017  |  eLife

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes

Jennifer C Volz, Alan Yap, Xavier Sisquella, Jenn K Thompson, Nicholas TY Lim, Lachlan W Whitehead, Lin Chen, Marko Lampe, Wai-Hong Tham, Danny Wilson, Thomas Nebl, Danushka Marapana, Tony Triglia, Wilson Wong, Kelly L Rogers, Alan F Cowman

Journal article  |  2016  |  Cell Host & Microbe

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman

Journal article  |  2014  |  eLife

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

Chris YH Chiu, Julie Healer, Jennifer K Thompson, Lin Chen, Aiki Kaul, Laxman Savergave, Arjun Raghuwanshi, Connie SN Li Wai Suen, Peter M Siba, Louis Schofield, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2014  |  Frontiers in Microbiology

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

Journal article  |  2013  |  PLoS One

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  Journal of Medicinal Chemistry

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

Lin Chen, Sash Lopaticki, David T Riglar, Chaitali Dekiwadia, Alex D Uboldi, Wai-Hong Tham, Matthew T O'Neill, Dave Richard, Jake Baum, Stuart A Ralph, Alan F Cowman

Journal article  |  2011  |  PLoS Pathogens

Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains

Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman

Journal article  |  2011  |  PLoS Pathogens

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

Rachel T Uren, Grant Dewson, Lin Chen, Stephanie C Coyne, David CS Huang, Jerry M Adams, Ruth M Kluck

Journal article  |  2007  |  Journal of Cell Biology