Lin Chen

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article  |  2017  |  ELIFE

Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of ery..

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes

Jennifer C Volz, Alan Yap, Xavier Sisquella, Jenn K Thompson, Nicholas TY Lim, Lachlan W Whitehead, Lin Chen, Marko Lampe, Wai-Hong Tham, Danny Wilson, Thomas Nebl, Danushka Marapana, Tony Triglia, Wilson Wong, Kelly L Rogers, Alan F Cowman

Journal article  |  2016  |  CELL HOST & MICROBE

Plasmodium falciparum parasites in the merozoite stage invade human erythrocytes and cause malaria. Invasion requires multiple int..

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman

Journal article  |  2014  |  ELIFE

Plasmodium falciparum causes the most severe form of malaria in humans and is responsible for over 700,000 deaths annually. It is ..

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

Chris YH Chiu, Julie Healer, Jennifer K Thompson, Lin Chen, Aiki Kaul, Laxman Savergave, Arjun Raghuwanshi, Connie SN Li Wai Suen, Peter M Siba, Louis Schofield, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2014  |  FRONTIERS IN MICROBIOLOGY

Emerging evidence suggests that antibodies against merozoite proteins involved in Plasmodium falciparum invasion into the red bloo..

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

Journal article  |  2013  |  PLOS ONE

BACKGROUND: A highly effective vaccine against Plasmodium falciparum malaria should induce potent, strain transcending immunity th..

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  JOURNAL OF MEDICINAL CHEMISTRY

Developing potent molecules that inhibit Bcl-2 family mediated apoptosis affords opportunities to treat cancers via reactivation o..

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

Lin Chen, Sash Lopaticki, David T Riglar, Chaitali Dekiwadia, Alex D Uboldi, Wai-Hong Tham, Matthew T O'Neill, Dave Richard, Jake Baum, Stuart A Ralph, Alan F Cowman

Journal article  |  2011  |  PLOS PATHOGENS

Invasion of erythrocytes by Plasmodium falciparum involves a complex cascade of protein-protein interactions between parasite liga..

Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains

Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman

Journal article  |  2011  |  PLOS PATHOGENS

Plasmodium falciparum, the causative agent of the most severe form of malaria in humans invades erythrocytes using multiple ligand..

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

Rachel T Uren, Grant Dewson, Lin Chen, Stephanie C Coyne, David CS Huang, Jerry M Adams, Ruth M Kluck

Journal article  |  2007  |  JOURNAL OF CELL BIOLOGY

The Bcl-2 family regulates apoptosis by controlling mitochondrial integrity. To clarify whether its prosurvival members function b..